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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:marginal zone lymphoma
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Accession:DOID:0050748 term browser browse the term
Definition:A B-cell lymphoma arising from the marginal zone of lymphoid tissues that is characterized by the presence of small to medium sized atypical lymphocytes. (DO)
Synonyms:exact_synonym: marginal zone B-cell lymphoma
 primary_id: MESH:D018442
 xref: EFO:1000630

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marginal zone lymphoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl10 BCL10 immune signaling adaptor ISO CTD Direct Evidence: marker/mechanism CTD NCBI chrNW_004955423:8,710,231...8,720,530
Ensembl chrNW_004955423:8,709,890...8,722,050 		JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor disease_progression ISO RGD PMID:15231650 RGD:1581305 NCBI chrNW_004955423:2,024,084...2,032,530
Ensembl chrNW_004955423:2,022,417...2,033,149 		JBrowse link
extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl10 BCL10 immune signaling adaptor ISO ClinVar Annotator: match by term: MALT lymphoma OMIM
ClinVar		 PMID:9989495 PMID:10380920 PMID:10408400 NCBI chrNW_004955423:8,710,231...8,720,530
Ensembl chrNW_004955423:8,709,890...8,722,050 		JBrowse link
G Birc3 baculoviral IAP repeat containing 3 treatment ISO DNA:gene fusion: (human) RGD PMID:21465313 RGD:153305955 NCBI chrNW_004955412:5,624,865...5,643,520
Ensembl chrNW_004955412:5,628,973...5,643,410 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 ISO protein:increased expression: mucosa-associated lymphoid tissue (human) RGD PMID:27544389 RGD:152023632 NCBI chrNW_004955440:3,456,165...3,460,024
Ensembl chrNW_004955440:3,455,153...3,460,109 		JBrowse link
splenic marginal zone lymphoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd79b CD79b molecule ISO protein:decreased expression:blood, B cell (human) RGD PMID:10329919 RGD:11531139 NCBI chrNW_004955478:7,909,353...7,912,814
Ensembl chrNW_004955478:7,909,153...7,913,166 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16063
    disease of anatomical entity 13820
      hematopoietic system disease 2941
        leukocyte disease 1139
          B-cell lymphoma 309
            marginal zone lymphoma 5
              extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue + 3
              nodal marginal zone lymphoma 0
              splenic marginal zone lymphoma 1
Path 2
Term Annotations click to browse term
  disease 16063
    disease of cellular proliferation 6683
      cancer 4843
        organ system cancer 4626
          immune system cancer 582
            lymphatic system cancer 582
              lymphoma 495
                non-Hodgkin lymphoma 419
                  B-cell lymphoma 309
                    marginal zone lymphoma 5
                      extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue + 3
                      nodal marginal zone lymphoma 0
                      splenic marginal zone lymphoma 1
paths to the root