The Clinical Measurement Ontology (CMO), Measurement Methods Ontology (MMO), and Experimental Condition Ontology (XCO) are currently being developed at the Rat Genome Database. For more information about these vocabularies please see Shimoyama et al. Three ontologies to define phenotype measurement data. Front Genet. 2012;3:87. Epub 2012 May 28 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:
lymph node-specific lymphocyte tracer radioactivity level to kidney-specific lymphocyte tracer radioactivity level ratio
A calculated measurement in which the level of radioactivity from a lymphocyte tracer found in lymph node is divided by the level of radioactivity from a lymphocyte tracer found in kidney from the same individual, and presented as a ratio, fraction, quotient or percentage. Lymphocyte tracer radioactivity level is the measurement in a specified sample of tissue of the amount of corpuscular or electromagnetic radiations emitted consequent to nuclear disintegration of a radioactive isotope which is replacing a stable chemical element in a compound that has been introduced into lymphocytes (small agranulocytic leukocytes that originate from fetal stem cells and develop in the bone marrow) rendering them able to be followed or tracked through the body. Lymph nodes are any of the accumulations of lymphoid tissue organized as definite lymphoid organs along the course of lymphatic vessels, consisting of an outer cortical and an inner medullary part; they are the main source of lymphocytes of the peripheral blood and, as part of the reticuloendothelial system, serve as a defense mechanism by removing noxious agents, e.g., bacteria and toxins, and probably play a role in antibody formation. Kidney is the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes.