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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Alveolar Bone Loss
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Accession:DOID:9000927 term browser browse the term
Definition:Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.
Synonyms:exact_synonym: Alveolar Bone Atrophies;   Alveolar Bone Atrophy;   Alveolar Bone Losses;   Alveolar Process Atrophies;   Alveolar Process Atrophy;   Alveolar Resorption;   Alveolar Resorptions;   Periodontal Bone Loss;   Periodontal Bone Losses;   Periodontal Resorption;   Periodontal Resorptions
 primary_id: MESH:D016301;   RDO:0006950


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Alveolar Bone Loss term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 treatment IEP associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant treatment IEP associated with hypertension, periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a treatment IEP associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 treatment IEP associated with hypertension, periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated treatment ISO
IEP		 CTD Direct Evidence: marker/mechanism
associated with hypertension, periodontal disease		 CTD
RGD		 PMID:20630305 PMID:33364953 RGD:329956421 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 ISO associated with Periodontitis; RGD PMID:21241302 RGD:8661687 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Ctsk cathepsin K treatment IEP associated with hypertension, periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 treatment IEP associated with hypertension, periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Il10 interleukin 10 treatment IEP associated with Diabetes Mellitus, Experimental
associated with periodontal disease		 RGD PMID:26270535 PMID:33364953 RGD:11049527, RGD:329956421 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta treatment IEP associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 treatment IEP associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgav integrin subunit alpha V treatment IEP associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639 		JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor treatment IEP associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709 		JBrowse link
G Mmp2 matrix metallopeptidase 2 treatment IEP associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment IEP associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Oscar osteoclast associated Ig-like receptor treatment IEP associated with hypertension, periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 1:65,607,214...65,615,395
Ensembl chr 1:65,607,410...65,613,758 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 ISO RGD PMID:14630900 RGD:10413909 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma treatment IEP associated with hypertension, periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Tnf tumor necrosis factor treatment IEP associated with Diabetes Mellitus, Experimental
associated with periodontal disease		 RGD PMID:26270535 PMID:33364953 RGD:11049527, RGD:329956421 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A treatment IEP associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B treatment IEP associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tnfsf11 TNF superfamily member 11 treatment ISO
IEP		 CTD Direct Evidence: marker/mechanism
associated with periodontal disease		 CTD
RGD		 PMID:19249596 PMID:33364953 RGD:329956421 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Vtn vitronectin treatment IEP associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr10:63,394,732...63,397,812
Ensembl chr10:63,394,719...63,397,810 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19099
    disease of anatomical entity 18440
      musculoskeletal system disease 8488
        bone disease 4411
          bone resorption disease 374
            Alveolar Bone Loss 23
Path 2
Term Annotations click to browse term
  disease 19099
    Pathological Conditions, Signs and Symptoms 13604
      Signs and Symptoms 11163
        Neurologic Manifestations 10417
          sensory system disease 7326
            mouth disease 1034
              tooth disease 463
                periodontal disease 138
                  Periodontal Atrophy 24
                    Alveolar Bone Loss 23
paths to the root