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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:graft-versus-host disease
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Accession:DOID:0081267 term browser browse the term
Definition:An immune system disease that is characterized by recognition by mature donor T cells, that contaminate the allogeneic bone marrow, of the recipient's tissue as foreign, causing a severe inflammatory disease characterized by rashes, diarrhea, and liver disease, and that has_material_basis_in an associated with variation in the interleukin-10 gene (IL10) on chromosome 1q32. (DO)
Synonyms:exact_synonym: GVHD;   GVHDS;   Graft vs Host Disease;   Graft-Versus-Host Diseases;   Graft-vs-Host Diseases;   Homologous Wasting Disease;   Runt Disease
 related_synonym: PLATELET-ENDOTHELIAL CELL ADHESION MOLECULE 1 POLYMORPHISM;   graft-versus-host disease, resistance to;   graft-versus-host disease, susceptibility to
 primary_id: MESH:D006086
 alt_id: DOID:9006073;   MIM:614395
 xref: ICD11:4B24;   ORDO:39812


show annotations for term's descendants           Sort by:
graft-versus-host disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABO ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase ISO RGD PMID:3289150 RGD:11100006 NCBI chr 9:49,746,749...49,758,317
Ensembl chr 9:49,748,693...49,758,479 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing severity ISO protein:increased expression:serum RGD PMID:21258011 RGD:5686893 NCBI chr34:19,398,310...19,410,519
Ensembl chr34:19,354,825...19,409,844 		JBrowse link
G APOA4 apolipoprotein A4 ISO protein:increased expression:blood serum (human) RGD PMID:19379511 RGD:5685691 NCBI chr 5:16,751,588...16,754,215
Ensembl chr 5:16,751,799...16,754,837 		JBrowse link
G CCL8 C-C motif chemokine ligand 8 ISO RGD PMID:19571824 RGD:4892067 NCBI chr 9:38,949,184...38,950,702
Ensembl chr 9:38,948,184...38,950,803 		JBrowse link
G CCR1 chemokine (C-C motif) receptor 1 severity ISO RGD PMID:17641205 RGD:5688177 NCBI chr20:42,421,356...42,427,177
Ensembl chr20:42,421,356...42,426,958 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 ISO mRNA:increased expression:lung, liver, intestine (mouse) RGD PMID:19571824 RGD:4892067 NCBI chr20:42,293,288...42,297,952
Ensembl chr20:42,294,996...42,297,952 		JBrowse link
G CD40 CD40 molecule treatment ISO RGD PMID:18981161 RGD:7248735 NCBI chr24:33,352,992...33,383,488
Ensembl chr24:33,372,930...33,383,301 		JBrowse link
G CD40LG CD40 ligand ISO RGD PMID:12970789 RGD:11352269 NCBI chr  X:107,001,421...107,023,007
Ensembl chr  X:107,010,890...107,023,006 		JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 treatment ISO CTD Direct Evidence: therapeutic CTD
RGD		 PMID:7515723 PMID:14642129 RGD:11344912 NCBI chr37:12,647,712...12,653,874
Ensembl chr37:12,634,563...12,653,874 		JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 severity ISO RGD PMID:17264819 RGD:4892014 NCBI chr23:8,937,069...8,954,738
Ensembl chr23:8,938,906...8,952,808 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 ISO mRNA, protein:increased expression:intestine, liver, lung RGD PMID:19218194 RGD:5135435 NCBI chr32:598,406...599,925
Ensembl chr32:597,987...599,979 		JBrowse link
G CXCL11 C-X-C motif chemokine ligand 11 ISO protein:increased expression:intestine, liver, lung RGD PMID:19218194 RGD:5135435 NCBI chr32:631,084...636,997
Ensembl chr32:631,478...632,868
Ensembl chr32:631,478...632,868 		JBrowse link
G CXCR3 C-X-C motif chemokine receptor 3 ISO RGD PMID:19218194 RGD:5135435 NCBI chr  X:55,882,433...55,884,582
Ensembl chr  X:55,882,433...55,884,582 		JBrowse link
G F3 coagulation factor III, tissue factor treatment ISO RGD PMID:20037809 RGD:11340209 NCBI chr 6:54,709,581...54,720,603
Ensembl chr 6:54,708,471...54,720,607 		JBrowse link
G FAS Fas cell surface death receptor ISO RGD PMID:9404931 RGD:11049160 NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321 		JBrowse link
G FASLG Fas ligand ISO mRNA,protein:increased expression:liver: RGD PMID:9404931 PMID:10452880 RGD:11049160 RGD:14700681 NCBI chr 7:26,335,837...26,344,224
Ensembl chr 7:26,335,846...26,344,224 		JBrowse link
G FOXP3 forkhead box P3 treatment ISO RGD PMID:22344929 RGD:38599140 NCBI chr  X:42,331,229...42,362,841
Ensembl chr  X:42,344,108...42,350,758 		JBrowse link
G HGF hepatocyte growth factor treatment ISO RGD PMID:11390418 RGD:8548544 NCBI chr18:21,329,688...21,410,257
Ensembl chr18:21,332,817...21,410,263 		JBrowse link
G HSP70 heat shock protein 70 severity ISO mRNA:increased expression:skin RGD PMID:18580475 RGD:8662845 NCBI chr12:1,285,282...1,287,670 JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 ISO RGD PMID:9557158 RGD:7242787 NCBI chr 5:11,292,219...11,296,851
Ensembl chr 5:11,292,262...11,296,797 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO protein:increased expression:liver,bile duct: RGD PMID:10051478 RGD:11520783 NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914 		JBrowse link
G IFNG interferon gamma susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:repeats:intron:
associated with Cytomegalovirus Infections; DNA:repeats:intron:		 CTD
RGD		 PMID:16409297 PMID:19747638 PMID:22077062 RGD:10755684 RGD:10755687 NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698 		JBrowse link
G IL10 interleukin 10 no_association
severity
disease_progression
treatment
susceptibility		 ISO DNA:polymorphisms
DNA:repeat:promoter
DNA:SNP: :rs1800872 (human)
ClinVar Annotator: match by term: Graft-versus-host disease, resistance to | ClinVar Annotator: match by term: Graft-versus-host disease, susceptibility to		 RGD
ClinVar
OMIM		 PMID:9808588 PMID:11121048 PMID:14657422 PMID:14657427 PMID:18550579 More... RGD:11041897 RGD:11046269 RGD:11049177 RGD:2316565 NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057 		JBrowse link
G IL10RB interleukin 10 receptor subunit beta disease_progression ISO DNA:SNP: :rs28341676 (human) RGD PMID:19409109 RGD:11046269 NCBI chr31:28,791,541...28,815,163
Ensembl chr31:27,892,394...27,915,637 		JBrowse link
G IL17A interleukin 17A ISO CTD Direct Evidence: marker/mechanism CTD PMID:22077062 NCBI chr12:19,854,129...19,862,521
Ensembl chr12:19,854,129...19,862,513 		JBrowse link
G IL19 interleukin 19 ISO ClinVar Annotator: match by term: Graft-versus-host disease, resistance to | ClinVar Annotator: match by term: Graft-versus-host disease, susceptibility to ClinVar PMID:11121048 PMID:14657422 PMID:14657427 PMID:18550579 PMID:25741868 More... NCBI chr 7:6,000,994...6,006,959
Ensembl chr 7:6,000,907...6,006,870 		JBrowse link
G IL1A interleukin 1 alpha ISO DNA:SNP:promoter:-889T>C (rs1800587) (human) RGD PMID:23645090 RGD:11049180 NCBI chr17:36,969,581...36,979,445
Ensembl chr17:36,970,573...36,979,435 		JBrowse link
G IL1RN interleukin 1 receptor antagonist ISO RGD PMID:8049450 RGD:6909143 NCBI chr17:37,236,690...37,250,424
Ensembl chr17:37,212,751...37,249,329 		JBrowse link
G IL2 interleukin 2 ISO RGD PMID:8704686 PMID:21734238 RGD:5147911 RGD:8662974 NCBI chr19:17,750,780...17,756,394
Ensembl chr19:17,750,780...17,756,394 		JBrowse link
G IL21R interleukin 21 receptor ISO RGD PMID:21596854 RGD:6892927 NCBI chr 6:19,181,846...19,217,915
Ensembl chr 6:19,182,071...19,217,931 		JBrowse link
G ITGA2 integrin subunit alpha 2 treatment ISO RGD PMID:11489992 RGD:8693305 NCBI chr 4:62,170,137...62,268,962
Ensembl chr 4:62,170,452...62,268,983 		JBrowse link
G JAK3 Janus kinase 3 treatment ISO RGD PMID:11781254 PMID:12010825 RGD:11531124 RGD:1600262 NCBI chr20:45,051,135...45,068,445
Ensembl chr20:45,050,526...45,072,805 		JBrowse link
G LOC478984 low affinity immunoglobulin gamma Fc region receptor III ISO DNA:polymorphism:cds:p. V158F(rs396991)(human) RGD PMID:20400988 RGD:11040884 NCBI chr38:21,054,870...21,060,948 JBrowse link
G LOC480777 UDP-glucuronosyltransferase 2A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19935662 NCBI chr13:58,911,301...58,932,594
Ensembl chr13:59,138,348...59,222,802
Ensembl chr13:59,138,348...59,222,802 		JBrowse link
G LST1 leukocyte specific transcript 1 ISO DNA:repeat:intron:IVS3dupGA (human) RGD PMID:9808588 RGD:2316565 NCBI chr12:1,084,739...1,086,182 JBrowse link
G MKI67 marker of proliferation Ki-67 ISO RGD PMID:21440078 RGD:6483534 NCBI chr28:36,920,679...36,939,336
Ensembl chr28:36,913,023...36,939,486 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase treatment ISO DNA:transition:cds:g.677C>T (human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:16518429 PMID:19005482 RGD:6893635 NCBI chr 2:84,445,526...84,457,435
Ensembl chr 2:84,380,919...84,536,818 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 severity ISO DNA:snps, insertion:exons:p.R675W, p.G1881R, c.2936_2937insC (human) RGD PMID:15090455 RGD:8158050 NCBI chr 2:64,636,850...64,667,232
Ensembl chr 2:64,635,519...64,667,232 		JBrowse link
G PDGFB platelet derived growth factor subunit B ISO RGD PMID:21211989 RGD:6482796 NCBI chr10:25,798,877...25,819,422
Ensembl chr10:25,798,938...25,817,746 		JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 ISO ClinVar Annotator: match by term: PLATELET-ENDOTHELIAL CELL ADHESION MOLECULE 1 POLYMORPHISM ClinVar PMID:8532023 NCBI chr 9:12,166,124...12,219,553
Ensembl chr 9:12,166,775...12,219,778 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO RGD PMID:21402770 RGD:6482681 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141 		JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 susceptibility ISO DNA:snp:promoter:g.-1123G>C (rs2488457) (human) RGD PMID:23025987 RGD:11534005 NCBI chr17:51,623,628...51,683,039
Ensembl chr17:51,623,623...51,682,858 		JBrowse link
G SELL selectin L ISO RGD PMID:21635226 RGD:5685693 NCBI chr 7:28,906,752...28,927,959
Ensembl chr 7:28,906,809...29,094,008 		JBrowse link
G SERPINE1 serpin family E member 1 Treatment ISO RGD PMID:26414805 RGD:11343779 NCBI chr 6:8,719,547...8,727,160
Ensembl chr 6:8,720,825...8,726,301 		JBrowse link
G TFPI tissue factor pathway inhibitor treatment ISO RGD PMID:20037809 RGD:11340209 NCBI chr36:29,457,131...29,546,455
Ensembl chr36:29,459,371...29,511,310 		JBrowse link
G TNFRSF8 TNF receptor superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15322151 NCBI chr 2:84,185,445...84,225,986
Ensembl chr 2:84,186,961...84,232,675 		JBrowse link
G TNFSF8 TNF superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15322151 NCBI chr11:68,979,498...69,006,898
Ensembl chr11:68,982,360...69,007,355 		JBrowse link
G TP53 tumor protein p53 ISO protein:increased expression:epithelium RGD PMID:16393253 RGD:8547841 NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109 		JBrowse link
G VEGFA vascular endothelial growth factor A ISO protein:decreased expression:serum: RGD PMID:25759146 RGD:11079181 NCBI chr12:12,209,032...12,224,978
Ensembl chr12:12,208,231...12,224,965 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15722
    disease of anatomical entity 15368
      immune system disease 4506
        graft-versus-host disease 49
          Bronchiolitis Obliterans Syndrome 0
Path 2
Term Annotations click to browse term
  disease 15722
    disease of anatomical entity 15368
      Immune & Inflammatory Diseases 5201
        immune system disease 4506
          graft-versus-host disease 49
            Bronchiolitis Obliterans Syndrome 0
paths to the root