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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Chemical and Drug Induced Liver Injury
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Accession:DOID:9007383 term browser browse the term
Definition:A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
Synonyms:exact_synonym: Chemically Induced Liver Toxicity;   Drug Induced Acute Liver Injury;   Drug Induced Liver Disease;   Drug Induced Liver Injury;   Drug-Induced Liver Diseases;   Drug-Induced Liver Injuries;   Toxic Hepatitis;   chemically-induced liver toxicities;   hepatotoxicity;   toxic hepatitides
 narrow_synonym: Drug-induced liver injury due to flucloxacillin
 primary_id: MESH:D056486
 alt_id: RDO:0007742
 xref: EFO:0004228;   EFO:0011052;   NCI:C84427

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Chemical and Drug Induced Liver Injury term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aass aminoadipate-semialdehyde synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955479:3,746,003...3,805,835
Ensembl chrNW_004955479:3,742,757...3,814,338 		JBrowse link
G Abcb1 ATP binding cassette subfamily B member 1 severity
susceptibility		 ISO CTD Direct Evidence: marker/mechanism
DNA:SNP::2677G>T/A(rs2032582)(human)		 RGD
CTD		 PMID:20623750 PMID:26134275 PMID:27296832 RGD:11041130 RGD:14700895 NCBI chrNW_004955432:4,911,774...5,085,349 JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 severity ISO DNA:SNP: :rs2287616(human) RGD PMID:27293027 RGD:14402413 NCBI chrNW_004955449:5,412,958...5,511,629
Ensembl chrNW_004955449:5,412,876...5,512,701 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) ISO CTD Direct Evidence: marker/mechanism CTD PMID:18466103 NCBI chrNW_004955442:729,322...858,826
Ensembl chrNW_004955442:729,316...860,290 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 susceptibility ISO DNA:polymorphism:promoter:-24C>T(human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:17241877 PMID:18381794 PMID:18466103 PMID:25196354 RGD:14700812 RGD:14700814 NCBI chrNW_004955507:5,724,788...5,791,281
Ensembl chrNW_004955507:5,724,762...5,790,812 		JBrowse link
G Abi1 abl interactor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955429:2,682,341...2,783,752
Ensembl chrNW_004955429:2,682,343...2,783,752 		JBrowse link
G Acox3 acyl-CoA oxidase 3, pristanoyl ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955514:2,653,502...2,690,452
Ensembl chrNW_004955514:2,656,144...2,685,896 		JBrowse link
G Acsl1 acyl-CoA synthetase long chain family member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955403:24,190,674...24,235,354
Ensembl chrNW_004955403:24,190,674...24,236,780 		JBrowse link
G Actb actin beta ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:liver		 CTD
RGD		 PMID:22563491 PMID:25231249 RGD:9587759 NCBI chrNW_004955460:10,358,100...10,361,585
Ensembl chrNW_004955460:10,356,699...10,361,585 		JBrowse link
G Actn4 actinin alpha 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955468:770,573...841,859
Ensembl chrNW_004955468:770,573...842,209 		JBrowse link
G Actr3 actin related protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955459:15,216,914...15,284,013
Ensembl chrNW_004955459:15,216,914...15,284,013 		JBrowse link
G Ada adenosine deaminase ISO protein:increased expression:liver RGD PMID:21161045 RGD:5128859 NCBI chrNW_004955445:12,696,096...12,717,488
Ensembl chrNW_004955445:12,696,096...12,717,488 		JBrowse link
G Adam8 ADAM metallopeptidase domain 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24646716 NCBI chrNW_004955477:10,894,288...10,906,961
Ensembl chrNW_004955477:10,895,446...10,907,215 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO CTD Direct Evidence: therapeutic CTD PMID:20709802 NCBI chrNW_004955420:20,911,181...20,922,992
Ensembl chrNW_004955420:20,912,348...20,914,402 		JBrowse link
G Adipor2 adiponectin receptor 2 severity ISO associated with obesity, LPS;mRNA:decreased expression:liver (rat) RGD PMID:23838384 RGD:8695926 NCBI chrNW_004955454:4,243,898...4,327,255
Ensembl chrNW_004955454:4,243,898...4,327,308 		JBrowse link
G Adora2b adenosine A2b receptor ISO CTD Direct Evidence: therapeutic CTD PMID:35292334 NCBI chrNW_004955467:1,342,271...1,363,149
Ensembl chrNW_004955467:1,342,271...1,363,138 		JBrowse link
G Agt angiotensinogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:29499335 NCBI chrNW_004955492:7,863,662...7,874,863
Ensembl chrNW_004955492:7,866,833...7,873,357 		JBrowse link
G Ahr aryl hydrocarbon receptor ISO CTD Direct Evidence: marker/mechanism|therapeutic
mRNA:decreased expression:liver (rat)		 CTD
RGD		 PMID:21890736 PMID:28959666 PMID:34848246 RGD:401794432 NCBI chrNW_004955410:20,428,531...20,459,482
Ensembl chrNW_004955410:20,428,546...20,456,836 		JBrowse link
G Aifm1 apoptosis inducing factor mitochondria associated 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25743375 NCBI chrNW_004955473:4,891,955...4,925,705
Ensembl chrNW_004955473:4,891,955...4,926,428 		JBrowse link
G Ak4 adenylate kinase 4 ISO protein:increased expression:liver (rat) RGD PMID:16538043 RGD:2301096 NCBI chrNW_004955423:25,395,086...25,402,324
Ensembl chrNW_004955423:25,395,836...25,427,474 		JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:29763686 PMID:32805337 RGD:27226688 NCBI chrNW_004955464:12,715,238...12,729,034
Ensembl chrNW_004955464:12,714,717...12,729,662 		JBrowse link
G Alb albumin treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:18779383 PMID:22310181 PMID:27567545 RGD:14694844 NCBI chrNW_004955447:9,327...21,212 JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family member L2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955405:39,387,949...39,437,282
Ensembl chrNW_004955405:39,387,527...39,437,322 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member severity
susceptibility		 ISO DNA:deletion:exon 3 (mouse)
protein:increased expression:liver		 RGD PMID:21138988 PMID:24492981 PMID:30121625 RGD:14975148 RGD:15036810 RGD:7241599 NCBI chrNW_004955482:8,352,569...8,383,097
Ensembl chrNW_004955482:8,352,569...8,384,899 		JBrowse link
G Aldh9a1 aldehyde dehydrogenase 9 family member A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955462:10,998,147...11,017,360 JBrowse link
G Aldob aldolase, fructose-bisphosphate B ISO CTD Direct Evidence: marker/mechanism CTD PMID:16115720 NCBI chrNW_004955419:24,377,427...24,389,909
Ensembl chrNW_004955419:24,377,427...24,389,909 		JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor ISO CTD Direct Evidence: marker/mechanism CTD PMID:18779383 NCBI chrNW_004955419:13,478,904...13,492,329
Ensembl chrNW_004955419:13,478,552...13,492,327 		JBrowse link
G Anxa2 annexin A2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955450:14,545,586...14,574,161
Ensembl chrNW_004955450:14,512,381...14,574,696 		JBrowse link
G Anxa6 annexin A6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955408:2,522,027...2,565,862
Ensembl chrNW_004955408:2,522,027...2,570,426 		JBrowse link
G Apoa1 apolipoprotein A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 NCBI chrNW_004955412:18,170,331...18,172,298
Ensembl chrNW_004955412:18,170,331...18,172,298 		JBrowse link
G Apoe apolipoprotein E ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888 		JBrowse link
G Apoh apolipoprotein H ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:plasma:		 CTD
RGD		 PMID:16099942 PMID:23288050 RGD:10054107 NCBI chrNW_004955478:5,612,258...5,626,061
Ensembl chrNW_004955478:5,610,164...5,626,020 		JBrowse link
G Arg1 arginase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22872058 NCBI chrNW_004955436:12,235,767...12,247,817
Ensembl chrNW_004955436:12,235,767...12,251,972 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator ISO CTD Direct Evidence: marker/mechanism CTD PMID:20935161 NCBI chrNW_004955588:159,462...233,047
Ensembl chrNW_004955588:159,462...233,047 		JBrowse link
G Atg5 autophagy related 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22491424 NCBI chrNW_004955411:31,501,191...31,646,407
Ensembl chrNW_004955411:31,522,420...31,646,827 		JBrowse link
G Atoh8 atonal bHLH transcription factor 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955424:1,775,139...1,803,106
Ensembl chrNW_004955424:1,776,127...1,802,763 		JBrowse link
G Atp6v1d ATPase H+ transporting V1 subunit D ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955466:2,855,597...2,869,319
Ensembl chrNW_004955466:2,854,889...2,869,950 		JBrowse link
G Bad BCL2 associated agonist of cell death treatment ISO RGD PMID:25447754 RGD:10053709 NCBI chrNW_004955422:20,795,585...20,809,039
Ensembl chrNW_004955422:20,795,676...20,809,245 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:17906064 NCBI chrNW_004955559:1,695,960...1,700,246
Ensembl chrNW_004955559:1,695,960...1,700,244 		JBrowse link
G Bdh1 3-hydroxybutyrate dehydrogenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955420:13,454,379...13,486,700
Ensembl chrNW_004955420:13,452,166...13,486,565 		JBrowse link
G Bdkrb2 bradykinin receptor B2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30685357 NCBI chrNW_004955438:16,514,300...16,537,160
Ensembl chrNW_004955438:16,511,759...16,537,172 		JBrowse link
G Blvrb biliverdin reductase B ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955578:813,834...834,675
Ensembl chrNW_004955578:813,480...838,151 		JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 ISO CTD Direct Evidence: therapeutic CTD PMID:36602574 NCBI chrNW_004955414:28,652,663...28,748,360
Ensembl chrNW_004955414:28,684,226...28,748,360 		JBrowse link
G Bpnt1 3'(2'), 5'-bisphosphate nucleotidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955520:3,521,096...3,543,255
Ensembl chrNW_004955520:3,524,684...3,544,666 		JBrowse link
G Brd4 bromodomain containing 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955495:7,959,033...7,989,216
Ensembl chrNW_004955495:7,957,510...7,988,498 		JBrowse link
G Btd biotinidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:15469856 NCBI chrNW_004955430:7,960,036...7,988,754
Ensembl chrNW_004955430:7,960,039...7,988,754 		JBrowse link
G C3 complement C3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697 		JBrowse link
G Ca3 carbonic anhydrase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 PMID:25231249 NCBI chrNW_004955417:3,362,091...3,372,270
Ensembl chrNW_004955417:3,362,492...3,372,932 		JBrowse link
G Cabp1 calcium binding protein 1 ISO protein:increased expression:liver RGD PMID:21138988 RGD:7241599 NCBI chrNW_004955455:11,000,763...11,068,922 JBrowse link
G Cadps2 calcium dependent secretion activator 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26881866 NCBI chrNW_004955479:3,961,877...4,485,710
Ensembl chrNW_004955479:3,961,731...4,485,710 		JBrowse link
G Canx calnexin ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955408:850,773...894,362
Ensembl chrNW_004955408:848,808...894,362 		JBrowse link
G Cap1 cyclase associated actin cytoskeleton regulatory protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955452:17,503,530...17,528,049
Ensembl chrNW_004955452:17,503,531...17,528,049 		JBrowse link
G Casp8 caspase 8 treatment ISO RGD PMID:25447754 RGD:10053709 NCBI chrNW_004955403:322,082...348,591
Ensembl chrNW_004955403:322,555...347,053 		JBrowse link
G Cast calpastatin ISO RGD PMID:16871587 RGD:5683869 NCBI chrNW_004955418:15,859,951...15,974,141
Ensembl chrNW_004955418:15,862,729...15,916,169 		JBrowse link
G Cat catalase ISO protein:decreased expression:liver
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:20623750 PMID:21138988 PMID:25231249 RGD:7241599 NCBI chrNW_004955422:11,783,973...11,826,970
Ensembl chrNW_004955422:11,781,835...11,827,464 		JBrowse link
G Ccdc80 coiled-coil domain containing 80 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955427:12,945,230...12,975,020
Ensembl chrNW_004955427:12,945,230...12,975,114 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20623750 NCBI chrNW_004955420:25,641,184...25,664,413 JBrowse link
G Cct3 chaperonin containing TCP1 subunit 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955545:2,444,988...2,460,976
Ensembl chrNW_004955545:2,444,988...2,461,113 		JBrowse link
G Cct5 chaperonin containing TCP1 subunit 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955426:132,106...144,251
Ensembl chrNW_004955426:131,871...144,354 		JBrowse link
G Cdc25b cell division cycle 25B ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955415:14,637,295...14,647,181
Ensembl chrNW_004955415:14,629,132...14,650,116 		JBrowse link
G Cds1 CDP-diacylglycerol synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955474:5,057,833...5,104,235
Ensembl chrNW_004955474:5,057,833...5,104,235 		JBrowse link
G Cela1 chymotrypsin like elastase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955547:1,810,680...1,823,938
Ensembl chrNW_004955547:1,810,670...1,824,409 		JBrowse link
G Cfap20 cilia and flagella associated protein 20 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955433:15,648,529...15,663,308
Ensembl chrNW_004955433:15,648,099...15,663,502 		JBrowse link
G Chrm3 cholinergic receptor muscarinic 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20197374 NCBI chrNW_004955492:958,347...1,429,832
Ensembl chrNW_004955492:958,949...960,721 		JBrowse link
G Ckb creatine kinase B ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955538:2,379,868...2,380,771 JBrowse link
G Clu clusterin ISO CTD Direct Evidence: marker/mechanism CTD PMID:20623750 NCBI chrNW_004955403:50,160,598...50,175,876
Ensembl chrNW_004955403:50,160,598...50,175,876 		JBrowse link
G Col14a1 collagen type XIV alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955417:25,579,547...25,774,067
Ensembl chrNW_004955417:25,579,547...25,774,127 		JBrowse link
G Col3a1 collagen type III alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:16679477 NCBI chrNW_004955403:9,720,831...9,758,019
Ensembl chrNW_004955403:9,721,114...9,757,887 		JBrowse link
G Comt catechol-O-methyltransferase ISO protein:decreased expression:liver RGD PMID:21138988 RGD:7241599 NCBI chrNW_004955442:18,130,282...18,152,153
Ensembl chrNW_004955442:18,130,987...18,137,412 		JBrowse link
G Coq9 coenzyme Q9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955433:15,081,390...15,094,441
Ensembl chrNW_004955433:15,081,390...15,094,441 		JBrowse link
G Cp ceruloplasmin ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955448:470,063...522,909
Ensembl chrNW_004955448:473,179...523,100 		JBrowse link
G Cpb2 carboxypeptidase B2 ISO mRNA,protein:increased expression,increased activity:liver,plasma RGD PMID:19386599 RGD:7243112 NCBI chrNW_004955518:3,740,348...3,803,540
Ensembl chrNW_004955518:3,740,348...3,803,539 		JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955457:4,848,116...4,961,384
Ensembl chrNW_004955457:4,844,152...4,961,246 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A ISO mRNA:decreased expression:liver (rat) RGD PMID:28959666 RGD:401794432 NCBI chrNW_004955422:17,105,887...17,159,696
Ensembl chrNW_004955422:17,109,256...17,159,838 		JBrowse link
G Csf3 colony stimulating factor 3 ISO CTD Direct Evidence: therapeutic CTD PMID:20005281 PMID:33882750 NCBI chrNW_004955451:14,688,181...14,690,126
Ensembl chrNW_004955451:14,688,181...14,690,126 		JBrowse link
G Ctnnb1 catenin beta 1 ISO CTD Direct Evidence: therapeutic CTD PMID:19679878 NCBI chrNW_004955420:29,030,716...29,047,447
Ensembl chrNW_004955420:29,030,716...29,047,449 		JBrowse link
G Ctse cathepsin E ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955406:41,641,412...41,653,261
Ensembl chrNW_004955406:41,641,311...41,653,296 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO CTD Direct Evidence: therapeutic CTD PMID:11739529 NCBI chrNW_004955433:748,392...750,890
Ensembl chrNW_004955433:748,284...750,927 		JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:38614205 NCBI chrNW_004955408:30,733,079...30,740,854
Ensembl chrNW_004955408:30,733,079...30,740,854 		JBrowse link
G Dbt dihydrolipoamide branched chain transacylase E2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955435:4,975,664...5,005,126
Ensembl chrNW_004955435:4,973,830...5,017,816 		JBrowse link
G Ddb1 damage specific DNA binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955511:6,209,777...6,233,594
Ensembl chrNW_004955511:6,209,777...6,233,594 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17984051 NCBI chrNW_004955414:16,059,781...16,089,727
Ensembl chrNW_004955414:16,059,781...16,089,727 		JBrowse link
G Dhfr dihydrofolate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19648163 NCBI chrNW_004955418:29,274,170...29,283,028 JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955412:13,718,091...13,746,220
Ensembl chrNW_004955412:13,718,067...13,744,239 		JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26881866 NCBI chrNW_004955410:12,814,993...12,820,852
Ensembl chrNW_004955410:12,814,479...12,822,777 		JBrowse link
G Dnajc12 DnaJ heat shock protein family (Hsp40) member C12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26881866 NCBI chrNW_004955425:20,202,264...20,236,416
Ensembl chrNW_004955425:20,200,239...20,236,408 		JBrowse link
G Dsc2 desmocollin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955402:18,465,631...18,496,948
Ensembl chrNW_004955402:18,464,989...18,489,475 		JBrowse link
G E2f1 E2F transcription factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30515189 NCBI chrNW_004955422:27,638,625...27,643,261
Ensembl chrNW_004955422:27,633,827...27,642,241 		JBrowse link
G Echdc1 ethylmalonyl-CoA decarboxylase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955436:8,332,066...8,365,200
Ensembl chrNW_004955436:8,332,066...8,365,200 		JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955477:11,012,451...11,021,487
Ensembl chrNW_004955477:11,012,451...11,021,486 		JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955421:8,196,631...8,225,561
Ensembl chrNW_004955421:8,196,557...8,225,561 		JBrowse link
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25411909 NCBI chrNW_004955460:13,723,674...13,754,545
Ensembl chrNW_004955460:13,723,777...13,754,150 		JBrowse link
G Eif4ebp2 eukaryotic translation initiation factor 4E binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955437:20,844,750...20,879,874
Ensembl chrNW_004955437:20,844,750...20,879,885 		JBrowse link
G Endog endonuclease G ISO protein:decreased expression:mitochondrion: RGD PMID:22509279 RGD:9685364 NCBI chrNW_004955570:1,200,461...1,203,566
Ensembl chrNW_004955570:1,200,996...1,203,566 		JBrowse link
G Eng endoglin ISO protein:increased expression:liver (rat) RGD PMID:21146604 RGD:7257529 NCBI chrNW_004955419:818,797...853,319
Ensembl chrNW_004955419:818,932...852,694 		JBrowse link
G Eno1 enolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 PMID:25231249 NCBI chrNW_004955486:4,275,371...4,287,152
Ensembl chrNW_004955486:4,274,238...4,289,809 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 ISO protein:increased activity:serum: RGD PMID:17850827 RGD:9685426 NCBI chrNW_004955417:25,308,424...25,384,307
Ensembl chrNW_004955417:25,308,361...25,384,443 		JBrowse link
G Ephx1 epoxide hydrolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955520:116,363...142,983
Ensembl chrNW_004955520:116,363...128,665 		JBrowse link
G Erlec1 endoplasmic reticulum lectin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26881866 NCBI chrNW_004955441:19,535,425...19,557,960
Ensembl chrNW_004955441:19,535,425...19,557,458 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30538632 NCBI chrNW_004955478:7,720,664...7,803,662
Ensembl chrNW_004955478:7,751,830...7,799,460 		JBrowse link
G F13a1 coagulation factor XIII A chain ISO RGD PMID:22019897 RGD:11041813 NCBI chrNW_004955465:7,444,118...7,617,366
Ensembl chrNW_004955465:7,443,166...7,617,436 		JBrowse link
G F2rl3 F2R like thrombin or trypsin receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20974703 NCBI chrNW_004955524:1,045,493...1,047,924
Ensembl chrNW_004955524:1,044,792...1,047,819 		JBrowse link
G F3 coagulation factor III, tissue factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:22407844 NCBI chrNW_004955423:254,060...264,448
Ensembl chrNW_004955423:254,189...264,159 		JBrowse link
G Fadd Fas associated via death domain treatment ISO RGD PMID:25447754 PMID:26062544 RGD:10053709 RGD:11341803 NCBI chrNW_004955422:16,026,323...16,035,808
Ensembl chrNW_004955422:16,031,280...16,036,281 		JBrowse link
G Fads1 fatty acid desaturase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955511:5,908,394...5,915,764
Ensembl chrNW_004955511:5,907,726...5,915,764 		JBrowse link
G Fads2 fatty acid desaturase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955511:5,827,797...5,842,745
Ensembl chrNW_004955511:5,827,797...5,842,760 		JBrowse link
G Fas Fas cell surface death receptor ISO protein:increased expression:liver (rat) RGD PMID:16831245 RGD:8662853 NCBI chrNW_004955425:3,961,671...3,987,513
Ensembl chrNW_004955425:3,961,013...3,987,455 		JBrowse link
G Fasn fatty acid synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955506:1,063,002...1,079,939
Ensembl chrNW_004955506:1,063,002...1,079,939 		JBrowse link
G Fcmr Fc mu receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955406:42,438,173...42,452,339
Ensembl chrNW_004955406:42,438,783...42,452,163 		JBrowse link
G Fga fibrinogen alpha chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:20974703 NCBI chrNW_004955471:8,806,964...8,814,671
Ensembl chrNW_004955471:8,806,650...8,816,791 		JBrowse link
G Fgf21 fibroblast growth factor 21 severity ISO mRNA:increased expression:liver (rat) RGD PMID:29883717 RGD:15045603 NCBI chrNW_004955559:1,818,400...1,821,423
Ensembl chrNW_004955559:1,817,110...1,820,417 		JBrowse link
G Flt1 fms related receptor tyrosine kinase 1 ISO CTD Direct Evidence: therapeutic CTD PMID:21135413 NCBI chrNW_004955497:7,653,309...7,831,737
Ensembl chrNW_004955497:7,653,248...7,831,472 		JBrowse link
G Ftl ferritin light chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955559:1,691,722...1,693,381 JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 ISO mRNA:decreased expression:liver (mouse) RGD PMID:28189721 RGD:14695531 NCBI chrNW_004955451:16,672,512...16,680,001
Ensembl chrNW_004955451:16,672,979...16,680,001 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase treatment ISO RGD PMID:21864513 RGD:10449168 NCBI chrNW_004955580:1,045,294...1,058,129
Ensembl chrNW_004955580:1,045,294...1,057,083 		JBrowse link
G Gadd45a growth arrest and DNA damage inducible alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:20623750 NCBI chrNW_004955423:23,656,516...23,658,367
Ensembl chrNW_004955423:23,656,458...23,658,367 		JBrowse link
G Ganab glucosidase II alpha subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955599:556,510...569,891
Ensembl chrNW_004955599:556,362...573,353 		JBrowse link
G Gc GC vitamin D binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 NCBI chrNW_004955447:1,361,698...1,400,633
Ensembl chrNW_004955447:1,361,566...1,402,491 		JBrowse link
G Gclc glutamate-cysteine ligase catalytic subunit ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17573345 PMID:19481141 RGD:10402383 NCBI chrNW_004955411:2,593,523...2,617,553
Ensembl chrNW_004955411:2,593,541...2,616,539 		JBrowse link
G Gclm glutamate-cysteine ligase modifier subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955423:782,468...805,384
Ensembl chrNW_004955423:782,468...805,384 		JBrowse link
G Gda guanine deaminase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955434:983,388...1,050,413
Ensembl chrNW_004955434:983,388...1,049,948 		JBrowse link
G Gdi1 GDP dissociation inhibitor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955580:935,021...941,081
Ensembl chrNW_004955580:934,798...941,081 		JBrowse link
G Gfer growth factor, augmenter of liver regeneration treatment ISO RGD PMID:15968720 PMID:22033404 RGD:9685722 RGD:9685727 NCBI chrNW_004955442:15,280,753...15,283,405
Ensembl chrNW_004955442:15,281,419...15,283,266 		JBrowse link
G Ggh gamma-glutamyl hydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:21219404 NCBI chrNW_004955444:15,901,225...15,930,358
Ensembl chrNW_004955444:15,900,485...15,931,338 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO RGD PMID:10934156 RGD:14701049 NCBI chrNW_004955455:8,082,578...8,099,523 JBrowse link
G Ghrl ghrelin and obestatin prepropeptide ISO CTD Direct Evidence: therapeutic CTD PMID:34151639 NCBI chrNW_004955561:1,676,475...1,682,205
Ensembl chrNW_004955561:1,676,576...1,681,812 		JBrowse link
G Glud1 glutamate dehydrogenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33483742 NCBI chrNW_004955510:5,987,811...6,021,001 JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955507:5,346,937...5,370,072
Ensembl chrNW_004955507:5,346,838...5,370,072 		JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955547:676,661...683,906
Ensembl chrNW_004955547:676,342...690,777 		JBrowse link
G Gpt glutamic--pyruvic transaminase treatment ISO CTD Direct Evidence: marker/mechanism
protein:increased expression, activity:serum:		 CTD
RGD		 PMID:145039 PMID:19085960 PMID:19481104 PMID:21772750 PMID:27293452 More... RGD:14975162 RGD:14975166 RGD:14975168 RGD:14975249 NCBI chrNW_004955454:3,127,997...3,132,459
Ensembl chrNW_004955454:3,127,997...3,132,459 		JBrowse link
G Gpt2 glutamic--pyruvic transaminase 2 ISO protein:increased expression, activity:serum: RGD PMID:19085960 RGD:14975249 NCBI chrNW_004955474:8,248,622...8,285,449
Ensembl chrNW_004955474:8,250,759...8,285,227 		JBrowse link
G Grk4 G protein-coupled receptor kinase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955514:1,837,141...1,895,785
Ensembl chrNW_004955514:1,837,141...1,895,785 		JBrowse link
G Gsn gelsolin ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 NCBI chrNW_004955419:6,682,202...6,733,361
Ensembl chrNW_004955419:6,682,058...6,733,361 		JBrowse link
G Gsr glutathione-disulfide reductase treatment ISO mRNA, protein:increased expression:liver
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:23554813 PMID:24154663 PMID:25226513 PMID:28069987 RGD:10401878 RGD:7257532 NCBI chrNW_004955463:7,130,459...7,153,631
Ensembl chrNW_004955463:7,131,364...7,153,583 		JBrowse link
G Gstm3 glutathione S-transferase mu 3 ISO CTD Direct Evidence: therapeutic CTD PMID:25743375 NCBI chrNW_004955435:13,253,947...13,256,965
Ensembl chrNW_004955435:13,253,947...13,256,965 		JBrowse link
G Gstm4 glutathione S-transferase mu 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955435:13,064,691...13,069,734
Ensembl chrNW_004955435:13,063,966...13,210,264 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20623750 PMID:25226513 NCBI chrNW_004955422:17,914,228...17,916,918
Ensembl chrNW_004955422:17,914,305...17,917,428 		JBrowse link
G Hacl1 2-hydroxyacyl-CoA lyase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26881866 NCBI chrNW_004955430:2,055,774...2,096,260
Ensembl chrNW_004955430:2,053,640...2,096,432 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955469:8,183,945...8,233,869
Ensembl chrNW_004955469:8,183,945...8,233,869 		JBrowse link
G Hamp hepcidin antimicrobial peptide ISO mRNA:increased expression:hepatocyte RGD PMID:24373749 RGD:11041724 NCBI chrNW_004955468:4,576,080...4,577,591
Ensembl chrNW_004955468:4,575,510...4,577,649 		JBrowse link
G Hao2 hydroxyacid oxidase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955435:22,380,395...22,404,426
Ensembl chrNW_004955435:22,380,388...22,404,052 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20623750 NCBI chrNW_004955408:11,047,679...11,070,492 JBrowse link
G Hmgb1 high mobility group box 1 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19783637 PMID:29091898 RGD:15090820 NCBI chrNW_004955431:15,373,207...15,377,339
Ensembl chrNW_004955431:15,373,207...15,377,339 		JBrowse link
G Hmox1 heme oxygenase 1 treatment ISO CTD Direct Evidence: marker/mechanism|therapeutic RGD
CTD		 PMID:18227147 PMID:22688006 PMID:22886620 PMID:29091898 RGD:10762620 RGD:15090820 NCBI chrNW_004955405:43,124,447...43,128,873
Ensembl chrNW_004955405:43,124,510...43,130,979 		JBrowse link
G Hpd 4-hydroxyphenylpyruvate dioxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 PMID:22872058 NCBI chrNW_004955482:6,586,975...6,595,034
Ensembl chrNW_004955482:6,586,975...6,595,034 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955473:462,940...510,006 JBrowse link
G Hpx hemopexin ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 NCBI chrNW_004955414:22,158,654...22,169,133
Ensembl chrNW_004955414:22,156,819...22,169,631 		JBrowse link
G Hrh2 histamine receptor H2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22926047 NCBI chrNW_004955408:28,186,316...28,225,146
Ensembl chrNW_004955408:28,186,249...28,229,411 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955419:3,055,420...3,060,208
Ensembl chrNW_004955419:3,055,420...3,062,131 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 ISO protein:altered localization:liver (rat) RGD PMID:12376827 RGD:10059389 NCBI chrNW_004955412:23,863,513...23,867,984
Ensembl chrNW_004955412:23,862,590...23,867,984 		JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment ISO RGD PMID:29091898 RGD:15090820 NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 severity ISO RGD PMID:31121248 RGD:14985250 NCBI chrNW_004955416:15,197,611...15,212,919
Ensembl chrNW_004955416:15,197,366...15,223,363 		JBrowse link
G Ido2 indoleamine 2,3-dioxygenase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32289347 NCBI chrNW_004955536:2,894,410...2,938,862
Ensembl chrNW_004955536:2,894,308...2,939,016 		JBrowse link
G Ifng interferon gamma ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:12153990 PMID:21245496 PMID:30013034 RGD:14975100 NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045 		JBrowse link
G Igf1 insulin like growth factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23639586 PMID:25226513 NCBI chrNW_004955405:37,505,830...37,582,152
Ensembl chrNW_004955405:37,512,201...37,582,152 		JBrowse link
G Il11 interleukin 11 ISO CTD Direct Evidence: therapeutic CTD PMID:11421492 NCBI chrNW_004955567:868,272...883,563
Ensembl chrNW_004955567:871,489...883,563 		JBrowse link
G Il12b interleukin 12B ISO CTD Direct Evidence: therapeutic CTD PMID:36520315 NCBI chrNW_004955408:13,302,506...13,316,300
Ensembl chrNW_004955408:13,304,219...13,312,620 		JBrowse link
G Il17a interleukin 17A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19633216 PMID:24949944 NCBI chrNW_004955411:5,896,435...5,899,911
Ensembl chrNW_004955411:5,896,702...5,900,962 		JBrowse link
G Il18 interleukin 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19164858 NCBI chrNW_004955412:13,807,361...13,826,007
Ensembl chrNW_004955412:13,806,553...13,825,634 		JBrowse link
G Il1a interleukin 1 alpha ISO CTD Direct Evidence: therapeutic CTD PMID:8218930 NCBI chrNW_004955470:1,527,710...1,538,418
Ensembl chrNW_004955470:1,527,674...1,538,466 		JBrowse link
G Il1b interleukin 1 beta treatment ISO CTD Direct Evidence: marker/mechanism|therapeutic RGD
CTD		 PMID:19164858 PMID:23102243 PMID:28138970 PMID:29091898 PMID:29278859 More... RGD:13793380 RGD:14975281 RGD:15036799 RGD:15090820 RGD:7204421 NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947 		JBrowse link
G Il1r2 interleukin 1 receptor type 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17984051 NCBI chrNW_004955470:7,518,565...7,562,219
Ensembl chrNW_004955470:7,518,663...7,559,470 		JBrowse link
G Il22 interleukin 22 ISO CTD Direct Evidence: therapeutic CTD PMID:15122762 PMID:16212920 PMID:23375450 NCBI chrNW_004955458:14,747,339...14,755,602
Ensembl chrNW_004955458:14,747,084...14,752,553 		JBrowse link
G Il4 interleukin 4 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:21094227 PMID:21735453 PMID:22107450 NCBI chrNW_004955408:4,058,052...4,065,999 JBrowse link
G Il6 interleukin 6 treatment ISO CTD Direct Evidence: therapeutic RGD
CTD		 PMID:7532385 PMID:15763341 PMID:29091898 RGD:15090820 NCBI chrNW_004955410:25,079,835...25,084,390 JBrowse link
G Immt inner membrane mitochondrial protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955424:1,438,158...1,476,552
Ensembl chrNW_004955424:1,438,158...1,476,552 		JBrowse link
G Irak1 interleukin 1 receptor associated kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955580:663,651...668,622
Ensembl chrNW_004955580:661,609...668,622 		JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:30515189 NCBI chrNW_004955524:3,176,849...3,177,936 JBrowse link
G Keap1 kelch like ECH associated protein 1 ISO RGD PMID:18417483 RGD:6893370 NCBI chrNW_004955495:1,704,695...1,711,339
Ensembl chrNW_004955495:1,704,695...1,711,290 		JBrowse link
G Kitlg KIT ligand ISO CTD Direct Evidence: therapeutic CTD PMID:12594235 NCBI chrNW_004955405:25,816,137...25,969,006
Ensembl chrNW_004955405:25,886,447...25,969,395 		JBrowse link
G Kng1 kininogen 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20362651 PMID:30685357 NCBI chrNW_004955420:20,989,197...21,016,084 JBrowse link
G Krt18 keratin 18 ISO mRNA, protein:increased expression:liver (mouse)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:17340120 PMID:19783637 PMID:33483742 PMID:38521541 RGD:18337498 NCBI chrNW_004955458:227,017...230,752
Ensembl chrNW_004955458:226,805...232,728 		JBrowse link
G Krt8 keratin 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955458:178,954...190,310 JBrowse link
G Lap3 leucine aminopeptidase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955480:6,565,071...6,588,682
Ensembl chrNW_004955480:6,560,718...6,588,682 		JBrowse link
G Lcat lecithin-cholesterol acyltransferase ISO mRNA:decreased expression:liver (rat) RGD PMID:28959666 RGD:401794432 NCBI chrNW_004955484:8,772,692...8,776,122
Ensembl chrNW_004955484:8,772,692...8,776,122 		JBrowse link
G Ldlr low density lipoprotein receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:36108984 NCBI chrNW_004955495:2,114,702...2,135,584
Ensembl chrNW_004955495:2,114,434...2,138,056 		JBrowse link
G Lgals3 galectin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22461450 NCBI chrNW_004955409:8,448,120...8,452,437
Ensembl chrNW_004955409:8,447,774...8,452,438 		JBrowse link
G Lipc lipase C, hepatic type ISO mRNA:decreased expression:liver (rat) RGD PMID:28959666 RGD:401794432 NCBI chrNW_004955450:15,947,869...16,062,449
Ensembl chrNW_004955450:15,948,187...16,048,766 		JBrowse link
G LOC102009223 cytochrome P450 1B1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33814510 NCBI chrNW_004955441:5,803,397...5,812,131
Ensembl chrNW_004955441:5,803,032...5,812,131 		JBrowse link
G LOC102010322 cytochrome P450 1A2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28762043 NCBI chrNW_004955450:3,165,107...3,171,894
Ensembl chrNW_004955450:3,165,106...3,171,942 		JBrowse link
G LOC102010850 cytochrome P450 1A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33814510 NCBI chrNW_004955450:3,183,958...3,189,488
Ensembl chrNW_004955450:3,183,750...3,189,488 		JBrowse link
G LOC102011841 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial ISO mRNA, protein:decreased expression:kidney (mouse) RGD PMID:26476181 RGD:25671412 NCBI chrNW_004955458:5,472,404...5,477,001
Ensembl chrNW_004955458:5,472,404...5,477,001 		JBrowse link
G LOC102019604 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25448281 NCBI chrNW_004955420:27,988,067...27,990,637 JBrowse link
G LOC102021597 alpha-1-antiproteinase S-like susceptibility ISO protein:decreased expression:plasma
DNA:missense mutation:cds:p.E264V(human)		 RGD PMID:11140575 PMID:20170533 RGD:14695048 RGD:1643168 NCBI chrNW_004955438:17,920,200...17,929,105 JBrowse link
G LOC102025775 histone H2AX treatment ISO RGD PMID:23265463 RGD:8693741 NCBI chrNW_004955412:20,203,173...20,204,714
Ensembl chrNW_004955412:20,203,772...20,204,203 		JBrowse link
G LOC102026028 cytochrome P450 2E1 treatment ISO DNA:hypermethylation:promoter
associated with Endotoxemia
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:12668988 PMID:16770646 PMID:21741958 PMID:25681370 PMID:27324775 More... RGD:14700872 RGD:14700873 RGD:14700878 RGD:14700879 RGD:14700901 NCBI chrNW_004955507:6,293,162...6,303,255
Ensembl chrNW_004955507:6,289,576...6,304,193 		JBrowse link
G LOC102027549 serotransferrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 NCBI chrNW_004955501:4,801,710...4,832,025
Ensembl chrNW_004955501:4,801,885...4,831,910 		JBrowse link
G Lpl lipoprotein lipase treatment ISO RGD PMID:27071702 RGD:13794380 NCBI chrNW_004955403:43,646,084...43,672,116
Ensembl chrNW_004955403:43,646,084...43,673,967 		JBrowse link
G Lrat lecithin retinol acyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955471:2,603,395...2,610,988
Ensembl chrNW_004955471:2,603,678...2,609,079 		JBrowse link
G Ltb4r leukotriene B4 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:28487374 NCBI chrNW_004955409:35,984,757...35,991,492
Ensembl chrNW_004955409:35,984,933...35,985,976 		JBrowse link
G Ltf lactotransferrin ISO CTD Direct Evidence: therapeutic CTD PMID:16141546 NCBI chrNW_004955420:25,580,449...25,604,277
Ensembl chrNW_004955420:25,580,359...25,604,331 		JBrowse link
G Map1lc3b microtubule associated protein 1 light chain 3 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955541:1,852,388...1,868,194 JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18700144 NCBI chrNW_004955439:162,499...376,919
Ensembl chrNW_004955439:163,103...377,808 		JBrowse link
G Mat1a methionine adenosyltransferase 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955510:283,860...300,991
Ensembl chrNW_004955510:281,331...300,985 		JBrowse link
G Mccc1 methylcrotonyl-CoA carboxylase subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955420:11,781,662...11,828,060
Ensembl chrNW_004955420:11,781,104...11,820,338 		JBrowse link
G Mdh1 malate dehydrogenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 NCBI chrNW_004955424:20,707,765...20,723,493
Ensembl chrNW_004955424:20,706,058...20,723,493 		JBrowse link
G Me1 malic enzyme 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955411:10,938,580...11,084,171
Ensembl chrNW_004955411:10,938,944...11,065,085 		JBrowse link
G Med1 mediator complex subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16109766 NCBI chrNW_004955451:14,204,326...14,237,809
Ensembl chrNW_004955451:14,202,744...14,237,797 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15763341 NCBI chrNW_004955433:13,024,844...13,050,041
Ensembl chrNW_004955433:13,024,418...13,052,775 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22507835 NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288 		JBrowse link
G Mst1 macrophage stimulating 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955532:1,590,685...1,595,655
Ensembl chrNW_004955532:1,590,755...1,595,148 		JBrowse link
G Mst1r macrophage stimulating 1 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:22575169 NCBI chrNW_004955532:1,774,726...1,789,662
Ensembl chrNW_004955532:1,775,033...1,787,990 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase treatment ISO associated with precursor lymphoblastic lymphoma/leukemia; DNA:SNP: :677C>T(human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:18551038 PMID:19648163 PMID:30545275 RGD:14696733 NCBI chrNW_004955486:2,096,379...2,112,240
Ensembl chrNW_004955486:2,096,379...2,112,240 		JBrowse link
G Mtpn myotrophin ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955494:6,805,518...6,844,454
Ensembl chrNW_004955494:6,805,262...6,845,394 		JBrowse link
G Myd88 MYD88 innate immune signal transduction adaptor ameliorates ISO RGD PMID:17615358 RGD:150521532 NCBI chrNW_004955427:25,553,589...25,557,654
Ensembl chrNW_004955427:25,553,589...25,559,138 		JBrowse link
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955422:713,370...717,926
Ensembl chrNW_004955422:709,784...717,926 		JBrowse link
G Nfatc4 nuclear factor of activated T cells 4 ISO CTD Direct Evidence: therapeutic CTD PMID:34192554 NCBI chrNW_004955409:35,931,208...35,941,555
Ensembl chrNW_004955409:35,931,173...35,940,696 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 treatment ISO induced by methotrexate (CHEBI:44185), treated by ferulic acid (CHEBI:17620)
CTD Direct Evidence: therapeutic		 RGD
CTD		 PMID:18417483 PMID:22491424 PMID:22627062 PMID:24813929 PMID:26958860 More... RGD:15090820 RGD:21201280 RGD:21201283 RGD:21201305 RGD:21201308 RGD:6893370 NCBI chrNW_004955403:19,510,122...19,536,428
Ensembl chrNW_004955403:19,532,103...19,535,944 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 susceptibility
treatment		 ISO associated with tuberculosis ;DNA:SNPs,haplotypes: 3'utr,5'utr: (rs78872571,rs4647992) (human) RGD PMID:29091898 PMID:31490979 RGD:15090820 RGD:40902984 NCBI chrNW_004955496:5,842,734...5,950,995
Ensembl chrNW_004955496:5,842,600...5,927,885 		JBrowse link
G Nfxl1 nuclear transcription factor, X-box binding like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26881866 NCBI chrNW_004955443:665,235...714,627
Ensembl chrNW_004955443:668,031...713,481 		JBrowse link
G Notch1 notch receptor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:30394310 NCBI chrNW_004955513:4,225,939...4,264,875
Ensembl chrNW_004955513:4,225,956...4,263,259 		JBrowse link
G Nox4 NADPH oxidase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955414:4,062,337...4,220,032
Ensembl chrNW_004955414:4,062,081...4,212,746 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 treatment ISO RGD PMID:28472605 PMID:28522909 PMID:29091898 RGD:13439737 RGD:13439739 RGD:15090820 NCBI chrNW_004955484:7,012,373...7,028,182
Ensembl chrNW_004955484:7,012,506...7,027,604 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0 group B member 2 ISO CTD Direct Evidence: therapeutic CTD PMID:29943110 NCBI chrNW_004955452:6,251,047...6,253,541
Ensembl chrNW_004955452:6,250,889...6,254,541 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1 group D member 1 treatment ISO RGD PMID:24497272 RGD:10448995 NCBI chrNW_004955451:14,743,763...14,750,903
Ensembl chrNW_004955451:14,742,735...14,750,999 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1 group H member 3 ISO CTD Direct Evidence: therapeutic CTD PMID:17256725 NCBI chrNW_004955422:940,310...954,170
Ensembl chrNW_004955422:940,310...949,049 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1 group H member 4 severity
treatment		 ISO mRNA:decreased expression:liver (rat)
CTD Direct Evidence: marker/mechanism
protein:decreased expression:liver (rat)		 RGD
CTD		 PMID:12875239 PMID:20573685 PMID:22711662 PMID:28827769 PMID:29091898 More... RGD:14701035 RGD:14701036 RGD:15042870 RGD:15045609 RGD:15090820 NCBI chrNW_004955405:36,160,360...36,236,258
Ensembl chrNW_004955405:36,160,049...36,237,751 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1 group I member 2 susceptibility ISO associated with tuberculosis ;DNA:SNP,haplotypes:promoter: (rs3814055) (human)
CTD Direct Evidence: marker/mechanism|therapeutic		 RGD
CTD		 PMID:19797606 PMID:28058446 PMID:31490979 RGD:40902984 NCBI chrNW_004955427:19,459,936...19,487,276
Ensembl chrNW_004955427:19,459,936...19,487,276 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1 group I member 3 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:14742670 PMID:25656644 PMID:28058446 NCBI chrNW_004955468:12,985,105...13,002,850 JBrowse link
G Nr2f2 nuclear receptor subfamily 2 group F member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955416:24,148,052...24,154,406
Ensembl chrNW_004955416:24,141,888...24,168,585 		JBrowse link
G Nr5a2 nuclear receptor subfamily 5 group A member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29515023 NCBI chrNW_004955406:36,263,257...36,415,494
Ensembl chrNW_004955406:36,263,184...36,415,525 		JBrowse link
G Nrep neuronal regeneration related protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955418:3,435,784...3,464,667
Ensembl chrNW_004955418:3,436,731...3,464,667 		JBrowse link
G Ntn1 netrin 1 ISO CTD Direct Evidence: therapeutic CTD PMID:35292334 NCBI chrNW_004955467:7,795,175...7,991,597
Ensembl chrNW_004955467:7,794,735...7,991,695 		JBrowse link
G Nus1 NUS1 dehydrodolichyl diphosphate synthase subunit ISO CTD Direct Evidence: therapeutic CTD PMID:33812996 NCBI chrNW_004955436:825,387...850,558
Ensembl chrNW_004955436:825,387...850,558 		JBrowse link
G Ociad1 OCIA domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955447:18,844,270...18,870,368
Ensembl chrNW_004955447:18,844,270...18,870,368 		JBrowse link
G Ogdh oxoglutarate dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955456:7,416,343...7,484,889
Ensembl chrNW_004955456:7,415,589...7,485,515 		JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955506:1,307,932...1,322,011
Ensembl chrNW_004955506:1,307,932...1,324,027 		JBrowse link
G Pah phenylalanine hydroxylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955405:37,848,486...37,909,163
Ensembl chrNW_004955405:37,846,354...37,909,457 		JBrowse link
G Pan2 poly(A) specific ribonuclease subunit PAN2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26881866 NCBI chrNW_004955458:3,925,356...3,946,879
Ensembl chrNW_004955458:3,926,070...3,941,506 		JBrowse link
G Panx1 pannexin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29246445 NCBI chrNW_004955414:405,483...448,470
Ensembl chrNW_004955414:401,188...448,470 		JBrowse link
G Park7 Parkinsonism associated deglycase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955486:4,974,130...4,985,927
Ensembl chrNW_004955486:4,969,497...4,985,885 		JBrowse link
G Pc pyruvate carboxylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955422:18,421,100...18,536,591
Ensembl chrNW_004955422:18,420,596...18,536,436 		JBrowse link
G Pcolce procollagen C-endopeptidase enhancer ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955573:299,443...304,672
Ensembl chrNW_004955573:299,521...304,325 		JBrowse link
G Pcyt1a phosphate cytidylyltransferase 1A, choline ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955420:12,464,857...12,513,017
Ensembl chrNW_004955420:12,464,857...12,500,574 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:21182459 PMID:31809757 NCBI chrNW_004955432:12,169,548...12,182,064
Ensembl chrNW_004955432:12,169,435...12,182,409 		JBrowse link
G Pdlim5 PDZ and LIM domain 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955405:5,109,778...5,312,192
Ensembl chrNW_004955405:5,109,778...5,315,092 		JBrowse link
G Pex11a peroxisomal biogenesis factor 11 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955416:15,527,925...15,537,497
Ensembl chrNW_004955416:15,527,941...15,534,424 		JBrowse link
G Pgm1 phosphoglucomutase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955423:26,408,775...26,437,527
Ensembl chrNW_004955423:26,408,595...26,437,527 		JBrowse link
G Plat plasminogen activator, tissue type ISO CTD Direct Evidence: marker/mechanism CTD PMID:22507835 NCBI chrNW_004955536:730,962...754,333
Ensembl chrNW_004955536:730,981...756,394 		JBrowse link
G Plg plasminogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:22507835 NCBI chrNW_004955439:20,317,814...20,366,724
Ensembl chrNW_004955439:20,317,552...20,366,475 		JBrowse link
G Pls3 plastin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955490:125,913...221,152
Ensembl chrNW_004955490:122,328...221,388 		JBrowse link
G Pnp purine nucleoside phosphorylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 NCBI chrNW_004955550:1,290,816...1,299,553
Ensembl chrNW_004955550:1,290,244...1,298,068 		JBrowse link
G Pnrc1 proline rich nuclear receptor coactivator 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955411:15,837,491...15,841,277
Ensembl chrNW_004955411:15,837,747...15,840,641 		JBrowse link
G Polg DNA polymerase gamma, catalytic subunit susceptibility
no_association		 ISO DNA:missense mutation:cds:p.W748S, p.E1143G (2243G>C, 3428A>G) (human)
DNA:missense mutations:cds:p.Q1236H, p.E1143G (33708G>T, 3428A>G) (human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:18208989 PMID:20138553 PMID:25065347 PMID:30255931 RGD:15039297 RGD:15039302 NCBI chrNW_004955416:15,773,005...15,788,736
Ensembl chrNW_004955416:15,773,473...15,788,651 		JBrowse link
G Polr2g RNA polymerase II subunit G ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955599:469,233...471,761
Ensembl chrNW_004955599:464,879...471,976 		JBrowse link
G Pon1 paraoxonase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 NCBI chrNW_004955432:11,893,473...11,923,035
Ensembl chrNW_004955432:11,893,473...11,923,339 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha ISO LPS-induced acute liver damage
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:21262334 PMID:24385052 PMID:38181850 RGD:5509941 NCBI chrNW_004955413:30,306,563...30,366,245
Ensembl chrNW_004955413:30,307,219...30,359,500 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma ISO mRNA, protein:decreased expression:liver RGD PMID:26599535 RGD:11554658 NCBI chrNW_004955429:14,814,690...14,936,869
Ensembl chrNW_004955429:14,873,908...14,937,387 		JBrowse link
G Pptc7 protein phosphatase targeting COQ7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955482:7,445,218...7,484,939
Ensembl chrNW_004955482:7,445,218...7,484,952 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 treatment ISO RGD PMID:29091898 RGD:15090820 NCBI chrNW_004955426:25,079,718...25,102,090
Ensembl chrNW_004955426:25,079,718...25,102,090 		JBrowse link
G Prkcd protein kinase C delta ISO CTD Direct Evidence: therapeutic CTD PMID:30393195 NCBI chrNW_004955430:3,125,066...3,151,857
Ensembl chrNW_004955430:3,124,738...3,153,274 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:21224054 NCBI chrNW_004955454:7,733,697...7,890,896
Ensembl chrNW_004955454:7,733,978...7,890,867 		JBrowse link
G Ptf1a pancreas associated transcription factor 1a ISO CTD Direct Evidence: therapeutic CTD PMID:21182459 NCBI chrNW_004955429:5,807,804...5,809,522
Ensembl chrNW_004955429:5,808,124...5,809,522 		JBrowse link
G Ptges2 prostaglandin E synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31444509 NCBI chrNW_004955419:608,313...612,813
Ensembl chrNW_004955419:608,365...612,479 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 treatment ISO CTD Direct Evidence: therapeutic RGD
CTD		 PMID:11743745 PMID:29091898 RGD:15090820 NCBI chrNW_004955406:25,077,988...25,086,259
Ensembl chrNW_004955406:25,079,945...25,086,171 		JBrowse link
G Pum1 pumilio RNA binding family member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955452:9,487,725...9,623,565
Ensembl chrNW_004955452:9,487,725...9,624,066 		JBrowse link
G Pygl glycogen phosphorylase L ISO protein:increased expression:serum (rat)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:25231249 PMID:25336395 RGD:21079733 NCBI chrNW_004955409:11,970,112...12,007,102
Ensembl chrNW_004955409:11,970,112...12,007,102 		JBrowse link
G Rasa1 RAS p21 protein activator 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955418:23,807,740...23,897,699
Ensembl chrNW_004955418:23,807,740...23,897,707 		JBrowse link
G Rbp1 retinol binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 NCBI chrNW_004955508:6,046,738...6,072,202
Ensembl chrNW_004955508:6,046,316...6,072,288 		JBrowse link
G Rdh13 retinol dehydrogenase 13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27865848 NCBI chrNW_004955567:1,091,636...1,108,648
Ensembl chrNW_004955567:1,091,636...1,108,732 		JBrowse link
G Reep5 receptor accessory protein 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26881866 NCBI chrNW_004955418:2,504,028...2,539,574
Ensembl chrNW_004955418:2,502,674...2,536,817 		JBrowse link
G Rgn regucalcin ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955516:958,416...978,829
Ensembl chrNW_004955516:955,680...978,910 		JBrowse link
G Ripk3 receptor interacting serine/threonine kinase 3 ISO protein:increased expression:liver (mouse)
CTD Direct Evidence: therapeutic		 RGD
CTD		 PMID:26769846 PMID:28205631 RGD:127229945 NCBI chrNW_004955409:35,961,604...35,965,477
Ensembl chrNW_004955409:35,937,880...35,965,712 		JBrowse link
G S100a11 S100 calcium binding protein A11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955589:405,544...409,936
Ensembl chrNW_004955589:408,319...413,971 		JBrowse link
G Scarb1 scavenger receptor class B member 1 ISO mRNA:increased expression:liver (rat) RGD PMID:28959666 RGD:401794432 NCBI chrNW_004955482:4,813,502...4,836,479
Ensembl chrNW_004955482:4,813,955...4,837,392 		JBrowse link
G Selenbp1 selenium binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20623750 NCBI chrNW_004955588:703,928...713,941
Ensembl chrNW_004955588:703,928...714,763 		JBrowse link
G Sema3a semaphorin 3A ISO CTD Direct Evidence: therapeutic CTD PMID:33290778 NCBI chrNW_004955410:2,146,088...2,344,342
Ensembl chrNW_004955410:2,144,388...2,338,973 		JBrowse link
G Sema4a semaphorin 4A ISO CTD Direct Evidence: marker/mechanism CTD PMID:33290778 NCBI chrNW_004955545:2,316,402...2,341,873
Ensembl chrNW_004955545:2,316,390...2,342,233 		JBrowse link
G Senp2 SUMO specific peptidase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:29535048 NCBI chrNW_004955420:21,969,537...22,005,094
Ensembl chrNW_004955420:21,969,537...22,005,856 		JBrowse link
G Serpina6 serpin family A member 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955438:16,356,600...16,380,861
Ensembl chrNW_004955438:16,356,540...16,380,872 		JBrowse link
G Serpine1 serpin family E member 1 treatment ISO associated with precursor lymphoblastic lymphoma/leukemia;DNA:SNPs: :DNA:SNPs: :677C>T, 1298A>C(human) RGD PMID:23183238 RGD:14696750 NCBI chrNW_004955456:16,147,523...16,157,040
Ensembl chrNW_004955456:16,145,944...16,157,142 		JBrowse link
G Serping1 serpin family G member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955511:2,545,337...2,557,850
Ensembl chrNW_004955511:2,545,285...2,557,982 		JBrowse link
G Sesn2 sestrin 2 ISO CTD Direct Evidence: therapeutic CTD PMID:28209544 NCBI chrNW_004955452:7,392,644...7,417,204
Ensembl chrNW_004955452:7,393,007...7,417,304 		JBrowse link
G Sgf29 SAGA complex associated factor 29 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955493:6,759,426...6,774,796
Ensembl chrNW_004955493:6,759,426...6,774,796 		JBrowse link
G Shc1 SHC adaptor protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 PMID:32659284 NCBI chrNW_004955545:1,468,391...1,479,209
Ensembl chrNW_004955545:1,468,391...1,476,814 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 ISO mRNA:decreased expression:liver (rat) RGD PMID:28827769 RGD:15045609 NCBI chrNW_004955466:597,081...609,254
Ensembl chrNW_004955466:597,204...608,756 		JBrowse link
G Slc10a7 solute carrier family 10 member 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26881866 NCBI chrNW_004955428:1,999,341...2,250,201
Ensembl chrNW_004955428:1,999,280...2,250,234 		JBrowse link
G Slc13a4 solute carrier family 13 member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955494:7,013,577...7,057,767
Ensembl chrNW_004955494:7,014,252...7,055,514 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955599:284,038...299,603
Ensembl chrNW_004955599:283,929...300,796 		JBrowse link
G Slc25a29 solute carrier family 25 member 29 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955438:21,383,805...21,393,897
Ensembl chrNW_004955438:21,389,057...21,394,124 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 treatment ISO RGD PMID:9200186 RGD:151357001 NCBI chrNW_004955541:2,103,437...2,129,668
Ensembl chrNW_004955541:2,103,384...2,130,310 		JBrowse link
G Snx18 sorting nexin 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17984051 NCBI chrNW_004955446:13,043,821...13,067,933
Ensembl chrNW_004955446:13,043,821...13,067,933 		JBrowse link
G Sod1 superoxide dismutase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20623750 PMID:27349771 NCBI chrNW_004955407:31,261,451...31,267,657
Ensembl chrNW_004955407:31,263,863...31,267,727 		JBrowse link
G Sod2 superoxide dismutase 2 susceptibility
severity
treatment		 ISO DNA:SNP:cds:p.Val16Ala(human)
associated with acute lymphoblastic leukemia;DNA:SNP: :(rs4880)(human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:19332662 PMID:19647030 PMID:20578157 PMID:25226513 PMID:27019981 RGD:11060605 RGD:26923957 RGD:26923959 RGD:26923961 NCBI chrNW_004955439:21,209,101...21,223,538
Ensembl chrNW_004955439:21,209,101...21,224,163 		JBrowse link
G Sod3 superoxide dismutase 3 ISO CTD Direct Evidence: therapeutic CTD PMID:11529661 NCBI chrNW_004955480:257,716...263,149 JBrowse link
G Sord sorbitol dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:12763371 NCBI chrNW_004955409:8,305,819...8,333,733
Ensembl chrNW_004955409:8,303,602...8,333,869 		JBrowse link
G Sorl1 sortilin related receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26881866 NCBI chrNW_004955412:22,421,984...22,576,179
Ensembl chrNW_004955412:22,421,984...22,576,179 		JBrowse link
G Spp1 secreted phosphoprotein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20623750 NCBI chrNW_004955474:1,914,477...1,922,025
Ensembl chrNW_004955474:1,913,829...1,922,016 		JBrowse link
G Srp72 signal recognition particle 72 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26881866 NCBI chrNW_004955447:14,519,978...14,552,758
Ensembl chrNW_004955447:14,519,064...14,552,758 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO CTD Direct Evidence: therapeutic CTD PMID:38460807 NCBI chrNW_004955451:16,320,326...16,348,505
Ensembl chrNW_004955451:16,319,904...16,357,687 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 severity ISO protein:increased phosphorylation:liver, inflammatory cell (mouse)
mRNA:increased expression:liver, macrophage (mouse)		 RGD PMID:23876342 PMID:24731448 RGD:25671417 RGD:25671422 NCBI chrNW_004955403:8,061,471...8,144,252
Ensembl chrNW_004955403:8,061,471...8,144,276 		JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:36520315 NCBI chrNW_004955418:1,091,022...1,097,064
Ensembl chrNW_004955418:1,083,613...1,100,448 		JBrowse link
G Sult2b1 sulfotransferase family 2B member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27052460 NCBI chrNW_004955559:1,942,878...1,968,895 JBrowse link
G Suox sulfite oxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955458:3,584,390...3,589,764
Ensembl chrNW_004955458:3,585,482...3,590,559 		JBrowse link
G Tagln2 transgelin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955468:11,713,809...11,721,125
Ensembl chrNW_004955468:11,713,515...11,721,870 		JBrowse link
G Taldo1 transaldolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19436114 NCBI chrNW_004955476:11,356,601...11,364,573
Ensembl chrNW_004955476:11,356,603...11,364,259 		JBrowse link
G Tbxa2r thromboxane A2 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:22206755 NCBI chrNW_004955495:5,539,382...5,557,441
Ensembl chrNW_004955495:5,539,889...5,557,441 		JBrowse link
G Tctn1 tectonic family member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17984051 NCBI chrNW_004955482:7,504,554...7,533,605
Ensembl chrNW_004955482:7,504,532...7,528,542 		JBrowse link
G Tgfb1 transforming growth factor beta 1 treatment ISO RGD PMID:27516150 RGD:14995464 NCBI chrNW_004955555:274,405...288,441
Ensembl chrNW_004955555:270,652...288,441 		JBrowse link
G Tgfbr1 transforming growth factor beta receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28560358 NCBI chrNW_004955419:26,490,899...26,546,349
Ensembl chrNW_004955419:26,490,899...26,547,017 		JBrowse link
G Thbs1 thrombospondin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35357534 NCBI chrNW_004955416:6,490,034...6,506,419
Ensembl chrNW_004955416:6,489,451...6,506,419 		JBrowse link
G Thpo thrombopoietin ISO CTD Direct Evidence: therapeutic CTD PMID:33122006 NCBI chrNW_004955420:23,120,828...23,128,894
Ensembl chrNW_004955420:23,123,637...23,129,198 		JBrowse link
G Tlr4 toll like receptor 4 disease_progression ISO RGD PMID:17504260 RGD:14697733 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135 		JBrowse link
G Tlr5 toll like receptor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30508503 NCBI chrNW_004955520:1,544,840...1,562,081
Ensembl chrNW_004955520:1,556,523...1,559,093 		JBrowse link
G Tlr9 toll like receptor 9 treatment
severity		 ISO protein:increased expression: blood, neutrophil (human) RGD PMID:19164858 PMID:23509352 PMID:26457748 RGD:18337465 RGD:18337473 RGD:18337476 NCBI chrNW_004955532:3,828,645...3,832,699
Ensembl chrNW_004955532:3,828,775...3,832,582 		JBrowse link
G Tmem117 transmembrane protein 117 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26881866 NCBI chrNW_004955500:3,097,088...3,566,616
Ensembl chrNW_004955500:3,087,715...3,568,105 		JBrowse link
G Tmem164 transmembrane protein 164 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955490:5,673,204...5,850,427
Ensembl chrNW_004955490:5,673,145...5,850,427 		JBrowse link
G Tmem38b transmembrane protein 38B ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955419:20,811,931...20,844,420
Ensembl chrNW_004955419:20,812,702...20,878,599 		JBrowse link
G Tnf tumor necrosis factor treatment
severity		 ISO protein:increased expression:serum (rat)
CTD Direct Evidence: marker/mechanism|therapeutic		 RGD
CTD		 PMID:7532385 PMID:9309314 PMID:9696492 PMID:10801287 PMID:10801288 More... RGD:10450531 RGD:14696804 RGD:14975281 RGD:14995429 RGD:14995432 RGD:14995435 RGD:14995437 RGD:14995485 RGD:15036799 RGD:15090820 NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700 		JBrowse link
G Trpm2 transient receptor potential cation channel subfamily M member 2 ISO RGD PMID:24569808 RGD:9999438 NCBI chrNW_004955407:41,062,217...41,110,500
Ensembl chrNW_004955407:41,057,941...41,110,668 		JBrowse link
G Ttr transthyretin ISO CTD Direct Evidence: marker/mechanism CTD PMID:16099942 NCBI chrNW_004955402:18,921,235...18,927,976
Ensembl chrNW_004955402:18,921,274...18,928,108 		JBrowse link
G Tubb4b tubulin beta 4B class IVb ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955513:5,237,050...5,239,370
Ensembl chrNW_004955513:5,235,629...5,239,370 		JBrowse link
G Uba5 ubiquitin like modifier activating enzyme 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26881866 NCBI chrNW_004955501:5,841,516...5,864,304
Ensembl chrNW_004955501:5,841,606...5,870,953 		JBrowse link
G Unc93b1 unc-93 homolog B1, TLR signaling regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955422:17,814,174...17,823,945
Ensembl chrNW_004955422:17,814,079...17,824,190 		JBrowse link
G Usp5 ubiquitin specific peptidase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955413:4,451,530...4,466,832
Ensembl chrNW_004955413:4,451,622...4,466,832 		JBrowse link
G Vegfa vascular endothelial growth factor A treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17784864 PMID:25231249 RGD:15003197 NCBI chrNW_004955437:9,527,445...9,541,908 JBrowse link
G Vim vimentin ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955429:10,708,852...10,716,743
Ensembl chrNW_004955429:10,707,719...10,717,554 		JBrowse link
G Vwf von Willebrand factor ISO protein:increased expression:liver:
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:7531171 PMID:28527913 RGD:11079232 NCBI chrNW_004955413:3,672,470...3,825,588
Ensembl chrNW_004955413:3,672,470...3,819,571 		JBrowse link
G Wasl WASP like actin nucleation promoting factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955479:5,167,851...5,200,512
Ensembl chrNW_004955479:5,166,393...5,200,512 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 susceptibility ISO DNA:haploinsufficiency: : (mouse) RGD PMID:21737425 RGD:15036796 NCBI chrNW_004955555:1,293,416...1,315,839
Ensembl chrNW_004955555:1,293,416...1,315,839 		JBrowse link
G Xylb xylulokinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231249 NCBI chrNW_004955427:25,492,505...25,528,674
Ensembl chrNW_004955427:25,492,505...25,528,740 		JBrowse link
G Zdhhc23 zinc finger DHHC-type palmitoyltransferase 23 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25226513 NCBI chrNW_004955427:14,045,659...14,057,226
Ensembl chrNW_004955427:14,045,657...14,057,202 		JBrowse link
drug-induced hepatitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 no_association
susceptibility		 ISO DNA:SNPs:multiple:
DNA:polymorphisms,haplotype:promoter:g.-1774delG,g.-1549G>A(human)		 RGD PMID:17502832 PMID:22178260 RGD:14700816 RGD:14700817 NCBI chrNW_004955507:5,724,788...5,791,281
Ensembl chrNW_004955507:5,724,762...5,790,812 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase ISO RGD PMID:16140414 RGD:2316848 NCBI chrNW_004955425:25,362,165...25,380,611
Ensembl chrNW_004955425:25,359,884...25,380,745 		JBrowse link
G LOC102026028 cytochrome P450 2E1 ISO DNA:hypermethylation:promoter RGD PMID:23619520 RGD:14700910 NCBI chrNW_004955507:6,293,162...6,303,255
Ensembl chrNW_004955507:6,289,576...6,304,193 		JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 ISO protein:increased expression:liver (mouse) RGD PMID:12201952 RGD:10054288 NCBI chrNW_004955419:16,190,109...16,324,702
Ensembl chrNW_004955419:16,191,244...16,325,602 		JBrowse link
Halothane Hepatitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpt glutamic--pyruvic transaminase treatment ISO RGD PMID:28921207 RGD:14975164 NCBI chrNW_004955454:3,127,997...3,132,459
Ensembl chrNW_004955454:3,127,997...3,132,459 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14336
    Chemically-Induced Disorders 1149
      Poisoning 597
        Chemical and Drug Induced Liver Injury 324
          Halothane Hepatitis 1
          drug-induced hepatitis 4
Path 2
Term Annotations click to browse term
  disease 14336
    disease of anatomical entity 14030
      gastrointestinal system disease 6103
        hepatobiliary disease 2679
          liver disease 2584
            Liver Injury 400
              Chemical and Drug Induced Liver Injury 324
                Halothane Hepatitis 1
                drug-induced hepatitis 4
paths to the root