Sepsis - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	Sepsis	go back to main search page
Accession:	DOID:9004484	browse the term
Definition:	Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Synonyms:	exact_synonym:	Blood Poisoning; Pyaemia; Pyaemias; Pyemia; Pyemias; Pyohemia; Pyohemias; Septicemia; Septicemias; blood poisonings
	narrow_synonym:	septic shock; severe sepsis
	related_synonym:	SEPSIS, SUSCEPTIBILITY TO
	primary_id:	MESH:D018805
	xref:	EFO:0001420

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Rat (396) Mouse (404) Human (860) Chinchilla (330) Bonobo (375) Dog (379) Squirrel (346) Pig (376) Green Monkey (368) Naked Mole-rat (332) All
Genes (375)

Sepsis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

severity

DNA:polymorphism:cds:allele A (human)

NCBI chr 9:104,354,115...104,399,057
Ensembl chr 9:132,989,574...133,010,324

G

angiotensin I converting enzyme

susceptibility

DNA:insertion/deletion:intron:

NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853

G

adiponectin, C1Q and collagen domain containing

mRNA, protein:decreasedexpression:serum, omental fat pad:

PMID:16488436 PMID:19481767 PMID:21962804

RGD:1599144 RGD:5686408 RGD:5686835

NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885

G

adrenomedullin

treatment

CTD Direct Evidence: marker/mechanism
protein:increased expression:plasma:
associated with Jaundice,Obstructive;

PMID:14766677 PMID:19009024 PMID:20132852

RGD:7364952 RGD:7364986

NCBI chr11:10,437,712...10,440,053
Ensembl chr11:10,165,418...10,167,842

G

adenosine A2a receptor

CTD Direct Evidence: marker/mechanism

NCBI chr22:5,233,876...5,248,622
Ensembl chr22:22,104,253...22,114,189

G

adenosine A2b receptor

CTD Direct Evidence: marker/mechanism

NCBI chr17:34,849,466...34,880,088

G

adrenoceptor alpha 2A

disease_progression

NCBI chr10:107,669,860...107,673,685

G

adrenoceptor beta 2

mRNA,protein:decreased expression:liver:

PMID:10409266 PMID:16603198

RGD:1598745 RGD:8548498

NCBI chr 5:144,259,756...144,398,421
Ensembl chr 5:150,267,554...150,315,892

G

adrenoceptor beta 3

mRNA, protein:increased expression:heart left ventricle (human)

NCBI chr 8:37,263,730...37,267,475
Ensembl chr 8:34,441,311...34,443,949

G

advanced glycosylation end-product specific receptor

treatment

NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641

G

5'-aminolevulinate synthase 1

mRNA:increased expression:duodenum, jejunum, ileum (rat)

NCBI chr 3:52,140,423...52,156,656
Ensembl chr 3:53,369,522...53,385,361

G

albumin

disease_progression

protein:decreased expression:serum:

NCBI chr 4:50,773,244...50,790,474
Ensembl chr 4:56,605,322...56,622,418

G

aldehyde dehydrogenase 2 family member

treatment

associated with heat shock treatment;protein:altered expression, altered phosphorylation:liver, mitochondria (rat)

NCBI chr12:109,343,020...109,385,060
Ensembl chr12:112,734,243...112,776,471

G

angiopoietin 1

CTD Direct Evidence: therapeutic

NCBI chr 8:103,893,234...104,137,661
Ensembl chr 8:106,042,041...106,286,783

G

apolipoprotein A1

treatment

NCBI chr11:111,673,539...111,675,428
Ensembl chr11:115,606,136...115,608,122

G

arginase 2

protein:decreased expression:lung

NCBI chr14:48,197,831...48,231,829
Ensembl chr14:67,075,941...67,109,962

G

ATM serine/threonine kinase

treatment

NCBI chr11:103,109,979...103,256,405
Ensembl chr11:106,584,228...106,727,041

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1

Ensembl chr16:29,265,516...29,290,807
Ensembl chr16:29,265,516...29,290,807

G

bile acid-CoA:amino acid N-acyltransferase

NCBI chr 9:72,568,002...72,593,179
Ensembl chr 9:100,563,040...100,586,189

G

BCL2 associated agonist of cell death

treatment

protein:increased localization:mitochondrion

PMID:22683079 PMID:24011917

RGD:10053647 RGD:10053707

NCBI chr11:59,626,981...59,641,824
Ensembl chr11:62,971,808...62,986,257

G

complement C3

protein:increased expression:liver
mRNA:increased expression:kidney

PMID:3339873 PMID:24154627

RGD:11040886 RGD:7411622

NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699

G

complement C5

protein:increased activation:plasma

PMID:14688199 PMID:18648551

RGD:1600599 RGD:5130170

NCBI chr 9:92,069,574...92,202,513
Ensembl chr 9:120,426,354...120,523,856

G

complement C5a receptor 1

disease_progression

PMID:12897064 PMID:18648551

RGD:5130170 RGD:5130176

NCBI chr19:44,293,612...44,310,430
Ensembl chr19:52,950,317...52,966,146

G

complement C6

severity

NCBI chr 5:69,174,411...69,245,801
Ensembl chr 5:74,216,244...74,288,588

G

calcium voltage-gated channel subunit alpha1 S

protein:decreased expression:diaphragmaticus muscle

NCBI chr 1:176,639,189...176,712,171
Ensembl chr 1:180,941,836...181,014,823

G

cathelicidin antimicrobial peptide

NCBI chr 3:48,137,785...48,139,893
Ensembl chr 3:49,222,110...49,224,250

G

caspase 3

treatment

CTD Direct Evidence: marker/mechanism

PMID:16003065 PMID:29180187 PMID:32062619

NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185

G

caspase 6

protein:increased activity:thymus, T cell

NCBI chr 4:102,186,215...102,201,992
Ensembl chr 4:112,753,988...112,768,836

G

caspase 8

treatment

PMID:18570579 PMID:29180187

RGD:13782295 RGD:2311435

NCBI chr2B:88,490,611...88,542,132
Ensembl chr2B:206,669,544...206,696,468

G

caspase 9

treatment

NCBI chr 1:14,630,659...14,662,865
Ensembl chr 1:15,624,666...15,656,266

G

calpastatin

NCBI chr 5:91,972,572...92,084,657
Ensembl chr 5:97,527,071...97,636,650

G

catalase

severity

NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160

G

cystathionine beta-synthase

susceptibility

DNA:SNP:intron (rs6586282, rs34758144) (human)

NCBI chr21:29,361,519...29,385,610
Ensembl chr21:42,670,530...42,690,932

G

C-C motif chemokine ligand 2

mRNA:increased expression:ileum

NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384

G

C-C motif chemokine ligand 5

protein:increased secretion:plasma (rat)

NCBI chr17:20,915,198...20,923,530
Ensembl chr17:21,210,798...21,219,172

G

CD163 molecule

protein:increased expression:blood serum, CD-14 positive monocyte (human)

NCBI chr12:7,616,714...7,649,768
Ensembl chr12:7,775,343...7,810,023

G

CD1d molecule

treatment

NCBI chr 1:133,549,258...133,557,752
Ensembl chr 1:137,341,690...137,348,173

G

CD274 molecule

disease_progression

protein:increased expression:monocyte
protein:increased expression:B cell,CD4T cell

PMID:27156867 PMID:29661225 PMID:29702526 PMID:30595665

RGD:40818235 RGD:40818424 RGD:40822808 RGD:41412183

NCBI chr 9:5,269,270...5,289,629
Ensembl chr 9:5,454,391...5,474,402

G

CD28 molecule

severity

Higher soluble CD28 in patients who died

NCBI chr2B:90,938,795...90,971,438
Ensembl chr2B:209,076,388...209,111,213

G

CD36 molecule (CD36 blood group)

NCBI chr 7:72,566,478...72,643,517
Ensembl chr 7:86,265,114...86,305,865

G

CD40 molecule

protein:decreased nitrosylation:monocyte

NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994

G

CD40 ligand

mRNA:increased expression:heart (rat)

NCBI chr X:125,776,138...125,788,820
Ensembl chr X:136,042,849...136,058,202

G

cyclin dependent kinase inhibitor 1A

NCBI chr 6:36,241,405...36,250,032
Ensembl chr 6:37,436,990...37,445,599

G

CCAAT enhancer binding protein beta

protein:increased expression:skeletal muscle

NCBI chr20:46,533,163...46,535,282

G

CCAAT enhancer binding protein delta

protein:increased expression:skeletal muscle

NCBI chr 8:44,167,256...44,168,545

G

complement factor B

treatment

NCBI chr 6:31,606,716...31,612,782

G

complement factor H

treatment

protein:decreased expression:plasma:
associated with Jaundice,Obstructive;

PMID:19009024 PMID:20132852

RGD:7364952 RGD:7364986

NCBI chr 1:172,155,882...172,251,632
Ensembl chr 1:176,455,247...176,525,521

G

carboxypeptidase B2

protein:increased activity:plasma:

NCBI chr13:26,926,788...26,979,767

G

corticotropin releasing hormone

protein:increased expression:hypothalamus (rat)

NCBI chr 8:62,714,721...62,716,979
Ensembl chr 8:64,383,419...64,384,009

G

C-reactive protein

protein:increased expression:blood:

PMID:19060982 PMID:21797109

RGD:6482315 RGD:9491784

NCBI chr 1:135,062,102...135,064,402

G

citrate synthase

protein:decreased expression:cerebral cortex

NCBI chr12:32,614,982...32,643,719
Ensembl chr12:32,867,225...32,895,854

G

colony stimulating factor 2

protein:increased expression:plasma:

NCBI chr 5:127,496,951...127,499,325
Ensembl chr 5:133,660,775...133,663,146

G

colony stimulating factor 3

treatment

CTD Direct Evidence: therapeutic

PMID:8706460 PMID:17505274

NCBI chr17:17,271,074...17,273,493
Ensembl chr17:17,491,276...17,493,729

G

C-X3-C motif chemokine receptor 1

protein:increased expression:lung, macrophage

NCBI chr 3:39,158,346...39,176,604
Ensembl chr 3:39,440,955...39,457,219

G

C-X-C motif chemokine ligand 6

protein:increased expression:multiple tissues

NCBI chr 4:50,357,643...50,359,822
Ensembl chr 4:56,189,961...56,192,402

G

C-X-C motif chemokine ligand 8

exacerbates

protein:increased expression:blood plasma (human)

NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083

G

C-X-C motif chemokine receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr2B:105,387,198...105,400,533
Ensembl chr2B:223,997,066...223,998,148

G

cytochrome P450 family 1 subfamily A member 1

mRNA, protein:decreased expression:liver

NCBI chr15:53,664,968...53,672,277
Ensembl chr15:73,284,566...73,290,636

G

cytochrome P450 family 1 subfamily A member 2

PMID:15665729 PMID:18360687

RGD:2303376 RGD:5147745

NCBI chr15:53,692,877...53,699,279
Ensembl chr15:73,311,720...73,319,447

G

cytochrome P450 family 2 subfamily E member 1

Ensembl chr10:134,839,025...134,852,719

G

cytochrome P450 family 2 subfamily J member 2

NCBI chr 1:59,151,079...59,184,625
Ensembl chr 1:60,856,269...60,889,810

G

endothelin 1

mRNA, protein:increased expression:multiple (rat)

NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545

G

eukaryotic translation initiation factor 2B subunit epsilon

protein:increased serine phosphorylation:gastrocnemius

NCBI chr 3:181,170,806...181,180,923
Ensembl chr 3:189,652,554...189,665,528

G

eukaryotic translation initiation factor 2 subunit alpha

NCBI chr14:47,935,691...47,960,055
Ensembl chr14:66,813,953...66,839,866

G

eukaryotic translation initiation factor 4E

NCBI chr 4:91,268,463...91,329,800
Ensembl chr 4:101,941,142...101,994,809

G

elastase, neutrophil expressed

associated with Klebsiella Infections;

NCBI chr19:276,499...280,598

G

ectonucleoside triphosphate diphosphohydrolase 1

protein:increased activity:lymphocyte:

NCBI chr10:92,365,267...92,511,852
Ensembl chr10:95,828,094...95,983,257

G

E1A binding protein p300

mRNA, protein:increased expression:muscle part of extensor digitorum longus (rat)

NCBI chr22:21,986,467...22,076,921
Ensembl chr22:40,079,503...40,168,604

G

estrogen receptor 2

NCBI chr14:44,807,875...44,919,780
Ensembl chr14:63,064,402...63,131,303

G

coagulation factor XI

NCBI chr 4:178,436,865...178,459,568
Ensembl chr 4:190,643,733...190,666,512

G

coagulation factor II, thrombin

treatment

PMID:12361199 PMID:19705256

RGD:10449428 RGD:7387324

NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157

G

coagulation factor III, tissue factor

treatment

PMID:9875912 PMID:26311287

RGD:11340217 RGD:11341736

NCBI chr 1:97,190,381...97,203,076
Ensembl chr 1:95,918,502...95,931,050

G

coagulation factor V

treatment
severity

PMID:12000738 PMID:16235188

RGD:1598921 RGD:4892622

NCBI chr 1:144,996,757...145,070,046
Ensembl chr 1:148,718,897...148,790,915

G

coagulation factor VII

treatment

protein:decreased activity:plasma (rat)

PMID:3660344 PMID:12000738

RGD:1598921 RGD:2312320

NCBI chr13:94,246,694...94,261,133
Ensembl chr13:113,315,868...113,329,995

G

coagulation factor IX

treatment

NCBI chr X:128,684,709...128,719,020
Ensembl chr X:138,934,167...138,967,087

G

Fas cell surface death receptor

mRNA:increased expression:liver

NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612

G

Fas ligand

mRNA:increased expression:liver

NCBI chr 1:148,159,826...148,167,785
Ensembl chr 1:151,868,430...151,876,281

G

fibrinogen alpha chain

protein:decreased expression:serum (rat)

NCBI chr 4:146,949,680...146,957,291

G

fms related receptor tyrosine kinase 1

disease_progression

Pneumonia associated sepsis

NCBI chr13:9,584,850...9,779,542

G

forkhead box P3

severity

NCBI chr X:41,550,462...41,567,492
Ensembl chr X:49,402,652...49,417,029

G

FYN proto-oncogene, Src family tyrosine kinase

protein:decreased phosphorylation, decreased activity:T cell (rat)

NCBI chr 6:109,469,750...109,684,086
Ensembl chr 6:113,545,944...113,604,451

G

growth arrest specific 6

Ensembl chr13:113,968,843...114,009,562

G

GATA binding protein 3

severity

NCBI chr10:8,075,951...8,105,573
Ensembl chr10:8,064,207...8,086,272

G

GTP cyclohydrolase 1

treatment

associated with Staphylococcal Infections

PMID:12441764 PMID:29428597

RGD:401700401 RGD:401717570

NCBI chr14:35,428,676...35,489,359
Ensembl chr14:53,706,723...53,767,393

G

growth factor, augmenter of liver regeneration

protein:increased expression:serum:

NCBI chr16:716,640...720,196
Ensembl chr16:2,073,064...2,076,592

G

growth hormone receptor

NCBI chr 5:67,654,326...67,953,140
Ensembl chr 5:72,700,150...72,871,278

G

ghrelin and obestatin prepropeptide

mRNA,protein:decreased expression:aorta,heart, intestine, plasma:

NCBI chr 3:10,221,829...10,229,229
Ensembl chr 3:10,573,537...10,580,723

G

growth hormone secretagogue receptor

disease_progression

NCBI chr 3:169,448,217...169,458,602
Ensembl chr 3:177,633,039...177,638,202

G

gap junction protein alpha 5

mRNA, protein:increased expression:aorta endothelium

NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413

G

glycoprotein Ib platelet subunit alpha

exacerbates

associated with thrombocytopenia

NCBI chr17:4,980,083...4,983,219

G

glutamic--pyruvic transaminase

treatment

PMID:25243423 PMID:26814114

RGD:14975161 RGD:401717564

Ensembl chr 8:144,259,991...144,263,737

G

glutamate ionotropic receptor NMDA type subunit 2A

protein:increased expression:lung (rat)

NCBI chr16:8,682,169...9,105,581
Ensembl chr16:9,919,143...10,336,167

G

G protein-coupled receptor kinase 2

protein: increased expression: neutrophils

NCBI chr11:62,624,647...62,644,846
Ensembl chr11:65,939,164...65,959,066

G

G protein-coupled receptor kinase 5

protein: increased expression: neutrophils

NCBI chr10:115,776,236...116,026,221
Ensembl chr10:119,200,688...119,450,809

G

glycogen synthase kinase 3 beta

protein:decreased phosphorylation,increased activity: :

NCBI chr 3:116,943,205...117,215,001
Ensembl chr 3:123,861,379...124,126,771

G

gelsolin

protein:decreased expression:blood serum (human)

NCBI chr 9:92,413,819...92,460,483
Ensembl chr 9:120,741,148...120,805,831

G

hepatitis A virus cellular receptor 1

disease_progression

NCBI chr 5:152,429,337...152,459,800
Ensembl chr 5:158,413,073...158,442,481

G

histone deacetylase 4

NCBI chr2B:126,287,745...126,649,815
Ensembl chr2B:245,123,061...245,427,054

G

histone deacetylase 6

NCBI chr X:41,099,539...41,122,650
Ensembl chr X:48,960,430...48,982,642

G

high mobility group box 1

treatment

CTD Direct Evidence: marker/mechanism

PMID:19265175 PMID:19623040 PMID:20936717 PMID:23146691

RGD:10402067 RGD:10402173

NCBI chr13:11,737,942...11,894,923
Ensembl chr13:30,174,899...30,179,527

G

15-hydroxyprostaglandin dehydrogenase

protein: decreased expression

NCBI chr 4:166,716,386...166,749,225
Ensembl chr 4:178,949,137...178,982,910

G

heat shock protein family D (Hsp60) member 1

associated with burns;protein:decreased expression:skeletal muscle

PMID:16483253 PMID:23143056

RGD:10402864 RGD:1624233

NCBI chr2B:84,729,615...84,743,352
Ensembl chr2B:202,623,497...202,636,959

G

HtrA serine peptidase 2

treatment

NCBI chr2A:74,596,020...74,599,790
Ensembl chr2A:76,102,240...76,106,152

G

intercellular adhesion molecule 1

mRNA:increased expression:brain (rat)

NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605

G

indoleamine 2,3-dioxygenase 1

treatment

NCBI chr 8:39,108,310...39,123,611
Ensembl chr 8:36,617,312...36,632,352

G

interferon gamma

treatment

CTD Direct Evidence: marker/mechanism

PMID:9806674 PMID:27598601 PMID:28711488

RGD:14974250 RGD:14975121

NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829

G

interleukin 10

treatment

CTD Direct Evidence: therapeutic
protein:increased expression:serum

PMID:11441115 PMID:19371254 PMID:24055021 PMID:27488951 PMID:28108420

RGD:14975261 RGD:14975262 RGD:2311053 RGD:7364867

NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371

G

interleukin 12B

protein:increased expression:peritoneal fluid, plasma

NCBI chr 5:154,706,467...154,722,231
Ensembl chr 5:161,325,303...161,335,381

G

interleukin 13

protein:decreased expression:ileum

PMID:10679115 PMID:21159497

RGD:4145654 RGD:8549643

NCBI chr 5:128,073,863...128,078,453
Ensembl chr 5:134,235,788...134,240,548

G

interleukin 16

associated with Shock, Hemorrhagic;protein:increased expression:lung

NCBI chr15:60,181,827...60,299,406
Ensembl chr15:79,122,988...79,250,861

G

interleukin 17A

NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074

G

interleukin 17D

severity
treatment

protein:increased expression:blood serum (human)

NCBI chr13:2,030,234...2,049,965
Ensembl chr13:20,343,537...20,361,535

G

interleukin 1 beta

treatment

protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism

PMID:17529909 PMID:21429520 PMID:32062619

RGD:1626657 RGD:7175319

NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424

G

interleukin 1 receptor like 1

severity

G

interleukin 1 receptor antagonist

disease_progression
severity
susceptibility

mRNA:increased expression:pituitary gland (rat)
DNA:repeats: :
protein:increased expression:serum (human)
mRNA, protein:increased expression:lung
associated with Premature Birth;DNA:polymorphism::

PMID:8196140 PMID:10048466 PMID:11876758 PMID:17014550 PMID:20454520 More...

RGD:11528543 RGD:12910846 RGD:4142852 RGD:6907358 RGD:6909139 RGD:7175061

NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839

G

interleukin 22

protein:increased expression:plasma

NCBI chr12:65,757,069...65,762,418
Ensembl chr12:68,542,076...68,547,421

G

interleukin 27

disease_progression
severity
exacerbates

DNA:SNP:promoter:-964A>G (rs153109) (human)
associated with Herpesviridae Infections;protein:increased expression:blood serum, spleen (mouse)
mRNA:increased expression:blood, leukocyte (human)
protein:increased expression:blood (human)

PMID:18227999 PMID:20493722 PMID:22965735 PMID:26767500 PMID:30268141

RGD:126790502 RGD:126790509 RGD:126790536 RGD:126790537 RGD:126790544

G

interleukin 33

severity

protein:increased expression:plasma,lung
protein:increased expression:plasma, peritoneal fluid:
protein:increased expression:plasma:

PMID:25665614 PMID:29672927 PMID:29935165

RGD:39939028 RGD:40400739 RGD:40400895

NCBI chr 9:6,027,014...6,069,540
Ensembl chr 9:6,234,178...6,248,624

G

interleukin 4

protein:increased expression:plasma

NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581

G

interleukin 6

treatment

associated with Diabetes Mellitus, Non-Insulin-Dependent; mRNA, protein:increased expression:liver, extracellular space (rat)
CTD Direct Evidence: marker/mechanism

PMID:19079684 PMID:25317848 PMID:27598601 PMID:32062619

RGD:11062009 RGD:14975121 RGD:2307280

NCBI chr 7:23,415,922...23,420,767

G

interleukin 1 receptor associated kinase 4

NCBI chr12:44,941,862...44,972,520
Ensembl chr12:45,810,917...45,841,492

G

insulin receptor substrate 1

protein:decreased tyrosine phosphorylation, increased serine phosphorylation:gastrocnemius

NCBI chr2B:113,973,191...114,041,127
Ensembl chr2B:232,849,239...232,852,967

G

integrin subunit alpha 4

protein:increased expression:neutrophil

NCBI chr2B:68,719,376...68,802,488
Ensembl chr2B:186,530,187...186,612,203

G

integrin subunit alpha M

exacerbates

protein:increased expression:neutrophil (rat)

NCBI chr16:23,634,476...23,707,147
Ensembl chr16:31,630,146...31,702,406

G

Janus kinase 2

treatment

NCBI chr 9:4,820,303...4,971,867
Ensembl chr 9:5,006,271...5,156,626

G

kelch like ECH associated protein 1

NCBI chr19:10,037,544...10,055,091
Ensembl chr19:10,701,303...10,717,604

G

kallikrein B1

NCBI chr 4:178,398,359...178,429,448
Ensembl chr 4:190,604,901...190,636,300

G

lipopolysaccharide binding protein

CTD Direct Evidence: marker/mechanism

NCBI chr20:34,670,128...34,703,046
Ensembl chr20:35,780,768...35,813,188

G

lipocalin 2

exacerbates

NCBI chr 9:99,259,278...99,274,494
Ensembl chr 9:127,940,799...127,944,798

G

leptin

NCBI chr 7:120,230,896...120,248,602
Ensembl chr 7:132,885,011...132,901,519

G

lipase C, hepatic type

protein:decreased expression:diaphragm, heart, adipose tissue (rat)

NCBI chr15:37,363,507...37,537,723
Ensembl chr15:55,814,017...55,847,005

G

interferon alpha-2

CTD Direct Evidence: marker/mechanism

NCBI chr 9:21,245,017...21,246,210
Ensembl chr 9:21,863,062...21,863,736

G

uncharacterized LOC100974886

NCBI chr 4:50,092,989...50,095,541
Ensembl chr 4:55,925,562...55,986,555

G

solute carrier organic anion transporter family member 1B3

mRNA:decreased expression:liver

NCBI chr12:65,386,042...65,492,240

G

alpha-2-macroglobulin

mRNA:increased expression:liver

PMID:9843780 PMID:15167684

RGD:10046033 RGD:1598509

NCBI chr12:9,154,457...9,202,833
Ensembl chr12:9,385,359...9,433,979

G

metallothionein-2

CTD Direct Evidence: marker/mechanism

NCBI chr16:36,894,853...36,895,826
Ensembl chr16:56,007,922...56,028,093

G

lipoprotein(a)

protein:decreased expression:plasma

NCBI chr 6:158,434,394...158,628,028

G

lymphotoxin alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 6:31,233,411...31,235,409
Ensembl chr 6:32,123,353...32,125,375

G

lactotransferrin

NCBI chr 3:46,337,738...46,367,476
Ensembl chr 3:47,442,440...47,471,532

G

mitogen-activated protein kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr22:3,883,119...3,990,368
Ensembl chr22:20,365,487...20,450,335

G

mitogen-activated protein kinase 3

CTD Direct Evidence: marker/mechanism

Ensembl chr16:30,489,362...30,498,017

G

mitogen-activated protein kinase 8

treatment

NCBI chr10:45,806,748...45,936,362

G

mannose binding lectin 2

susceptibility

associated with Premature Birth;DNA:polymorphism:exon:

NCBI chr10:49,401,364...49,409,328
Ensembl chr10:51,527,758...51,543,432

G

mitofusin 2

mRNA:decreased expression:liver (rat)

NCBI chr 1:10,729,933...10,764,865
Ensembl chr 1:11,945,880...11,981,077

G

macrophage migration inhibitory factor

CTD Direct Evidence: therapeutic
protein:increased expression:serum

PMID:9892616 PMID:17585860

NCBI chr22:4,646,986...4,647,831
Ensembl chr22:22,730,807...22,732,009

G

matrix metallopeptidase 1

NCBI chr11:97,730,545...97,739,190
Ensembl chr11:101,221,393...101,230,104

G

matrix metallopeptidase 2

treatment

NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279

G

matrix metallopeptidase 9

treatment

CTD Direct Evidence: marker/mechanism

PMID:16003065 PMID:23479197

NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129

G

myeloperoxidase

NCBI chr17:52,333,882...52,357,838
Ensembl chr17:57,201,073...57,212,111

G

metallothionein 1X

CTD Direct Evidence: marker/mechanism

NCBI chr16:36,959,854...36,961,632
Ensembl chr16:56,092,218...56,093,976

G

mechanistic target of rapamycin kinase

NCBI chr 1:9,871,700...10,028,704
Ensembl chr 1:11,093,765...11,249,841

G

myosin light chain kinase

NCBI chr 3:120,711,705...120,983,432
Ensembl chr 3:127,614,173...127,793,261

G

NADH:ubiquinone oxidoreductase subunit B8

NCBI chr10:97,123,826...97,129,919
Ensembl chr10:100,604,914...100,611,016

G

neurofilament heavy chain

severity

NCBI chr22:10,525,738...10,536,788

G

neurofilament light chain

disease_progression

NCBI chr 8:24,218,510...24,224,627
Ensembl chr 8:21,134,533...21,140,694

G

NFKB inhibitor alpha

treatment

NCBI chr14:16,155,331...16,158,588

G

nucleotide binding oligomerization domain containing 2

susceptibility

mRNA:increased expression:intestine mucosa (rat)
DNA:missense mutations, frameshift mutation:cds:p.R702W, p.G908R, 3020_3021insC (human)

PMID:21460759 PMID:24059417

RGD:5508752 RGD:8547531

NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773

G

nitric oxide synthase 1

NCBI chr12:114,784,232...114,938,385
Ensembl chr12:118,163,655...118,314,005

G

nitric oxide synthase 2

associated with lung injury
CTD Direct Evidence: marker/mechanism

PMID:15665729 PMID:17138957 PMID:20035746 PMID:21184738

RGD:4891414 RGD:5147745

NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093

G

nitric oxide synthase 3

protein:increased expression:heart
CTD Direct Evidence: marker/mechanism

PMID:17999941 PMID:20035746

NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233

G

NADPH oxidase 1

ameliorates

NCBI chr X:90,046,023...90,076,968
Ensembl chr X:100,182,398...100,215,192

G

nuclear receptor subfamily 3 group C member 1

treatment

protein:decreased expression:alveolar macrophage

PMID:21057058 PMID:21787473

RGD:4892317 RGD:7174711

NCBI chr 5:138,634,278...139,089,171
Ensembl chr 5:144,741,452...144,865,269

G

ornithine transcarbamylase

mRNA:decreased expression:liver (rat)

NCBI chr X:30,796,828...30,868,144
Ensembl chr X:38,505,232...38,575,819

G

programmed cell death 1

disease_progression

protein:increased expression:T cell
protein:increased expression:B cell,CD4T cell

PMID:19332785 PMID:27156867 PMID:29661225 PMID:29702526 PMID:30595665

RGD:40818235 RGD:40818273 RGD:40818424 RGD:40822808 RGD:41412183

NCBI chr12:130,849,353...130,858,776

G

programmed cell death 1 ligand 2

protein:increased expression:CD27B cell

NCBI chr 9:5,313,071...5,391,676
Ensembl chr 9:5,514,449...5,575,688

G

platelet and endothelial cell adhesion molecule 1

disease_progression

protein:increased expression:myeloid suppressor cell (mouse)

NCBI chr17:58,417,134...58,526,409
Ensembl chr17:63,511,784...63,579,067

G

placental growth factor

protein:increased expression:plasma

NCBI chr14:55,494,152...55,508,066
Ensembl chr14:74,338,976...74,352,964

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

NCBI chr 7:98,841,974...98,885,446
Ensembl chr 7:111,570,148...111,611,614

G

phospholipase A2 group IVA

protein:increased activity:liver

NCBI chr 1:162,362,600...162,521,974
Ensembl chr 1:166,512,870...166,672,101

G

plasminogen activator, tissue type

treatment

NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779

G

plasminogen activator, urokinase

disease_progression

Pneumonia associated sepsis

NCBI chr10:70,433,340...70,441,569
Ensembl chr10:73,105,895...73,113,136

G

plasminogen activator, urokinase receptor

protein:increased expression:plasma

NCBI chr19:40,588,100...40,616,479
Ensembl chr19:49,197,341...49,222,561
Ensembl chr19:49,197,341...49,222,561

G

peroxisome proliferator activated receptor alpha

severity

RNA:decreased expression:blood:associated with more severe disease
DNA:knockout::associated with more severe disease

Ensembl chr22:45,218,364...45,302,970

G

PPARG coactivator 1 alpha

mRNA:decreased expression:skeletal muscle

NCBI chr 4:18,196,431...18,876,889
Ensembl chr 4:23,483,377...23,581,212

G

PPARG coactivator 1 beta

mRNA:decreased expression:skeletal muscle

NCBI chr 5:145,154,517...145,315,567
Ensembl chr 5:151,203,088...151,278,837

G

peptidylprolyl isomerase A

treatment

NCBI chr 7:45,510,450...45,515,448
Ensembl chr 7:45,578,765...45,605,545

G

protein kinase C theta

protein:decreased expression:lymphocyte

NCBI chr10:6,458,138...6,610,781
Ensembl chr10:6,440,316...6,593,900

G

protein C, inactivator of coagulation factors Va and VIIIa

disease_progression
treatment

CTD Direct Evidence: therapeutic
mRNA, protein:decreased expression:liver, plasma

PMID:11820775 PMID:15241104 PMID:17556722 PMID:22940033

RGD:11100029 RGD:11250412

NCBI chr2B:32,846,899...32,859,060
Ensembl chr2B:128,083,794...128,094,625

G

Rac family small GTPase 1

mRNA:increased expression:blood serum (human)

NCBI chr 7:7,039,379...7,068,866

G

RELA proto-oncogene, NF-kB subunit

protein:increased expression:nucleus, lung

NCBI chr11:61,012,839...61,022,225
Ensembl chr11:64,347,859...64,356,868

G

resistin

protein:increased expression:serum

NCBI chr19:6,958,536...6,960,032
Ensembl chr19:7,812,942...7,814,909

G

receptor interacting serine/threonine kinase 3

ameliorates
no_association

PMID:22195746 PMID:23835476 PMID:32152555

RGD:127229908 RGD:127229909 RGD:127229919

NCBI chr14:5,112,512...5,116,486
Ensembl chr14:23,235,796...23,239,821

G

ribosomal protein L4

CTD Direct Evidence: marker/mechanism

NCBI chr15:45,446,582...45,452,173
Ensembl chr15:63,721,912...63,727,477

G

ribosomal protein L9

CTD Direct Evidence: marker/mechanism

NCBI chr 4:33,782,911...33,787,737
Ensembl chr 4:39,635,067...39,639,810

G

retinoid X receptor alpha

protein:altered localization:liver
protein:decreased expression:liver

PMID:17483744 PMID:19008781

RGD:1643106 RGD:2317466

NCBI chr 9:105,424,046...105,539,241
Ensembl chr 9:134,082,865...134,144,704

G

ryanodine receptor 1

protein:decreased expression:diaphragmaticus muscle
mRNA:increased expression:fast muscle tissue

PMID:18520643 PMID:28044347

RGD:329849107 RGD:329849111

NCBI chr19:35,527,466...35,685,446
Ensembl chr19:44,106,036...44,256,327

G

S100 calcium binding protein B

NCBI chr21:33,063,845...33,070,073
Ensembl chr21:46,197,750...46,203,953

G

selectin L

PMID:15677732 PMID:16026013

RGD:5685706 RGD:5686285

NCBI chr 1:145,173,700...145,194,927
Ensembl chr 1:148,895,373...148,916,393

G

selectin P

protein:increased expression:multiple

NCBI chr 1:145,071,094...145,112,851
Ensembl chr 1:148,793,677...148,834,701

G

serpin family E member 1

treatment

associated with Pneumonia; protein:increased expression:plasma

PMID:12000738 PMID:19753144

RGD:1598921 RGD:4144830

NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450

G

solute carrier family 38 member 2

NCBI chr12:42,359,637...42,374,251
Ensembl chr12:43,230,007...43,244,343

G

suppressor of cytokine signaling 1

protein:increased expression:gastrocnemius
mRNA:increased expression:liver

PMID:11312157 PMID:12644450

RGD:2298924 RGD:634751

NCBI chr16:10,196,432...10,198,205

G

suppressor of cytokine signaling 2

protein:increased expression:gastrocnemius

NCBI chr12:91,115,319...91,134,191
Ensembl chr12:94,514,455...94,520,748

G

suppressor of cytokine signaling 3

protein:increased expression:gastrocnemius
mRNA:increased expression:liver

PMID:11312157 PMID:12644450

RGD:2298924 RGD:634751

NCBI chr17:72,433,206...72,436,500
Ensembl chr17:77,983,389...77,984,066

G

superoxide dismutase 1

NCBI chr21:18,029,831...18,037,526

G

superoxide dismutase 2

mRNA, protein:increased expression:lung

NCBI chr 6:157,562,814...157,610,155
Ensembl chr 6:162,576,082...162,589,960

G

superoxide dismutase 3

NCBI chr 4:19,195,941...19,201,298
Ensembl chr 4:24,485,059...24,485,781

G

signal transducer and activator of transcription 1

protein:increased activity:liver, lung, small intestine

NCBI chr2B:78,270,642...78,316,074
Ensembl chr2B:196,186,906...196,232,280

G

signal transducer and activator of transcription 3

treatment

NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067

G

signal transducer and activator of transcription 4

NCBI chr2B:78,331,402...78,549,231
Ensembl chr2B:196,247,881...196,366,011

G

signal transducer and activator of transcription 6

severity

Ensembl chr12:32,068,679...32,085,099

G

T-box transcription factor 21

severity

NCBI chr17:9,791,008...9,803,894
Ensembl chr17:9,973,920...9,985,660

G

tissue factor pathway inhibitor

protein:decreased activity:plasma:

NCBI chr2B:74,744,154...74,834,338
Ensembl chr2B:192,541,881...192,581,384

G

transforming growth factor beta 1

CTD Direct Evidence: marker/mechanism

NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973

G

transforming growth factor beta induced

CTD Direct Evidence: marker/mechanism

NCBI chr 5:131,420,403...131,455,265
Ensembl chr 5:137,559,321...137,596,392

G

thrombomodulin

NCBI chr20:22,992,341...22,996,415
Ensembl chr20:23,345,917...23,347,812

G

toll like receptor 2

associated with Burns;mRNA:increased expression:liver, lung, kidney
associated with Liver Diseases;mRNA:increased expression:liver

PMID:12831613 PMID:14604479 PMID:19489280

RGD:1302750 RGD:2312497 RGD:2312732

NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331

G

toll like receptor 4

CTD Direct Evidence: marker/mechanism
associated with Liver Diseases;mRNA:increased expression:liver

PMID:14604479 PMID:19489280 PMID:20624996

RGD:2312497 RGD:2312732

NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711

G

toll like receptor 6

mRNA:increased expression:plasma

NCBI chr 4:33,153,151...33,174,053
Ensembl chr 4:39,009,103...39,011,490

G

tumor necrosis factor

treatment

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:heart

PMID:8741040 PMID:9806674 PMID:15489642 PMID:15665729 PMID:19695174 More...

RGD:14975262 RGD:4144094 RGD:5147745 RGD:7364867

NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381

G

DNA topoisomerase II alpha

CTD Direct Evidence: marker/mechanism

NCBI chr17:16,872,169...16,901,605
Ensembl chr17:17,097,778...17,126,207

G

tripeptidyl peptidase 2

mRNA, protein:increased expression, increased activity:extensor digitorum longus (rat)

NCBI chr13:83,756,757...83,838,997
Ensembl chr13:102,892,037...102,974,974

G

triggering receptor expressed on myeloid cells 1

disease_progression
treatment

mRNA:decreased expression:polymorph nuclear cell:

PMID:22147417 PMID:22809118 PMID:22996209

RGD:126925981 RGD:126925987 RGD:127284847

NCBI chr 6:40,861,283...40,874,446
Ensembl chr 6:42,163,337...42,183,091

G

thymic stromal lymphopoietin

treatment
disease_progression

protein:increased expression:peritoneum, plasma (mouse)

PMID:24990542 PMID:26934097

RGD:38549375 RGD:38596335

NCBI chr 5:106,440,136...106,446,849
Ensembl chr 5:112,242,490...112,250,130

G

xanthine dehydrogenase

treatment

NCBI chr2A:31,356,011...31,435,111
Ensembl chr2A:31,425,183...31,504,455

G

X-linked inhibitor of apoptosis

ClinVar Annotator: match by term: Sepsis

PMID:17080092 PMID:21119115 PMID:25666262 PMID:25741868 PMID:27747465 More...

NCBI chr X:113,052,164...113,105,160
Ensembl chr X:123,232,643...123,278,606

Bacteremia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

complement C3

associated with Experimental Liver Cirrhosis; protein:decreased expression:serum

NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699

G

C-C motif chemokine ligand 2

associated with Febrile Neutropenia;protein:increased expression:serum (human)

NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384

G

CCAAT enhancer binding protein beta

associated with alcohol use disorder;mRNA:increased expression:bone marrow (mouse)

NCBI chr20:46,533,163...46,535,282

G

complement factor H

associated with Meningococcal Infections;

NCBI chr 1:172,155,882...172,251,632
Ensembl chr 1:176,455,247...176,525,521

G

cytokine inducible SH2 containing protein

susceptibility

ClinVar Annotator: match by term: Bacteremia, susceptibility to, 2

NCBI chr 3:50,531,870...50,537,319
Ensembl chr 3:51,769,194...51,774,548

G

carboxypeptidase B2

protein:decreased activity:plasma

NCBI chr13:26,926,788...26,979,767

G

C-reactive protein

protein:increased expression:serum:

NCBI chr 1:135,062,102...135,064,402

G

colony stimulating factor 2

treatment

NCBI chr 5:127,496,951...127,499,325
Ensembl chr 5:133,660,775...133,663,146

G

3-hydroxy-3-methylglutaryl-CoA reductase

severity

NCBI chr 5:39,936,630...39,961,519
Ensembl chr 5:40,548,919...40,573,785

G

intercellular adhesion molecule 1

mRNA:increased expression:lung,thymus,spleen:

NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605

G

interleukin 17A

associated with Respiratory Distress Syndrome, Adult; protein:increased expression:serum

NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074

G

interleukin 27

protein:increased expression:blood serum (human)

G

inter-alpha-trypsin inhibitor heavy chain 4

protein:increased expression:liver, serum

NCBI chr 3:52,754,664...52,774,867
Ensembl chr 3:53,980,668...53,998,038

G

low affinity immunoglobulin gamma Fc region receptor II-a

associated with Pneumonia;DNA:SNP: :p.H131R (rs1801274) (human)

NCBI chr 1:136,892,311...136,906,450

G

MAPK activated protein kinase 3

ClinVar Annotator: match by term: Bacteremia, susceptibility to, 2

NCBI chr 3:50,542,547...50,574,817
Ensembl chr 3:51,779,912...51,812,124

G

mannose binding lectin 2

treatment

associated with Multiple Myeloma:DNA:polymorphism:exon:

NCBI chr10:49,401,364...49,409,328
Ensembl chr10:51,527,758...51,543,432

G

nucleotide binding oligomerization domain containing 2

severity

associated with Staphylococcal Infections;

NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773

G

plasminogen activator, tissue type

CTD Direct Evidence: therapeutic

NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779

G

plasminogen activator, urokinase receptor

severity

NCBI chr19:40,588,100...40,616,479
Ensembl chr19:49,197,341...49,222,561
Ensembl chr19:49,197,341...49,222,561

G

serpin family C member 1

treatment

NCBI chr 1:149,421,737...149,435,301
Ensembl chr 1:153,126,031...153,139,369

G

superoxide dismutase 2

mRNA:increased expression:liver:

NCBI chr 6:157,562,814...157,610,155
Ensembl chr 6:162,576,082...162,589,960

G

TIR domain containing adaptor protein

ClinVar Annotator: match by term: Bacteremia, susceptibility to, 1

PMID:16991088 PMID:17322885 PMID:18305471 PMID:25741868

NCBI chr11:121,100,558...121,112,844
Ensembl chr11:125,018,064...125,022,309

G

toll like receptor 4

susceptibility

DNA:polymorphisms:cds:p.D299G, T399I (human)

NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711

bacterial sepsis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

triggering receptor expressed on myeloid cells 1

exacerbates
ameliorates
treatment

associated with bacterial pneumonia

PMID:16960786 PMID:17230441 PMID:21507332

RGD:126925982 RGD:126928125 RGD:127229902

NCBI chr 6:40,861,283...40,874,446
Ensembl chr 6:42,163,337...42,183,091

Candidemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CD1d molecule

ameliorates

associated with endotoxemia

NCBI chr 1:133,549,258...133,557,752
Ensembl chr 1:137,341,690...137,348,173

G

EPH receptor B2

exacerbates

NCBI chr 1:21,895,961...22,107,649
Ensembl chr 1:22,912,570...23,047,118

cerebral malaria

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin converting enzyme 2

susceptibility

DNA:SNP:intron 1: C>T

NCBI chr X:8,189,267...8,229,415
Ensembl chr X:15,470,896...15,510,891

G

aquaporin 4

disease_progression

protein:increased expression:astrocyte:

NCBI chr18:20,108,607...20,122,381
Ensembl chr18:23,713,146...23,726,919

G

calpastatin

protein:increased express:brain

NCBI chr 5:91,972,572...92,084,657
Ensembl chr 5:97,527,071...97,636,650

G

CD36 molecule (CD36 blood group)

NCBI chr 7:72,566,478...72,643,517
Ensembl chr 7:86,265,114...86,305,865

G

C-type lectin domain family 12 member A

ameliorates

NCBI chr12:9,999,334...10,056,108
Ensembl chr12:10,248,209...10,272,070

G

interleukin 1 receptor like 1

treatment

G

interleukin 33

treatment

protein:increased expression:brain

PMID:25659095 PMID:25682948

RGD:39938955 RGD:40400741

NCBI chr 9:6,027,014...6,069,540
Ensembl chr 9:6,234,178...6,248,624

G

Janus kinase 3

NCBI chr19:17,299,129...17,330,700
Ensembl chr19:18,283,560...18,300,964

G

lymphotoxin alpha

NCBI chr 6:31,233,411...31,235,409
Ensembl chr 6:32,123,353...32,125,375

G

neuregulin 1

treatment

mRNA, protein:increased expression:cerebral cortex (mouse)
human protein in a mouse model

PMID:24433482 PMID:29636063

RGD:39456084 RGD:39456102

NCBI chr 8:30,954,852...32,084,411
Ensembl chr 8:29,050,222...29,263,977

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

NCBI chr 7:98,841,974...98,885,446
Ensembl chr 7:111,570,148...111,611,614

G

protein kinase AMP-activated catalytic subunit alpha 2

mRNA:decreased expression:brain (mouse)

NCBI chr 1:55,928,577...55,998,628
Ensembl chr 1:57,664,237...57,702,227

G

TNF receptor superfamily member 1B

NCBI chr 1:10,915,743...10,957,765
Ensembl chr 1:12,130,663...12,172,646

Endotoxemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

mRNA:decreased expression:liver (rat)

NCBI chr 7:79,497,536...79,706,277
Ensembl chr 7:93,147,950...93,243,238

G

ATP binding cassette subfamily B member 11

NCBI chr2B:56,199,434...56,311,773
Ensembl chr2B:173,664,518...173,776,379

G

ATP binding cassette subfamily C member 2

NCBI chr10:96,385,534...96,458,571
Ensembl chr10:99,889,160...99,947,270

G

ATP binding cassette subfamily C member 8

NCBI chr11:17,447,564...17,531,513
Ensembl chr11:17,133,063...17,216,870

G

angiotensin I converting enzyme

associated with Hemorrhage;protein:decreased activity:plasma (rat)

NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853

G

acetylcholinesterase (Yt blood group)

NCBI chr 7:92,915,065...92,922,079
Ensembl chr 7:106,311,944...106,318,184

G

ADAM metallopeptidase with thrombospondin type 1 motif 1

protein:increased expression:plasma, spleen

NCBI chr21:13,270,668...13,279,217
Ensembl chr21:26,656,370...26,665,485

G

adiponectin, C1Q and collagen domain containing

associated with Obesity

NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885

G

adiponectin receptor 2

severity

associated with obesity;mRNA:decreased expression:liver (rat)

NCBI chr12:1,772,426...1,902,070
Ensembl chr12:1,817,620...1,852,251

G

adrenoceptor alpha 2A

onset

mRNA:increased expression:spleen

NCBI chr10:107,669,860...107,673,685

G

angiotensin II receptor type 2

protein:decreased expression:kidney

NCBI chr X:105,252,903...105,257,171
Ensembl chr X:115,671,594...115,672,685

G

aryl hydrocarbon receptor

severity

NCBI chr 7:17,949,254...17,998,737
Ensembl chr 7:17,278,637...17,326,171

G

AKT serine/threonine kinase 1

NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756

G

aldolase, fructose-bisphosphate A

G

arachidonate 5-lipoxygenase

CTD Direct Evidence: marker/mechanism

NCBI chr10:42,461,398...42,531,576
Ensembl chr10:45,639,946...45,710,016

G

apolipoprotein A1

treatment

PMID:18593575 PMID:23227448

RGD:7241573 RGD:7241868

NCBI chr11:111,673,539...111,675,428
Ensembl chr11:115,606,136...115,608,122

G

apolipoprotein B

NCBI chr2A:20,986,464...21,029,004
Ensembl chr2A:21,100,356...21,145,129

G

apolipoprotein E

rat model treated with human protein

NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490

G

argininosuccinate synthase 1

NCBI chr 9:101,569,442...101,625,899
Ensembl chr 9:130,219,993...130,276,036

G

activating transcription factor 2

treatment

protein:increased expression, increased activity:small intestine mucosa

PMID:21641970 PMID:24312512

RGD:10047418 RGD:5135029

NCBI chr2B:62,348,245...62,444,428
Ensembl chr2B:179,799,365...179,895,007

G

ATP synthase F1 subunit alpha

CTD Direct Evidence: marker/mechanism

NCBI chr18:39,366,384...39,380,514
Ensembl chr18:42,904,136...42,923,326

G

BCL2 associated X, apoptosis regulator

mRNA:increased expression:diaphragm

NCBI chr19:45,955,926...45,962,870
Ensembl chr19:54,793,594...54,800,468

G

butyrylcholinesterase

NCBI chr 3:162,794,184...162,858,574
Ensembl chr 3:170,845,494...170,911,481

G

BCL2 apoptosis regulator

mRNA:decreased expression:diaphragm

NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100

G

complement C5a receptor 1

mRNA:increased expression:lung

NCBI chr19:44,293,612...44,310,430
Ensembl chr19:52,950,317...52,966,146

G

caspase 1

NCBI chr11:99,965,964...99,975,640
Ensembl chr11:103,448,497...103,458,149
Ensembl chr11:103,448,497...103,458,149

G

caspase 3

mRNA:increased expression:diaphragm

NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185

G

caspase 7

NCBI chr10:110,273,318...110,324,800
Ensembl chr10:113,707,780...113,758,626

G

caspase 9

treatment

NCBI chr 1:14,630,659...14,662,865
Ensembl chr 1:15,624,666...15,656,266

G

cystathionine beta-synthase

severity

mRNA:increased expression:liver (rat)
Protein:increased expression:spleen, lung (mouse)

PMID:16100527 PMID:24702258 PMID:27748832

RGD:40903019 RGD:40903035 RGD:40903049

NCBI chr21:29,361,519...29,385,610
Ensembl chr21:42,670,530...42,690,932

G

C-C motif chemokine ligand 2

protein:increased expression:plasma

NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384

G

C-C motif chemokine ligand 5

protein:increased expression:plasma

NCBI chr17:20,915,198...20,923,530
Ensembl chr17:21,210,798...21,219,172

G

C-C motif chemokine receptor 1

NCBI chr 3:46,107,526...46,114,229
Ensembl chr 3:47,214,688...47,215,755

G

CD14 molecule

protein:increased expression:liver, endothelial cell of sinusoid

NCBI chr 5:135,996,265...135,997,909
Ensembl chr 5:142,113,082...142,118,966

G

CD40 molecule

protein:decreased nitrosylation:macrophage

NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994

G

CCAAT enhancer binding protein beta

treatment

PMID:14659593 PMID:15192048

RGD:1625687 RGD:40903034

NCBI chr20:46,533,163...46,535,282

G

carbamoyl-phosphate synthase 1

CTD Direct Evidence: marker/mechanism

NCBI chr2B:97,735,486...97,936,623
Ensembl chr2B:216,136,857...216,337,728

G

citrate synthase

protein:increased expression:gastrocnemius

NCBI chr12:32,614,982...32,643,719
Ensembl chr12:32,867,225...32,895,854

G

colony stimulating factor 3

treatment

NCBI chr17:17,271,074...17,273,493
Ensembl chr17:17,491,276...17,493,729

G

C-X3-C motif chemokine ligand 1

protein:increased expression:atrium endocardium

NCBI chr16:37,646,447...37,659,078
Ensembl chr16:56,779,065...56,791,760

G

C-X-C motif chemokine ligand 6

mRNA:increased expression:multiple organs

NCBI chr 4:50,357,643...50,359,822
Ensembl chr 4:56,189,961...56,192,402

G

endothelin 1

mRNA, protein:increased expression:liver (rat)

NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545

G

E1A binding protein p300

associated with Kidney Reperfusion Injury; protein:altered localization:kidney (rat)

NCBI chr22:21,986,467...22,076,921
Ensembl chr22:40,079,503...40,168,604

G

epoxide hydrolase 2

NCBI chr 8:26,761,090...26,818,436
Ensembl chr 8:23,964,094...24,017,749

G

erythropoietin

treatment

NCBI chr 7:92,747,671...92,750,886
Ensembl chr 7:106,148,062...106,150,974

G

coagulation factor XII

NCBI chr 5:172,703,724...172,711,618
Ensembl chr 5:179,766,243...179,773,485

G

coagulation factor II, thrombin

treatment
severity

protein:increased expression:blood plasma (human)
associated with liver cirrhosis;protein:increased expression:blood plasma (human)
associated with liver cirrhosis;protein:increased expression:plasma (human)

PMID:7615203 PMID:9863491 PMID:10604885 PMID:10887118 PMID:20519137 More...

RGD:10449434 RGD:14401592 RGD:14974253 RGD:40818427 RGD:40818436 RGD:5147765 RGD:5147779 RGD:6893482

NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157

G

coagulation factor III, tissue factor

treatment

associated with Protein C Deficiency

PMID:8956768 PMID:20858853 PMID:21396682

RGD:11340208 RGD:11341685 RGD:5147765

NCBI chr 1:97,190,381...97,203,076
Ensembl chr 1:95,918,502...95,931,050

G

coagulation factor V

NCBI chr 1:144,996,757...145,070,046
Ensembl chr 1:148,718,897...148,790,915

G

coagulation factor VII

treatment

PMID:11092686 PMID:16378835

RGD:11041650 RGD:7394782

NCBI chr13:94,246,694...94,261,133
Ensembl chr13:113,315,868...113,329,995

G

coagulation factor VIII

NCBI chr X:144,316,192...144,505,773
Ensembl chr X:154,156,873...154,341,317

G

Fas cell surface death receptor

mRNA, protein:increased expression:spleen (rat)

NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612

G

fibrinogen alpha chain

treatment

NCBI chr 4:146,949,680...146,957,291

G

forkhead box P3

protein:increased expression:intestinal mucosa

NCBI chr X:41,550,462...41,567,492
Ensembl chr X:49,402,652...49,417,029

G

GTP cyclohydrolase 1

treatment

mRNA:increased expression:lung
associated with liver cirrhosis

PMID:9388472 PMID:14647062 PMID:16845913

RGD:329961576 RGD:401700399 RGD:401793756

NCBI chr14:35,428,676...35,489,359
Ensembl chr14:53,706,723...53,767,393

G

growth factor, augmenter of liver regeneration

NCBI chr16:716,640...720,196
Ensembl chr16:2,073,064...2,076,592

G

growth hormone receptor

mRNA:decreased expression:liver

PMID:12217886 PMID:12654216

RGD:2307380 RGD:625688

NCBI chr 5:67,654,326...67,953,140
Ensembl chr 5:72,700,150...72,871,278

G

glutamic--pyruvic transaminase

treatment

Ensembl chr 8:144,259,991...144,263,737

G

glutathione-disulfide reductase

treatment

NCBI chr 8:29,990,543...30,040,157
Ensembl chr 8:27,180,300...27,229,557

G

high mobility group box 1

protein:increased expression:heart, serum

NCBI chr13:11,737,942...11,894,923
Ensembl chr13:30,174,899...30,179,527

G

heme oxygenase 1

treatment

NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063

G

heat shock transcription factor 1

treatment

NCBI chr 8:141,055,310...141,078,360
Ensembl chr 8:144,062,137...144,067,866

G

heat shock protein family A (Hsp70) member 9

CTD Direct Evidence: marker/mechanism

NCBI chr 5:133,934,859...133,955,048
Ensembl chr 5:140,064,207...140,084,551

G

heat shock protein family D (Hsp60) member 1

mRNA, protein:increased expression:medulla oblongata
CTD Direct Evidence: marker/mechanism

PMID:16675490 PMID:16741687

NCBI chr2B:84,729,615...84,743,352
Ensembl chr2B:202,623,497...202,636,959

G

intercellular adhesion molecule 1

protein:increased expression:lung (rat)

NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605

G

indoleamine 2,3-dioxygenase 1

PMID:24930766 PMID:28077574

RGD:39939032 RGD:39939117

NCBI chr 8:39,108,310...39,123,611
Ensembl chr 8:36,617,312...36,632,352

G

indoleamine 2,3-dioxygenase 2

NCBI chr 8:39,149,045...39,209,671
Ensembl chr 8:36,665,240...36,717,420

G

interferon gamma

protein:increased expression:serum:

NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829

G

insulin like growth factor 1

mRNA, protein:decreased expression:liver, serum

PMID:12217886 PMID:18492809

RGD:10402757 RGD:625688

NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177

G

insulin like growth factor binding protein acid labile subunit

NCBI chr16:412,671...418,351
Ensembl chr16:1,843,979...1,848,442

G

insulin like growth factor binding protein 1

NCBI chr 7:46,538,566...46,545,536
Ensembl chr 7:46,658,097...46,662,584

G

insulin like growth factor binding protein 3

mRNA, protein:decreased expression:liver, serum

NCBI chr 7:46,564,234...46,573,145

G

insulin like growth factor binding protein 5

NCBI chr2B:103,932,983...103,956,475
Ensembl chr2B:222,534,967...222,558,432

G

interleukin 10

treatment

protein:increased expression:plasma

PMID:19302852 PMID:27943364 PMID:28664613

RGD:14975137 RGD:14975170 RGD:2311055

NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371

G

interleukin 13

treatment

NCBI chr 5:128,073,863...128,078,453
Ensembl chr 5:134,235,788...134,240,548

G

interleukin 1 alpha

protein:increased expression:plasma

PMID:9636192 PMID:22426124

RGD:6907109 RGD:7794786

NCBI chr2A:89,273,482...89,284,421
Ensembl chr2A:113,784,854...113,795,801

G

interleukin 1 beta

protein:increased expression:plasma

NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424

G

interleukin 1 receptor antagonist

treatment

mRNA:increased expression:lung, spleen, liver (rat)

PMID:1385928 PMID:8855299

RGD:11522760 RGD:8551846

NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839

G

interleukin 32

ameliorates

human gene in a mouse model

NCBI chr16:2,007,018...2,023,757
Ensembl chr16:3,179,637...3,203,929

G

interleukin 6

protein:increased expression:serum (rat)
associated with Diabetes Mellitus, Experimental; Protein:increased expression:extracellular space (rat)

PMID:19449282 PMID:21396682 PMID:22227956

RGD:2307179 RGD:5147765 RGD:6893482

NCBI chr 7:23,415,922...23,420,767

G

interleukin 1 receptor associated kinase 3

mRNA, protein:increased expression:blood (human)

NCBI chr12:22,661,613...22,721,203
Ensembl chr12:23,168,346...23,227,148

G

insulin receptor substrate 1

protein:increased tyrosine nitration, decreased tyrosine phosphorylation:skeletal muscle

NCBI chr2B:113,973,191...114,041,127
Ensembl chr2B:232,849,239...232,852,967

G

integrin subunit alpha 2b

NCBI chr17:13,009,514...13,027,289
Ensembl chr17:13,176,843...13,193,269

G

integrin subunit beta 3

NCBI chr17:10,134,450...10,194,596
Ensembl chr17:10,353,111...10,392,382

G

kelch like ECH associated protein 1

NCBI chr19:10,037,544...10,055,091
Ensembl chr19:10,701,303...10,717,604

G

lipopolysaccharide binding protein

treatment

mRNA:increased expression:hepatocyte

PMID:8418776 PMID:8593028 PMID:16307218

RGD:9685191 RGD:9685193 RGD:9685196

NCBI chr20:34,670,128...34,703,046
Ensembl chr20:35,780,768...35,813,188

G

lipocalin 2

mRNA:increased expression:brain,liver

NCBI chr 9:99,259,278...99,274,494
Ensembl chr 9:127,940,799...127,944,798

G

uncharacterized LOC100974886

mRNA:increased expression:multiple organs

NCBI chr 4:50,092,989...50,095,541
Ensembl chr 4:55,925,562...55,986,555

G

growth-regulated alpha protein

mRNA:increased expression:multiple organs

NCBI chr 4:50,325,248...50,327,165
Ensembl chr 4:56,153,899...56,159,474

G

myosin-7

NCBI chr14:4,231,344...4,254,295
Ensembl chr14:22,325,812...22,348,763

G

metallothionein-2

mRNA:increased expression:liver (rat)

NCBI chr16:36,894,853...36,895,826
Ensembl chr16:56,007,922...56,028,093

G

actin alpha cardiac muscle 1

NCBI chr15:13,707,475...13,712,905
Ensembl chr15:31,966,278...31,971,782

G

signal transducer and activator of transcription 5B

protein:decreased tyrosine phosphorylation:liver

NCBI chr17:15,040,303...15,116,682
Ensembl chr17:15,306,418...15,336,463

G

alkaline phosphatase, placental type

NCBI chr2B:119,594,655...119,600,138
Ensembl chr2B:238,383,768...238,388,105

G

microtubule associated protein 2

mRNA, protein:decreased expression:neuron

NCBI chr2B:96,681,268...96,991,650
Ensembl chr2B:215,314,857...215,391,728

G

mitogen-activated protein kinase 14

treatment

protein:increased activity:small intestine mucosa

PMID:21641970 PMID:24312512

RGD:10047418 RGD:5135029

NCBI chr 6:35,586,847...35,683,041
Ensembl chr 6:36,788,233...36,871,114

G

mitogen-activated protein kinase 8

protein:increased phophorylation:hippocampus (rat)

NCBI chr10:45,806,748...45,936,362

G

melanocortin 4 receptor

mRNA:increased expression:paraventricular nucleus (rat)

NCBI chr18:53,744,172...53,747,282
Ensembl chr18:57,069,259...57,070,257

G

macrophage migration inhibitory factor

protein:increased expression:plasma

NCBI chr22:4,646,986...4,647,831
Ensembl chr22:22,730,807...22,732,009

G

membrane metalloendopeptidase

severity

NCBI chr 3:152,085,694...152,240,148
Ensembl chr 3:160,197,566...160,292,119

G

matrix metallopeptidase 3

NCBI chr11:97,776,729...97,784,549
Ensembl chr11:101,267,566...101,275,354

G

metallothionein 3

NCBI chr16:36,875,919...36,877,558
Ensembl chr16:56,007,922...56,028,093

G

mucin 2, oligomeric mucus/gel-forming

NCBI chr11:1,106,716...1,144,489
Ensembl chr11:1,143,625...1,169,741

G

myosin heavy chain 6

NCBI chr14:4,200,616...4,226,193
Ensembl chr14:22,294,965...22,321,331

G

NFE2 like bZIP transcription factor 2

treatment

NCBI chr2B:64,509,446...64,544,600
Ensembl chr2B:182,214,116...182,248,085

G

NFKB inhibitor alpha

exacerbates
treatment

PMID:10229101 PMID:19098124

RGD:126908017 RGD:126928139

NCBI chr14:16,155,331...16,158,588

G

nitric oxide synthase 2

mRNA, protein:increased expression:intestine
CTD Direct Evidence: marker/mechanism

PMID:12620498 PMID:16787348 PMID:20519137

RGD:4891470 RGD:5147779

NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093

G

nitric oxide synthase 3

protein:increased expression:aorta (rat)

NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233

G

neuropeptide Y

treatment

NCBI chr 7:24,963,056...24,970,803
Ensembl chr 7:24,568,041...24,574,657

G

nuclear receptor subfamily 3 group C member 1

NCBI chr 5:138,634,278...139,089,171
Ensembl chr 5:144,741,452...144,865,269

G

ornithine transcarbamylase

CTD Direct Evidence: marker/mechanism

NCBI chr X:30,796,828...30,868,144
Ensembl chr X:38,505,232...38,575,819

G

phosphoenolpyruvate carboxykinase 1

PMID:12217886 PMID:19268478

RGD:10427879 RGD:625688

NCBI chr20:53,901,738...53,907,090
Ensembl chr20:55,179,429...55,184,920

G

phosphoenolpyruvate carboxykinase 2, mitochondrial

mRNA,protein:decreased expression,decreased activity:liver:

NCBI chr14:4,872,276...4,882,118
Ensembl chr14:22,996,813...23,006,775

G

proprotein convertase subtilisin/kexin type 1

NCBI chr 5:18,917,488...18,960,102
Ensembl chr 5:19,064,004...19,106,486

G

proprotein convertase subtilisin/kexin type 2

NCBI chr20:17,184,878...17,443,355
Ensembl chr20:17,163,675...17,421,157

G

platelet and endothelial cell adhesion molecule 1

NCBI chr17:58,417,134...58,526,409
Ensembl chr17:63,511,784...63,579,067

G

platelet factor 4

treatment

NCBI chr 4:50,208,806...50,210,570
Ensembl chr 4:56,041,833...56,043,750

G

placental growth factor

protein:increased expression:multiple

NCBI chr14:55,494,152...55,508,066
Ensembl chr14:74,338,976...74,352,964

G

phospholipase A2 group VII

protein:increased expression: :

NCBI chr 6:46,264,262...46,318,487
Ensembl chr 6:47,558,861...47,590,212

G

plasminogen activator, tissue type

treatment

NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779

G

peroxisome proliferator activated receptor gamma

protein:increased expression:small intestine mucosa

NCBI chr 3:12,215,322...12,361,669
Ensembl chr 3:12,622,397...12,705,060

G

protein kinase AMP-activated catalytic subunit alpha 1

mRNA:decreased expression:epididymal fat pad

NCBI chr 5:69,581,748...69,620,721
Ensembl chr 5:74,627,830...74,666,505

G

parkin RBR E3 ubiquitin protein ligase

protein:increased expression:liver, mitochondrion (mouse)

NCBI chr 6:159,293,016...160,679,106
Ensembl chr 6:164,314,990...165,678,770

G

protein C, inactivator of coagulation factors Va and VIIIa

treatment

PMID:18205901 PMID:23170801

RGD:11100030 RGD:11100034

NCBI chr2B:32,846,899...32,859,060
Ensembl chr2B:128,083,794...128,094,625

G

platelet activating factor receptor

treatment

NCBI chr 1:27,405,880...27,436,184
Ensembl chr 1:28,447,833...28,448,861

G

prostaglandin E receptor 4

protein:increased expression:paraventricular hypothalamic nucleus parvicellular division (rat)

NCBI chr 5:69,686,906...69,700,739
Ensembl chr 5:74,731,470...74,745,148

G

prostaglandin I2 synthase

treatment

NCBI chr20:45,841,238...45,905,641
Ensembl chr20:46,905,665...46,971,612

G

prostaglandin-endoperoxide synthase 2

NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519

G

renin

protein:increased activity:blood plasma (rat)
protein:increased activity:blood plasma (mouse)

PMID:16512638 PMID:30027346

RGD:125097481 RGD:125097499

NCBI chr 1:179,757,653...179,769,530
Ensembl chr 1:184,046,117...184,057,393

G

serpin family C member 1

treatment

PMID:15995859 PMID:16457847 PMID:20519137 PMID:21396682

RGD:1599326 RGD:1599332 RGD:5147765 RGD:5147779

NCBI chr 1:149,421,737...149,435,301
Ensembl chr 1:153,126,031...153,139,369

G

serpin family E member 1

treatment

PMID:21396682 PMID:25396762

RGD:10449434 RGD:5147765

NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450

G

serpin family F member 1

protein:increased expression:plasma (human)

NCBI chr17:1,745,597...1,761,399
Ensembl chr17:1,638,556...1,653,568

G

serpin family G member 1

treatment

NCBI chr11:52,838,502...52,855,781
Ensembl chr11:56,309,686...56,326,639

G

solute carrier family 18 member A3

protein:decreased expression:parietal cortex

NCBI chr10:44,630,006...44,632,419

G

solute carrier family 22 member 1

treatment

NCBI chr 6:158,004,545...158,046,428
Ensembl chr 6:163,014,663...163,054,681

G

solute carrier family 22 member 2

treatment

NCBI chr 6:158,058,226...158,150,917
Ensembl chr 6:163,065,317...163,158,931

G

solute carrier family 38 member 3

NCBI chr 3:50,133,631...50,149,394
Ensembl chr 3:51,367,939...51,383,657

G

solute carrier family 38 member 5

NCBI chr X:40,756,423...40,768,327
Ensembl chr X:48,621,018...48,632,682

G

solute carrier family 7 member 5

NCBI chr16:68,512,407...68,552,763

G

secretory leukocyte peptidase inhibitor

NCBI chr20:41,583,429...41,585,773
Ensembl chr20:42,673,417...42,675,773

G

suppressor of cytokine signaling 1

mRNA:increased expression:liver, skeletal muscle

NCBI chr16:10,196,432...10,198,205

G

suppressor of cytokine signaling 3

mRNA:increased expression:liver, skeletal muscle

PMID:12217886 PMID:15169905

RGD:2298923 RGD:625688

NCBI chr17:72,433,206...72,436,500
Ensembl chr17:77,983,389...77,984,066

G

superoxide dismutase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:157,562,814...157,610,155
Ensembl chr 6:162,576,082...162,589,960

G

secreted protein acidic and cysteine rich

mRNA, protein:decreased expression:kidney

NCBI chr 5:147,087,903...147,112,466
Ensembl chr 5:153,090,181...153,115,750

G

thromboxane A2 receptor

PMID:2580129 PMID:15647606

RGD:11059531 RGD:1601450

NCBI chr19:2,621,606...2,632,800
Ensembl chr19:3,570,290...3,581,924

G

thromboxane A synthase 1

NCBI chr 7:131,772,947...131,958,647
Ensembl chr 7:144,255,211...144,439,523

G

tryptophan 2,3-dioxygenase

severity

NCBI chr 4:148,269,097...148,285,533
Ensembl chr 4:160,085,645...160,102,266

G

tissue factor pathway inhibitor

treatment

NCBI chr2B:74,744,154...74,834,338
Ensembl chr2B:192,541,881...192,581,384

G

thrombomodulin

mRNA:decreased expression:endothelial cell

PMID:12611420 PMID:19487933 PMID:20348393

RGD:1601652 RGD:5684988 RGD:5685037

NCBI chr20:22,992,341...22,996,415
Ensembl chr20:23,345,917...23,347,812

G

TIMP metallopeptidase inhibitor 3

NCBI chr22:13,811,297...13,872,799
Ensembl chr22:31,662,562...31,723,964

G

toll like receptor 2

treatment

NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331

G

toll like receptor 4

treatment
disease_progression

mRNA:increased expression:liver:

PMID:22172266 PMID:23977376

RGD:14697731 RGD:7241094

NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711

G

tumor necrosis factor

treatment

XCO:0000822 JTE-607
associated with liver cirrhosis
protein:increased expression:plasma
protein:increased expression:plasma (rat)

PMID:8283134 PMID:10493164 PMID:12813371 PMID:15242491 PMID:17324147 More...

RGD:14995427 RGD:14995443 RGD:15023464 RGD:38501090 RGD:40903016 RGD:4891465 RGD:5147765 RGD:5147779

NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381

G

triggering receptor expressed on myeloid cells 1

treatment

PMID:15585833 PMID:21507332

RGD:126925982 RGD:126928122

NCBI chr 6:40,861,283...40,874,446
Ensembl chr 6:42,163,337...42,183,091

G

vascular cell adhesion molecule 1

mRNA:increased expression:brain:

NCBI chr 1:103,377,815...103,395,118
Ensembl chr 1:102,091,336...102,107,732

G

von Willebrand factor

protein:increased expression:endothelial cell:

NCBI chr12:6,073,836...6,249,806
Ensembl chr12:5,990,612...6,165,153

endotoxin shock

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

GTP cyclohydrolase 1

treatment

NCBI chr14:35,428,676...35,489,359
Ensembl chr14:53,706,723...53,767,393

G

5-hydroxytryptamine receptor 2A

treatment

NCBI chr13:27,976,415...28,042,941
Ensembl chr13:46,694,273...46,759,826

Fungemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CD274 molecule

treatment

NCBI chr 9:5,269,270...5,289,629
Ensembl chr 9:5,454,391...5,474,402

G

programmed cell death 1

treatment

protein:increased expression:CD4 Tcell, CD8 Tcell:

NCBI chr12:130,849,353...130,858,776

malaria

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

treatment
susceptibility

DNA:haplotype: :1236C>T, 2677G>T,3435C>T (human)
DNA:hypermethylation:promoter
DNA:SNP: :c3435C>T(human)
DNA:SNPs,haplotype: :rs2032582, rs1128503 (human)

PMID:17015054 PMID:19331170 PMID:28422980 PMID:28934955

RGD:39456120 RGD:39456123 RGD:39457679 RGD:39457680

NCBI chr 7:79,497,536...79,706,277
Ensembl chr 7:93,147,950...93,243,238

G

angiotensin I converting enzyme

severity

NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853

G

atypical chemokine receptor 1 (Duffy blood group)

ClinVar Annotator: match by term: Plasmodium vivax, resistance to

PMID:7663520 PMID:8547665 PMID:8651934 PMID:10570183 PMID:10791881 More...

NCBI chr 1:134,554,406...134,557,386
Ensembl chr 1:138,352,086...138,354,733

G

activation induced cytidine deaminase

protein:increased expression: B cell

NCBI chr12:8,688,392...8,699,008
Ensembl chr12:8,904,273...8,913,917

G

ankyrin 1

OMIM:609148 | OMIM:611162

NCBI chr 8:40,897,879...41,140,290
Ensembl chr 8:38,346,503...38,588,549

G

apolipoprotein E

DNA:missense mutations:cds:p.C112R, p.C158R (human)

NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490

G

aquaporin 4

OMIM:609148 | OMIM:611162

NCBI chr18:20,108,607...20,122,381
Ensembl chr18:23,713,146...23,726,919

G

cystathionine beta-synthase

susceptibility

DNA:insertion:cds: (844ins68) (human)

NCBI chr21:29,361,519...29,385,610
Ensembl chr21:42,670,530...42,690,932

G

CD163 molecule

exacerbates
severity

protein:increased expression:blood plasma (human)
protein:altered expression:blood plasma (human)

PMID:18632918 PMID:22290142

RGD:127285797 RGD:149735529

NCBI chr12:7,616,714...7,649,768
Ensembl chr12:7,775,343...7,810,023

G

CD1d molecule

exacerbates
ameliorates

PMID:12938235 PMID:24703850

RGD:127345117 RGD:127345121

NCBI chr 1:133,549,258...133,557,752
Ensembl chr 1:137,341,690...137,348,173

G

CD36 molecule (CD36 blood group)

ClinVar Annotator: match by term: Malaria, cerebral, susceptibility to | ClinVar Annotator: match by term: Malaria, susceptibility to

PMID:10890433 PMID:18305138 PMID:19403559 PMID:25741868 PMID:28960434 More...

NCBI chr 7:72,566,478...72,643,517
Ensembl chr 7:86,265,114...86,305,865

G

CD40 molecule

severity

NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994

G

CD40 ligand

severity

NCBI chr X:125,776,138...125,788,820
Ensembl chr X:136,042,849...136,058,202

G

cytokine inducible SH2 containing protein

susceptibility

ClinVar Annotator: match by term: Malaria, susceptibility to

NCBI chr 3:50,531,870...50,537,319
Ensembl chr 3:51,769,194...51,774,548

G

complement C3b/C4b receptor 1 (Knops blood group)

ClinVar Annotator: match by term: Malaria, severe, resistance to | ClinVar Annotator: match by term: Malaria, susceptibility to

PMID:10528197 PMID:14694201 PMID:20855594 PMID:25741868

NCBI chr 1:183,094,601...183,246,957

G

C-reactive protein

CTD Direct Evidence: marker/mechanism

NCBI chr 1:135,062,102...135,064,402

G

cytotoxic T-lymphocyte associated protein 4

disease_progression
treatment

NCBI chr2B:91,054,917...91,106,234
Ensembl chr2B:209,239,417...209,244,498

G

EPH receptor B2

mRNA:increased expression:liver

NCBI chr 1:21,895,961...22,107,649
Ensembl chr 1:22,912,570...23,047,118

G

EPH receptor B3

NCBI chr 3:181,604,188...181,624,744
Ensembl chr 3:190,089,522...190,104,905

G

EPH receptor B6

NCBI chr 7:134,845,936...134,862,114
Ensembl chr 7:147,337,558...147,353,575

G

Fc gamma receptor IIb

ClinVar Annotator: match by term: Malaria, resistance to

PMID:12115230 PMID:15459183 PMID:16115811 PMID:16170323 PMID:17435165 More...

NCBI chr 1:137,074,342...137,090,962
Ensembl chr 1:140,882,043...140,890,637

G

forkhead box P3

disease_progression

PMID:16169501 PMID:19338000

RGD:38455985 RGD:38455992

NCBI chr X:41,550,462...41,567,492
Ensembl chr X:49,402,652...49,417,029

G

glucose-6-phosphate dehydrogenase

severity
susceptibility

DNA:point mutation:cds:c.968T>C (human)
ClinVar Annotator: match by term: Malaria, susceptibility to
DNA:SNPs: :multiple

RGD
ClinVar
OMIM

PMID:5448 PMID:16832 PMID:511159 PMID:736032 PMID:853376 More...

RGD:10449111 RGD:10449115

NCBI chr X:143,972,798...143,988,960
Ensembl chr X:153,843,092...153,860,674

G

glycophorin A (MNS blood group)

NCBI chr 4:136,455,397...136,486,858
Ensembl chr 4:147,987,750...148,019,005
Ensembl chr 4:147,987,750...148,019,005

G

glycophorin C (Gerbich blood group)

ClinVar Annotator: match by term: Malaria, resistance to

PMID:1991173 PMID:5011657 PMID:8157284 PMID:11719395 PMID:12469115 More...

NCBI chr2B:33,578,851...33,619,869

G

heme oxygenase 1

OMIM:609148 | OMIM:611162

NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063

G

intercellular adhesion molecule 1

susceptibility

ClinVar Annotator: match by term: Malaria, cerebral, susceptibility to | ClinVar Annotator: match by term: Malaria, susceptibility to

PMID:9259284 PMID:9861406 PMID:10417733 PMID:10699175 PMID:23609612 More...

NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605

G

interferon gamma

OMIM:609148 | OMIM:611162

NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

ClinVar Annotator: match by term: Malaria, susceptibility to

PMID:1945893 PMID:3198117 PMID:6805883 PMID:7803800 PMID:8244337 More...

NCBI chr X:143,988,720...144,010,078
Ensembl chr X:153,854,493...153,876,092

G

interleukin 1 receptor like 1

G

interleukin 21

exacerbates

NCBI chr 4:114,795,979...114,806,936
Ensembl chr 4:125,943,495...125,951,915

G

interleukin 27

ameliorates

PMID:24522137 PMID:26968425

RGD:11530371 RGD:126790512

G

interleukin 33

protein:increased expression:serum:

NCBI chr 9:6,027,014...6,069,540
Ensembl chr 9:6,234,178...6,248,624

G

low affinity immunoglobulin gamma Fc region receptor II-a

susceptibility

ClinVar Annotator: match by term: Malaria, severe, susceptibility to

PMID:8636449 PMID:9843982 PMID:10675363 PMID:15367919 PMID:19915573 More...

NCBI chr 1:136,892,311...136,906,450

G

uncharacterized LOC117974307

NCBI chr 4:136,335,881...136,359,518

G

lymphotoxin beta receptor

CTD Direct Evidence: marker/mechanism

NCBI chr12:6,514,432...6,521,966
Ensembl chr12:6,422,470...6,438,510

G

MAPK activated protein kinase 3

ClinVar Annotator: match by term: Malaria, susceptibility to

NCBI chr 3:50,542,547...50,574,817
Ensembl chr 3:51,779,912...51,812,124

G

marker of proliferation Ki-67

associated with Lung Neoplasms

NCBI chr10:124,684,336...124,714,143
Ensembl chr10:128,936,037...128,962,555

G

natural cytotoxicity triggering receptor 3

susceptibility

ClinVar Annotator: match by term: Malaria, severe, susceptibility to

NCBI chr 6:31,249,947...31,281,613
Ensembl chr 6:32,139,981...32,171,525

G

nitric oxide synthase 2

ClinVar Annotator: match by term: Malaria, resistance to | ClinVar Annotator: match by term: Malaria, severe, resistance to | ClinVar Annotator: match by term: Malaria, susceptibility to

PMID:9457101 PMID:12433515 PMID:31995689

NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093

G

pyruvate kinase L/R

susceptibility

DNA:missense mutation:cds:p.I90N (mouse)
OMIM:609148 | OMIM:611162
DNA:mutations, haplotype:multiple (human)

PMID:14595440 PMID:20377593

RGD:11535999 RGD:11537407

NCBI chr 1:130,634,111...130,646,644
Ensembl chr 1:134,239,565...134,251,351

G

perforin 1

NCBI chr10:67,071,141...67,078,057
Ensembl chr10:69,597,574...69,603,070

G

protein C receptor

disease_progression

NCBI chr20:31,500,838...31,543,928
Ensembl chr20:32,622,876...32,628,320

G

solute carrier family 19 member 1

DNA:SNP::g.80G>A (human)

NCBI chr21:31,836,774...31,883,829
Ensembl chr21:45,090,595...45,134,752

G

solute carrier family 4 member 1 (Diego blood group)

ClinVar Annotator: match by term: Malaria, cerebral, resistance to | ClinVar Annotator: match by term: Malaria, susceptibility to

PMID:1378323 PMID:1722314 PMID:1737855 PMID:2146504 PMID:6338046 More...

NCBI chr17:13,131,851...13,150,872
Ensembl chr17:13,302,796...13,317,312

G

secreted phosphoprotein 1

NCBI chr 4:80,263,711...80,271,466
Ensembl chr 4:90,988,200...90,995,935

G

T-box transcription factor 21

NCBI chr17:9,791,008...9,803,894
Ensembl chr17:9,973,920...9,985,660

G

TIR domain containing adaptor protein

ClinVar Annotator: match by term: Malaria, resistance to

PMID:16991088 PMID:17322885 PMID:18305471 PMID:25741868

NCBI chr11:121,100,558...121,112,844
Ensembl chr11:125,018,064...125,022,309

G

tumor necrosis factor

susceptibility

ClinVar Annotator: match by term: Malaria, cerebral, susceptibility to

PMID:8056188 PMID:9818939 PMID:10369255 PMID:10450718 PMID:11261930 More...

NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381

G

triggering receptor expressed on myeloid cells 1

severity

NCBI chr 6:40,861,283...40,874,446
Ensembl chr 6:42,163,337...42,183,091

G

thymic stromal lymphopoietin

mRNA:altered expression:multiple (mouse)

NCBI chr 5:106,440,136...106,446,849
Ensembl chr 5:112,242,490...112,250,130

Malarial Anemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Fc gamma receptor IIIa

severity
susceptibility

DNA:polymorphism: :p.F176V (human)

PMID:20231419 PMID:23045477

RGD:11040771 RGD:11344971

NCBI chr 1:137,027,943...137,036,738

G

solute carrier family 4 member 1 (Diego blood group)

severity

DNA:snp:promoter:g.-5699T>C (human)

NCBI chr17:13,131,851...13,150,872
Ensembl chr17:13,302,796...13,317,312

Neonatal Sepsis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 27

protein:increased expression:blood serum (mouse)
protien:increased expression:blood serum (human)

PMID:22766719 PMID:31818960

RGD:126790524 RGD:126790543

G

phospholipase A2 group IIA

susceptibility

DNA:SNP:enhancer: (rs1891320) (human)

NCBI chr 1:18,930,294...18,934,563
Ensembl chr 1:19,971,084...19,977,627

Plasmodium falciparum malaria

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

susceptibility

DNA:SNPs,haplotype:multiple

NCBI chr 9:104,354,115...104,399,057
Ensembl chr 9:132,989,574...133,010,324

G

ADAM metallopeptidase with thrombospondin type 1 motif 13

protein:decreased activity:plasma (human)

NCBI chr 9:104,541,051...104,582,574
Ensembl chr 9:133,156,761...133,193,707

G

basigin (Ok blood group)

CTD Direct Evidence: therapeutic

PMID:22080952 PMID:26195724

Ensembl chr19:539,815...551,456

G

calpastatin

protein:alter localization:erythrocyte

NCBI chr 5:91,972,572...92,084,657
Ensembl chr 5:97,527,071...97,636,650

G

C-type lectin domain containing 11A

CTD Direct Evidence: marker/mechanism

NCBI chr19:47,682,806...47,690,389
Ensembl chr19:56,586,183...56,588,580

G

complement C3b/C4b receptor 1 (Knops blood group)

CTD Direct Evidence: marker/mechanism

PMID:9230440 PMID:11724985

NCBI chr 1:183,094,601...183,246,957

G

cytochrome P450 family 2 subfamily C member 19

treatment

DNA:polymorphisms::

NCBI chr10:91,375,255...91,465,215
Ensembl chr10:94,884,472...94,970,065

G

Fas cell surface death receptor

CTD Direct Evidence: marker/mechanism

NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612

G

glucose-6-phosphate dehydrogenase

severity

DNA:missense mutation:cds:202G>A (p.V68M) (human)

NCBI chr X:143,972,798...143,988,960
Ensembl chr X:153,843,092...153,860,674

G

glutathione S-transferase pi 1

severity

NCBI chr11:62,942,756...62,945,701
Ensembl chr11:66,253,421...66,256,472

G

interleukin 13

protein:increased expression:plasma

NCBI chr 5:128,073,863...128,078,453
Ensembl chr 5:134,235,788...134,240,548

G

HLA class II histocompatibility antigen, DQ beta 1 chain

susceptibility

DNA:polymorphism:cds:HLA-DQB1*0501 (human)

NCBI chr 6:32,237,395...32,244,201
Ensembl chr 6:33,353,599...33,360,272

G

low affinity immunoglobulin gamma Fc region receptor II-a

severity

DNA:missense mutation:cds:p.R131H (rs1801274) (human)

NCBI chr 1:136,892,311...136,906,450

G

mannose binding lectin 2

susceptibility

DNA:haplotype:exon:

NCBI chr10:49,401,364...49,409,328
Ensembl chr10:51,527,758...51,543,432

G

tumor necrosis factor

severity

protein:increased expression:plasma

NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381

Plasmodium vivax malaria

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

atypical chemokine receptor 1 (Duffy blood group)

ClinVar Annotator: match by term: Resistance to Plasmodium vivax infection

PMID:7663520 PMID:8547665 PMID:8651934 PMID:10570183 PMID:10791881 More...

NCBI chr 1:134,554,406...134,557,386
Ensembl chr 1:138,352,086...138,354,733

Pregnancy-associated Malaria

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 10

NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371

toxic shock syndrome

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

severity

DNA:SNP, insertion/deletion:promoter, intron: (rs4291, rs4646994)

NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853

G

adenosine kinase

NCBI chr10:70,672,967...71,236,950
Ensembl chr10:73,342,900...73,902,490

G

adrenomedullin

PMID:17318497 PMID:17766482

RGD:1625310 RGD:1642599

NCBI chr11:10,437,712...10,440,053
Ensembl chr11:10,165,418...10,167,842

G

adrenoceptor beta 2

disease_progression
treatment

DNA:polymorphism: :rs1042717(human)

PMID:16076286 PMID:19850944

RGD:8548487 RGD:8548529

NCBI chr 5:144,259,756...144,398,421
Ensembl chr 5:150,267,554...150,315,892

G

advanced glycosylation end-product specific receptor

NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641

G

aquaporin 1 (Colton blood group)

CTD Direct Evidence: marker/mechanism

NCBI chr 7:31,524,933...31,538,602
Ensembl chr 7:31,644,331...31,658,141

G

complement C5a receptor 1

CTD Direct Evidence: marker/mechanism

NCBI chr19:44,293,612...44,310,430
Ensembl chr19:52,950,317...52,966,146

G

cholecystokinin B receptor

mRNA:increased expression:myocardium

NCBI chr11:6,393,435...6,405,821
Ensembl chr11:6,075,816...6,088,145

G

C-C motif chemokine ligand 2

disease_progression

NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384

G

CD274 molecule

severity

protein:increased expression:serum
protein:increased expression:lymphocyte, mononcyte

PMID:26063974 PMID:29702526

RGD:40822808 RGD:41410786

NCBI chr 9:5,269,270...5,289,629
Ensembl chr 9:5,454,391...5,474,402

G

elastase, neutrophil expressed

treatment

NCBI chr19:276,499...280,598

G

enolase 2

proteiin:increased expression:serum

NCBI chr12:7,043,807...7,053,178
Ensembl chr12:6,958,960...6,968,342

G

coagulation factor II, thrombin

severity

protein:decreased expression:blood plasma (human)

NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157

G

FA complementation group C

NCBI chr 9:66,201,581...66,418,229
Ensembl chr 9:94,329,971...94,477,198

G

GC vitamin D binding protein

CTD Direct Evidence: marker/mechanism

NCBI chr 4:52,431,196...52,473,762
Ensembl chr 4:58,729,236...58,792,073

G

G protein-coupled receptor kinase 2

mRNA:decreased expression:polymorphonuclear leukocyte

NCBI chr11:62,624,647...62,644,846
Ensembl chr11:65,939,164...65,959,066

G

heme oxygenase 1

NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063

G

heat shock protein family A (Hsp70) member 1B

susceptibility

associated wit community-acquired pneumonia;DNA:SNP: :1267A>G (human)

NCBI chr 6:31,488,882...31,491,412

G

indoleamine 2,3-dioxygenase 1

severity

protein:increased activity, increased expression:plasma, heart (human)

NCBI chr 8:39,108,310...39,123,611
Ensembl chr 8:36,617,312...36,632,352

G

interferon gamma

protein:increased expression:plasma

NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829

G

interleukin 10

severity
onset

protein:increased expression:lung (mouse)
protein:increased expression:plasma

PMID:7593621 PMID:12117955 PMID:25403265 PMID:28659355

RGD:11049456 RGD:1598471 RGD:38455982 RGD:40890272

NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371

G

interleukin 19

protein:increased expression:serum

NCBI chr 1:182,372,339...182,446,147
Ensembl chr 1:186,651,640...186,724,748

G

interleukin 1 beta

severity

protein:increased expression:lung (mouse)

NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424

G

interleukin 1 receptor antagonist

treatment
susceptibility

human gene in a mouse model
associated with Precursor Cell Lymphoblastic Leukemia-Lymphoma;DNA:polymorphism::

PMID:15516267 PMID:23014359

RGD:11522756 RGD:8551736

NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839

G

interleukin 20 receptor subunit alpha

mRNA:increased expression:multiple

NCBI chr 6:134,762,355...134,805,937
Ensembl chr 6:138,848,400...138,866,098

G

interleukin 20 receptor subunit beta

mRNA:increased expression:multiple

NCBI chr 3:133,995,863...134,045,206
Ensembl chr 3:141,474,161...141,504,744

G

interleukin 27

protein, mRNA:increased expression:blood serum, spleen (mouse)

G

interleukin 6

treatment

NCBI chr 7:23,415,922...23,420,767

G

alpha-2-macroglobulin

treatment

NCBI chr12:9,154,457...9,202,833
Ensembl chr12:9,385,359...9,433,979

G

HLA class II histocompatibility antigen, DR alpha chain

disease_progression

CTD Direct Evidence: marker/mechanism
associated with Burns

PMID:15644645 PMID:17568330 PMID:28771573

RGD:5490160 RGD:5490203

NCBI chr 6:32,105,421...32,110,579
Ensembl chr 6:32,982,228...32,987,417

G

mannose binding lectin 2

susceptibility

associated with acute pyelonephritis;DNA:SNPs, missense mutations, haplotypes:promoter, cds:multiple

NCBI chr10:49,401,364...49,409,328
Ensembl chr10:51,527,758...51,543,432

G

melanocortin 2 receptor

protein:increased expression:liver (rat)

NCBI chr18:409,141...442,578
Ensembl chr18:2,608,691...2,609,584

G

macrophage migration inhibitory factor

PMID:17381395 PMID:17565848

RGD:1641978 RGD:4891013

NCBI chr22:4,646,986...4,647,831
Ensembl chr22:22,730,807...22,732,009

G

NFKB inhibitor alpha

treatment

NCBI chr14:16,155,331...16,158,588

G

nitric oxide synthase 2

CTD Direct Evidence: marker/mechanism

PMID:8745224 PMID:16601845

NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093

G

natriuretic peptide C

protein:increased expression:plasma

NCBI chr2B:119,148,774...119,153,381
Ensembl chr2B:237,936,939...237,941,244

G

8-oxoguanine DNA glycosylase

NCBI chr 3:9,702,311...9,742,283
Ensembl chr 3:9,940,955...9,947,335

G

poly(ADP-ribose) polymerase 1

NCBI chr 1:201,820,355...201,867,673
Ensembl chr 1:206,812,981...206,860,356

G

programmed cell death 1

severity

protein:increased expression:lymphocyte, mononcyte
protein:increased expression:serum

PMID:26063974 PMID:29702526

RGD:40822808 RGD:41410786

NCBI chr12:130,849,353...130,858,776

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

severity

NCBI chr 1:8,418,570...8,495,435
Ensembl chr 1:9,686,208...9,724,633

G

protein C, inactivator of coagulation factors Va and VIIIa

treatment

PMID:19320827 PMID:21850534

RGD:11100015 RGD:11100041

NCBI chr2B:32,846,899...32,859,060
Ensembl chr2B:128,083,794...128,094,625

G

pentraxin 3

protein:increased expression:plasma (human)

NCBI chr 3:154,485,470...154,492,293
Ensembl chr 3:162,537,577...162,543,652

G

renin

exacerbates

protein:increased activity:blood plasma (human)

NCBI chr 1:179,757,653...179,769,530
Ensembl chr 1:184,046,117...184,057,393

G

selectin L

protein:increased expression:plasma

NCBI chr 1:145,173,700...145,194,927
Ensembl chr 1:148,895,373...148,916,393

G

serpin family C member 1

treatment

NCBI chr 1:149,421,737...149,435,301
Ensembl chr 1:153,126,031...153,139,369

G

serpin family E member 1

susceptibility

associated with Pneumonia; DNA:polymorphism:promoter:rs1799768 (human)

NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450

G

serpin family F member 1

severity

protein:decreased expression:plasma (human)

NCBI chr17:1,745,597...1,761,399
Ensembl chr17:1,638,556...1,653,568

G

serpin family G member 1

treatment

NCBI chr11:52,838,502...52,855,781
Ensembl chr11:56,309,686...56,326,639

G

surfactant protein B

associated with Pneumonia;DNA:polymorphism: :1580C>T (human)

NCBI chr2A:85,708,485...85,718,120
Ensembl chr2A:87,257,244...87,268,332

G

suppressor of cytokine signaling 1

severity

NCBI chr16:10,196,432...10,198,205

G

thromboxane A2 receptor

treatment

NCBI chr19:2,621,606...2,632,800
Ensembl chr19:3,570,290...3,581,924

G

tissue factor pathway inhibitor

treatment

NCBI chr2B:74,744,154...74,834,338
Ensembl chr2B:192,541,881...192,581,384

G

thrombopoietin

protein:increased expression:serum:

NCBI chr 3:181,409,038...181,416,986
Ensembl chr 3:189,891,025...189,897,429

G

tumor necrosis factor

treatment

protein:increased expression:peritoneal macrophage, cell surface (rat)
CTD Direct Evidence: marker/mechanism

PMID:2213560 PMID:12622907 PMID:20054000

RGD:10449465 RGD:1598936

NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381

G

triggering receptor expressed on myeloid cells 1

mRNA:decreased expression:polymorphonuclear leukocyte

NCBI chr 6:40,861,283...40,874,446
Ensembl chr 6:42,163,337...42,183,091

G

zinc finger CCCH-type containing 12A

NCBI chr 1:36,743,341...36,753,261
Ensembl chr 1:38,093,917...38,103,556

Viremia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

bone marrow stromal cell antigen 2

associated with Retroviridae Infections;

NCBI chr19:16,890,257...16,892,989
Ensembl chr19:17,863,991...17,866,728

G

interleukin 2 receptor subunit beta

NCBI chr22:18,039,469...18,069,952
Ensembl chr22:35,874,898...35,899,038

G

interferon alpha-2

CTD Direct Evidence: therapeutic

NCBI chr 9:21,245,017...21,246,210
Ensembl chr 9:21,863,062...21,863,736

Term paths to the root

Path 1
Term	Annotations
disease	15805
syndrome	10605
Systemic Inflammatory Response Syndrome	377
Sepsis	375
Fungemia +	4
Neonatal Sepsis	2
Parasitemia +	72
Viremia +	3
bacterial sepsis +	173
toxic shock syndrome	56
Path 2
Term	Annotations
disease	15805
Pathological Conditions, Signs and Symptoms	12318
Pathologic Processes	7704
Shock	396
Systemic Inflammatory Response Syndrome	377
Sepsis	375
Fungemia +	4
Neonatal Sepsis	2
Parasitemia +	72
Viremia +	3
bacterial sepsis +	173
toxic shock syndrome	56

paths to the root