Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Acute Lung Injury
go back to main search page
Accession:DOID:9004610 term browser browse the term
Definition:A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
Synonyms:exact_synonym: Acute Lung Injuries
 primary_id: MESH:D055371;   RDO:0007706
 xref: EFO:0004610


show annotations for term's descendants           Sort by:
Acute Lung Injury term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme treatment ISO associated wit Escherichia coli Infections RGD PMID:29990483 RGD:40400897 NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853 		JBrowse link
G ACE2 angiotensin converting enzyme 2 treatment
severity		 ISO human protein in a mouse model
CTD Direct Evidence: therapeutic
associated with avian influenza;protein:decreased expression:lung (mouse)
associated with Escherichia coli Infections		 RGD
CTD		 PMID:16001071 PMID:25391767 PMID:27302421 PMID:29990483 RGD:32716389 RGD:40400897 RGD:40818412 NCBI chr  X:8,189,267...8,229,415
Ensembl chr  X:15,470,896...15,510,891 		JBrowse link
G ACVR1 activin A receptor type 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21297076 NCBI chr2B:44,994,175...45,133,490
Ensembl chr2B:162,234,823...162,297,805 		JBrowse link
G ADAR adenosine deaminase RNA specific treatment ISO RGD PMID:18520702 RGD:10755331 NCBI chr 1:129,937,993...129,983,747 JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing treatment ISO associated with Sepsis RGD PMID:22156343 PMID:23522481 RGD:5686380 RGD:8695940 NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885 		JBrowse link
G ADRA2A adrenoceptor alpha 2A ISO RGD PMID:21542970 RGD:6480481 NCBI chr10:107,669,860...107,673,685 JBrowse link
G AFF4 ALF transcription elongation factor 4 treatment ISO RGD PMID:31466050 RGD:155631268 NCBI chr 5:128,292,700...128,374,511
Ensembl chr 5:134,457,398...134,532,625 		JBrowse link
G AGER advanced glycosylation end-product specific receptor ISO associated with Hyperoxia; protein:decreased expression:bronchoalveolar lavage fluid (rat) RGD PMID:23576805 RGD:7244254 NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641 		JBrowse link
G AKAP12 A-kinase anchoring protein 12 ISO mRNA,protein:increased expression:lung RGD PMID:23912647 RGD:14348970 NCBI chr 6:149,058,350...149,176,710
Ensembl chr 6:153,757,081...153,873,925 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 severity ISO RGD PMID:23904165 RGD:38676478 NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756 		JBrowse link
G ALB albumin ISO RGD PMID:22592748 RGD:6483494 NCBI chr 4:50,773,244...50,790,474
Ensembl chr 4:56,605,322...56,622,418 		JBrowse link
G ALOX15 arachidonate 15-lipoxygenase ISO RGD PMID:19752233 RGD:5509626 NCBI chr17:4,686,339...4,696,877
Ensembl chr17:4,677,125...4,687,669 		JBrowse link
G APOA1 apolipoprotein A1 ISO CTD Direct Evidence: therapeutic CTD PMID:20972769 NCBI chr11:111,673,539...111,675,428
Ensembl chr11:115,606,136...115,608,122 		JBrowse link
G AQP5 aquaporin 5 ISO associated with Disseminated Intravascular Coagulation;mRNA,protein:decreased expression:lung: RGD PMID:24806323 RGD:11553933 NCBI chr12:38,789,505...38,793,305
Ensembl chr12:39,684,008...39,687,127 		JBrowse link
G ASCL1 achaete-scute family bHLH transcription factor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:20554700 NCBI chr12:100,536,895...100,539,737
Ensembl chr12:103,932,302...103,932,999 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator ISO associated with Endotoxemia RGD PMID:20663300 RGD:10054109 NCBI chr19:45,955,926...45,962,870
Ensembl chr19:54,793,594...54,800,468 		JBrowse link
G BCL2 BCL2 apoptosis regulator ISO associated with Endotoxemia RGD PMID:20663300 RGD:10054109 NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100 		JBrowse link
G C3 complement C3 treatment ISO RGD PMID:22763771 RGD:11040808 NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699 		JBrowse link
G CASP3 caspase 3 treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:29755641 PMID:32062619 RGD:13782288 NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185 		JBrowse link
G CASP8 caspase 8 treatment ISO RGD PMID:29755641 RGD:13782288 NCBI chr2B:88,490,611...88,542,132
Ensembl chr2B:206,669,544...206,696,468 		JBrowse link
G CAT catalase ISO CTD Direct Evidence: therapeutic CTD PMID:15612528 NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160 		JBrowse link
G CAV1 caveolin 1 treatment ISO RGD PMID:24919947 RGD:10045573 NCBI chr 7:108,497,125...108,533,090
Ensembl chr 7:121,193,424...121,229,655 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO mRNA, protein:increased expression:lung RGD PMID:21767135 RGD:6480432 NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384 		JBrowse link
G CCR1 C-C motif chemokine receptor 1 ISO associated with Pancreatitis RGD PMID:17312463 RGD:5688151 NCBI chr 3:46,107,526...46,114,229
Ensembl chr 3:47,214,688...47,215,755 		JBrowse link
G CD36 CD36 molecule (CD36 blood group) ISO associated with Malaria RGD PMID:18483551 RGD:6893505 NCBI chr 7:72,566,478...72,643,517
Ensembl chr 7:86,265,114...86,305,865 		JBrowse link
G CXCL6 C-X-C motif chemokine ligand 6 ISO associated with Reperfusion Injury
mRNA, protein:increased expression:lung		 RGD PMID:7814607 PMID:15557650 RGD:5135247 RGD:5135256 NCBI chr 4:50,357,643...50,359,822
Ensembl chr 4:56,189,961...56,192,402 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 disease_progression ISO associated with sepsis;protein:increased expression:blood serum (human) RGD PMID:28506137 RGD:40925937 NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083 		JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 treatment ISO associated with Pancreatitis RGD PMID:17014919 RGD:7257703 NCBI chr2B:105,387,198...105,400,533
Ensembl chr2B:223,997,066...223,998,148 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 ISO mRNA:increased expression:lung RGD PMID:16882535 PMID:18367723 RGD:5135235 RGD:5147744 NCBI chr15:53,664,968...53,672,277
Ensembl chr15:73,284,566...73,290,636 		JBrowse link
G CYSLTR1 cysteinyl leukotriene receptor 1 treatment ISO associated with Endotoxemia RGD PMID:27703200 RGD:40903067 NCBI chr  X:67,412,410...67,469,366
Ensembl chr  X:77,524,455...77,525,468 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 treatment ISO associated with Crush Injuries RGD PMID:30465396 RGD:34901874 NCBI chr12:31,406,332...31,410,293
Ensembl chr12:31,664,743...31,668,701 		JBrowse link
G EDN1 endothelin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16625121 NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545 		JBrowse link
G EGFR epidermal growth factor receptor ISO RGD PMID:20935109 RGD:5131862 NCBI chr 7:55,614,042...55,807,285
Ensembl chr 7:56,046,296...56,111,615 		JBrowse link
G ELANE elastase, neutrophil expressed treatment ISO associated with Shock, Hemorrhagic;
protein:increased expression:perfusate:		 RGD PMID:15257085 PMID:17203197 PMID:18283562 RGD:10450548 RGD:10450585 RGD:10450587 NCBI chr19:276,499...280,598 JBrowse link
G EPHX1 epoxide hydrolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26840748 NCBI chr 1:201,271,366...201,306,635
Ensembl chr 1:206,272,866...206,307,581 		JBrowse link
G EPHX2 epoxide hydrolase 2 ISO RGD PMID:22051199 RGD:5688354 NCBI chr 8:26,761,090...26,818,436
Ensembl chr 8:23,964,094...24,017,749 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 treatment ISO associated with Crush Injuries RGD PMID:30465396 RGD:34901874 NCBI chr17:58,132,889...58,224,012
Ensembl chr17:63,226,949...63,317,825 		JBrowse link
G F2 coagulation factor II, thrombin ISO RGD PMID:22804886 RGD:7387313 NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157 		JBrowse link
G F3 coagulation factor III, tissue factor ISO protein:increased expression: respiratory system fluid/secretion RGD PMID:21964405 RGD:11341740 NCBI chr 1:97,190,381...97,203,076
Ensembl chr 1:95,918,502...95,931,050 		JBrowse link
G FADD Fas associated via death domain treatment ISO associated with Shock, Hemorrhagic RGD PMID:24122010 RGD:11341811 NCBI chr11:65,300,889...65,305,020 JBrowse link
G FAS Fas cell surface death receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:11778176 NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612 		JBrowse link
G FASLG Fas ligand ISO CTD Direct Evidence: marker/mechanism CTD PMID:11778176 NCBI chr 1:148,159,826...148,167,785
Ensembl chr 1:151,868,430...151,876,281 		JBrowse link
G FCGR1A Fc gamma receptor Ia ISO RGD PMID:19106808 RGD:5147925 NCBI chr 1:125,127,073...125,136,911
Ensembl chr 1:128,805,484...128,814,220 		JBrowse link
G FCGR2B Fc gamma receptor IIb treatment ISO RGD PMID:19106808 RGD:5147925 NCBI chr 1:137,074,342...137,090,962
Ensembl chr 1:140,882,043...140,890,637 		JBrowse link
G FGA fibrinogen alpha chain ISO protein:increased expression:blood (rat) RGD PMID:22804886 RGD:7387313 NCBI chr 4:146,949,680...146,957,291 JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 ISO associated with Endotoxemia RGD PMID:21528367 RGD:5684427 NCBI chr13:9,584,850...9,779,542 JBrowse link
G FOXA1 forkhead box A1 ISO mRNA,protein:increased expression:lung RGD PMID:19649697 RGD:151665511 NCBI chr14:18,347,284...18,352,705 JBrowse link
G GJA1 gap junction protein alpha 1 treatment ISO RGD PMID:23576849 RGD:8662452 NCBI chr 6:119,213,513...119,227,617 JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 ISO protein:decreased expression:lung (rat) RGD PMID:25581610 RGD:13504847 NCBI chr10:96,012,345...96,046,266
Ensembl chr10:99,506,205...99,540,178 		JBrowse link
G GSR glutathione-disulfide reductase ISO RGD PMID:7896613 RGD:7257562 NCBI chr 8:29,990,543...30,040,157
Ensembl chr 8:27,180,300...27,229,557 		JBrowse link
G GZMB granzyme B ISO RGD PMID:20018616 RGD:5135517 NCBI chr14:5,399,888...5,403,200
Ensembl chr14:23,523,619...23,526,931 		JBrowse link
G HMGB1 high mobility group box 1 treatment ISO associated with Endotoxemia
associated with Crush Injuries
associated with Burns		 RGD PMID:19766246 PMID:23874764 PMID:30465396 RGD:10402098 RGD:34901874 RGD:4892587 NCBI chr13:11,737,942...11,894,923
Ensembl chr13:30,174,899...30,179,527 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase ISO RGD PMID:16922808 RGD:5508470 NCBI chr 5:39,936,630...39,961,519
Ensembl chr 5:40,548,919...40,573,785 		JBrowse link
G HMOX1 heme oxygenase 1 treatment ISO associated with Reperfusion Injury RGD PMID:20360627 PMID:20850789 RGD:4140418 RGD:4145326 NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063 		JBrowse link
G HNRNPC heterogeneous nuclear ribonucleoprotein C ISO protein:altered localization:lung (mouse) RGD PMID:19029002 RGD:10054390 NCBI chr14:2,022,280...2,083,215 JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 treatment ISO associated with Crush Injuries RGD PMID:30465396 RGD:34901874 NCBI chr 9:96,351,645...96,356,761
Ensembl chr 9:124,865,211...124,870,458 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17973899 PMID:20569121 PMID:27525872 RGD:8547719 NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605 		JBrowse link
G IDO1 indoleamine 2,3-dioxygenase 1 treatment ISO RGD PMID:25278421 RGD:39939031 NCBI chr 8:39,108,310...39,123,611
Ensembl chr 8:36,617,312...36,632,352 		JBrowse link
G IFNG interferon gamma ISO RGD PMID:21767135 RGD:6480432 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829 		JBrowse link
G IL10 interleukin 10 no_association
treatment		 ISO associated with Reperfusion Injury;protein:increased expression:lung, plasma
DNA:SNP:promoter:rs3021097 (human)
DNA:SNP:promoter:-1082G>A (rs1800896) (human)		 RGD PMID:23801594 PMID:23902576 PMID:30412745 RGD:14975158 RGD:7364984 RGD:7365008 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371 		JBrowse link
G IL13 interleukin 13 ISO mRNA:increased expression:lung RGD PMID:15461830 RGD:4145512 NCBI chr 5:128,073,863...128,078,453
Ensembl chr 5:134,235,788...134,240,548 		JBrowse link
G IL17A interleukin 17A ISO CTD Direct Evidence: marker/mechanism CTD PMID:28600744 NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074 		JBrowse link
G IL18 interleukin 18 treatment ISO associated with Myocardial Reperfusion Injury RGD PMID:24223666 RGD:8655952 NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371 		JBrowse link
G IL1B interleukin 1 beta ISO protein:increased expression:serum
CTD Direct Evidence: marker/mechanism
protein:increased expression:lung
mRNA, protein:increased expression:lung		 RGD
CTD		 PMID:8613550 PMID:20153312 PMID:20663306 PMID:21767135 PMID:22982561 More... RGD:4142531 RGD:4142807 RGD:4143193 RGD:6480432 RGD:7204498 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424 		JBrowse link
G IL1RL1 interleukin 1 receptor like 1 ISO CTD Direct Evidence: therapeutic CTD
RGD		 PMID:21352201 RGD:5144222
G IL1RN interleukin 1 receptor antagonist ISO mRNA:increased expression:lung RGD PMID:8613550 PMID:15970097 RGD:4143168 RGD:4143193 NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839 		JBrowse link
G IL2 interleukin 2 ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:21767135 RGD:6480432 NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984 		JBrowse link
G IL4 interleukin 4 treatment ISO RGD PMID:24681349 RGD:10402798 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581 		JBrowse link
G IL4I1 interleukin 4 induced 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:36537648 NCBI chr19:46,902,656...46,942,213
Ensembl chr19:55,819,080...55,858,389 		JBrowse link
G IL6 interleukin 6 ISO protein:increased expression:bronchoalveolar lavage, blood, lung (rat)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:19995278 PMID:32062619 RGD:11062103 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G IRAK3 interleukin 1 receptor associated kinase 3 ISO mRNA, protein:increased expression:lung (mouse) RGD PMID:21577093 RGD:36049795 NCBI chr12:22,661,613...22,721,203
Ensembl chr12:23,168,346...23,227,148 		JBrowse link
G ITGAM integrin subunit alpha M treatment ISO associated with Hemorrhagic Shock RGD PMID:1347308 PMID:16096539 RGD:329901922 RGD:329901935 NCBI chr16:23,634,476...23,707,147
Ensembl chr16:31,630,146...31,702,406 		JBrowse link
G ITGB2 integrin subunit beta 2 ISO RGD PMID:1374449 RGD:6482199 NCBI chr21:31,181,228...31,216,033
Ensembl chr21:44,470,999...44,505,963 		JBrowse link
G JAK3 Janus kinase 3 ISO RGD PMID:22359619 RGD:11531100 NCBI chr19:17,299,129...17,330,700
Ensembl chr19:18,283,560...18,300,964 		JBrowse link
G KDR kinase insert domain receptor ISO associated with Endotoxemia;mRNA, protein:decreased expression:lung RGD PMID:21528367 RGD:5684427 NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109 		JBrowse link
G LOC100974886 uncharacterized LOC100974886 ISO associated with Sepsis;mRNA:increased expression:lung
mRNA, protein:increased expression:lung
protein:increased expression:respiratory system fluid/secretion
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:10069420 PMID:15557650 PMID:19106808 PMID:27525872 RGD:5135247 RGD:5135253 RGD:5147925 NCBI chr 4:50,092,989...50,095,541
Ensembl chr 4:55,925,562...55,986,555 		JBrowse link
G LOC100976904 growth-regulated alpha protein ISO associated with Sepsis;mRNA:increased expression:lung RGD PMID:10069420 RGD:5135253 NCBI chr 4:50,325,248...50,327,165
Ensembl chr 4:56,153,899...56,159,474 		JBrowse link
G LOC100986475 metallothionein-2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16166738 NCBI chr16:36,894,853...36,895,826
Ensembl chr16:56,007,922...56,028,093 		JBrowse link
G LOC100991644 low affinity immunoglobulin gamma Fc region receptor II-a ISO RGD PMID:19106808 RGD:5147925 NCBI chr 1:136,892,311...136,906,450 JBrowse link
G LOC103783265 pulmonary surfactant-associated protein A1 ISO mRNA, protein:increased expression:pneumocyte RGD PMID:8569184 RGD:4143451 NCBI chr10:76,571,312...76,575,820 JBrowse link
G MFN1 mitofusin 1 ISO mRNA, protein:altered expression:lung (rat) RGD PMID:25560372 RGD:12437080 NCBI chr 3:176,378,175...176,423,943
Ensembl chr 3:184,552,108...184,596,763 		JBrowse link
G MFN2 mitofusin 2 ISO mRNA, protein:increased expression:lung (rat) RGD PMID:25560372 RGD:12437080 NCBI chr 1:10,729,933...10,764,865
Ensembl chr 1:11,945,880...11,981,077 		JBrowse link
G MMP2 matrix metallopeptidase 2 ISO RGD PMID:23040778 RGD:13207316 NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279 		JBrowse link
G MMP7 matrix metallopeptidase 7 ISO associated with Sepsis RGD PMID:21567117 RGD:9685338 NCBI chr11:97,467,037...97,477,305
Ensembl chr11:100,960,032...100,971,099 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO RGD PMID:23040778 RGD:13207316 NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129 		JBrowse link
G MPO myeloperoxidase ISO associated with Kidney Reperfusion Injury; protein:increased activity:lung RGD PMID:22092133 RGD:6909173 NCBI chr17:52,333,882...52,357,838
Ensembl chr17:57,201,073...57,212,111 		JBrowse link
G MT1X metallothionein 1X ISO CTD Direct Evidence: marker/mechanism CTD PMID:16166738 NCBI chr16:36,959,854...36,961,632
Ensembl chr16:56,092,218...56,093,976 		JBrowse link
G MYLK myosin light chain kinase ISO associated with Sepsis
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:16399953 PMID:19374788 RGD:1581052 NCBI chr 3:120,711,705...120,983,432
Ensembl chr 3:127,614,173...127,793,261 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 ISO CTD Direct Evidence: therapeutic CTD PMID:24812154 NCBI chr2B:64,509,446...64,544,600
Ensembl chr2B:182,214,116...182,248,085 		JBrowse link
G NGF nerve growth factor ISO RGD PMID:17673270 RGD:5144065 NCBI chr 1:87,223,597...87,276,759 JBrowse link
G NLRP3 NLR family pyrin domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33012731 NCBI chr 1:223,052,307...223,084,736
Ensembl chr 1:228,505,147...228,537,216 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 treatment ISO associated with Sepsis RGD PMID:22575870 RGD:8547530 NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO RGD PMID:16882535 RGD:5147744 NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093 		JBrowse link
G NPPA natriuretic peptide A ISO RGD PMID:23422200 RGD:7247713 NCBI chr 1:10,608,025...10,610,287
Ensembl chr 1:11,825,072...11,827,373 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 treatment ISO RGD PMID:24669282 PMID:28065220 RGD:11035223 RGD:13442501 NCBI chr16:50,090,696...50,106,495
Ensembl chr16:69,470,288...69,489,731 		JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase ISO mRNA, protein:altered expression:lung (rat) RGD PMID:25560372 RGD:12437080 NCBI chr 3:190,890,242...190,995,133
Ensembl chr 3:201,207,607...201,312,358 		JBrowse link
G P2RY12 purinergic receptor P2Y12 ISO associated with Shock, Hemorrhagic RGD PMID:21841533 RGD:6480522 NCBI chr 3:148,364,151...148,412,231 JBrowse link
G PAK1 p21 (RAC1) activated kinase 1 ISO DNA:hypermethylation RGD PMID:23546543 RGD:11533951 NCBI chr11:72,372,577...72,524,817
Ensembl chr11:76,015,998...76,104,197 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 ISO associated with Pancreatitis, Experimental, Acute RGD PMID:16127429 RGD:11075069 NCBI chr 1:201,820,355...201,867,673
Ensembl chr 1:206,812,981...206,860,356 		JBrowse link
G PAWR pro-apoptotic WT1 regulator ISO mRNA,protein:increased expression:lung,blood vessel: RGD PMID:17136598 RGD:9835397 NCBI chr12:77,114,282...77,224,116
Ensembl chr12:79,969,517...80,070,796 		JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 ISO RGD PMID:22592748 RGD:6483494 NCBI chr17:58,417,134...58,526,409
Ensembl chr17:63,511,784...63,579,067 		JBrowse link
G PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 ISO associated with Endotoxemia;mRNA, protein:increased expression:lung (mouse) RGD PMID:31167111 RGD:41410778 NCBI chr10:6,185,415...6,294,641
Ensembl chr10:6,167,841...6,275,940 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO associated with endotoxemia RGD PMID:11714830 PMID:22198681 RGD:38599213 RGD:6482677 NCBI chr 7:98,841,974...98,885,446
Ensembl chr 7:111,570,148...111,611,614 		JBrowse link
G PLA2G2A phospholipase A2 group IIA severity ISO RGD PMID:19235614 RGD:6482722 NCBI chr 1:18,930,294...18,934,563
Ensembl chr 1:19,971,084...19,977,627 		JBrowse link
G PLAU plasminogen activator, urokinase treatment ISO associated with Endotoxemia RGD PMID:21473829 PMID:23324284 RGD:5147760 RGD:7241552 NCBI chr10:70,433,340...70,441,569
Ensembl chr10:73,105,895...73,113,136 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma ISO protein:decreased expression:lung (rat)
CTD Direct Evidence: therapeutic		 RGD
CTD		 PMID:16083301 PMID:21153920 RGD:8553030 NCBI chr 3:12,215,322...12,361,669
Ensembl chr 3:12,622,397...12,705,060 		JBrowse link
G PRDM1 PR/SET domain 1 ISO CTD Direct Evidence: therapeutic CTD PMID:33109608 NCBI chr 6:103,899,410...103,923,389
Ensembl chr 6:107,773,229...107,796,815 		JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 ISO RGD PMID:21595935 RGD:6484539 NCBI chr 5:69,581,748...69,620,721
Ensembl chr 5:74,627,830...74,666,505 		JBrowse link
G PROC protein C, inactivator of coagulation factors Va and VIIIa treatment ISO associated with Pseudomonas Infections
associated with Intestinal Reperfusion Injury		 RGD PMID:16553944 PMID:18367148 RGD:11100043 RGD:11250405 NCBI chr2B:32,846,899...32,859,060
Ensembl chr2B:128,083,794...128,094,625 		JBrowse link
G PROCR protein C receptor treatment ISO RGD PMID:20095324 RGD:13515130 NCBI chr20:31,500,838...31,543,928
Ensembl chr20:32,622,876...32,628,320 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO protein:increased expression:lung RGD PMID:19567182 PMID:20926798 RGD:5135287 RGD:5135496 NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519 		JBrowse link
G SCGB1A1 secretoglobin family 1A member 1 ISO protein:decreased expression:lung RGD PMID:16226776 PMID:18420837 RGD:5143982 RGD:5144142 NCBI chr11:57,774,560...57,780,334
Ensembl chr11:61,133,649...61,137,873 		JBrowse link
G SERPINC1 serpin family C member 1 treatment ISO associated with Endotoxemia RGD PMID:17940748 RGD:11035256 NCBI chr 1:149,421,737...149,435,301
Ensembl chr 1:153,126,031...153,139,369 		JBrowse link
G SERPINE1 serpin family E member 1 treatment ISO associated with Sepsis
associated with Shock, Hemorrhagic;mRNA:increased expression:lung (rat)		 RGD PMID:10745022 PMID:18182560 PMID:25934465 RGD:11075078 RGD:11080962 RGD:11080967 NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450 		JBrowse link
G SERPING1 serpin family G member 1 treatment ISO RGD PMID:11685347 RGD:8661650 NCBI chr11:52,838,502...52,855,781
Ensembl chr11:56,309,686...56,326,639 		JBrowse link
G SFTPB surfactant protein B treatment ISO RGD PMID:22295533 RGD:151667443 NCBI chr2A:85,708,485...85,718,120
Ensembl chr2A:87,257,244...87,268,332 		JBrowse link
G SFTPD surfactant protein D ISO CTD Direct Evidence: therapeutic CTD PMID:30060251 NCBI chr10:76,275,147...76,318,952
Ensembl chr10:78,965,252...78,974,181 		JBrowse link
G SIRT2 sirtuin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32063085 NCBI chr19:35,984,453...36,005,582
Ensembl chr19:44,533,965...44,554,799 		JBrowse link
G SLPI secretory leukocyte peptidase inhibitor treatment
severity		 ISO associated with Endotoxemia RGD PMID:10092827 PMID:25466948 RGD:9999422 RGD:9999425 NCBI chr20:41,583,429...41,585,773
Ensembl chr20:42,673,417...42,675,773 		JBrowse link
G TAC1 tachykinin precursor 1 ISO RGD PMID:19797759 RGD:5147812 NCBI chr 7:89,675,834...89,684,391
Ensembl chr 7:103,257,501...103,266,389 		JBrowse link
G TACR1 tachykinin receptor 1 ISO mRNA:increased expression:lung RGD PMID:18523300 RGD:5147819 NCBI chr2A:75,111,339...75,267,320
Ensembl chr2A:76,614,478...76,771,018 		JBrowse link
G TFF1 trefoil factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19880587 NCBI chr21:28,669,323...28,673,556
Ensembl chr21:41,988,039...41,992,270 		JBrowse link
G TFF2 trefoil factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19880587 NCBI chr21:28,653,077...28,657,709
Ensembl chr21:41,973,111...41,977,227 		JBrowse link
G TGFB1 transforming growth factor beta 1 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16100012 PMID:25278421 RGD:39939031 NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973 		JBrowse link
G THBD thrombomodulin treatment ISO associated with Endotoxemia RGD PMID:19342415 PMID:19536047 PMID:20095324 RGD:13515130 RGD:5131887 RGD:5685372 NCBI chr20:22,992,341...22,996,415
Ensembl chr20:23,345,917...23,347,812 		JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 severity ISO RGD PMID:10092827 RGD:9999422 NCBI chr17:72,928,692...73,001,892
Ensembl chr17:78,476,807...78,495,649 		JBrowse link
G TLR4 toll like receptor 4 ISO RGD PMID:19567182 RGD:5135496 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
G TNF tumor necrosis factor no_association
treatment		 ISO protein:increased expression:respiratory system fluid/secretion
CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:lung
DNA:SNP:promoter:rs1799964 (human)
DNA:SNP:promoter:-308G>A (rs1800629) (human)
associated with Liver Reperfusion Injury		 RGD
CTD		 PMID:11129814 PMID:19106808 PMID:21767135 PMID:30412745 PMID:34390737 RGD:14975158 RGD:14995473 RGD:5147925 RGD:6480432 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
G TNFAIP6 TNF alpha induced protein 6 ISO CTD Direct Evidence: therapeutic CTD PMID:26313688 NCBI chr2B:38,669,652...38,692,037
Ensembl chr2B:155,933,842...155,956,382 		JBrowse link
G TREM1 triggering receptor expressed on myeloid cells 1 exacerbates
ameliorates		 ISO RGD PMID:26832696 RGD:127284840 NCBI chr 6:40,861,283...40,874,446
Ensembl chr 6:42,163,337...42,183,091 		JBrowse link
G TXN thioredoxin ISO CTD Direct Evidence: therapeutic CTD PMID:16298680 NCBI chr 9:81,399,056...81,411,607
Ensembl chr 9:109,565,557...109,578,311 		JBrowse link
G USP18 ubiquitin specific peptidase 18 ISO CTD Direct Evidence: therapeutic CTD PMID:33930521
G VEGFA vascular endothelial growth factor A ISO associated with Endotoxemia;mRNA, protein:altered expression:lung, plasma RGD PMID:21528367 RGD:5684427 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353 		JBrowse link
G VIP vasoactive intestinal peptide ISO CTD Direct Evidence: therapeutic
associated with Endotoxemia		 CTD
RGD		 PMID:8643465 PMID:20441697 RGD:4145303 NCBI chr 6:150,564,545...150,573,582
Ensembl chr 6:155,254,652...155,263,730 		JBrowse link
G XDH xanthine dehydrogenase treatment ISO RGD PMID:9655743 RGD:13209002 NCBI chr2A:31,356,011...31,435,111
Ensembl chr2A:31,425,183...31,504,455 		JBrowse link
G ZC3H12A zinc finger CCCH-type containing 12A severity ISO associated with toxic shock syndrome RGD PMID:23422584 RGD:39938961 NCBI chr 1:36,743,341...36,753,261
Ensembl chr 1:38,093,917...38,103,556 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15805
    Wounds and Injuries 946
      Thoracic Injuries 289
        Lung Injury 284
          Acute Lung Injury 136
Path 2
Term Annotations click to browse term
  disease 15805
    disease of anatomical entity 15483
      respiratory system disease 4883
        lower respiratory tract disease 2203
          lung disease 2163
            Lung Injury 284
              Acute Lung Injury 136
paths to the root