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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:inflammatory bowel disease
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Accession:DOID:0050589 term browser browse the term
Definition:An intestinal disease characterized by inflammation located in all parts of digestive tract. (DO)
Synonyms:exact_synonym: inflammatory bowel diseases
 narrow_synonym: CROHN DISEASE-ASSOCIATED GROWTH FAILURE, SUSCEPTIBILITY TO;   VERY EARLY ONSET INFLAMMATORY BOWEL DISEASE;   regional enteritis;   ulcerative colitis
 related_synonym: Inflammatory bowel disease 1, susceptibility to
 primary_id: MESH:D015212
 xref: NCI:C3138;   OMIM:PS266600;   OMIM:PS614328
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
inflammatory bowel disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing ISO protein:decreased expression:serum RGD PMID:18849144 RGD:5686819 NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885
JBrowse link
G AGER advanced glycosylation end-product specific receptor ISO RGD PMID:21939913 RGD:6767556 NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641
JBrowse link
G AGT angiotensinogen ISO DNA:polymorphism: :p.M235T (human) RGD PMID:20717043 RGD:11039049 NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044
JBrowse link
G ALPI alkaline phosphatase, intestinal ISO DNA:mutations:cds: RGD PMID:29567797 RGD:14367877 NCBI chr2B:119,687,673...119,692,300
Ensembl chr2B:238,606,722...238,611,350
JBrowse link
G ANG angiogenin ISO protein:increased expression:serum RGD PMID:20629092 RGD:6892712 NCBI chr14:1,548,693...1,558,528
Ensembl chr14:19,614,950...19,615,393
JBrowse link
G ANO6 anoctamin 6 ISO associated with Spondylitis, Ankylosing;DNA:SNP: :rs17095830(human) RGD PMID:23308121 RGD:9684849 NCBI chr12:43,295,928...43,512,073
Ensembl chr12:44,164,375...44,303,259
JBrowse link
G APC APC regulator of WNT signaling pathway ISO CTD Direct Evidence: marker/mechanism CTD PMID:18716850 NCBI chr 5:108,070,697...108,208,273
Ensembl chr 5:113,904,352...114,009,709
JBrowse link
G ATG16L1 autophagy related 16 like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26192919 NCBI chr2B:120,479,534...120,523,563
Ensembl chr2B:239,392,990...239,436,766
JBrowse link
G B2M beta-2-microglobulin ISO RGD PMID:20015205 RGD:6482693 NCBI chr15:23,668,108...23,674,791
Ensembl chr15:41,836,345...41,842,991
JBrowse link
G CARD9 caspase recruitment domain family member 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21983784 NCBI chr 9:107,432,709...107,446,271
Ensembl chr 9:136,416,279...136,424,756
JBrowse link
G CDH2 cadherin 2 ISO RGD PMID:7502046 RGD:734737 NCBI chr18:21,210,001...21,435,919
Ensembl chr18:24,812,019...25,008,325
JBrowse link
G CRP C-reactive protein ISO RGD PMID:22483567 RGD:6482301 NCBI chr 1:135,062,102...135,064,402 JBrowse link
G CUL2 cullin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21983784 NCBI chr10:35,127,771...35,210,108
Ensembl chr10:35,704,964...35,787,014
JBrowse link
G ESR2 estrogen receptor 2 ISO RGD PMID:14500559 RGD:5509042 NCBI chr14:44,807,875...44,919,780
Ensembl chr14:63,064,402...63,131,303
JBrowse link
G FGF23 fibroblast growth factor 23 disease_progression ISO protein:increased expression:serum: RGD PMID:22551310 RGD:10044237 NCBI chr12:4,479,116...4,488,797
Ensembl chr12:4,400,802...4,412,000
JBrowse link
G GSTM1 glutathione S-transferase mu 1 ISO DNA:deletion: : RGD PMID:21243434 RGD:5490537 Ensembl chr 1:127,979,238...128,010,411 JBrowse link
G HPGD 15-hydroxyprostaglandin dehydrogenase ISO protein, mRNA:increased expression: colonic mucosa: inflamed tissue only RGD PMID:16195422 RGD:5688766 NCBI chr 4:166,716,386...166,749,225
Ensembl chr 4:178,949,137...178,982,910
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO protein:increased expression RGD PMID:21864296 RGD:5685671 NCBI chr 9:96,351,645...96,356,761
Ensembl chr 9:124,865,211...124,870,458
JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 ISO RGD PMID:21135124 RGD:6218980 NCBI chr11:117,890,545...117,895,262
Ensembl chr11:121,809,800...121,815,773
JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:15638228 PMID:28067908 RGD:1625756 NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605
JBrowse link
G IFNG interferon gamma treatment ISO RGD PMID:31062617 RGD:14975125 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829
JBrowse link
G IGF2 insulin like growth factor 2 disease_progression ISO protein:increased expression:serum RGD PMID:12548059 PMID:20683203 RGD:5509948 RGD:5509968 NCBI chr11:2,170,190...2,199,442
Ensembl chr11:2,202,743...2,228,890
JBrowse link
G IGFBP3 insulin like growth factor binding protein 3 ISO RGD PMID:15844718 RGD:1626117 NCBI chr 7:46,564,234...46,573,145 JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta treatment ISO RGD PMID:22018461 RGD:7495770 NCBI chr 8:41,515,613...41,576,229
Ensembl chr 8:38,960,594...39,020,971
JBrowse link
G IL10 interleukin 10 no_association
treatment
ISO DNA:SNP: :rs3024505 (human)
ClinVar Annotator: match by term: Inflammatory bowel disease
DNA:SNP: :rs1800896 (human)
CTD Direct Evidence: marker/mechanism
RGD
ClinVar
CTD
PMID:22511846 PMID:23291587 PMID:25741868 PMID:27468578 PMID:27783946 PMID:28411859 PMID:28492532 PMID:30290665 PMID:31062617 RGD:11534627 RGD:14975125 RGD:7364854 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371
JBrowse link
G IL10RA interleukin 10 receptor subunit alpha ISO ClinVar Annotator: match by term: Inflammatory bowel disease ClinVar NCBI chr11:112,820,445...112,835,603
Ensembl chr11:116,752,619...116,767,771
JBrowse link
G IL10RB interleukin 10 receptor subunit beta ISO ClinVar Annotator: match by term: Inflammatory bowel disease ClinVar NCBI chr21:19,628,808...19,668,268
Ensembl chr21:33,005,505...33,032,738
JBrowse link
G IL18RAP interleukin 18 receptor accessory protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:21983784 NCBI chr2A:99,363,823...99,393,346
Ensembl chr2A:103,510,109...103,544,916
JBrowse link
G IL19 interleukin 19 ISO ClinVar Annotator: match by term: Inflammatory bowel disease ClinVar PMID:25741868 PMID:28492532 NCBI chr 1:182,372,339...182,446,147
Ensembl chr 1:186,651,640...186,724,748
JBrowse link
G IL21R interleukin 21 receptor ISO protein:increased expression:gut mucosa,leukocytes, mononuclear RGD PMID:19322899 RGD:6892935 Ensembl chr16:27,774,864...27,821,769 JBrowse link
G IL23R interleukin 23 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:21983784 PMID:23291587 PMID:26192919 NCBI chr 1:66,408,839...66,502,535
Ensembl chr 1:68,293,514...68,386,815
JBrowse link
G IL33 interleukin 33 severity ISO RGD PMID:24491821 RGD:39938952 NCBI chr 9:6,027,014...6,069,540
Ensembl chr 9:6,234,178...6,248,624
JBrowse link
G IL5 interleukin 5 susceptibility ISO RGD PMID:22018693 RGD:5687148 NCBI chr 5:127,955,377...127,961,726
Ensembl chr 5:134,119,608...134,121,675
JBrowse link
G IL6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Crohn disease-associated growth failure, susceptibility to
CTD
ClinVar
PMID:9769329 PMID:10720087 PMID:11001912 PMID:11889177 PMID:12519862 PMID:12560873 PMID:12719374 PMID:15070960 PMID:15331795 PMID:15472205 PMID:16150725 PMID:16278864 PMID:17623760 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G INAVA innate immunity activator ISO CTD Direct Evidence: marker/mechanism CTD PMID:21983784 NCBI chr 1:176,491,264...176,514,719
Ensembl chr 1:180,794,646...180,818,853
JBrowse link
G IRGM immunity related GTPase M ISO CTD Direct Evidence: marker/mechanism CTD PMID:26192919 NCBI chr 5:146,274,097...146,329,979
Ensembl chr 5:152,278,581...152,308,182
JBrowse link
G ITGA4 integrin subunit alpha 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28067908 NCBI chr2B:68,719,376...68,802,488
Ensembl chr2B:186,530,187...186,612,203
JBrowse link
G ITGAL integrin subunit alpha L ISO CTD Direct Evidence: marker/mechanism CTD PMID:28067908 NCBI chr16:24,445,966...24,496,037
Ensembl chr16:30,843,747...30,892,597
JBrowse link
G ITGB8 integrin subunit beta 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28067908 NCBI chr 7:21,019,917...21,105,143
Ensembl chr 7:20,336,031...20,415,666
JBrowse link
G KLKB1 kallikrein B1 ISO RGD PMID:8625762 RGD:7327139 NCBI chr 4:178,398,359...178,429,448
Ensembl chr 4:190,604,901...190,636,300
JBrowse link
G KRT8 keratin 8 ISO ClinVar Annotator: match by term: Inflammatory bowel disease ClinVar PMID:15090596 PMID:25741868 NCBI chr12:35,855,367...35,863,248
Ensembl chr12:36,634,582...36,642,564
JBrowse link
G LOC100978332 pantetheinase ISO CTD Direct Evidence: therapeutic CTD PMID:17145956 NCBI chr 6:130,459,268...130,491,167
Ensembl chr 6:134,566,117...134,598,784
JBrowse link
G LOC100986914 cytochrome b-245 light chain ISO ClinVar Annotator: match by term: Very early onset inflammatory bowel disease ClinVar PMID:3368442 PMID:9445163 PMID:10440830 PMID:19388116 PMID:25741868 PMID:30709874 NCBI chr16:69,356,396...69,364,225 JBrowse link
G LOC100991079 interleukin-1 receptor antagonist protein treatment ISO RGD PMID:12184521 RGD:10450573 NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839
JBrowse link
G LOC100991118 defensin-5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18394979 NCBI chr 8:264,298...265,962 JBrowse link
G LTF lactotransferrin ISO RGD PMID:9791051 RGD:7243943 NCBI chr 3:46,337,738...46,367,476
Ensembl chr 3:47,442,440...47,471,532
JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO DNA:SNP: :1298A>C (human) RGD PMID:17111197 RGD:10449410 NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419
JBrowse link
G MUC19 mucin 19, oligomeric ISO CTD Direct Evidence: marker/mechanism CTD PMID:21983784 NCBI chr12:48,135,613...48,319,443 JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: REGIONAL ENTERITIS
ClinVar Annotator: match by term: Inflammatory bowel disease 1, susceptibility to
CTD
ClinVar
PMID:11385576 PMID:11385577 PMID:11425413 PMID:11875755 PMID:11910337 PMID:12019468 PMID:12512038 PMID:12557156 PMID:12577202 PMID:14765395 PMID:15024686 PMID:15190267 PMID:15198989 PMID:15571588 PMID:15770725 PMID:15967635 PMID:18240302 PMID:18489434 PMID:18541930 PMID:19467619 PMID:19713276 PMID:20959815 PMID:21274544 PMID:21335489 PMID:21548950 PMID:21830272 PMID:21914217 PMID:21983784 PMID:22684479 PMID:23102769 PMID:24033266 PMID:25741868 PMID:26070941 PMID:26192919 PMID:26500656 PMID:28450277 PMID:28492532 NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773
JBrowse link
G NOS2 nitric oxide synthase 2 ISO protein:increased expression:colon (rat) RGD PMID:21958875 RGD:5508753 NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093
JBrowse link
G NOX1 NADPH oxidase 1 ISO ClinVar Annotator: match by term: Very early onset inflammatory bowel disease ClinVar PMID:28492532 PMID:30709874 NCBI chr  X:90,046,023...90,076,968
Ensembl chr  X:100,182,398...100,215,192
JBrowse link
G NPSR1 neuropeptide S receptor 1 ISO RGD PMID:17854592 RGD:4891931 NCBI chr 7:35,274,102...35,494,389
Ensembl chr 7:35,663,335...35,883,988
JBrowse link
G PDGFB platelet derived growth factor subunit B ISO RGD PMID:11780721 RGD:6482691 NCBI chr22:20,127,223...20,148,407
Ensembl chr22:37,944,018...37,964,883
JBrowse link
G PLCG2 phospholipase C gamma 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28067908 NCBI chr16:62,383,270...62,561,579
Ensembl chr16:81,812,565...81,984,064
JBrowse link
G POMC proopiomelanocortin ISO protein:alternative form:large intestine epithelium: alphaMSH RGD PMID:9145424 PMID:21741932 RGD:5508804 RGD:5508805 NCBI chr2A:25,161,668...25,165,600
Ensembl chr2A:25,258,768...25,262,706
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11820457 NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519
JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21983784 NCBI chr 1:88,685,736...88,743,164
Ensembl chr 1:123,734,511...123,790,830
JBrowse link
G RASSF1 Ras association domain family member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24146755 NCBI chr 3:50,255,897...50,267,042
Ensembl chr 3:51,491,548...51,502,392
JBrowse link
G SFRP1 secreted frizzled related protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18716850 NCBI chr 8:40,507,027...40,555,053 JBrowse link
G SFRP2 secreted frizzled related protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18716850 NCBI chr 4:146,123,075...146,131,543
Ensembl chr 4:157,944,733...157,953,258
JBrowse link
G SLAMF8 SLAM family member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28067908 NCBI chr 1:135,178,241...135,189,005 JBrowse link
G SLC11A1 solute carrier family 11 member 1 ISO DNA:polymorphisms: :1730G>A (human)
CTD Direct Evidence: marker/mechanism
DNA:point mutation:promoter:-237C>T (human)
RGD
CTD
PMID:16059695 PMID:16597321 PMID:21128323 RGD:5684929 RGD:5684952 NCBI chr2B:105,640,613...105,655,524
Ensembl chr2B:224,238,284...224,252,941
JBrowse link
G SLC6A14 solute carrier family 6 member 14 ISO protein:decreased expression:epithelial cell, colon RGD PMID:17065219 RGD:1625272 NCBI chr  X:105,496,347...105,521,217
Ensembl chr  X:115,912,873...115,939,693
JBrowse link
G TGFB1 transforming growth factor beta 1 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:28891831 PMID:29483653 RGD:14995457 NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973
JBrowse link
G THEMIS thymocyte selection associated ISO DNA:frameshift mutation: RGD PMID:22275874 RGD:38599149 NCBI chr 6:125,489,491...125,685,995
Ensembl chr 6:129,601,176...129,797,112
JBrowse link
G TNF tumor necrosis factor treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:12184521 PMID:15086448 PMID:27793764 RGD:10450573 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
JBrowse link
G TNFSF15 TNF superfamily member 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26192919 NCBI chr 9:85,881,800...85,904,191
Ensembl chr 9:114,249,472...114,265,441
JBrowse link
G TPMT thiopurine S-methyltransferase treatment ISO RGD PMID:17026564 RGD:11038726 NCBI chr 6:17,977,544...18,002,839
Ensembl chr 6:18,330,000...18,355,157
JBrowse link
G VEGFA vascular endothelial growth factor A disease_progression ISO protein:increased expression:serum,colon: RGD PMID:23642997 RGD:11079180 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353
JBrowse link
chemical colitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme ISO protein:increased expression:small intestine, large intestine:extracellular space (mouse) RGD PMID:26401072 RGD:11555935 NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853
JBrowse link
G CASP3 caspase 3 treatment ISO RGD PMID:28740344 RGD:13782278 NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185
JBrowse link
G CASP7 caspase 7 treatment ISO RGD PMID:28740344 RGD:13782278 NCBI chr10:110,273,318...110,324,800
Ensembl chr10:113,707,780...113,758,626
JBrowse link
G SERPINA1 serpin family A member 1 treatment ISO RGD PMID:23835442 RGD:14695050 NCBI chr14:75,001,714...75,014,214
Ensembl chr14:94,334,258...94,345,419
JBrowse link
Clostridium difficile colitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL23A interleukin 23 subunit alpha severity ISO RGD PMID:26455347 RGD:11097134 NCBI chr12:32,575,321...32,576,856
Ensembl chr12:32,828,902...32,830,617
JBrowse link
G IL33 interleukin 33 severity
treatment
ISO RGD PMID:32156806 RGD:40400894 NCBI chr 9:6,027,014...6,069,540
Ensembl chr 9:6,234,178...6,248,624
JBrowse link
colitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM17 ADAM metallopeptidase domain 17 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24548422 NCBI chr2A:9,478,080...9,545,363
Ensembl chr2A:9,641,201...9,708,054
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing ISO RGD PMID:17604368 PMID:21479819 RGD:5686754 RGD:5686898 NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885
JBrowse link
G ADK adenosine kinase ISO RGD PMID:11123368 RGD:6482664 NCBI chr10:70,672,967...71,236,950
Ensembl chr10:73,342,900...73,902,490
JBrowse link
G ADRB3 adrenoceptor beta 3 ISO mRNA:decreased expression:distal colon, mucosa (rat) RGD PMID:18492028 RGD:5684890 NCBI chr 8:37,263,730...37,267,475 JBrowse link
G AHR aryl hydrocarbon receptor ISO CTD Direct Evidence: therapeutic CTD PMID:27783946 NCBI chr 7:17,949,254...17,998,737 JBrowse link
G ALOX5 arachidonate 5-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:15821759 NCBI chr10:42,461,398...42,531,576
Ensembl chr10:45,639,946...45,710,016
JBrowse link
G ANXA1 annexin A1 ISO protein:increased expression:colon, neutrophil RGD PMID:10489933 RGD:2306920 NCBI chr 9:51,647,404...51,665,990
Ensembl chr 9:71,929,728...71,948,779
JBrowse link
G APLN apelin ISO RGD PMID:17391779 RGD:1626177 NCBI chr  X:118,775,509...118,785,224 JBrowse link
G APOA4 apolipoprotein A4 ISO human protein in mouse model RGD PMID:15254593 RGD:5685667 NCBI chr11:111,659,186...111,661,790
Ensembl chr11:115,591,788...115,594,382
JBrowse link
G AQP7 aquaporin 7 ISO associated with Infection;mRNA, protein:decreased expression:colon RGD PMID:15338270 RGD:1626292 NCBI chr 9:33,160,982...33,180,638 JBrowse link
G ARG1 arginase 1 severity ISO RGD PMID:28423665 RGD:39939041 NCBI chr 6:129,372,747...129,383,880
Ensembl chr 6:133,479,966...133,491,162
JBrowse link
G ARRB1 arrestin beta 1 ISO protein:increased expression:colon (rat) RGD PMID:21066892 RGD:5509893 NCBI chr11:70,319,935...70,411,276
Ensembl chr11:73,630,276...73,654,155
JBrowse link
G ATP5F1D ATP synthase F1 subunit delta treatment ISO RGD PMID:23840258 RGD:13792680
G BDNF brain derived neurotrophic factor ISO protein:increased expression:dorsal root ganglion: RGD PMID:19932037 RGD:8657331 NCBI chr11:27,618,322...27,687,661
Ensembl chr11:27,520,312...27,589,239
JBrowse link
G BMP6 bone morphogenetic protein 6 ISO RGD PMID:22361727 RGD:7242194 NCBI chr 6:7,564,164...7,720,341
Ensembl chr 6:7,848,249...8,000,649
JBrowse link
G CAT catalase ISO RGD PMID:21463646 RGD:5130869 NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160
JBrowse link
G CCKBR cholecystokinin B receptor ISO RGD PMID:15102523 RGD:2311333 NCBI chr11:6,393,435...6,405,821
Ensembl chr11:6,075,816...6,088,145
JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO RGD PMID:18690297 RGD:2307009 NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384
JBrowse link
G CCR1 C-C motif chemokine receptor 1 ISO RGD PMID:16399111 RGD:2307162 NCBI chr 3:46,107,526...46,114,229
Ensembl chr 3:47,214,688...47,215,755
JBrowse link
G CD36 CD36 molecule ISO RGD PMID:19117124 RGD:6893503 NCBI chr 7:72,566,478...72,643,517
Ensembl chr 7:86,265,114...86,305,865
JBrowse link
G CD40 CD40 molecule ISO RGD PMID:15591506 RGD:5508169 NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994
JBrowse link
G CHEK2 checkpoint kinase 2 ISO ClinVar Annotator: match by term: Colitis ClinVar PMID:10617473 PMID:11053450 PMID:11479205 PMID:11719428 PMID:11967536 PMID:12094328 PMID:12533788 PMID:12690581 PMID:14648717 PMID:14648718 PMID:14648719 PMID:15122511 PMID:15488637 PMID:15492928 PMID:15520402 PMID:16257342 PMID:16492927 PMID:16880452 PMID:17085682 PMID:18172190 PMID:19338683 PMID:19805189 PMID:21807500 PMID:21956126 PMID:22006311 PMID:22058428 PMID:22419737 PMID:22811390 PMID:22994785 PMID:23469205 PMID:24033266 PMID:24884479 PMID:25431674 PMID:25741868 PMID:26084796 PMID:26467025 PMID:26641009 PMID:26681312 PMID:26822237 PMID:26845104 PMID:26884562 PMID:27083775 PMID:27153395 PMID:27269948 PMID:27433846 PMID:27751358 PMID:27798748 PMID:28125075 PMID:28135145 PMID:28195393 PMID:28492532 PMID:28503720 PMID:28514723 PMID:28727877 PMID:28734145 PMID:28779002 PMID:28802053 PMID:28874143 PMID:29351919 PMID:29489754 PMID:30311386 NCBI chr22:9,757,038...9,811,171 JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex treatment ISO RGD PMID:17543437 RGD:2298659 NCBI chr10:96,794,228...96,835,449
Ensembl chr10:100,280,490...100,316,918
JBrowse link
G CIITA class II major histocompatibility complex transactivator severity ISO protein:increased expression:T cells:constitutive expression of transgene increases severity
ClinVar Annotator: match by term: Colitis
RGD
ClinVar
PMID:17043423 PMID:25741868 PMID:28492532 RGD:5491188 NCBI chr16:9,819,440...9,885,379
Ensembl chr16:11,041,434...11,090,485
JBrowse link
G CRHR2 corticotropin releasing hormone receptor 2 ISO mRNA, protein:decreased expression:intestine, myenteric nerve plexus RGD PMID:17586086 PMID:21330446 RGD:5131259 RGD:5490987 NCBI chr 7:31,265,619...31,313,902
Ensembl chr 7:31,386,026...31,434,220
JBrowse link
G CTSB cathepsin B ISO protein:increased activity:cecum, colon, spinal cord RGD PMID:21802389 RGD:5686873 NCBI chr 8:7,333,498...7,359,264 JBrowse link
G CTSL cathepsin L ISO protein:increased activity:cecum, colon, spinal cord RGD PMID:21802389 RGD:5686873 NCBI chr 9:58,851,899...58,857,170
Ensembl chr 9:86,903,006...86,908,303
JBrowse link
G CTSS cathepsin S ISO protein:increased activity:cecum, colon, spinal cord RGD PMID:21802389 RGD:5686873 NCBI chr 1:126,084,249...126,118,221
Ensembl chr 1:129,733,996...129,768,318
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 ISO associated with Helicobacter Infections;mRNA:decreased expression:colon (mouse, Helicobacter hepaticus) RGD PMID:17242461 RGD:38549339 NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083
JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 ISO RGD PMID:14738862 RGD:7257706 NCBI chr2B:105,387,198...105,400,533
Ensembl chr2B:223,997,066...223,998,148
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 ISO mRNA:increased expression:large intestine epithelium RGD PMID:21374063 RGD:5147670 NCBI chr15:53,664,968...53,672,277
Ensembl chr15:73,284,566...73,290,636
JBrowse link
G DUSP1 dual specificity phosphatase 1 severity ISO RGD PMID:22461024 RGD:7771532 NCBI chr 5:168,121,536...168,124,671
Ensembl chr 5:175,032,803...175,035,960
JBrowse link
G ESR2 estrogen receptor 2 ISO mRNA:decreased expression:colon RGD PMID:21252046 RGD:5508810 NCBI chr14:44,807,875...44,919,780
Ensembl chr14:63,064,402...63,131,303
JBrowse link
G FGF19 fibroblast growth factor 19 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27580383 NCBI chr11:64,794,157...64,800,512
Ensembl chr11:68,085,306...68,090,028
JBrowse link
G FLNA filamin A ISO ClinVar Annotator: match by term: Colitis ClinVar PMID:25741868 PMID:28492532 NCBI chr  X:143,799,088...143,825,282 JBrowse link
G GCG glucagon ISO CTD Direct Evidence: therapeutic CTD PMID:22323126 NCBI chr2B:49,436,379...49,446,559
Ensembl chr2B:166,806,016...166,811,155
JBrowse link
G GHRL ghrelin and obestatin prepropeptide ISO CTD Direct Evidence: therapeutic CTD PMID:19617644 NCBI chr 3:10,221,829...10,229,229
Ensembl chr 3:10,573,537...10,580,723
JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 ISO mRNA:increased expression:kidney: RGD PMID:23307618 RGD:7245473 NCBI chr 5:152,429,337...152,459,800
Ensembl chr 5:158,413,073...158,442,481
JBrowse link
G HMOX1 heme oxygenase 1 treatment ISO protein:increased expression:colon:
CTD Direct Evidence: therapeutic
RGD
CTD
PMID:16365149 PMID:21444764 PMID:21853095 PMID:22261574 RGD:10766442 RGD:7207796 NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063
JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO protein:increased expression:colon: RGD PMID:22261574 RGD:7207796 NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605
JBrowse link
G ICOS inducible T cell costimulator ISO protein:increased expression:T-cell RGD PMID:14731127 RGD:1624274 NCBI chr2B:91,168,998...91,193,808
Ensembl chr2B:209,307,938...209,332,734
JBrowse link
G IFNG interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:24548422 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829
JBrowse link
G IGF1 insulin like growth factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24782617 NCBI chr12:99,986,887...100,066,773 JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta treatment ISO RGD PMID:17543437 RGD:2298659 NCBI chr 8:41,515,613...41,576,229
Ensembl chr 8:38,960,594...39,020,971
JBrowse link
G IL10 interleukin 10 treatment ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD
RGD
PMID:19238344 PMID:21807089 PMID:21949848 PMID:22119709 PMID:22461024 PMID:23771723 PMID:24314293 RGD:7349385 RGD:7365024 RGD:7771532 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371
JBrowse link
G IL17A interleukin 17A ISO mRNA:increased expression:colon
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:14962796 PMID:20881082 PMID:24548422 RGD:4781448 RGD:4888509 NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074
JBrowse link
G IL1B interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:22969190 PMID:23810507 PMID:24548422 RGD:7204699 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424
JBrowse link
G IL33 interleukin 33 severity ISO RGD PMID:23172891 PMID:28423665 RGD:39939041 RGD:40400694 NCBI chr 9:6,027,014...6,069,540
Ensembl chr 9:6,234,178...6,248,624
JBrowse link
G IL4 interleukin 4 treatment ISO CTD Direct Evidence: therapeutic CTD
RGD
PMID:9389741 PMID:24314293 RGD:8142400 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581
JBrowse link
G IL5 interleukin 5 ISO protein: increased expression RGD PMID:22018693 RGD:5687148 NCBI chr 5:127,955,377...127,961,726
Ensembl chr 5:134,119,608...134,121,675
JBrowse link
G IL6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22410118 PMID:24548422 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G ITGB2 integrin subunit beta 2 ISO associated with Spirochaetales infections RGD PMID:11031123 RGD:6482227 NCBI chr21:31,181,228...31,216,033
Ensembl chr21:44,470,999...44,505,963
JBrowse link
G KDR kinase insert domain receptor ISO protein:increased expression:colon: RGD PMID:22261574 RGD:7207796 NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109
JBrowse link
G LCT lactase ISO protein:decreased expression, increased expression:jejunum RGD PMID:17218984 RGD:1600240 NCBI chr2B:24,025,383...24,079,779
Ensembl chr2B:139,855,605...139,908,764
JBrowse link
G LOC100982859 patr class I histocompatibility antigen, B-2 alpha chain ISO human gene in rat model; DNA:polymorphism:cds:HLA-B27 (human) RGD PMID:2257626 RGD:7387221 NCBI chr 6:31,106,562...31,109,933
Ensembl chr 6:31,997,381...32,000,067
JBrowse link
G LRRK2 leucine rich repeat kinase 2 ISO RGD PMID:21983832 RGD:5508401 NCBI chr12:48,343,621...48,488,337
Ensembl chr12:49,205,930...49,350,462
JBrowse link
G MADCAM1 mucosal vascular addressin cell adhesion molecule 1 ISO CTD Direct Evidence: therapeutic CTD PMID:16917232 NCBI chr19:627,526...636,684
Ensembl chr19:468,026...477,830
JBrowse link
G MIF macrophage migration inhibitory factor ISO CTD Direct Evidence: therapeutic RGD
CTD
PMID:12105854 PMID:17324399 RGD:1641979 NCBI chr22:4,646,986...4,647,831
Ensembl chr22:22,730,807...22,732,009
JBrowse link
G MPO myeloperoxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23810507 NCBI chr17:52,333,882...52,357,838
Ensembl chr17:57,201,073...57,212,111
JBrowse link
G MSH2 mutS homolog 2 ISO RGD PMID:23883737 RGD:10412318 NCBI chr2A:47,524,468...47,602,376
Ensembl chr2A:48,447,207...48,554,461
JBrowse link
G MUC2 mucin 2, oligomeric mucus/gel-forming treatment ISO protein:decreased sulfation:descending colon
mRNA:decreased expression:colon
RGD PMID:12395902 PMID:19220658 PMID:21949848 PMID:23395625 RGD:2324675 RGD:7349356 RGD:7349360 RGD:7349385 NCBI chr11:1,106,716...1,144,489
Ensembl chr11:1,143,625...1,169,741
JBrowse link
G NAMPT nicotinamide phosphoribosyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23810507 NCBI chr 7:98,227,071...98,262,254 JBrowse link
G NOD1 nucleotide binding oligomerization domain containing 1 ISO RGD PMID:20921147 RGD:5508755 NCBI chr 7:31,060,245...31,109,012
Ensembl chr 7:31,182,275...31,208,742
JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 ISO mRNA:increased expression:colon RGD PMID:16891783 PMID:20921147 PMID:21471573 RGD:1600781 RGD:5508727 RGD:5508755 NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773
JBrowse link
G NOS2 nitric oxide synthase 2 ISO mRNA:increased expression:colon (mouse)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:8698225 PMID:16866779 PMID:17449036 PMID:21930116 RGD:4891411 RGD:5509045 NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093
JBrowse link
G NOS3 nitric oxide synthase 3 ISO mRNA:increased expression:colon RGD PMID:17947450 RGD:2292124 NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233
JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 ISO mRNA, protein:increased expression:dorsal root ganglion RGD PMID:20638179 RGD:5684542 NCBI chr 9:39,663,986...40,208,770
Ensembl chr 9:84,021,837...84,372,678
JBrowse link
G PGF placental growth factor ISO RGD PMID:20142801 RGD:6483587 NCBI chr14:55,494,152...55,508,066 JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO RGD PMID:21244371 RGD:6482682 NCBI chr 7:98,841,974...98,885,446
Ensembl chr 7:111,570,148...111,611,614
JBrowse link
G PLA2G2A phospholipase A2 group IIA ISO RGD PMID:17982090 RGD:6482729 NCBI chr 1:18,930,294...18,934,563
Ensembl chr 1:19,971,084...19,977,627
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha susceptibility ISO RGD PMID:20650341 RGD:5509936 Ensembl chr22:45,218,364...45,302,970 JBrowse link
G PPARGC1A PPARG coactivator 1 alpha ISO RGD PMID:22126533 RGD:6484264 NCBI chr 4:18,196,431...18,876,889
Ensembl chr 4:23,483,377...23,581,212
JBrowse link
G PTGER4 prostaglandin E receptor 4 ISO RGD PMID:20833794 RGD:6483551 NCBI chr 5:69,686,906...69,700,739
Ensembl chr 5:74,731,470...74,745,148
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:11820457 PMID:17543437 RGD:2298659 NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit ISO protein:increased expression:nucleus
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:18623154 PMID:23810507 RGD:2298776 NCBI chr11:61,012,839...61,022,225
Ensembl chr11:64,347,859...64,356,868
JBrowse link
G RETN resistin treatment ISO RGD PMID:22630819 RGD:7207222 NCBI chr19:6,958,536...6,960,032
Ensembl chr19:7,812,942...7,814,909
JBrowse link
G SELL selectin L ISO RGD PMID:18054560 RGD:5685703 NCBI chr 1:145,173,700...145,194,927
Ensembl chr 1:148,895,373...148,916,393
JBrowse link
G SELP selectin P ISO protein:increased expression:colon RGD PMID:19147805 RGD:2312310 NCBI chr 1:145,071,094...145,112,851
Ensembl chr 1:148,793,677...148,834,701
JBrowse link
G SELPLG selectin P ligand ISO RGD PMID:22009715 RGD:6218987 NCBI chr12:106,197,975...106,209,627
Ensembl chr12:109,594,990...109,603,941
JBrowse link
G SI sucrase-isomaltase ISO mRNA, protein:decreased expression:ileum RGD PMID:16964428 RGD:1625545 NCBI chr 3:161,961,038...162,104,054
Ensembl chr 3:170,057,750...170,154,502
JBrowse link
G SIRT1 sirtuin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19940103 PMID:24548422 PMID:24782617 NCBI chr10:64,368,878...64,401,684
Ensembl chr10:66,681,598...66,715,069
JBrowse link
G SLC11A1 solute carrier family 11 member 1 ISO RGD PMID:19016783 RGD:5684975 NCBI chr2B:105,640,613...105,655,524
Ensembl chr2B:224,238,284...224,252,941
JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:17551092 NCBI chr20:33,667,614...33,727,126
Ensembl chr20:34,822,271...34,839,634
JBrowse link
G TAC1 tachykinin precursor 1 ISO RGD PMID:18715640 RGD:2304260 NCBI chr 7:89,675,834...89,684,391
Ensembl chr 7:103,257,501...103,266,389
JBrowse link
G TACR1 tachykinin receptor 1 ISO RGD PMID:18715640 RGD:2304260 NCBI chr2A:75,111,339...75,267,320
Ensembl chr2A:76,614,478...76,771,018
JBrowse link
G TACR2 tachykinin receptor 2 ISO RGD PMID:12490601 PMID:18715640 RGD:2304260 RGD:5147478 NCBI chr10:65,872,795...65,885,154
Ensembl chr10:68,403,979...68,415,224
JBrowse link
G TFF1 trefoil factor 1 ISO RGD PMID:8836141 RGD:625375 NCBI chr21:28,669,323...28,673,556
Ensembl chr21:41,988,039...41,992,270
JBrowse link
G TIMP3 TIMP metallopeptidase inhibitor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24548422 NCBI chr22:13,811,297...13,872,799
Ensembl chr22:31,662,562...31,723,964
JBrowse link
G TLR3 toll like receptor 3 ISO mRNA:increased expression:large intestine mucosa (rat) RGD PMID:20011045 RGD:5128708 NCBI chr 4:178,238,352...178,256,264
Ensembl chr 4:190,446,487...190,462,728
JBrowse link
G TLR4 toll like receptor 4 ISO protein:increased expression:colon RGD PMID:19002562 PMID:19924809 RGD:2312573 RGD:7794773 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711
JBrowse link
G TNF tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:23810507 PMID:24548422 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
JBrowse link
G TST thiosulfate sulfurtransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19647029 NCBI chr22:17,925,215...17,933,919
Ensembl chr22:35,761,073...35,768,992
JBrowse link
G UCN urocortin ISO mRNA:altered expression:distal colon (rat) RGD PMID:21330446 RGD:5490987 NCBI chr2A:27,309,458...27,311,268
Ensembl chr2A:27,397,295...27,397,669
JBrowse link
G UCN2 urocortin 2 ISO mRNA:increased expression:colon (rat) RGD PMID:17586086 RGD:5131259 NCBI chr 3:48,484,628...48,485,179 JBrowse link
G VCAM1 vascular cell adhesion molecule 1 ISO protein:increased expression:colon: RGD PMID:22261574 RGD:7207796 NCBI chr 1:103,377,815...103,395,118
Ensembl chr 1:102,091,336...102,107,732
JBrowse link
G VIP vasoactive intestinal peptide ISO associated with Gram-Negative Bacterial Infections RGD PMID:19661153 RGD:5685605 NCBI chr 6:150,564,545...150,573,582
Ensembl chr 6:155,254,652...155,263,730
JBrowse link
G VIPR2 vasoactive intestinal peptide receptor 2 ISO RGD PMID:21295288 RGD:5685384
Crohn's disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 susceptibility ISO RGD PMID:15505619 RGD:1598568 NCBI chr 7:79,497,536...79,706,277
Ensembl chr 7:93,147,950...93,243,238
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing ISO protein:increased expression:serum
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:16432373 PMID:21829567 RGD:5686726 NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885
JBrowse link
G AGT angiotensinogen ISO ClinVar Annotator: match by term: Crohn disease, association with ClinVar PMID:9120024 PMID:9894356 PMID:13937884 PMID:15077204 PMID:17047091 PMID:20978123 NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044
JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type ISO protein:increased expression:large intestine epithelium RGD PMID:7679252 RGD:5509621 NCBI chr17:7,026,839...7,041,598
Ensembl chr17:7,014,591...7,029,602
JBrowse link
G ALPI alkaline phosphatase, intestinal ISO protein:decreased expression:colonic mucosa RGD PMID:22783049 RGD:14367879 NCBI chr2B:119,687,673...119,692,300
Ensembl chr2B:238,606,722...238,611,350
JBrowse link
G APLN apelin ISO protein:increased expression:intestine RGD PMID:17391779 RGD:1626177 NCBI chr  X:118,775,509...118,785,224 JBrowse link
G APOA4 apolipoprotein A4 severity ISO protein:decreased expression:blood plasma (human) RGD PMID:17206692 RGD:5685660 NCBI chr11:111,659,186...111,661,790
Ensembl chr11:115,591,788...115,594,382
JBrowse link
G AQP7 aquaporin 7 severity ISO mRNA, protein:decreased expression:colon RGD PMID:15338270 RGD:1626292 NCBI chr 9:33,160,982...33,180,638 JBrowse link
G ATG16L1 autophagy related 16 like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17435756 PMID:18438406 NCBI chr2B:120,479,534...120,523,563
Ensembl chr2B:239,392,990...239,436,766
JBrowse link
G BACH2 BTB domain and CNC homolog 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21102463 NCBI chr 6:87,806,188...88,175,840
Ensembl chr 6:91,083,533...91,160,552
JBrowse link
G BGLAP bone gamma-carboxyglutamate protein ISO protein:undercarboxylated:serum
mRNA:decreased expression:bone
RGD PMID:21482072 PMID:22535626 RGD:6483321 RGD:6483546 NCBI chr 1:131,583,789...131,586,459
Ensembl chr 1:135,413,871...135,416,432
JBrowse link
G BPI bactericidal permeability increasing protein ISO RGD PMID:15758620 RGD:1580079 NCBI chr20:34,633,243...34,661,171
Ensembl chr20:35,739,700...35,771,910
JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21829567 NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384
JBrowse link
G CCNY cyclin Y ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438405 NCBI chr10:35,458,092...35,698,142
Ensembl chr10:36,035,729...36,273,282
JBrowse link
G CD40 CD40 molecule susceptibility ISO DNA:SNP:5' utr:c.-1C>T (rs1883832) (human)
protein:increased expression:intestine, epithelial cell
RGD PMID:20133813 PMID:20634952 RGD:5490590 RGD:5490971 NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994
JBrowse link
G CIBAR2 CBY1 interacting BAR domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17435756 NCBI chr16:65,768,014...65,782,236
Ensembl chr16:85,106,709...85,120,815
JBrowse link
G CLDN1 claudin 1 ISO RGD PMID:21748286 RGD:11341809 NCBI chr 3:187,328,629...187,345,360
Ensembl chr 3:195,882,239...195,899,248
JBrowse link
G CRP C-reactive protein severity ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:serum
CTD
RGD
PMID:11339241 PMID:22421709 RGD:6482309 NCBI chr 1:135,062,102...135,064,402 JBrowse link
G DENND1B DENN domain containing 1B ISO CTD Direct Evidence: marker/mechanism CTD PMID:21102463 NCBI chr 1:173,102,371...173,365,024
Ensembl chr 1:177,420,565...177,676,293
JBrowse link
G DNMT3A DNA methyltransferase 3 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:21102463 NCBI chr2A:25,229,593...25,344,733
Ensembl chr2A:25,331,095...25,412,605
JBrowse link
G ERAP2 endoplasmic reticulum aminopeptidase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21102463 NCBI chr 5:92,186,786...92,231,020
Ensembl chr 5:97,741,678...97,785,071
JBrowse link
G ESR2 estrogen receptor 2 disease_progression ISO mRNA:decreased expression:colon RGD PMID:21252046 RGD:5508810 NCBI chr14:44,807,875...44,919,780
Ensembl chr14:63,064,402...63,131,303
JBrowse link
G F13A1 coagulation factor XIII A chain ISO associated with Fistula;protein:decreased activity:plasma: RGD PMID:7611208 RGD:10450739 NCBI chr 6:5,978,505...6,156,705
Ensembl chr 6:6,157,926...6,513,961
JBrowse link
G F2 coagulation factor II, thrombin ISO RGD PMID:21593018 RGD:5147754 NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157
JBrowse link
G FCGR2A Fc fragment of IgG receptor IIa susceptibility ISO DNA:polymorphism: :p.A519G (human) RGD PMID:20848524 RGD:5147918 NCBI chr 1:136,892,311...136,906,450 JBrowse link
G FGA fibrinogen alpha chain ISO RGD PMID:19683480 RGD:5688758 NCBI chr 4:146,949,680...146,957,291 JBrowse link
G FN1 fibronectin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19751734 NCBI chr2B:102,623,568...102,698,747
Ensembl chr2B:221,208,431...221,284,003
JBrowse link
G FPR2 formyl peptide receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21659618 NCBI chr19:48,663,622...48,715,535 JBrowse link
G GC GC vitamin D binding protein susceptibility ISO DNA:polymorphism:cds:p.T420K(human) RGD PMID:21832969 RGD:5509866 NCBI chr 4:52,431,196...52,473,762
Ensembl chr 4:58,729,236...58,792,073
JBrowse link
G GPBAR1 G protein-coupled bile acid receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23566200 NCBI chr2B:105,520,364...105,523,229
Ensembl chr2B:224,120,127...224,121,119
JBrowse link
G GPX1 glutathione peroxidase 1 ISO protein:decreased expression:erythrocyte RGD PMID:20186929 RGD:11352754 NCBI chr 3:49,280,038...49,281,455
Ensembl chr 3:50,360,947...50,361,826
JBrowse link
G GSTM1 glutathione S-transferase mu 1 ISO RGD PMID:26604430 RGD:11538341 Ensembl chr 1:127,979,238...128,010,411 JBrowse link
G HFE homeostatic iron regulator treatment ISO DNA:SNP: :rs2071303 (human) RGD PMID:27115882 RGD:14701051 NCBI chr 6:25,921,663...25,930,852
Ensembl chr 6:26,580,358...26,588,591
JBrowse link
G HSPA1L heat shock protein family A (Hsp70) member 1 like ISO ClinVar Annotator: match by term: Inflammatory bowel disease 1 ClinVar PMID:28126021 NCBI chr 6:31,470,745...31,483,615
Ensembl chr 6:32,358,054...32,359,979
JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO RGD PMID:15638228 RGD:1625756 NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605
JBrowse link
G IFNG interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:21829567 PMID:28070144 RGD:14974261 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829
JBrowse link
G IGF1 insulin like growth factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19751734 NCBI chr12:99,986,887...100,066,773 JBrowse link
G IL10 interleukin 10 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:11113068 PMID:21102463 PMID:29899181 RGD:11049181 RGD:14975133 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371
JBrowse link
G IL12B interleukin 12B ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438406 NCBI chr 5:154,706,467...154,722,231
Ensembl chr 5:161,325,303...161,335,381
JBrowse link
G IL21R interleukin 21 receptor ISO DNA:altered methylation: : RGD PMID:22021194 RGD:6482789 Ensembl chr16:27,774,864...27,821,769 JBrowse link
G IL23R interleukin 23 receptor susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:SNPs:multiple:
CTD
RGD
PMID:17068223 PMID:17435756 PMID:18438406 RGD:8549568 NCBI chr 1:66,408,839...66,502,535
Ensembl chr 1:68,293,514...68,386,815
JBrowse link
G IL2RA interleukin 2 receptor subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:21102463 NCBI chr10:6,053,549...6,103,863 JBrowse link
G IL6 interleukin 6 ISO OMIM NCBI chr 7:23,415,922...23,420,767 JBrowse link
G IRGM immunity related GTPase M ISO CTD Direct Evidence: marker/mechanism CTD PMID:17554261 PMID:18438406 PMID:19165925 PMID:21278745 NCBI chr 5:146,274,097...146,329,979
Ensembl chr 5:152,278,581...152,308,182
JBrowse link
G JAK2 Janus kinase 2 ISO DNA:SNP: :rs10758669 (human) RGD PMID:22269120 RGD:6483020 NCBI chr 9:4,820,303...4,971,867
Ensembl chr 9:5,006,271...5,156,626
JBrowse link
G KDR kinase insert domain receptor ISO protein:increased expression:colon RGD PMID:19013462 RGD:5684406 NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109
JBrowse link
G LEP leptin ISO CTD Direct Evidence: marker/mechanism CTD PMID:21829567 NCBI chr 7:120,230,896...120,248,602
Ensembl chr 7:132,885,011...132,901,519
JBrowse link
G LOC100972994 HLA class II histocompatibility antigen, DQ beta 1 chain ISO RGD PMID:29358886 RGD:14974239 NCBI chr 6:32,237,395...32,244,201
Ensembl chr 6:33,353,599...33,360,272
JBrowse link
G LOC100995577 HLA class II histocompatibility antigen, DP alpha 1 chain ISO RGD PMID:12073072 RGD:6480648 NCBI chr 6:32,637,826...32,646,501
Ensembl chr 6:33,752,638...33,761,417
JBrowse link
G LRRK2 leucine rich repeat kinase 2 ISO DNA:point mutation: :p.T2397M (rs3761863) (human) RGD PMID:21983832 RGD:5508401 NCBI chr12:48,343,621...48,488,337
Ensembl chr12:49,205,930...49,350,462
JBrowse link
G MADCAM1 mucosal vascular addressin cell adhesion molecule 1 ISO RGD PMID:11703369 RGD:2311550 NCBI chr19:627,526...636,684
Ensembl chr19:468,026...477,830
JBrowse link
G MBL2 mannose binding lectin 2 susceptibility ISO DNA:polymorphisms:cds: RGD PMID:21702710 RGD:12910842 NCBI chr10:49,401,364...49,409,328
Ensembl chr10:51,527,758...51,543,432
JBrowse link
G MKI67 marker of proliferation Ki-67 ISO RGD PMID:21364546 RGD:6483536 NCBI chr10:124,684,336...124,714,143
Ensembl chr10:128,936,037...128,962,555
JBrowse link
G MST1 macrophage stimulating 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438406 NCBI chr 3:49,616,339...49,621,749 JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:28002332 NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419
JBrowse link
G NCF4 neutrophil cytosolic factor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17435756 NCBI chr22:17,775,590...17,795,725 JBrowse link
G NKX2-3 NK2 homeobox 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17554261 PMID:18438405 PMID:18438406 NCBI chr10:96,146,636...96,150,238 JBrowse link
G NLRP3 NLR family pyrin domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19098911 NCBI chr 1:223,052,307...223,084,736
Ensembl chr 1:228,505,147...228,537,216
JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 susceptibility
no_association
ISO DNA:frameshift mutation, missense mutations
DNA:missense mutations, frameshift mutation: :p.R702W, p.G908R, 3020_3021insC (human)
OMIM
RGD
PMID:11385576 PMID:21155887 RGD:1600778 RGD:5508730 NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773
JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21829567 NCBI chr12:98,052,778...98,144,085
Ensembl chr12:101,457,885...101,548,058
JBrowse link
G OCLN occludin ISO RGD PMID:21748286 RGD:11341809 NCBI chr 5:44,447,230...44,509,637
Ensembl chr 5:46,023,437...46,069,342
JBrowse link
G PGF placental growth factor ISO protein:increased expression:serum RGD PMID:17980128 RGD:6483592 NCBI chr14:55,494,152...55,508,066 JBrowse link
G PHOX2B paired like homeobox 2B ISO CTD Direct Evidence: marker/mechanism CTD PMID:17435756 NCBI chr 4:36,070,924...36,074,532
Ensembl chr 4:41,919,742...41,922,449
JBrowse link
G PLAUR plasminogen activator, urokinase receptor ISO RGD PMID:21114432 RGD:6483800 NCBI chr19:40,588,100...40,616,479
Ensembl chr19:49,197,341...49,222,561
Ensembl chr19:49,197,341...49,222,561
JBrowse link
G PON1 paraoxonase 1 ISO mRNA:decreased expression:terminal ileum RGD PMID:17664137 RGD:5509924 NCBI chr 7:87,253,476...87,279,650
Ensembl chr 7:100,841,286...100,867,493
JBrowse link
G PON3 paraoxonase 3 ISO mRNA:decreased expression:terminal ileum RGD PMID:17664137 RGD:5509924 NCBI chr 7:87,314,788...87,354,020
Ensembl chr 7:100,902,432...100,941,611
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:21829567 Ensembl chr22:45,218,364...45,302,970 JBrowse link
G PPARG peroxisome proliferator activated receptor gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:21829567 NCBI chr 3:12,215,322...12,361,669
Ensembl chr 3:12,622,397...12,705,060
JBrowse link
G PRF1 perforin 1 ISO DNA:hypermethylation RGD PMID:22021194 RGD:6482789 NCBI chr10:67,071,141...67,078,057
Ensembl chr10:69,597,574...69,603,070
JBrowse link
G PRKCQ protein kinase C theta ISO ClinVar Annotator: match by term: Inflammatory bowel disease 1 ClinVar NCBI chr10:6,458,138...6,610,781
Ensembl chr10:6,440,316...6,593,900
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO protein:increased expression:colon RGD PMID:21763290 RGD:5508200 NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519
JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17554261 NCBI chr18:1,440,837...1,538,501
Ensembl chr18:16,562,052...16,659,570
JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 ISO DNA:SNP:cds:rs2476601 (human) RGD PMID:18587394 RGD:6484668 NCBI chr 1:88,685,736...88,743,164
Ensembl chr 1:123,734,511...123,790,830
JBrowse link
G SELL selectin L ISO DNA:polymorphism: :p.F206L (human) RGD PMID:19212205 RGD:13464267 NCBI chr 1:145,173,700...145,194,927
Ensembl chr 1:148,895,373...148,916,393
JBrowse link
G SLC11A1 solute carrier family 11 member 1 no_association ISO DNA:point mutation:promoter:-237C>T (human)
DNA:repeat, polymorphisms:promoter, intron:p.D543N (human)
DNA:polymorphism:promoter (human)
DNA:polymorphisms:promoter (human)
DNA:polymorphism: :823C>T (human)
DNA:insertion/deletion:3' utr (human)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:11929588 PMID:15757519 PMID:16059695 PMID:17131479 PMID:17385031 PMID:18340647 PMID:18454481 RGD:5684938 RGD:5684939 RGD:5684941 RGD:5684942 RGD:5684952 RGD:5684956 RGD:5684968 NCBI chr2B:105,640,613...105,655,524
Ensembl chr2B:224,238,284...224,252,941
JBrowse link
G SLC22A5 solute carrier family 22 member 5 susceptibility ISO DNA:snp, haplotype:promoter:g.-207G>C (human) RGD PMID:15107849 RGD:1580609 NCBI chr 5:127,791,984...127,817,870
Ensembl chr 5:133,954,678...133,979,066
JBrowse link
G SMAD3 SMAD family member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21102463 NCBI chr15:46,013,764...46,143,126
Ensembl chr15:64,284,949...64,414,185
JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO DNA:SNP: :rs744166 (human)
DNA:SNPs: :rs744166, rs3816769 (human)
RGD PMID:20109474 PMID:22269120 RGD:6483020 RGD:6483027 NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067
JBrowse link
G TAGAP T cell activation RhoGTPase activating protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:21102463 NCBI chr 6:156,923,859...156,934,714
Ensembl chr 6:161,938,457...161,949,158
JBrowse link
G TCF7 transcription factor 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24994854 NCBI chr 5:129,518,134...129,549,972 JBrowse link
G THBD thrombomodulin ISO protein:decreased expression:colon, blood vessel RGD PMID:17557119 RGD:5685011 NCBI chr20:22,992,341...22,996,415
Ensembl chr20:23,345,917...23,347,812
JBrowse link
G TLR4 toll like receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17914947 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711
JBrowse link
G TNF tumor necrosis factor treatment ISO protein:increased expression:intestine mucosa
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:10700533 PMID:21359923 PMID:21829567 PMID:22531889 RGD:5130893 RGD:8661753 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A treatment ISO protein:increased expression:large intestine mucosa (rat) RGD PMID:21359923 PMID:22531889 RGD:5130893 RGD:8661753 NCBI chr12:6,457,617...6,470,969
Ensembl chr12:6,374,257...6,387,613
JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B ISO protein:increased expression:large intestine mucosa (rat) RGD PMID:21359923 RGD:5130893 NCBI chr 1:10,915,743...10,957,765
Ensembl chr 1:12,130,663...12,172,646
JBrowse link
G TYK2 tyrosine kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21102463 NCBI chr19:9,901,612...9,932,623
Ensembl chr19:10,565,490...10,594,541
JBrowse link
G VEGFA vascular endothelial growth factor A ISO protein:increased expression:colon, plasma RGD PMID:19013462 RGD:5684406 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353
JBrowse link
G VIPR1 vasoactive intestinal peptide receptor 1 ISO RGD PMID:17611633 RGD:5685618 NCBI chr 3:42,407,591...42,442,565
Ensembl chr 3:42,670,195...42,705,170
JBrowse link
G VTN vitronectin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19751734 NCBI chr17:28,403,813...28,407,202
Ensembl chr17:28,906,508...28,909,583
JBrowse link
Experimental Colitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme treatment ISO RGD PMID:17342403 PMID:24239644 RGD:40400720 RGD:40400748 NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853
JBrowse link
G ACER3 alkaline ceramidase 3 severity ISO mRNA,protein:decreased expression, decreased activity:colon: RGD PMID:26938296 RGD:35673322 NCBI chr11:71,911,204...72,077,528
Ensembl chr11:75,557,846...75,717,586
JBrowse link
G ADAM17 ADAM metallopeptidase domain 17 treatment ISO RGD PMID:11884025 RGD:632022 NCBI chr2A:9,478,080...9,545,363
Ensembl chr2A:9,641,201...9,708,054
JBrowse link
G ADRB3 adrenoceptor beta 3 no_association ISO mRNA:unaltered expression:colon (rat) RGD PMID:11803250 RGD:5684894 NCBI chr 8:37,263,730...37,267,475 JBrowse link
G ATP5F1A ATP synthase F1 subunit alpha treatment ISO RGD PMID:25689466 RGD:13703055 NCBI chr18:39,366,384...39,380,514
Ensembl chr18:42,904,136...42,923,326
JBrowse link
G CSF3 colony stimulating factor 3 treatment ISO RGD PMID:16689657 RGD:11039462 NCBI chr17:17,271,074...17,273,493
Ensembl chr17:17,491,276...17,493,729
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 treatment ISO RGD PMID:29655167 RGD:39939058 NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083
JBrowse link
G EREG epiregulin ISO protein:increased expression:colonic mucosa (mouse) RGD PMID:20498653 RGD:39457688 NCBI chr 4:49,806,505...49,827,961
Ensembl chr 4:55,641,014...55,660,568
JBrowse link
G FAS Fas cell surface death receptor treatment ISO RGD PMID:22368862 RGD:10054108 NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612
JBrowse link
G FOXP3 forkhead box P3 treatment ISO mRNA:increased expression:mucosa:
protein:increased expression:colon:
RGD PMID:17229795 PMID:26925602 PMID:27498708 PMID:28733028 RGD:14975101 RGD:38455994 RGD:38455995 RGD:38549362 NCBI chr  X:41,550,462...41,567,492
Ensembl chr  X:49,402,652...49,417,029
JBrowse link
G HAMP hepcidin antimicrobial peptide ISO protein:increased expression:colon RGD PMID:24764672 RGD:11041628 NCBI chr19:32,228,701...32,231,494
Ensembl chr19:40,964,445...40,968,861
JBrowse link
G HSF1 heat shock transcription factor 1 ISO protein:increased acetylation:colon (rat) RGD PMID:25608526 RGD:10402402 NCBI chr 8:141,055,310...141,078,360
Ensembl chr 8:144,062,137...144,067,866
JBrowse link
G ICAM1 intercellular adhesion molecule 1 treatment ISO RGD PMID:10092309 RGD:11522714 NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605
JBrowse link
G IFNG interferon gamma ISO protein:increased expression:plasma: RGD PMID:15030379 PMID:27498708 RGD:10755756 RGD:14975101 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829
JBrowse link
G IL10 interleukin 10 treatment ISO associated with Helicobacter Infections RGD PMID:16982822 PMID:25727887 PMID:27815529 RGD:11049170 RGD:11049485 RGD:14975260 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371
JBrowse link
G IL1B interleukin 1 beta treatment ISO RGD PMID:31175857 RGD:14975282 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424
JBrowse link
G IL2 interleukin 2 ISO RGD PMID:16630696 RGD:8662978 NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984
JBrowse link
G IL23A interleukin 23 subunit alpha severity ISO mRNA:increased expression:colon (mouse) RGD PMID:24028683 RGD:39458035 NCBI chr12:32,575,321...32,576,856
Ensembl chr12:32,828,902...32,830,617
JBrowse link
G IL33 interleukin 33 severity
treatment
ISO RGD PMID:25112700 PMID:28423665 RGD:39938951 RGD:39939041 NCBI chr 9:6,027,014...6,069,540
Ensembl chr 9:6,234,178...6,248,624
JBrowse link
G IL6 interleukin 6 treatment ISO RGD PMID:16133010 PMID:16630696 PMID:27096537 RGD:11062139 RGD:11062146 RGD:8662978 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G ITGA2 integrin subunit alpha 2 treatment ISO RGD PMID:16534417 RGD:11530069 NCBI chr 5:60,935,452...61,040,726
Ensembl chr 5:62,555,370...62,659,720
JBrowse link
G ITGA4 integrin subunit alpha 4 ISO protein:increased expression:colon (rat) RGD PMID:12183646 RGD:729408 NCBI chr2B:68,719,376...68,802,488
Ensembl chr2B:186,530,187...186,612,203
JBrowse link
G KCNMA1 potassium calcium-activated channel subfamily M alpha 1 ISO mRNA, protein:increased expression:colon RGD PMID:23986198 RGD:10412026 NCBI chr10:73,391,297...74,158,488
Ensembl chr10:76,062,047...76,820,644
JBrowse link
G KDR kinase insert domain receptor ISO protein:increased expression:colon RGD PMID:19013462 RGD:5684406 NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109
JBrowse link
G KL klotho ISO mRNA:decreased expression:kidney: RGD PMID:20004202 RGD:10403055 NCBI chr13:14,272,463...14,321,122
Ensembl chr13:32,702,336...32,751,458
JBrowse link
G LOC100978434 C-type lectin domain family 4 member M ISO RGD PMID:20130211 RGD:39938984 NCBI chr19:7,062,961...7,069,381 JBrowse link
G LOC100991079 interleukin-1 receptor antagonist protein treatment ISO human protein in a rat model RGD PMID:8978354 RGD:8551835 NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 treatment ISO RGD PMID:27028006 RGD:13800882 NCBI chr22:3,883,119...3,990,368
Ensembl chr22:20,365,487...20,450,335
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 treatment ISO RGD PMID:29037916 RGD:13800567 Ensembl chr16:30,489,362...30,498,017 JBrowse link
G MIF macrophage migration inhibitory factor severity ISO RGD PMID:15807847 RGD:36947390 NCBI chr22:4,646,986...4,647,831
Ensembl chr22:22,730,807...22,732,009
JBrowse link
G MMP2 matrix metallopeptidase 2 treatment ISO RGD PMID:23323009 RGD:13207328 NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279
JBrowse link
G MMP9 matrix metallopeptidase 9 treatment ISO RGD PMID:23323009 RGD:13207328 NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129
JBrowse link
G MYDGF myeloid derived growth factor severity
treatment
ISO associated with hymenolepiasis RGD PMID:19118508 PMID:20490892 PMID:27055194 RGD:11532263 RGD:39456118 RGD:39456129 NCBI chr19:3,674,001...3,689,123
Ensembl chr19:4,627,108...4,639,608
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 treatment ISO RGD PMID:22350949 RGD:10412739 NCBI chr2B:64,509,446...64,544,600
Ensembl chr2B:182,214,116...182,248,085
JBrowse link
G NFKBIA NFKB inhibitor alpha treatment ISO RGD PMID:21642017 RGD:10413866 NCBI chr14:16,155,331...16,158,588 JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 ISO protein:increased expression:colonic mucosa: RGD PMID:22997830 RGD:13204727 NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773
JBrowse link
G NPY neuropeptide Y treatment ISO RGD PMID:20533056 RGD:10448943 NCBI chr 7:24,963,056...24,970,803
Ensembl chr 7:24,568,041...24,574,657
JBrowse link
G PDGFRA platelet derived growth factor receptor alpha treatment ISO RGD PMID:24115822 RGD:11080973 NCBI chr 4:69,639,081...69,709,870
Ensembl chr 4:76,199,382...76,271,097
JBrowse link
G PDGFRB platelet derived growth factor receptor beta treatment ISO RGD PMID:24115822 RGD:11080973 NCBI chr 5:145,538,330...145,580,312
Ensembl chr 5:151,543,891...151,585,530
JBrowse link
G PHEX phosphate regulating endopeptidase homolog X-linked ISO mRNA:decreased expression:bone: RGD PMID:16890604 RGD:11556253 NCBI chr  X:14,663,847...14,859,294
Ensembl chr  X:22,017,681...22,232,501
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma susceptibility ISO RGD PMID:20347874 RGD:38599183 NCBI chr 7:98,841,974...98,885,446
Ensembl chr 7:111,570,148...111,611,614
JBrowse link
G PTGER4 prostaglandin E receptor 4 treatment ISO RGD PMID:12100473 RGD:727388 NCBI chr 5:69,686,906...69,700,739
Ensembl chr 5:74,731,470...74,745,148
JBrowse link
G SLC11A1 solute carrier family 11 member 1 ISO RGD PMID:19116231 RGD:5684934 NCBI chr2B:105,640,613...105,655,524
Ensembl chr2B:224,238,284...224,252,941
JBrowse link
G SMAD4 SMAD family member 4 susceptibility ISO RGD PMID:23090737 RGD:12880038 NCBI chr18:44,402,112...44,456,779
Ensembl chr18:47,764,568...47,797,359
JBrowse link
G TNF tumor necrosis factor treatment ISO RGD PMID:21296062 RGD:8661763 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A treatment ISO RGD PMID:21296062 RGD:8661763 NCBI chr12:6,457,617...6,470,969
Ensembl chr12:6,374,257...6,387,613
JBrowse link
G VEGFA vascular endothelial growth factor A ISO protein:increased expression:colon RGD PMID:19013462 RGD:5684406 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353
JBrowse link
ileitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR2 C-C motif chemokine receptor 2 ISO RGD PMID:22848538 RGD:8661712 NCBI chr 3:46,255,725...46,263,285
Ensembl chr 3:47,361,124...47,368,312
JBrowse link
G CCR3 C-C motif chemokine receptor 3 ISO RGD PMID:21945903 RGD:6892917 NCBI chr 3:46,147,928...46,172,947
Ensembl chr 3:47,253,878...47,278,630
JBrowse link
G CD80 CD80 molecule ISO RGD PMID:22068168 RGD:6902902 NCBI chr 3:116,646,590...116,683,725
Ensembl chr 3:123,559,559...123,594,870
JBrowse link
G IL10 interleukin 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27580383 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371
JBrowse link
G IL17A interleukin 17A ISO mRNA:increased expression:ileum RGD PMID:18536735 RGD:4837793 NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074
JBrowse link
G ITGAM integrin subunit alpha M ISO CTD Direct Evidence: marker/mechanism CTD PMID:10647630 NCBI chr16:23,634,476...23,707,147
Ensembl chr16:31,630,146...31,702,406
JBrowse link
G SERPINA1 serpin family A member 1 treatment ISO RGD PMID:23835442 RGD:14695050 NCBI chr14:75,001,714...75,014,214
Ensembl chr14:94,334,258...94,345,419
JBrowse link
G TLR2 toll like receptor 2 ISO RGD PMID:18266231 RGD:2312714 NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331
JBrowse link
G TLR4 toll like receptor 4 ISO RGD PMID:17255219 PMID:18266231 RGD:2312714 RGD:7241089 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711
JBrowse link
inflammatory bowel disease 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA1L heat shock protein family A (Hsp70) member 1 like ISO ClinVar Annotator: match by term: Inflammatory bowel disease 1 ClinVar PMID:28126021 NCBI chr 6:31,470,745...31,483,615
Ensembl chr 6:32,358,054...32,359,979
JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 ISO ClinVar Annotator: match by term: Inflammatory bowel disease 1 ClinVar PMID:11385576 PMID:11385577 PMID:11425413 PMID:11875755 PMID:11910337 PMID:12019468 PMID:12115249 PMID:12512038 PMID:12557156 PMID:12577202 PMID:12626759 PMID:12630966 PMID:14508222 PMID:14765395 PMID:15024686 PMID:15044951 PMID:15190267 PMID:15198989 PMID:15320482 PMID:15459013 PMID:15571588 PMID:15712650 PMID:15770725 PMID:15967635 PMID:16278823 PMID:16485124 PMID:18056399 PMID:18240302 PMID:18419343 PMID:18489434 PMID:18507017 PMID:18541930 PMID:19467619 PMID:19713276 PMID:20032092 PMID:20230816 PMID:20959815 PMID:21274544 PMID:21335489 PMID:21548950 PMID:21830272 PMID:21914217 PMID:21983784 PMID:22319155 PMID:22684479 PMID:22926499 PMID:22942351 PMID:23102769 PMID:24033266 PMID:24391456 PMID:24583628 PMID:24803813 PMID:24960071 PMID:25741868 PMID:26070941 PMID:26164256 PMID:26316104 PMID:26500656 PMID:27306066 PMID:28492532 PMID:28814775 NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773
JBrowse link
G PRKCQ protein kinase C theta ISO ClinVar Annotator: match by term: Inflammatory bowel disease 1 ClinVar NCBI chr10:6,458,138...6,610,781
Ensembl chr10:6,440,316...6,593,900
JBrowse link
inflammatory bowel disease 10 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATG16L1 autophagy related 16 like 1 ISO OMIM NCBI chr2B:120,479,534...120,523,563
Ensembl chr2B:239,392,990...239,436,766
JBrowse link
inflammatory bowel disease 13 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO OMIM NCBI chr 7:79,497,536...79,706,277
Ensembl chr 7:93,147,950...93,243,238
JBrowse link
inflammatory bowel disease 14 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IRF5 interferon regulatory factor 5 ISO OMIM NCBI chr 7:120,889,752...120,902,096
Ensembl chr 7:133,415,170...133,426,356
JBrowse link
inflammatory bowel disease 17 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL23R interleukin 23 receptor ISO OMIM NCBI chr 1:66,408,839...66,502,535
Ensembl chr 1:68,293,514...68,386,815
JBrowse link
inflammatory bowel disease 19 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IRGM immunity related GTPase M ISO OMIM NCBI chr 5:146,274,097...146,329,979
Ensembl chr 5:152,278,581...152,308,182
JBrowse link
inflammatory bowel disease 25 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL10RB interleukin 10 receptor subunit beta ISO OMIM NCBI chr21:19,628,808...19,668,268
Ensembl chr21:33,005,505...33,032,738
JBrowse link
inflammatory bowel disease 28 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL10RA interleukin 10 receptor subunit alpha ISO OMIM NCBI chr11:112,820,445...112,835,603
Ensembl chr11:116,752,619...116,767,771
JBrowse link
G SMIM35 small integral membrane protein 35 ISO ClinVar Annotator: match by term: Inflammatory bowel disease 28, autosomal recessive ClinVar NCBI chr11:112,828,277...112,922,461 JBrowse link
Inflammatory Bowel Disease 29 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INAVA innate immunity activator ISO OMIM NCBI chr 1:176,491,264...176,514,719
Ensembl chr 1:180,794,646...180,818,853
JBrowse link
Inflammatory Bowel Disease 30 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100969375 caspase recruitment domain-containing protein 8 ISO OMIM NCBI chr19:45,204,735...45,256,481
Ensembl chr19:53,798,967...53,850,328
JBrowse link
inflammatory bowel disease 5 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A5 solute carrier family 22 member 5 ISO ClinVar Annotator: match by term: Inflammatory bowel disease 5 ClinVar PMID:15107849 PMID:16333318 PMID:17213842 NCBI chr 5:127,791,984...127,817,870
Ensembl chr 5:133,954,678...133,979,066
JBrowse link
INFLAMMATORY BOWEL DISEASE, IMMUNODEFICIENCY, AND ENCEPHALOPATHY term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TGFB1 transforming growth factor beta 1 ISO OMIM NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973
JBrowse link
ischemic colitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SERPINE1 serpin family E member 1 susceptibility ISO DNA:polymorphism:promoter:rs1799768 (human) RGD PMID:25656775 RGD:13208543 NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450
JBrowse link
G VEGFA vascular endothelial growth factor A ISO RGD PMID:15770733 RGD:1580570 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353
JBrowse link
Neonatal Inflammatory Skin and Bowel Disease 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM17 ADAM metallopeptidase domain 17 ISO OMIM NCBI chr2A:9,478,080...9,545,363
Ensembl chr2A:9,641,201...9,708,054
JBrowse link
G IAH1 isoamyl acetate hydrolyzing esterase 1 (putative) ISO ClinVar Annotator: match by term: Inflammatory skin and bowel disease, neonatal 1 ClinVar PMID:28492532 NCBI chr2A:9,464,138...9,478,218
Ensembl chr2A:9,627,683...9,641,336
JBrowse link
Neonatal Inflammatory Skin and Bowel Disease 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EGFR epidermal growth factor receptor ISO OMIM NCBI chr 7:55,614,042...55,807,285
Ensembl chr 7:56,046,296...56,111,615
JBrowse link
Pediatric Crohn's Disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 ISO mRNA:increased expression:duodenum:non-inflamed tissue RGD PMID:16917230 RGD:5685614 NCBI chr 7:91,621,561...91,654,164
Ensembl chr 7:105,123,437...105,155,322
JBrowse link
G F2 coagulation factor II, thrombin ISO RGD PMID:21287673 RGD:5147769 NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157
JBrowse link
G TNF tumor necrosis factor ISO RGD PMID:11321389 RGD:7394742 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
JBrowse link
Proctocolitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100991079 interleukin-1 receptor antagonist protein ISO protein:increased concentration:serum (human) RGD PMID:9802632 RGD:6909134 NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839
JBrowse link
ulcerative colitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 susceptibility ISO RGD PMID:15505619 RGD:1598568 NCBI chr 7:79,497,536...79,706,277
Ensembl chr 7:93,147,950...93,243,238
JBrowse link
G ACSM3 acyl-CoA synthetase medium chain family member 3 ISO mRNA:decreased expression:colonic mucosa RGD PMID:21987487 RGD:7241281 NCBI chr16:17,611,715...17,644,587
Ensembl chr16:20,796,425...20,829,315
JBrowse link
G ADCY7 adenylate cyclase 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28067910 NCBI chr16:30,507,836...30,581,068
Ensembl chr16:49,410,143...49,462,278
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing ISO protein:increased expression:serum RGD PMID:16432373 RGD:5686726 NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885
JBrowse link
G ADRB2 adrenoceptor beta 2 ISO protein:decreased expression:large intestine mucosa,spleen RGD PMID:22772914 RGD:7175063 NCBI chr 5:144,259,756...144,398,421
Ensembl chr 5:150,267,554...150,315,892
JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type ISO protein:increased expression:large intestine epithelium RGD PMID:7679252 RGD:5509621 NCBI chr17:7,026,839...7,041,598
Ensembl chr17:7,014,591...7,029,602
JBrowse link
G ALPI alkaline phosphatase, intestinal ISO protein:decreased expression:colonic mucosa RGD PMID:22783049 RGD:14367879 NCBI chr2B:119,687,673...119,692,300
Ensembl chr2B:238,606,722...238,611,350
JBrowse link
G APLN apelin ISO protein:increased expression:intestine RGD PMID:17391779 RGD:1626177 NCBI chr  X:118,775,509...118,785,224 JBrowse link
G APOA4 apolipoprotein A4 severity ISO DNA:missense mutation:cds:p.Q360H (human) RGD PMID:17206692 RGD:5685660 NCBI chr11:111,659,186...111,661,790
Ensembl chr11:115,591,788...115,594,382
JBrowse link
G AQP7 aquaporin 7 severity ISO mRNA, protein:decreased expression:colon RGD PMID:15338270 RGD:1626292 NCBI chr 9:33,160,982...33,180,638 JBrowse link
G ARPC2 actin related protein 2/3 complex subunit 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18836448 NCBI chr2B:105,478,035...105,513,665
Ensembl chr2B:224,076,356...224,111,643
JBrowse link
G BRINP3 BMP/retinoic acid inducible neural specific 3 ISO mRNA,protein:decreased expression:intestine RGD PMID:25171508 RGD:14398484 NCBI chr 1:165,586,510...165,972,173
Ensembl chr 1:169,873,541...170,258,015
JBrowse link
G BTNL2 butyrophilin like 2 susceptibility ISO DNA:SNPs: : rs2294881,rs9268480,rs2076523(human) RGD PMID:19659809 RGD:9685032 NCBI chr 6:32,067,223...32,126,032 JBrowse link
G CARD9 caspase recruitment domain family member 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20228799 NCBI chr 9:107,432,709...107,446,271
Ensembl chr 9:136,416,279...136,424,756
JBrowse link
G CASP3 caspase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24055189 NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185
JBrowse link
G CCL20 C-C motif chemokine ligand 20 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:16306769 PMID:21887805 RGD:7488892 NCBI chr2B:115,052,768...115,056,479
Ensembl chr2B:233,862,505...233,866,225
JBrowse link
G CCNY cyclin Y ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438405 NCBI chr10:35,458,092...35,698,142
Ensembl chr10:36,035,729...36,273,282
JBrowse link
G CCR3 C-C motif chemokine receptor 3 ISO RGD PMID:21077277 RGD:6892920 NCBI chr 3:46,147,928...46,172,947
Ensembl chr 3:47,253,878...47,278,630
JBrowse link
G CCR6 C-C motif chemokine receptor 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16306769 NCBI chr 6:165,094,563...165,109,774
Ensembl chr 6:170,069,689...170,084,779
JBrowse link
G CD40 CD40 molecule ISO protein:increased expression:intestine, epithelial cell RGD PMID:20133813 RGD:5490590 NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994
JBrowse link
G CDH1 cadherin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19915572 NCBI chr16:49,108,745...49,206,347
Ensembl chr16:68,502,584...68,596,488
JBrowse link
G CDH3 cadherin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19915572 NCBI chr16:49,015,115...49,071,903
Ensembl chr16:68,407,625...68,465,287
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A disease_progression ISO RGD PMID:15743319 RGD:8662406 NCBI chr 6:36,241,405...36,250,032
Ensembl chr 6:37,436,990...37,445,599
JBrowse link
G COL18A1 collagen type XVIII alpha 1 chain ISO Protein:increased expression:large intestine mucosa RGD PMID:17011522 RGD:1600887 NCBI chr21:31,720,358...31,834,470 JBrowse link
G COL1A1 collagen type I alpha 1 chain ISO RGD PMID:17939044 RGD:5688304 NCBI chr17:44,274,349...44,291,764
Ensembl chr17:49,150,677...49,166,677
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12133438 PMID:15955209 NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083
JBrowse link
G CXCR1 C-X-C motif chemokine receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21297633 NCBI chr2B:105,429,576...105,433,243
Ensembl chr2B:224,028,838...224,029,890
JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21297633 NCBI chr2B:105,387,198...105,400,533
Ensembl chr2B:223,997,066...223,998,148
JBrowse link
G CXCR3 C-X-C motif chemokine receptor 3 ISO mRNA:increased expression:peripheral blood immature plasma cells RGD PMID:21087446 RGD:6480657 NCBI chr  X:60,880,759...60,883,355
Ensembl chr  X:70,933,160...70,935,756
JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 ISO mRNA:increased expression:peripheral blood immature plasma cells RGD PMID:21087446 RGD:6480657 NCBI chr2B:23,744,271...23,748,106
Ensembl chr2B:140,181,829...140,189,647
JBrowse link
G DAP death associated protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:21297633 NCBI chr 5:10,991,599...11,078,154
Ensembl chr 5:10,846,394...10,927,869
JBrowse link
G ECM1 extracellular matrix protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438406 NCBI chr 1:125,853,337...125,858,904
Ensembl chr 1:129,502,041...129,507,819
JBrowse link
G ESR2 estrogen receptor 2 ISO mRNA:decreased expression:colon RGD PMID:21252046 RGD:5508810 NCBI chr14:44,807,875...44,919,780
Ensembl chr14:63,064,402...63,131,303
JBrowse link
G F2 coagulation factor II, thrombin ISO RGD PMID:21593018 RGD:5147754 NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157
JBrowse link
G FAS Fas cell surface death receptor treatment ISO RGD PMID:30122878 RGD:13792562 NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612
JBrowse link
G FASLG Fas ligand treatment ISO RGD PMID:30122878 RGD:13792562 NCBI chr 1:148,159,826...148,167,785
Ensembl chr 1:151,868,430...151,876,281
JBrowse link
G FCGR2A Fc fragment of IgG receptor IIa susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:polymorphism: :p.A519G (human)
DNA:SNP: :rs1801274 (human)
CTD
RGD
PMID:19915573 PMID:20228799 PMID:20848524 RGD:5147918 RGD:5147922 NCBI chr 1:136,892,311...136,906,450 JBrowse link
G GC GC vitamin D binding protein susceptibility ISO DNA:polymorphism:cds:p.T420K(human) RGD PMID:21832969 RGD:5509866 NCBI chr 4:52,431,196...52,473,762
Ensembl chr 4:58,729,236...58,792,073
JBrowse link
G GHRL ghrelin and obestatin prepropeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:19617644 NCBI chr 3:10,221,829...10,229,229
Ensembl chr 3:10,573,537...10,580,723
JBrowse link
G GNA12 G protein subunit alpha 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21297633 NCBI chr 7:2,989,832...3,104,848 JBrowse link
G GPR65 G protein-coupled receptor 65 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30616622 NCBI chr14:68,617,219...68,624,158
Ensembl chr14:87,983,034...87,984,047
JBrowse link
G GPX1 glutathione peroxidase 1 ISO protein:decreased expression:erythrocyte RGD PMID:20186929 RGD:11352754 NCBI chr 3:49,280,038...49,281,455
Ensembl chr 3:50,360,947...50,361,826
JBrowse link
G GSTM1 glutathione S-transferase mu 1 susceptibility ISO DNA:deletion: : RGD PMID:17565649 PMID:26604430 PMID:28626742 RGD:11538341 RGD:14700999 RGD:5490554 Ensembl chr 1:127,979,238...128,010,411 JBrowse link
G HNF4A hepatocyte nuclear factor 4 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:19915572 NCBI chr20:40,684,450...40,763,824
Ensembl chr20:41,779,034...41,856,536
JBrowse link
G HNMT histamine N-methyltransferase ISO RGD PMID:18340362 RGD:5509777 NCBI chr2B:21,840,342...21,892,744
Ensembl chr2B:142,036,321...142,088,315
JBrowse link
G HSPA4 heat shock protein family A (Hsp70) member 4 ISO protein:increased expression:colon mucosa, epithelium (human) RGD PMID:22297444 RGD:5688753 NCBI chr 5:128,463,186...128,517,563
Ensembl chr 5:134,619,076...134,673,658
JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO mRNA:increased expression:substantia nigra (rat)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:15553846 PMID:20584104 RGD:4145388 NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605
JBrowse link
G ICOSLG inducible T cell costimulator ligand ISO CTD Direct Evidence: marker/mechanism CTD PMID:20228799 NCBI chr21:30,474,655...30,499,302 JBrowse link
G IGF1R insulin like growth factor 1 receptor ISO protein:altered expression:colon RGD PMID:18938767 RGD:5686432 NCBI chr15:77,332,926...77,648,474
Ensembl chr15:96,535,164...96,832,974
JBrowse link
G IGF2 insulin like growth factor 2 disease_progression ISO RGD PMID:16088202 RGD:5509966 NCBI chr11:2,170,190...2,199,442
Ensembl chr11:2,202,743...2,228,890
JBrowse link
G IKZF1 IKAROS family zinc finger 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20228799 NCBI chr 7:50,946,817...51,047,168
Ensembl chr 7:51,191,685...51,291,245
JBrowse link
G IL10 interleukin 10 ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:18836448 PMID:20228799 PMID:26660358 PMID:28120341 RGD:14975153 RGD:14975255 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371
JBrowse link
G IL12B interleukin 12B ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438406 PMID:20228799 PMID:21297633 NCBI chr 5:154,706,467...154,722,231
Ensembl chr 5:161,325,303...161,335,381
JBrowse link
G IL17REL interleukin 17 receptor E like ISO CTD Direct Evidence: marker/mechanism CTD PMID:20228798 NCBI chr22:30,221,096...30,240,052
Ensembl chr22:49,226,640...49,231,051
JBrowse link
G IL18RAP interleukin 18 receptor accessory protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:20228799 NCBI chr2A:99,363,823...99,393,346
Ensembl chr2A:103,510,109...103,544,916
JBrowse link
G IL1B interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:lung
CTD
RGD
PMID:12133438 PMID:15955209 PMID:20452301 PMID:22119283 PMID:24812904 RGD:10450593 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424
JBrowse link
G IL1R2 interleukin 1 receptor type 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21297633 Ensembl chr2A:103,042,328...103,078,190 JBrowse link
G IL23R interleukin 23 receptor ISO CTD Direct Evidence: marker/mechanism
DNA:SNP,Haplotype: :rs1884444(human)
CTD
RGD
PMID:18438406 PMID:19122664 PMID:20228799 PMID:23093364 RGD:8549574 NCBI chr 1:66,408,839...66,502,535
Ensembl chr 1:68,293,514...68,386,815
JBrowse link
G IL33 interleukin 33 severity
treatment
ISO mRNA:increased expression:sigmoid colon RGD PMID:21037074 PMID:25112700 PMID:28802904 RGD:39938951 RGD:39938966 RGD:40813742 NCBI chr 9:6,027,014...6,069,540
Ensembl chr 9:6,234,178...6,248,624
JBrowse link
G IL7R interleukin 7 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:21297633 NCBI chr 5:74,489,188...74,516,330
Ensembl chr 5:79,769,859...79,792,612
JBrowse link
G IRF5 interferon regulatory factor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21297633 NCBI chr 7:120,889,752...120,902,096
Ensembl chr 7:133,415,170...133,426,356
JBrowse link
G IRGM immunity related GTPase M ISO CTD Direct Evidence: marker/mechanism CTD PMID:20228799 NCBI chr 5:146,274,097...146,329,979
Ensembl chr 5:152,278,581...152,308,182
JBrowse link
G JAK2 Janus kinase 2 ISO CTD Direct Evidence: marker/mechanism
DNA:SNP: :rs10758669 (human)
CTD
RGD
PMID:20228799 PMID:21297633 PMID:22269120 RGD:6483020 NCBI chr 9:4,820,303...4,971,867
Ensembl chr 9:5,006,271...5,156,626
JBrowse link
G KDR kinase insert domain receptor ISO protein:increased expression:colon RGD PMID:19013462 RGD:5684406 NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109
JBrowse link
G KIF21B kinesin family member 21B ISO CTD Direct Evidence: marker/mechanism CTD PMID:20228799 NCBI chr 1:176,569,305...176,623,403
Ensembl chr 1:180,872,306...180,925,725
JBrowse link
G LAMB1 laminin subunit beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19915572 NCBI chr 7:99,905,761...99,985,233
Ensembl chr 7:112,627,488...112,706,554
JBrowse link
G LOC100972994 HLA class II histocompatibility antigen, DQ beta 1 chain ISO RGD PMID:31038770 RGD:14865009 NCBI chr 6:32,237,395...32,244,201
Ensembl chr 6:33,353,599...33,360,272
JBrowse link
G LOC100976978 E3 ubiquitin-protein ligase HERC2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438405 NCBI chr15:1,590,558...1,800,023
Ensembl chr15:25,536,483...25,746,074
JBrowse link
G LOC100978828 defensin-6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20452301 NCBI chr 8:356,058...357,659
Ensembl chr 8:6,927,326...6,928,970
JBrowse link
G LOC100991079 interleukin-1 receptor antagonist protein ISO DNA:repeats:intron:IVS2+914_1000dup IL1RN*2 (human) RGD PMID:8119534 RGD:6909136 NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839
JBrowse link
G LOC100991118 defensin-5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20452301 NCBI chr 8:264,298...265,962 JBrowse link
G LSP1 lymphocyte specific protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21297633 NCBI chr11:1,889,625...1,931,192
Ensembl chr11:1,921,905...1,963,192
JBrowse link
G LTF lactotransferrin ISO CTD Direct Evidence: therapeutic CTD PMID:16640825 NCBI chr 3:46,337,738...46,367,476
Ensembl chr 3:47,442,440...47,471,532
JBrowse link
G MASP2 mannan binding lectin serine peptidase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12904520 NCBI chr 1:9,787,565...9,810,276
Ensembl chr 1:11,009,760...11,030,734
JBrowse link
G MMP1 matrix metallopeptidase 1 ISO RGD PMID:18837084 RGD:7207395 NCBI chr11:97,730,545...97,739,190
Ensembl chr11:101,221,393...101,230,104
JBrowse link
G MMP9 matrix metallopeptidase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22119283 NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129
JBrowse link
G MPO myeloperoxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:20380826 PMID:22119283 PMID:24055189 NCBI chr17:52,333,882...52,357,838
Ensembl chr17:57,201,073...57,212,111
JBrowse link
G MST1 macrophage stimulating 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438406 PMID:20228799 NCBI chr 3:49,616,339...49,621,749 JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase susceptibility ISO DNA:polymorphism: :66A>G (human) RGD PMID:21947961 RGD:5508217 NCBI chr 5:8,195,868...8,228,071
Ensembl chr 5:8,017,403...8,049,322
JBrowse link
G MUC2 mucin 2, oligomeric mucus/gel-forming ISO mRNA:altered expression: : RGD PMID:12870797 RGD:2324685 NCBI chr11:1,106,716...1,144,489
Ensembl chr11:1,143,625...1,169,741
JBrowse link
G NKX2-3 NK2 homeobox 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438405 PMID:18438406 PMID:20228799 NCBI chr10:96,146,636...96,150,238 JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20452301 NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773
JBrowse link
G ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20228799 NCBI chr17:17,361,624...17,368,194
Ensembl chr17:17,581,612...17,587,741
JBrowse link
G PON1 paraoxonase 1 ISO mRNA:decreased expression:colon RGD PMID:17664137 RGD:5509924 NCBI chr 7:87,253,476...87,279,650
Ensembl chr 7:100,841,286...100,867,493
JBrowse link
G PON3 paraoxonase 3 ISO mRNA:decreased expression:colon RGD PMID:17664137 RGD:5509924 NCBI chr 7:87,314,788...87,354,020
Ensembl chr 7:100,902,432...100,941,611
JBrowse link
G PRDM1 PR/SET domain 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21297633 NCBI chr 6:103,899,410...103,923,389
Ensembl chr 6:107,773,229...107,796,815
JBrowse link
G PSMG1 proteasome assembly chaperone 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20228799 NCBI chr21:25,526,270...25,535,005
Ensembl chr21:38,876,026...38,884,027
JBrowse link
G PTGER4 prostaglandin E receptor 4 ISO RGD PMID:21818367 RGD:6483532 NCBI chr 5:69,686,906...69,700,739
Ensembl chr 5:74,731,470...74,745,148
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO RGD PMID:17429720 RGD:2300267 NCBI chr 9:93,495,365...93,517,557
Ensembl chr 9:121,837,095...121,859,283
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:17429720 RGD:2300267 NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519
JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438405 NCBI chr18:1,440,837...1,538,501
Ensembl chr18:16,562,052...16,659,570
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:15955209 NCBI chr11:61,012,839...61,022,225
Ensembl chr11:64,347,859...64,356,868
JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20452301 NCBI chr 8:86,447,216...86,480,511
Ensembl chr 8:88,398,468...88,456,268
JBrowse link
G RNF170 ring finger protein 170 ISO ClinVar Annotator: match by term: Ulcerative colitis ClinVar PMID:30311386 NCBI chr 8:42,097,900...42,145,327
Ensembl chr 8:39,541,479...39,588,163
JBrowse link
G SELL selectin L ISO DNA:polymorphism: :p.F206L (human) RGD PMID:19212205 RGD:13464267 NCBI chr 1:145,173,700...145,194,927
Ensembl chr 1:148,895,373...148,916,393
JBrowse link
G SELP selectin P ISO protein:increased expression:serum RGD PMID:21526498 RGD:6218993 NCBI chr 1:145,071,094...145,112,851
Ensembl chr 1:148,793,677...148,834,701
JBrowse link
G SLC11A1 solute carrier family 11 member 1 ISO CTD Direct Evidence: marker/mechanism
DNA:polymorphism:promoter (human)
DNA:transition, repeat:promoter:-237C>T (human)
CTD
RGD
PMID:11929588 PMID:16059695 PMID:18340647 RGD:5684939 RGD:5684968 NCBI chr2B:105,640,613...105,655,524
Ensembl chr2B:224,238,284...224,252,941
JBrowse link
G SLC26A3 solute carrier family 26 member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19915573 NCBI chr 7:99,747,405...99,776,763
Ensembl chr 7:112,470,041...112,507,671
JBrowse link
G SPHK1 sphingosine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24055189 NCBI chr17:70,331,370...70,336,043
Ensembl chr17:75,883,329...75,886,481
JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO DNA:SNP: :rs744166 (human)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:18438405 PMID:20228799 PMID:22269120 RGD:6483020 NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067
JBrowse link
G SYNE1 spectrin repeat containing nuclear envelope protein 1 ISO ClinVar Annotator: match by term: Ulcerative colitis ClinVar PMID:30311386 NCBI chr 6:149,936,306...150,454,822
Ensembl chr 6:154,627,904...155,144,076
JBrowse link
G THBD thrombomodulin ISO protein:decreased expression:colon, blood vessel RGD PMID:17557119 RGD:5685011 NCBI chr20:22,992,341...22,996,415
Ensembl chr20:23,345,917...23,347,812
JBrowse link
G TNF tumor necrosis factor treatment ISO protein:increased expression:lung
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:19617644 PMID:20452301 PMID:22119283 PMID:24812904 PMID:25204186 PMID:28120341 RGD:10450577 RGD:10450593 RGD:14975153 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
JBrowse link
G TNFSF15 TNF superfamily member 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20228799 NCBI chr 9:85,881,800...85,904,191
Ensembl chr 9:114,249,472...114,265,441
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15553846 NCBI chr 1:103,377,815...103,395,118
Ensembl chr 1:102,091,336...102,107,732
JBrowse link
G VEGFA vascular endothelial growth factor A ISO protein:increased expression:colon, plasma RGD PMID:19013462 RGD:5684406 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353
JBrowse link
G VIP vasoactive intestinal peptide severity ISO mRNA:decreased expression:colon RGD PMID:22143367 RGD:5685619 NCBI chr 6:150,564,545...150,573,582
Ensembl chr 6:155,254,652...155,263,730
JBrowse link
G VIPR1 vasoactive intestinal peptide receptor 1 ISO RGD PMID:17611633 RGD:5685618 NCBI chr 3:42,407,591...42,442,565
Ensembl chr 3:42,670,195...42,705,170
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 12771
    disease of anatomical entity 12303
      gastrointestinal system disease 3968
        intestinal disease 1370
          inflammatory bowel disease 296
            Crohn's disease + 97
            INFLAMMATORY BOWEL DISEASE, IMMUNODEFICIENCY, AND ENCEPHALOPATHY 1
            Inflammatory Bowel Disease 29 1
            Inflammatory Bowel Disease 30 1
            Neonatal Inflammatory Skin and Bowel Disease + 3
            colitis + 209
            inflammatory bowel disease 1 3
            inflammatory bowel disease 10 1
            inflammatory bowel disease 11 0
            inflammatory bowel disease 12 0
            inflammatory bowel disease 13 1
            inflammatory bowel disease 14 1
            inflammatory bowel disease 15 0
            inflammatory bowel disease 16 0
            inflammatory bowel disease 17 1
            inflammatory bowel disease 18 0
            inflammatory bowel disease 19 1
            inflammatory bowel disease 2 0
            inflammatory bowel disease 20 0
            inflammatory bowel disease 21 0
            inflammatory bowel disease 22 0
            inflammatory bowel disease 23 0
            inflammatory bowel disease 24 0
            inflammatory bowel disease 25 1
            inflammatory bowel disease 26 0
            inflammatory bowel disease 27 0
            inflammatory bowel disease 28 2
            inflammatory bowel disease 3 0
            inflammatory bowel disease 4 0
            inflammatory bowel disease 5 1
            inflammatory bowel disease 6 0
            inflammatory bowel disease 7 0
            inflammatory bowel disease 8 0
            inflammatory bowel disease 9 0
            ulcerative colitis + 108
Path 2
Term Annotations click to browse term
  disease 12771
    disease of anatomical entity 12303
      Immune & Inflammatory Diseases 2913
        Inflammation 1778
          gastroenteritis 372
            inflammatory bowel disease 296
              Crohn's disease + 97
              INFLAMMATORY BOWEL DISEASE, IMMUNODEFICIENCY, AND ENCEPHALOPATHY 1
              Inflammatory Bowel Disease 29 1
              Inflammatory Bowel Disease 30 1
              Neonatal Inflammatory Skin and Bowel Disease + 3
              colitis + 209
              inflammatory bowel disease 1 3
              inflammatory bowel disease 10 1
              inflammatory bowel disease 11 0
              inflammatory bowel disease 12 0
              inflammatory bowel disease 13 1
              inflammatory bowel disease 14 1
              inflammatory bowel disease 15 0
              inflammatory bowel disease 16 0
              inflammatory bowel disease 17 1
              inflammatory bowel disease 18 0
              inflammatory bowel disease 19 1
              inflammatory bowel disease 2 0
              inflammatory bowel disease 20 0
              inflammatory bowel disease 21 0
              inflammatory bowel disease 22 0
              inflammatory bowel disease 23 0
              inflammatory bowel disease 24 0
              inflammatory bowel disease 25 1
              inflammatory bowel disease 26 0
              inflammatory bowel disease 27 0
              inflammatory bowel disease 28 2
              inflammatory bowel disease 3 0
              inflammatory bowel disease 4 0
              inflammatory bowel disease 5 1
              inflammatory bowel disease 6 0
              inflammatory bowel disease 7 0
              inflammatory bowel disease 8 0
              inflammatory bowel disease 9 0
              ulcerative colitis + 108
paths to the root