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ONTOLOGY REPORT - ANNOTATIONS


Term:diffuse large B-cell lymphoma
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Accession:DOID:0050745 term browser browse the term
Definition:Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.
Synonyms:exact_synonym: Diffuse Histiocytic Lymphoma;   Diffuse Histiocytic Lymphomas;   Diffuse Large Cell Lymphoma;   Diffuse Large-Cell Lymphomas;   Histiocytic Lymphoma;   Histiocytic Lymphomas;   Large Lymphoid Lymphoma, Diffuse
 narrow_synonym: PCLBCL;   primary cutaneous large B-cell lymphoma
 primary_id: MESH:D016403;   RDO:0006954
 xref: GARD:3178
For additional species annotation, visit the Alliance of Genome Resources.


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diffuse large B-cell lymphoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABCB1 ATP binding cassette subfamily B member 1 JBrowse link 7 87,503,017 87,713,323 RGD:11554173
G ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) JBrowse link 4 88,090,264 88,231,626 RGD:11554173
G ALK ALK receptor tyrosine kinase JBrowse link 2 29,190,992 29,921,589 RGD:11554173
G B2M beta-2-microglobulin JBrowse link 15 44,711,492 44,718,877 RGD:11554173
G BCAS2 BCAS2 pre-mRNA processing factor JBrowse link 1 114,567,557 114,581,615 RGD:11554173
G BCL2 BCL2 apoptosis regulator JBrowse link 18 63,123,346 63,320,280 RGD:11554173
G BCL2L2 BCL2 like 2 JBrowse link 14 23,306,833 23,311,759 RGD:14394511
G BCL6 BCL6 transcription repressor JBrowse link 3 187,721,377 187,745,472 RGD:1600111
RGD:11530023
G CARD11 caspase recruitment domain family member 11 JBrowse link 7 2,906,075 3,043,867 RGD:11100036
RGD:11554173
G CAT catalase JBrowse link 11 34,438,934 34,472,060 RGD:11554173
G CCDC86 coiled-coil domain containing 86 JBrowse link 11 60,842,113 60,851,081 RGD:11554173
G CD40 CD40 molecule JBrowse link 20 46,118,242 46,129,858 RGD:5490541
G CD79A CD79a molecule JBrowse link 19 41,877,279 41,881,372 RGD:11554173
G CD79B CD79b molecule JBrowse link 17 63,928,740 63,932,331 RGD:11554173
G CDK1 cyclin dependent kinase 1 JBrowse link 10 60,778,331 60,794,852 RGD:11554173
G CDKN2A cyclin dependent kinase inhibitor 2A JBrowse link 9 21,967,752 21,995,324 RGD:11554173
G CLTC clathrin heavy chain JBrowse link 17 59,619,689 59,696,956 RGD:11554173
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit JBrowse link 7 148,807,374 148,884,344 RGD:11554173
G FAS Fas cell surface death receptor JBrowse link 10 88,968,429 89,017,059 RGD:11554173
G FCGR2A Fc fragment of IgG receptor IIa JBrowse link 1 161,505,430 161,524,048 RGD:11344967
G GLI1 GLI family zinc finger 1 JBrowse link 12 57,459,785 57,472,451 RGD:11554173
G GSTM1 glutathione S-transferase mu 1 JBrowse link 1 109,687,817 109,693,745 RGD:10450835
G GSTP1 glutathione S-transferase pi 1 JBrowse link 11 67,583,812 67,586,653 RGD:8547939
G GSTT1 glutathione S-transferase theta 1 RGD:10450835
G ICAM1 intercellular adhesion molecule 1 JBrowse link 19 10,271,120 10,286,615 RGD:11354982
G IL21R interleukin 21 receptor JBrowse link 16 27,402,162 27,452,043 RGD:1600111
G IMMP2L inner mitochondrial membrane peptidase subunit 2 JBrowse link 7 110,662,644 111,562,531 RGD:11554173
G IRF4 interferon regulatory factor 4 JBrowse link 6 391,752 411,443 RGD:11530023
G KMT2D lysine methyltransferase 2D JBrowse link 12 49,018,975 49,060,884 RGD:11554173
G MALT1 MALT1 paracaspase JBrowse link 18 58,671,420 58,754,477 RGD:11554173
G MKI67 marker of proliferation Ki-67 JBrowse link 10 128,096,659 128,126,423 RGD:6483541
G MTHFR methylenetetrahydrofolate reductase JBrowse link 1 11,785,723 11,806,103 RGD:6893517
G MYC MYC proto-oncogene, bHLH transcription factor JBrowse link 8 127,735,434 127,742,951 RGD:11554173
G MYD88 MYD88 innate immune signal transduction adaptor JBrowse link 3 38,138,661 38,143,022 RGD:11554173
G NECTIN2 nectin cell adhesion molecule 2 JBrowse link 19 44,846,297 44,889,223 RGD:11554173
G NFKBIA NFKB inhibitor alpha JBrowse link 14 35,401,513 35,404,749 RGD:2298905
G NOM1 nucleolar protein with MIF4G domain 1 JBrowse link 7 156,949,712 156,973,176 RGD:11554173
G PDPK1 3-phosphoinositide dependent protein kinase 1 JBrowse link 16 2,538,014 2,603,190 RGD:11554173
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link 3 179,148,114 179,240,093 RGD:11554173
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta JBrowse link 3 138,652,698 138,834,928 RGD:11554173
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta JBrowse link 1 9,629,889 9,729,114 RGD:11554173
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma JBrowse link 7 106,865,282 106,908,980 RGD:11554173
G PRDX3 peroxiredoxin 3 JBrowse link 10 119,167,720 119,178,812 RGD:11554173
G PRDX4 peroxiredoxin 4 JBrowse link X 23,667,493 23,686,397 RGD:11554173
G RANGAP1 Ran GTPase activating protein 1 JBrowse link 22 41,244,779 41,302,369 RGD:11554173
G RPS6KB1 ribosomal protein S6 kinase B1 JBrowse link 17 59,893,046 59,950,574 RGD:11554173
G SEC31A SEC31 homolog A, COPII coat complex component JBrowse link 4 82,818,509 82,900,571 RGD:11554173
G SKP2 S-phase kinase associated protein 2 JBrowse link 5 36,152,043 36,184,319 RGD:11554173
G SMURF2 SMAD specific E3 ubiquitin protein ligase 2 JBrowse link 17 64,542,282 64,662,307 RGD:13592920
G SOD2 superoxide dismutase 2 JBrowse link 6 159,669,069 159,762,281 RGD:11554173
G SOD3 superoxide dismutase 3 JBrowse link 4 24,795,478 24,800,845 RGD:11554173
G TP53 tumor protein p53 JBrowse link 17 7,668,402 7,687,550 RGD:13592920
G TXNIP thioredoxin interacting protein JBrowse link 1 145,992,435 145,996,579 RGD:11554173

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16528
    disease of anatomical entity 15508
      hematopoietic system disease 1484
        leukocyte disease 446
          B-cell lymphoma 266
            diffuse large B-cell lymphoma 53
              Plasmablastic Lymphoma 0
              primary mediastinal B-cell lymphoma 0
              relapsed/refractory diffuse large B-cell lymphoma 0
Path 2
Term Annotations click to browse term
  disease 16528
    disease of anatomical entity 15508
      Immune & Inflammatory Diseases 2999
        immune system disease 2475
          primary immunodeficiency disease 975
            lymphoproliferative syndrome 643
              lymphoma 364
                non-Hodgkin lymphoma 336
                  B-cell lymphoma 266
                    diffuse large B-cell lymphoma 53
                      Plasmablastic Lymphoma 0
                      primary mediastinal B-cell lymphoma 0
                      relapsed/refractory diffuse large B-cell lymphoma 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.