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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Wallerian Degeneration
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Accession:DOID:9002498 term browser browse the term
Definition:Degeneration of distal aspects of a nerve axon following injury to the cell body or proximal portion of the axon. The process is characterized by fragmentation of the axon and its MYELIN SHEATH.
Synonyms:primary_id: MESH:D014855


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Wallerian Degeneration term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCAR2 cell cycle and apoptosis regulator 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:24252177 NCBI chr 8:22,604,757...22,621,514
Ensembl chr 8:22,604,757...22,620,964 		JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:9030624 RGD:68774 NCBI chr17:39,688,094...39,728,658
Ensembl chr17:39,687,914...39,730,426 		JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 ISO RGD PMID:9030624 RGD:68774 NCBI chr12:56,080,108...56,103,505
Ensembl chr12:56,076,799...56,103,505 		JBrowse link
G FCGR2A Fc gamma receptor IIa ISO mRNA:increased expression:sciatic nerve, macrophage RGD PMID:1533683 RGD:2316290 NCBI chr 1:161,505,457...161,524,048
Ensembl chr 1:161,505,430...161,524,013 		JBrowse link
G IL18 interleukin 18 ISO mRNA, protein:increased expression:macrophage, microglia: RGD PMID:11494369 RGD:4889526 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,251...112,164,096 		JBrowse link
G MAG myelin associated glycoprotein ISO RGD PMID:12730963 RGD:9685301 NCBI chr19:35,292,161...35,313,807
Ensembl chr19:35,292,125...35,313,807 		JBrowse link
G NEFH neurofilament heavy chain ISO protein:decreased expression:neuron RGD PMID:10646539 RGD:9698439 NCBI chr22:29,480,218...29,491,390
Ensembl chr22:29,480,218...29,491,390 		JBrowse link
G NEFL neurofilament light chain ISO protein:decreased expression:neuron RGD PMID:10646539 RGD:9698439 NCBI chr 8:24,950,955...24,956,612
Ensembl chr 8:24,950,955...24,956,721 		JBrowse link
G NEFM neurofilament medium chain ISO protein:decreased expression:neuron RGD PMID:10646539 RGD:9698439 NCBI chr 8:24,913,761...24,919,093
Ensembl chr 8:24,913,758...24,919,098 		JBrowse link
G NF1 neurofibromin 1 ISO protein:increased expression:sciatic nerve: RGD PMID:8847098 RGD:12790590 NCBI chr17:31,094,927...31,377,677
Ensembl chr17:31,094,927...31,382,116 		JBrowse link
G NMNAT1 nicotinamide nucleotide adenylyltransferase 1 EXP CTD Direct Evidence: therapeutic CTD PMID:27822499 NCBI chr 1:9,942,923...9,996,892
Ensembl chr 1:9,943,428...9,985,501 		JBrowse link
G NPY1R neuropeptide Y receptor Y1 ISO RGD PMID:10320723 RGD:1642322 NCBI chr 4:163,323,962...163,344,689
Ensembl chr 4:163,323,962...163,344,832 		JBrowse link
G PGF placental growth factor ISO RGD PMID:21264946 RGD:6483582 NCBI chr14:74,941,830...74,955,764
Ensembl chr14:74,941,834...74,955,626 		JBrowse link
G PLA2G4A phospholipase A2 group IVA ISO RGD PMID:14664823 PMID:18718965 RGD:1642469, RGD:6482738 NCBI chr 1:186,828,949...186,988,981
Ensembl chr 1:186,828,949...186,988,981 		JBrowse link
G PLA2G6 phospholipase A2 group VI ISO RGD PMID:18718965 RGD:6482738 NCBI chr22:38,111,495...38,181,830
Ensembl chr22:38,111,495...38,214,778 		JBrowse link
G RXRA retinoid X receptor alpha ISO mRNA:increased expression:sciatic nerve RGD PMID:16782282 RGD:1643108 NCBI chr 9:134,326,455...134,440,585
Ensembl chr 9:134,317,098...134,440,585 		JBrowse link
G SIRT1 sirtuin 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:24252177 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
G SRSF3 serine and arginine rich splicing factor 3 ISO associated with Sciatic Neuropathy RGD PMID:8568916 RGD:10059662 NCBI chr 6:36,594,362...36,605,600
Ensembl chr 6:36,594,353...36,605,911 		JBrowse link
G TGFB1 transforming growth factor beta 1 ISO mRNA:increased expression:optic (II) nerve, sciatic nerve RGD PMID:14997937 RGD:2302105 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TGFB2 transforming growth factor beta 2 ISO protein:decreased expression:sciatic nerve RGD PMID:14997937 RGD:2302105 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619 		JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 ISO mRNA, protein:increased expression:dorsal root ganglion RGD PMID:16683235 RGD:1600154 NCBI chr17:78,852,977...78,925,387
Ensembl chr17:78,852,977...78,925,387 		JBrowse link
G TIMP3 TIMP metallopeptidase inhibitor 3 ISO mRNA, protein:increased expression:dorsal root ganglion RGD PMID:16683235 RGD:1600154 NCBI chr22:32,801,705...32,863,041
Ensembl chr22:32,801,705...32,863,041 		JBrowse link
G TLR2 toll like receptor 2 ISO RGD PMID:18003835 RGD:2312723 NCBI chr 4:153,684,280...153,710,637
Ensembl chr 4:153,684,050...153,706,260 		JBrowse link
G TLR4 toll like receptor 4 ISO RGD PMID:18003835 RGD:2312723 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
G UBE4B ubiquitination factor E4B EXP CTD Direct Evidence: therapeutic CTD PMID:27822499 NCBI chr 1:10,032,958...10,181,239
Ensembl chr 1:10,032,832...10,181,239 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 97394
    Pathological Conditions, Signs and Symptoms 53660
      Pathologic Processes 28393
        Nerve Degeneration 138
          Wallerian Degeneration 25
            Wallerian Degeneration of the Pyramidal Tract 0
paths to the root