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CLINICAL MEASUREMENT - ANNOTATIONS

The Clinical Measurement Ontology (CMO), Measurement Methods Ontology (MMO), and Experimental Condition Ontology (XCO) are currently being developed at the Rat Genome Database. For more information about these vocabularies please see Shimoyama et al. Three ontologies to define phenotype measurement data. Front Genet. 2012;3:87. Epub 2012 May 28 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:concentration of GSK2181236A at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
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Accession:CMO:0003416 term browser browse the term
Definition:A calculated value for the concentration of GSK2181236A, a small molecule activator of soluble guanylate cyclase, at which the energy exerted during the active expansion in the diameter of a blood vessel in response to the application of GSK2181236A is halfway between the highest value, that is the force at greatest constriction (often measured in a pre-constricted blood vessel), and the lowest achievable value of such contractile energy during GSK2181236A-induced relaxation of the vessel wall (i.e. the maximum effect of GSK2181236A which is the minimum contractile energy).
Synonyms:xref: PMID:22783192



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Related Phenotype Data for Term "concentration of GSK2181236A at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)" (CMO:0003416)

Rat Strains:
Clinical Measurements:
Experimental Conditions:
Measurement Methods:

Term paths to the root
Path 1
Term Annotations click to browse term
  clinical measurement 2369
    chemical response/sensitivity measurement 0
      GSK2181236A response/sensitivity measurement 0
        concentration of GSK2181236A at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) 0
Path 2
Term Annotations click to browse term
  clinical measurement 2369
    cardiovascular measurement 610
      blood vessel measurement 44
        blood vessel dilation measurement 0
          blood vessel dilation force reduction measurement 0
            calculated blood vessel dilation force reduction measurement 0
              concentration of GSK2181236A at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) 0
paths to the root