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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:angiosarcoma
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Accession:DOID:0001816 term browser browse the term
Definition:A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed)
Synonyms:exact_synonym: angiosarcomas;   hemangiosarcoma;   hemangiosarcomas
 primary_id: MESH:D006394
 alt_id: RDO:0001774
 xref: NCI:C122783;   NCI:C24016;   NCI:C3088;   NCI:C9275
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
angiosarcoma term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANGPT2 angiopoietin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17569031 NCBI chr 8:718,367...782,534
Ensembl chr 8:6,506,014...6,566,915
JBrowse link
G CCND1 cyclin D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17569031 NCBI chr11:64,737,006...64,750,353 JBrowse link
G COL18A1 collagen type XVIII alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:17569031 NCBI chr21:31,720,358...31,834,470 JBrowse link
G CSF3 colony stimulating factor 3 ISO CTD Direct Evidence: therapeutic CTD PMID:9774950 NCBI chr17:17,271,074...17,273,493
Ensembl chr17:17,491,276...17,493,729
JBrowse link
G CTNNB1 catenin beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:13678655 NCBI chr 3:41,104,940...41,145,934
Ensembl chr 3:41,373,726...41,414,030
JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17569031 NCBI chr13:9,584,850...9,779,542 JBrowse link
G GJA4 gap junction protein alpha 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17569031 NCBI chr 1:34,059,901...34,063,181 JBrowse link
G HRAS HRas proto-oncogene, GTPase ISO CTD Direct Evidence: marker/mechanism CTD PMID:10930038 NCBI chr11:537,488...540,810
Ensembl chr11:568,305...571,078
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:17569031 NCBI chr 1:58,042,794...58,045,536 JBrowse link
G KDR kinase insert domain receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:17569031 NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109
JBrowse link
G KRAS KRAS proto-oncogene, GTPase ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Angiosarcoma
CTD
ClinVar
PMID:8456858 PMID:10930038 PMID:12211074 PMID:13678655 PMID:20737008 PMID:24740626 PMID:25157968 PMID:25808193 NCBI chr12:61,062,689...61,108,524
Ensembl chr12:63,679,293...63,724,335
JBrowse link
G MED12 mediator complex subunit 12 ISO ClinVar Annotator: match by term: Angiosarcoma ClinVar PMID:26822237 NCBI chr  X:60,386,820...60,410,730
Ensembl chr  X:70,443,667...70,466,942
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:17569031 NCBI chr 8:124,387,561...124,393,551
Ensembl chr 8:127,131,512...127,136,863
JBrowse link
G PLCG1 phospholipase C gamma 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24633157 NCBI chr20:37,477,077...37,515,854
Ensembl chr20:38,572,709...38,615,145
JBrowse link
G PTPRB protein tyrosine phosphatase receptor type B ISO CTD Direct Evidence: marker/mechanism CTD PMID:24633157 NCBI chr12:68,025,973...68,147,613
Ensembl chr12:70,797,843...70,915,308
JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO protein:increased phosphorylation:blood vessel RGD PMID:18700251 RGD:8694308 NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067
JBrowse link
G TEK TEK receptor tyrosine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:17569031 NCBI chr 9:26,955,339...27,077,809
Ensembl chr 9:27,561,421...27,683,572
JBrowse link
G TP53 tumor protein p53 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10626228 PMID:10930038 PMID:13678655 PMID:20737008 NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120
JBrowse link
G VEGFA vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD PMID:17569031 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353
JBrowse link
G VEGFC vascular endothelial growth factor C ISO CTD Direct Evidence: marker/mechanism CTD PMID:17569031 NCBI chr 4:168,870,941...168,999,160
Ensembl chr 4:181,104,737...181,236,030
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 13663
    disease of cellular proliferation 6499
      Neoplasms by Histologic Type 4249
        cell type cancer 3236
          sarcoma 228
            angiosarcoma 20
              Postmastectomy Angiosarcoma 0
              Radiation Induced Angiosarcoma of the Breast 0
              Stewart Treves Syndrome 0
              aorta angiosarcoma 0
              breast angiosarcoma 0
              central nervous system angiosarcoma 0
              childhood angiosarcoma 0
              conventional angiosarcoma 0
              gallbladder angiosarcoma 0
              liver angiosarcoma + 0
              mediastinum angiosarcoma 0
              ovarian angiosarcoma 0
              prostate angiosarcoma 0
              skin angiosarcoma 0
              spleen angiosarcoma 0
              superior vena cava angiosarcoma 0
              thyroid angiosarcoma 0
Path 2
Term Annotations click to browse term
  disease 13663
    disease of cellular proliferation 6499
      cancer 4644
        organ system cancer 4491
          cardiovascular cancer 37
            vascular cancer 37
              angiosarcoma 20
                Postmastectomy Angiosarcoma 0
                Radiation Induced Angiosarcoma of the Breast 0
                Stewart Treves Syndrome 0
                aorta angiosarcoma 0
                breast angiosarcoma 0
                central nervous system angiosarcoma 0
                childhood angiosarcoma 0
                conventional angiosarcoma 0
                gallbladder angiosarcoma 0
                liver angiosarcoma + 0
                mediastinum angiosarcoma 0
                ovarian angiosarcoma 0
                prostate angiosarcoma 0
                skin angiosarcoma 0
                spleen angiosarcoma 0
                superior vena cava angiosarcoma 0
                thyroid angiosarcoma 0
paths to the root