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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:limb ischemia
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Accession:DOID:0050852 term browser browse the term
Definition:An ischemia that is characterized by low blood supply to tissues in the limb due to interruption in the arterial blood supply. (DO)


show annotations for term's descendants           Sort by:
limb ischemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a IMP RGD PMID:11877468 RGD:737810 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 IMP RGD PMID:26315408 RGD:14367880 NCBI chr 9:71,123,071...71,203,525
Ensembl chr 9:71,123,071...71,203,525 		JBrowse link
G Cs citrate synthase ISO RGD PMID:571116 RGD:243049254 NCBI chr10:128,173,596...128,198,351
Ensembl chr10:128,173,603...128,198,348 		JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) IEP protein:increased expression:plasma: RGD PMID:16648859 RGD:10449511 NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493 		JBrowse link
G Csf3 colony stimulating factor 3 (granulocyte) treatment ISO RGD PMID:23294128 PMID:16224058 RGD:10400895, RGD:11039414 NCBI chr11:98,591,287...98,594,457
Ensembl chr11:98,592,089...98,594,455 		JBrowse link
G Dll4 delta like canonical Notch ligand 4 exacerbates
ameliorates		 IMP
ISO		 RGD PMID:20508179 PMID:35301145 PMID:22252294 RGD:155641249, RGD:155663375, RGD:155663358 NCBI chr 2:119,156,286...119,166,145
Ensembl chr 2:119,156,265...119,166,443 		JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:23294128 RGD:10400895 NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504 		JBrowse link
G Etv2 ets variant 2 exacerbates
ameliorates		 IMP
ISO
IDA		 RGD PMID:26586661 PMID:28466428 PMID:32075417 PMID:28424975 PMID:28424975 RGD:11076207, RGD:192379484, RGD:192186227, RGD:156451664, RGD:156451664 NCBI chr 7:30,333,041...30,335,934
Ensembl chr 7:30,333,041...30,335,277 		JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 treatment ISO RGD PMID:25388665 RGD:11568031 NCBI chr 8:26,008,808...26,067,819
Ensembl chr 8:26,003,670...26,065,734 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 treatment ISO RGD PMID:26604244 RGD:13514042 NCBI chr19:4,336,029...4,356,356
Ensembl chr19:4,336,029...4,356,250 		JBrowse link
G Hgf hepatocyte growth factor treatment ISO RGD PMID:15238569 RGD:8548639 NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit ISO protein:increased expression:skeletal muscle RGD PMID:17522350 RGD:1626332 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Hmox1 heme oxygenase 1 ISO RGD PMID:12593860 RGD:1598394 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Itgam integrin alpha M ISO protein:increased expression:monocyte (human) RGD PMID:20816321 RGD:329901827 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663 		JBrowse link
G Itgav integrin alpha V IEP RGD PMID:15750161 RGD:1582449 NCBI chr 2:83,554,796...83,637,261
Ensembl chr 2:83,554,741...83,637,260 		JBrowse link
G Mir126a microRNA 126a ameliorates IDA
IMP		 associated with type 1 diabetes mellitus; RGD PMID:29242072 PMID:35151721 RGD:401851035, RGD:401851044 NCBI chr 2:26,481,369...26,481,441
Ensembl chr 2:26,481,369...26,481,441 		JBrowse link
G Mir210 microRNA 210 severity IMP RGD PMID:31878120 RGD:155882482 NCBI chr 7:140,801,297...140,801,406
Ensembl chr 7:140,801,297...140,801,406 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell treatment ISO associated with Diabetes Mellitus, Experimental
human gene in rat model		 RGD PMID:19080171 PMID:12171788 PMID:28979692 RGD:7794710, RGD:7794776, RGD:13450931 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Pecam1 platelet/endothelial cell adhesion molecule 1 IDA RGD PMID:22369073 PMID:21940947 RGD:6767285, RGD:6906905 NCBI chr11:106,545,039...106,606,107
Ensembl chr11:106,545,043...106,641,454 		JBrowse link
G Ppbp pro-platelet basic protein ISO protein:increased expression:plasma RGD PMID:30638058 RGD:401794451 NCBI chr 5:90,916,377...90,917,922
Ensembl chr 5:90,916,377...90,917,922 		JBrowse link
G Ptgis prostaglandin I2 (prostacyclin) synthase treatment ISO human gene in a mouse model
rat gene in human cells in a mouse model		 RGD PMID:12586736 PMID:14568901 PMID:19344900 RGD:401959585, RGD:401960079, RGD:401960096 NCBI chr 2:167,045,114...167,095,069
Ensembl chr 2:167,033,725...167,082,524 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 IEP protein:increased expression, increased activity:hindlimb muscle (mouse) RGD PMID:18451337 RGD:401965417 NCBI chr 2:167,772,670...167,821,305
Ensembl chr 2:167,773,977...167,821,305 		JBrowse link
G Vegfa vascular endothelial growth factor A treatment ISO RGD PMID:23562340 RGD:7421600 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
limb reperfusion injury term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpt glutamic pyruvic transaminase, soluble treatment ISO RGD PMID:36495512 RGD:401717522 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16193
    Pathological Conditions, Signs and Symptoms 12529
      Pathologic Processes 7960
        ischemia 1497
          limb ischemia 24
            limb reperfusion injury 1
Path 2
Term Annotations click to browse term
  disease 16193
    disease of anatomical entity 15759
      cardiovascular system disease 4717
        vascular disease 3303
          ischemia 1497
            limb ischemia 24
              limb reperfusion injury 1
paths to the root