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G |
Abca8 |
ATP binding cassette subfamily A member 8 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide] |
CTD |
PMID:12379217 |
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NCBI chr10:94,917,520...94,991,199
Ensembl chr10:94,917,520...94,990,988
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases transport multiple interactions decreases activity decreases expression increases activity increases expression affects response to substance |
ISO EXP |
ABCB1 protein results in increased transport of Verapamil [Endosulfan co-treated with Verapamil] inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [Endosulfan co-treated with Verapamil] results in decreased activity of ABCB1 protein; [phosalone co-treated with Verapamil] inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [phosalone co-treated with Verapamil] results in decreased activity of ABCB1 protein; [Verapamil binds to and results in decreased activity of ABCB1 protein] inhibits the reaction [sodium arsenite promotes the reaction [ABCB1 protein results in increased secretion of calcein AM]]; [Verapamil binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Verapamil binds to and results in decreased activity of ABCB1 protein] which results in decreased transport of N-cyano-1-((3,4-dimethoxyphenyl)methyl)-3,4-dihydro-6,7-dimethoxy-N'-octyl-2(1H)-isoquinoline-carboximidamide; [Verapamil co-treated with kaempferol] results in decreased expression of ABCB1 mRNA; [Verapamil co-treated with kaempferol] results in decreased expression of ABCB1 protein; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased export of calcein AM; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased export of Rhodamine 123; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased export of Topotecan; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylaconine; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylhypaconine; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylmesaconine; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of Digoxin; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of hypaconitine; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of mesaconitine; [Verapamil results in decreased activity of ABCB1 protein] which results in increased susceptibility to Doxorubicin; [Verapamil results in decreased activity of ABCB1 protein] which results in increased susceptibility to Paclitaxel; [Verapamil results in decreased activity of ABCB1 protein] which results in increased uptake of fluorexon; Colchicine inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form]; Cyclosporine inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form]; Demecolcine inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form]; Diazinon promotes the reaction [Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [Verapamil results in decreased activity of ABCB1 protein]; Glycyrrhetinic Acid inhibits the reaction [Verapamil results in increased activity of ABCB1 protein]; propiconazole promotes the reaction [Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole promotes the reaction [Verapamil results in decreased activity of ABCB1 protein]; Verapamil affects the reaction [ABCB1 protein results in increased export of Tacrolimus]; Verapamil binds to and affects the activity of ABCB1 protein; Verapamil binds to and results in decreased activity of ABCB1 protein; Verapamil inhibits the reaction [5-Methoxypsoralen results in decreased activity of ABCB1 protein]; Verapamil inhibits the reaction [[5-Methoxypsoralen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin]; Verapamil inhibits the reaction [[Methoxsalen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin]; Verapamil inhibits the reaction [ABCB1 protein affects the transport of traumatic acid]; Verapamil inhibits the reaction [ABCB1 protein affects the uptake of Vinblastine]; Verapamil inhibits the reaction [ABCB1 protein results in decreased abundance of Quercetin]; Verapamil inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; Verapamil inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Verapamil inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]; Verapamil inhibits the reaction [ABCB1 protein results in decreased uptake of Doxorubicin]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of calcein AM]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of Doxorubicin]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of Fluorescent Dyes]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of cyazofamid]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Doxorubicin]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of huperzine A]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of N-cyano-1-((3,4-dimethoxyphenyl)methyl)-3,4-dihydro-6,7-dimethoxy-N'-octyl-2(1H)-isoquinoline-carboximidamide]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Paclitaxel]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Sulpiride]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Vinblastine]; Verapamil inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Verapamil inhibits the reaction [Acetaminophen results in increased activity of ABCB1 protein]; Verapamil inhibits the reaction [Doxorubicin results in increased activity of ABCB1 protein]; Verapamil inhibits the reaction [Methoxsalen results in decreased activity of ABCB1 protein]; Verapamil inhibits the reaction [tangeretin results in increased activity of ABCB1 protein]; Verapamil inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form]; Verapamil promotes the reaction [ABCB1 protein mutant form binds to 8-azidoadenosine 5'-triphosphate]; Verapamil promotes the reaction [galangin results in increased activity of ABCB1 protein]; Verapamil promotes the reaction [kaempferol results in increased activity of ABCB1 protein]; Verapamil promotes the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Verapamil promotes the reaction [propiconazole results in decreased activity of ABCB1 protein]; Verapamil promotes the reaction [Quercetin results in increased activity of ABCB1 protein]; Vinblastine inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form]; yu ping feng san inhibits the reaction [Verapamil results in increased activity of ABCB1 protein] Verapamil results in decreased expression of ABCB1 protein Verapamil analog results in increased activity of ABCB1 protein mutant form; Verapamil results in increased activity of ABCB1 protein Verapamil results in increased expression of ABCB1 mRNA [Verapamil results in decreased expression of ABCB1] promotes the reaction [Doxorubicin results in increased activity of CASP3 protein]; [Verapamil results in decreased expression of ABCB1] promotes the reaction [Doxorubicin results in increased activity of CASP7 protein]; Verapamil promotes the reaction [Vanadates results in decreased activity of ABCB1A protein] [Verapamil results in decreased activity of ABCB1 protein] inhibits the reaction [P-glycoprotein inducer and activator TX5 results in increased export of Rhodamine 123]; Verapamil inhibits the reaction [ABCB1 results in decreased susceptibility to Cadmium Chloride] ABCB1A protein affects the susceptibility to Verapamil Verapamil results in decreased activity of ABCB1A protein Verapamil results in decreased activity of ABCB1 protein; Verapamil results in decreased activity of ABCB1A protein Verapamil results in decreased expression of ABCB1A mRNA |
CTD |
PMID:2900677 PMID:7083125 PMID:7476894 PMID:8917702 PMID:10527640 PMID:10571255 PMID:10636889 PMID:10997946 PMID:11027628 PMID:11836167 PMID:11895100 PMID:11920757 PMID:12202523 PMID:12387747 PMID:12670938 PMID:12708479 PMID:12711602 PMID:15112361 PMID:15276086 PMID:15451006 PMID:15502009 PMID:15627040 PMID:15640379 PMID:15725475 PMID:15861398 PMID:16033948 PMID:16049968 PMID:16121039 PMID:16442095 PMID:16904803 PMID:16930294 PMID:16959878 PMID:17134887 PMID:17526808 PMID:17947497 PMID:17973928 PMID:18204840 PMID:18408562 PMID:18673531 PMID:19070657 PMID:19505989 PMID:19528478 PMID:19944135 PMID:20457140 PMID:21783720 PMID:22079615 PMID:22233293 PMID:23200901 PMID:23273999 PMID:23976943 PMID:24321342 PMID:24380838 PMID:24446304 PMID:25058526 PMID:25268938 PMID:25625052 PMID:26995013 PMID:28587984 PMID:28597291 PMID:28669723 PMID:29079042 PMID:29174985 PMID:29625142 PMID:30102254 PMID:30391378 PMID:31348918 PMID:31756430 PMID:32003934 PMID:32497533 PMID:33321149 PMID:34135758 PMID:34217736 PMID:35063459 PMID:35550413 PMID:35753429 PMID:37259354 PMID:37985955 PMID:38367674 PMID:39041788 More...
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcb1b |
ATP-binding cassette, sub-family B member 1B |
decreases activity affects response to substance |
EXP ISO |
Verapamil results in decreased activity of ABCB1B protein ABCB1B protein affects the susceptibility to Verapamil |
CTD |
PMID:12202523 PMID:15502009 |
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NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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G |
Abcb4 |
ATP binding cassette subfamily B member 4 |
decreases activity decreases expression |
EXP ISO |
Verapamil results in decreased activity of ABCB4 protein Verapamil results in decreased expression of ABCB4 mRNA |
CTD |
PMID:12202523 PMID:28437613 PMID:28552422 |
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NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
affects activity multiple interactions decreases activity |
ISO |
Verapamil affects the activity of ABCC1 protein Verapamil inhibits the reaction [ABCC1 protein affects the export of 5-carboxyfluorescein diacetate]; Verapamil inhibits the reaction [ABCC1 protein affects the export of Daunorubicin]; Verapamil inhibits the reaction [ABCC1 protein results in decreased susceptibility to Doxorubicin]; Verapamil inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; Verapamil inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]; Verapamil promotes the reaction [ABCC1 protein affects the export of Glutathione]; Verapamil promotes the reaction [ABCC1 protein affects the transport of Glutathione]; Verapamil promotes the reaction [ABCC1 protein results in increased uptake of Glutathione] Verapamil results in decreased activity of ABCC1 protein Verapamil inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; Verapamil inhibits the reaction [ABCC1 protein results in decreased uptake of Daunorubicin]; Verapamil inhibits the reaction [ABCC1 protein results in decreased uptake of Etoposide] |
CTD |
PMID:7954421 PMID:9334814 PMID:10856430 PMID:11278867 PMID:12485947 PMID:15044619 PMID:15451006 PMID:15498506 PMID:16101123 PMID:16636798 More...
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NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [ABCC2 protein affects the export of 5-carboxyfluorescein diacetate] |
CTD |
PMID:16636798 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [ABCC3 protein affects the export of 5-carboxyfluorescein diacetate] |
CTD |
PMID:16636798 |
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NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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G |
Abcc6 |
ATP binding cassette subfamily C member 6 |
decreases activity |
ISO |
Verapamil results in decreased activity of ABCC6 protein |
CTD |
PMID:14667841 |
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NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
EXP |
Verapamil inhibits the reaction [[Carbon Tetrachloride co-treated with lard co-treated with Ethanol] results in increased expression of ACTA2 protein] |
CTD |
PMID:17223571 |
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Adra1a |
adrenoceptor alpha 1A |
multiple interactions affects binding |
ISO |
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Verapamil inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate] Verapamil binds to ADRA1A protein |
CTD |
PMID:9570190 |
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NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
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G |
Adra1b |
adrenoceptor alpha 1B |
affects binding multiple interactions |
ISO |
Verapamil binds to ADRA1B protein [Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Verapamil inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate] |
CTD |
PMID:9570190 |
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NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919
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G |
Adra1d |
adrenoceptor alpha 1D |
multiple interactions affects binding |
ISO |
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Verapamil inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate] Verapamil binds to ADRA1D protein |
CTD |
PMID:9570190 |
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NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354
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G |
Adrb1 |
adrenoceptor beta 1 |
affects response to substance |
ISO |
ADRB1 protein polymorphism affects the susceptibility to Verapamil |
CTD |
PMID:22192668 |
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NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
Verapamil inhibits the reaction [Thioacetamide results in decreased expression of AKT1 mRNA] |
CTD |
PMID:30526075 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Aqp1 |
aquaporin 1 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [cobaltous chloride results in increased expression of AQP1 protein] |
CTD |
PMID:22415096 |
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NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
ISO |
Verapamil results in increased expression of BAX protein [Verapamil co-treated with Temozolomide] results in increased expression of BAX mRNA; Temozolomide promotes the reaction [Verapamil results in increased expression of BAX protein] |
CTD |
PMID:30003979 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression |
ISO |
[Temozolomide co-treated with Verapamil] results in decreased expression of BCL2 mRNA; [Temozolomide co-treated with Verapamil] results in decreased expression of BCL2 protein; [Verapamil co-treated with gambogic acid] results in decreased expression of BCL2 protein Verapamil results in decreased expression of BCL2 mRNA; Verapamil results in decreased expression of BCL2 protein |
CTD |
PMID:24373880 PMID:30003979 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Cacna1c |
calcium voltage-gated channel subunit alpha1 C |
increases response to substance multiple interactions decreases expression |
ISO EXP |
CACNA1C gene polymorphism results in increased susceptibility to Verapamil Mevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1C mRNA]; Mevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1C protein] Verapamil results in decreased expression of CACNA1C mRNA; Verapamil results in decreased expression of CACNA1C protein Verapamil inhibits the reaction [Iron-Dextran Complex affects the expression of CACNA1C protein] |
CTD |
PMID:19791473 PMID:20031608 PMID:27095094 |
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NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
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G |
Cacna1f |
calcium voltage-gated channel subunit alpha1 F |
multiple interactions |
ISO |
Verapamil inhibits the reaction [CACNA1F protein results in increased transport of Barium] |
CTD |
PMID:14744918 |
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NCBI chr X:14,868,096...14,896,413
Ensembl chr X:14,868,024...14,896,413
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G |
Cacna1h |
calcium voltage-gated channel subunit alpha1 H |
multiple interactions decreases expression |
EXP |
Mevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1H mRNA]; Mevalonic Acid inhibits the reaction [Verapamil results in decreased expression of CACNA1H protein] Verapamil results in decreased expression of CACNA1H mRNA; Verapamil results in decreased expression of CACNA1H protein |
CTD |
PMID:19791473 |
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NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
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G |
Calca |
calcitonin-related polypeptide alpha |
multiple interactions |
ISO |
Verapamil inhibits the reaction [[Ionomycin co-treated with Lipopolysaccharides] results in increased expression of CALCA protein]; Verapamil inhibits the reaction [Lipopolysaccharides results in increased expression of CALCA mRNA] |
CTD |
PMID:20682585 |
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NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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G |
Camk2a |
calcium/calmodulin-dependent protein kinase II alpha |
multiple interactions |
EXP |
Verapamil inhibits the reaction [LIF protein results in increased activity of CAMK2A protein]; Verapamil inhibits the reaction [LIF protein results in increased phosphorylation of CAMK2A protein] |
CTD |
PMID:11073891 |
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NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
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G |
Camk4 |
calcium/calmodulin-dependent protein kinase IV |
multiple interactions |
EXP |
Verapamil inhibits the reaction [LIF protein results in increased activity of CAMK4 protein] |
CTD |
PMID:11073891 |
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NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487
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G |
Casp1 |
caspase 1 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [7-ketocholesterol results in increased activity of CASP1 protein]; Verapamil inhibits the reaction [Cholesterol analog results in increased activity of CASP1 protein] |
CTD |
PMID:28633109 |
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NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp12 |
caspase 12 |
multiple interactions |
ISO |
[Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP12 protein] |
CTD |
PMID:19631781 |
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NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
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G |
Casp3 |
caspase 3 |
multiple interactions increases expression |
ISO EXP |
[Doxorubicin co-treated with Verapamil] results in increased activity of CASP3 protein; [Verapamil co-treated with gambogic acid] results in increased cleavage of and results in increased activity of CASP3 protein; [Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP3 protein]; Verapamil inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein] [Verapamil results in decreased expression of ABCB1] promotes the reaction [Doxorubicin results in increased activity of CASP3 protein] Verapamil inhibits the reaction [Simvastatin results in increased activity of CASP3 protein] Verapamil results in increased expression of CASP3 mRNA |
CTD |
PMID:14527821 PMID:15861398 PMID:18358092 PMID:19631781 PMID:19815060 PMID:19927300 PMID:24373880 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp7 |
caspase 7 |
multiple interactions |
ISO |
[Verapamil results in decreased expression of ABCB1] promotes the reaction [Doxorubicin results in increased activity of CASP7 protein] |
CTD |
PMID:15861398 |
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NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
[Verapamil co-treated with gambogic acid] results in increased cleavage of and results in increased activity of CASP8 protein |
CTD |
PMID:24373880 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
[Verapamil co-treated with gambogic acid] results in increased cleavage of and results in increased activity of CASP9 protein |
CTD |
PMID:24373880 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cd44 |
CD44 molecule |
multiple interactions |
ISO |
Verapamil inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [CD44 protein binds to Hyaluronic Acid]]; Verapamil inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of CD44 protein] [Verapamil co-treated with kaempferol] results in decreased expression of CD44 mRNA; [Verapamil co-treated with kaempferol] results in decreased expression of CD44 protein |
CTD |
PMID:9929743 PMID:35063459 |
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NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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G |
Cdh1 |
cadherin 1 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; Verapamil inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein] |
CTD |
PMID:34217686 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Ciita |
class II, major histocompatibility complex, transactivator |
affects expression |
ISO |
Verapamil affects the expression of CIITA mRNA |
CTD |
PMID:25811541 |
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NCBI chr10:5,139,947...5,187,493
Ensembl chr10:5,140,178...5,187,440
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G |
Clu |
clusterin |
affects expression |
ISO |
Verapamil affects the expression of CLU protein |
CTD |
PMID:12388792 |
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NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
ISO |
Verapamil inhibits the reaction [Iron-Dextran Complex results in increased expression of COL1A1 protein] Verapamil inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein] |
CTD |
PMID:27095094 PMID:34217686 |
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NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col3a1 |
collagen type III alpha 1 chain |
multiple interactions |
ISO |
Verapamil inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 protein] |
CTD |
PMID:34217686 |
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NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Csrp3 |
cysteine and glycine rich protein 3 |
decreases localization |
EXP |
Verapamil results in decreased localization of CSRP3 protein |
CTD |
PMID:19376126 |
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NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
decreases activity |
ISO |
Verapamil results in decreased activity of CYP1A1 protein |
CTD |
PMID:18420780 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity |
ISO |
Verapamil results in decreased activity of CYP1A2 protein |
CTD |
PMID:18420780 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases activity |
ISO |
Verapamil results in decreased activity of CYP1B1 protein |
CTD |
PMID:18420780 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp2a3 |
cytochrome P450, family 2, subfamily a, polypeptide 3 |
decreases activity |
ISO |
Verapamil results in decreased activity of CYP2A4 protein |
CTD |
PMID:18420780 |
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NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
decreases activity |
ISO |
Verapamil results in decreased activity of CYP2B10 protein |
CTD |
PMID:18420780 |
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NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
multiple interactions |
EXP |
Verapamil inhibits the reaction [Cyclosporine results in increased expression of CYP2C11 protein] |
CTD |
PMID:28899749 |
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NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
decreases activity |
ISO |
Verapamil results in decreased activity of CYP2C29 protein |
CTD |
PMID:18420780 |
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
multiple interactions decreases activity |
ISO |
torsemide inhibits the reaction [Verapamil results in decreased activity of CYP2C8 protein] |
CTD |
PMID:15304522 |
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
decreases activity |
ISO |
Verapamil results in decreased activity of CYP2D22 protein; Verapamil results in decreased activity of CYP2D6 protein |
CTD |
PMID:18420780 |
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NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Cyp3a18 |
cytochrome P450, family 3, subfamily a, polypeptide 18 |
decreases expression |
EXP |
Verapamil results in decreased expression of CYP3A18 mRNA |
CTD |
PMID:17973928 |
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NCBI chr12:8,880,509...8,930,382
Ensembl chr12:8,880,528...8,930,381
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases activity multiple interactions affects metabolic processing |
ISO |
Verapamil results in decreased activity of CYP3A4 protein [Verapamil results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; naringin inhibits the reaction [CYP3A4 protein affects the metabolism of Verapamil]; Verapamil inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Verapamil inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Verapamil inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; Verapamil inhibits the reaction [CYP3A4 protein results in increased metabolism of Testosterone]; Verapamil inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] |
CTD |
PMID:15286053 PMID:15689501 PMID:15692829 PMID:15860655 PMID:16013069 PMID:19299527 PMID:21915887 PMID:25455453 More...
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
decreases activity decreases expression |
ISO EXP |
Verapamil results in decreased activity of CYP3A5 protein Verapamil results in decreased expression of CYP3A9 mRNA |
CTD |
PMID:15689501 PMID:17973928 |
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NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions |
ISO |
[Verapamil co-treated with gambogic acid] results in increased expression of DDIT3 protein |
CTD |
PMID:24373880 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Dnm1l |
dynamin 1-like |
multiple interactions increases phosphorylation |
ISO |
Verapamil inhibits the reaction [bisphenol A affects the localization of DNM1L protein] Verapamil results in increased phosphorylation of DNM1L protein |
CTD |
PMID:31830493 PMID:34023961 |
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NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
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G |
Drd1 |
dopamine receptor D1 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [SCH 23390 binds to DRD1 protein] |
CTD |
PMID:9533112 |
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NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
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G |
Drd2 |
dopamine receptor D2 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [Raclopride binds to DRD2 protein] |
CTD |
PMID:9533112 |
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NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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G |
Edn1 |
endothelin 1 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]; Verapamil inhibits the reaction [EDN1 protein results in increased expression of NPPB protein] |
CTD |
PMID:28942281 |
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NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Fn1 |
fibronectin 1 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein] |
CTD |
PMID:34217686 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
Verapamil results in increased expression of FOS mRNA |
CTD |
PMID:12730611 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Fth1 |
ferritin heavy chain 1 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [Iron-Dextran Complex results in increased expression of FTH1 protein] |
CTD |
PMID:27095094 |
|
NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
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G |
Gal |
galanin and GMAP prepropeptide |
affects expression |
ISO |
Verapamil affects the expression of GAL protein |
CTD |
PMID:12388792 |
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NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
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G |
Gap43 |
growth associated protein 43 |
affects expression |
ISO |
Verapamil affects the expression of GAP43 protein |
CTD |
PMID:12388792 |
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NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
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G |
Gc |
GC, vitamin D binding protein |
affects expression |
EXP |
Verapamil affects the expression of GC protein |
CTD |
PMID:23533533 |
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NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567
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G |
Gfap |
glial fibrillary acidic protein |
multiple interactions increases expression |
EXP |
Verapamil inhibits the reaction [diphenylditelluride results in decreased phosphorylation of GFAP protein]; Verapamil inhibits the reaction [diphenylditelluride results in increased phosphorylation of GFAP protein] Verapamil results in increased expression of GFAP mRNA |
CTD |
PMID:21863293 PMID:21879721 PMID:22954530 |
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NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
Verapamil inhibits the reaction [Thioacetamide results in increased expression of GPT protein] |
CTD |
PMID:30526075 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gsn |
gelsolin |
affects expression |
EXP |
Verapamil affects the expression of GSN protein |
CTD |
PMID:23533533 |
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NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
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G |
Hamp |
hepcidin antimicrobial peptide |
multiple interactions |
ISO |
Verapamil promotes the reaction [Iron-Dextran Complex results in increased expression of HAMP mRNA] |
CTD |
PMID:27095094 |
|
NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
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G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
ISO EXP |
Verapamil results in increased expression of HMOX1 protein Verapamil inhibits the reaction [Thioacetamide results in decreased expression of HMOX1 mRNA] |
CTD |
PMID:21525764 PMID:30526075 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Iapp |
islet amyloid polypeptide |
multiple interactions |
EXP |
Verapamil inhibits the reaction [Glucose results in increased expression of IAPP mRNA] |
CTD |
PMID:9142872 |
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NCBI chr 4:175,237,107...175,244,373
Ensembl chr 4:175,237,115...175,242,920
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G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO |
Verapamil inhibits the reaction [Particulate Matter results in increased expression of IL1A mRNA] |
CTD |
PMID:15613243 |
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NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO EXP |
Verapamil inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] Verapamil inhibits the reaction [Diethylhexyl Phthalate results in increased secretion of IL6 protein] |
CTD |
PMID:20682585 PMID:35460826 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Insr |
insulin receptor |
multiple interactions |
EXP |
Verapamil inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of INSR mRNA]; Verapamil inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of INSR protein] |
CTD |
PMID:35460826 |
|
NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
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G |
Kcna10 |
potassium voltage-gated channel subfamily A member 10 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [KCNA10 protein results in increased transport of Potassium] |
CTD |
PMID:10836990 |
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NCBI chr 2:194,786,500...194,798,575
Ensembl chr 2:194,786,500...194,798,575
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G |
Kcna3 |
potassium voltage-gated channel subfamily A member 3 |
decreases activity multiple interactions |
ISO |
Verapamil results in decreased activity of KCNA3 protein [Verapamil results in decreased activity of KCNA3 protein] which results in decreased import of Thallium |
CTD |
PMID:21362439 |
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NCBI chr 2:194,632,106...194,634,059
Ensembl chr 2:194,632,196...194,650,138
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G |
Kcnd3 |
potassium voltage-gated channel subfamily D member 3 |
decreases activity |
ISO |
Verapamil results in decreased activity of KCND3 protein |
CTD |
PMID:11181069 |
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NCBI chr 2:192,937,950...193,155,345
Ensembl chr 2:192,937,950...193,155,345
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
multiple interactions decreases activity |
ISO |
[Verapamil results in decreased activity of KCNH2 protein] which results in decreased import of Thallium; Verapamil inhibits the reaction [KCNH2 protein results in increased transport of Thallium] |
CTD |
PMID:15671647 PMID:19583963 PMID:21158687 PMID:21362439 PMID:24052561 PMID:30561737 More...
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Kcnmb1 |
potassium calcium-activated channel subfamily M regulatory beta subunit 1 |
affects response to substance |
ISO |
KCNMB1 gene SNP affects the susceptibility to Verapamil |
CTD |
PMID:17700361 |
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NCBI chr10:18,557,510...18,614,824
Ensembl chr10:18,557,904...18,565,798
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G |
Lif |
LIF, interleukin 6 family cytokine |
multiple interactions |
EXP |
Verapamil inhibits the reaction [LIF protein results in increased activity of CAMK2A protein]; Verapamil inhibits the reaction [LIF protein results in increased activity of CAMK4 protein]; Verapamil inhibits the reaction [LIF protein results in increased phosphorylation of CAMK2A protein] |
CTD |
PMID:11073891 |
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NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [tetrabromobisphenol A results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:15456914 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [tetrabromobisphenol A results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:15456914 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP |
Verapamil inhibits the reaction [Gentamicins results in increased phosphorylation of and results in increased activity of MAPK8 protein] |
CTD |
PMID:15936777 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mmp13 |
matrix metallopeptidase 13 |
multiple interactions |
EXP |
Verapamil promotes the reaction [ferrous sulfate results in increased expression of MMP13 protein] |
CTD |
PMID:27095094 |
|
NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
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G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
Verapamil promotes the reaction [Paraquat results in increased activity of MPO protein] |
CTD |
PMID:17015168 |
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NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions |
EXP |
Verapamil inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of MTOR mRNA]; Verapamil inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of MTOR protein] |
CTD |
PMID:35460826 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Mybpc3 |
myosin binding protein C3 |
affects response to substance |
ISO |
MYBPC3 protein affects the susceptibility to Verapamil |
CTD |
PMID:23896226 |
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NCBI chr 3:77,095,165...77,113,406
Ensembl chr 3:77,095,252...77,113,405
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G |
Myh7 |
myosin heavy chain 7 |
multiple interactions decreases expression |
ISO |
Dexamethasone inhibits the reaction [Verapamil results in decreased expression of MYH7 mRNA]; Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [Verapamil results in decreased expression of MYH7 mRNA]] |
CTD |
PMID:19596060 |
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NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
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G |
Myl2 |
myosin light chain 2 |
multiple interactions decreases expression |
ISO |
[Verapamil co-treated with Doxorubicin] results in decreased expression of MYL2 mRNA; Dexamethasone inhibits the reaction [[Verapamil co-treated with Doxorubicin] results in decreased expression of MYL2 mRNA]; Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [[Verapamil co-treated with Doxorubicin] results in decreased expression of MYL2 mRNA]] Verapamil results in decreased expression of MYL2 mRNA |
CTD |
PMID:19596060 |
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NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983
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G |
Nanog |
Nanog homeobox |
multiple interactions |
ISO |
[Verapamil co-treated with kaempferol] results in decreased expression of NANOG mRNA; [Verapamil co-treated with kaempferol] results in decreased expression of NANOG protein |
CTD |
PMID:35063459 |
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NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
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G |
Nefl |
neurofilament light chain |
multiple interactions |
EXP |
Verapamil inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFL protein]; Verapamil inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFL protein] |
CTD |
PMID:21863293 PMID:21879721 |
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NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
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G |
Nefm |
neurofilament medium chain |
multiple interactions |
EXP |
Verapamil inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFM protein]; Verapamil inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFM protein] |
CTD |
PMID:21863293 PMID:21879721 |
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NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
affects localization multiple interactions |
ISO EXP |
Verapamil affects the localization of NFE2L2 protein Verapamil inhibits the reaction [Thioacetamide results in decreased expression of NFE2L2 mRNA]; Verapamil inhibits the reaction [Thioacetamide results in decreased expression of NFE2L2 protein]; Verapamil promotes the reaction [Cilostazol inhibits the reaction [Thioacetamide results in decreased expression of NFE2L2 protein]] |
CTD |
PMID:21525764 PMID:30295103 PMID:30526075 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
EXP |
Verapamil inhibits the reaction [Diethylhexyl Phthalate results in increased expression of NLRP3 mRNA]; Verapamil inhibits the reaction [Diethylhexyl Phthalate results in increased expression of NLRP3 protein] |
CTD |
PMID:35460826 |
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NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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G |
Nppa |
natriuretic peptide A |
multiple interactions affects secretion increases expression |
ISO |
[Cilazapril co-treated with Verapamil] affects the secretion of NPPA protein Verapamil affects the secretion of NPPA protein Verapamil results in increased expression of NPPA protein |
CTD |
PMID:1457087 PMID:11996326 |
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NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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G |
Nppb |
natriuretic peptide B |
multiple interactions |
ISO |
Verapamil inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]; Verapamil inhibits the reaction [EDN1 protein results in increased expression of NPPB protein] |
CTD |
PMID:28942281 |
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NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
EXP |
Verapamil inhibits the reaction [Thioacetamide results in decreased expression of NQO1 protein]; Verapamil promotes the reaction [Cilostazol inhibits the reaction [Thioacetamide results in decreased expression of NQO1 protein]] |
CTD |
PMID:30295103 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Nr0b1 |
nuclear receptor subfamily 0, group B, member 1 |
multiple interactions decreases expression |
ISO |
Verapamil promotes the reaction [Cyclic AMP results in decreased expression of NR0B1 mRNA] Verapamil results in decreased expression of NR0B1 mRNA |
CTD |
PMID:19822634 |
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NCBI chr X:50,756,886...50,761,014
Ensembl chr X:50,756,886...50,761,011
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases activity multiple interactions |
ISO |
Verapamil results in increased activity of NR1I2 protein [Verapamil results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA |
CTD |
PMID:25455453 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
multiple interactions |
ISO |
Verapamil promotes the reaction [Dexamethasone results in increased activity of NR3C1 protein] |
CTD |
PMID:12871829 |
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NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [PARP1 gene mutant form results in decreased uptake of Doxorubicin] [Verapamil co-treated with gambogic acid] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[Verapamil co-treated with gambogic acid] results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [[Verapamil co-treated with gambogic acid] results in increased cleavage of PARP1 protein] |
CTD |
PMID:15861398 PMID:24373880 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pf4 |
platelet factor 4 |
decreases expression |
ISO |
Verapamil results in decreased expression of PF4 protein |
CTD |
PMID:2962587 |
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NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365
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G |
Polr1h |
RNA polymerase I subunit H |
multiple interactions |
ISO |
Verapamil inhibits the reaction [POLR1H protein results in decreased susceptibility to Doxorubicin]; Verapamil inhibits the reaction [POLR1H protein results in decreased susceptibility to Etoposide]; Verapamil inhibits the reaction [POLR1H protein results in decreased susceptibility to Vincristine]; Verapamil inhibits the reaction [POLR1H protein results in increased secretion of Doxorubicin] |
CTD |
PMID:14726695 |
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NCBI chr20:1,594,936...1,598,854
Ensembl chr20:1,594,936...1,598,854
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G |
Pou5f1 |
POU class 5 homeobox 1 |
multiple interactions |
ISO |
[Verapamil co-treated with kaempferol] results in decreased expression of POU5F1 mRNA; [Verapamil co-treated with kaempferol] results in decreased expression of POU5F1 protein |
CTD |
PMID:35063459 |
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NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
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G |
Ppbp |
pro-platelet basic protein |
decreases expression |
ISO |
Verapamil results in decreased expression of PPBP protein |
CTD |
PMID:2962587 |
|
NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130
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G |
Ppp3cb |
protein phosphatase 3 catalytic subunit beta |
multiple interactions |
ISO |
Verapamil inhibits the reaction [bisphenol F results in increased expression of PPP3CB protein] |
CTD |
PMID:34023961 |
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NCBI chr15:3,759,950...3,804,976
Ensembl chr15:3,760,030...3,804,981
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G |
Prl |
prolactin |
multiple interactions increases expression increases secretion |
ISO |
Verapamil inhibits the reaction [Sulpiride results in increased secretion of PRL protein]; Verapamil promotes the reaction [TRH protein results in increased secretion of PRL protein] Verapamil results in increased expression of PRL protein Verapamil results in increased secretion of PRL protein |
CTD |
PMID:7851873 PMID:8845563 PMID:8977754 PMID:20595935 |
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NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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G |
Ret |
ret proto-oncogene |
affects expression |
ISO |
Verapamil affects the expression of RET protein |
CTD |
PMID:12388792 |
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NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176
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G |
Slc11a2 |
solute carrier family 11 member 2 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [Iron-Dextran Complex results in increased expression of SLC11A2 protein] |
CTD |
PMID:27095094 |
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NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145
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G |
Slc19a3 |
solute carrier family 19 member 3 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Verapamil inhibits the reaction [SLC19A3 protein results in increased uptake of Thiamine] |
CTD |
PMID:26528626 |
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NCBI chr 9:84,275,722...84,299,368
Ensembl chr 9:84,277,024...84,299,337
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G |
Slc22a1 |
solute carrier family 22 member 1 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium]; Verapamil inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Verapamil inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Verapamil inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium] |
CTD |
PMID:21641380 PMID:25466967 PMID:25862123 PMID:27450509 PMID:27989701 |
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NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO EXP |
Verapamil inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] Verapamil inhibits the reaction [SLC22A2 protein results in increased uptake of mepiquat] |
CTD |
PMID:21599003 PMID:33639197 |
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NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G |
Slc22a3 |
solute carrier family 22 member 3 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Verapamil inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin] |
CTD |
PMID:21641380 PMID:21697722 |
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NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
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G |
Slc22a4 |
solute carrier family 22 member 4 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] |
CTD |
PMID:21641380 |
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NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720
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G |
Slc22a5 |
solute carrier family 22 member 5 |
decreases activity |
ISO |
Verapamil results in decreased activity of SLC22A5 protein |
CTD |
PMID:15486076 |
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NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
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G |
Slc2a4 |
solute carrier family 2 member 4 |
multiple interactions |
EXP |
Verapamil inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SLC2A4 mRNA]; Verapamil inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SLC2A4 protein] |
CTD |
PMID:35460826 |
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NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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G |
Slc47a1 |
solute carrier family 47 member 1 |
multiple interactions decreases activity |
ISO |
Verapamil inhibits the reaction [SLC47A1 protein results in increased import of Tetraethylammonium]; Verapamil inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Verapamil inhibits the reaction [SLC47A1 protein results in increased uptake of Tetraethylammonium] Verapamil results in decreased activity of SLC47A1 protein |
CTD |
PMID:22419765 PMID:27450509 PMID:27989701 PMID:31364238 |
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NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
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G |
Slc47a2 |
solute carrier family 47 member 2 |
multiple interactions decreases activity |
ISO |
Verapamil inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Verapamil inhibits the reaction [SLC47A2 protein results in increased uptake of Tetraethylammonium] Verapamil results in decreased activity of SLC47A2 protein |
CTD |
PMID:22419765 PMID:27989701 PMID:28629854 PMID:31364238 |
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NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
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G |
Slco1a4 |
solute carrier organic anion transporter family, member 1a4 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [SLCO1A2 protein results in increased uptake of Quercetin] |
CTD |
PMID:24947867 |
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NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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G |
Smad2 |
SMAD family member 2 |
multiple interactions |
ISO |
Verapamil inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] |
CTD |
PMID:34217686 |
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NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
EXP |
[Verapamil co-treated with Cilostazol] inhibits the reaction [Thioacetamide results in decreased activity of SOD1 protein]; Verapamil inhibits the reaction [Dexamethasone inhibits the reaction [Paraquat results in increased activity of SOD1 protein]]; Verapamil inhibits the reaction [Thioacetamide results in decreased activity of SOD1 protein] |
CTD |
PMID:17015168 PMID:30295103 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
EXP |
Verapamil inhibits the reaction [Dexamethasone inhibits the reaction [Paraquat results in increased activity of SOD2 protein]] |
CTD |
PMID:17015168 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Sox2 |
SRY-box transcription factor 2 |
multiple interactions |
ISO |
[Verapamil co-treated with kaempferol] results in decreased expression of SOX2 mRNA |
CTD |
PMID:35063459 |
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NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338
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G |
Star |
steroidogenic acute regulatory protein |
multiple interactions |
ISO |
[Cyclic AMP co-treated with Verapamil] results in increased expression of STAR protein; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Cyclic AMP co-treated with Verapamil] results in increased expression of STAR protein]; N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Cyclic AMP co-treated with Verapamil] results in increased expression of STAR protein]; Verapamil promotes the reaction [Cyclic AMP results in increased expression of STAR mRNA]; Verapamil promotes the reaction [Cyclic AMP results in increased expression of STAR protein] |
CTD |
PMID:19822634 |
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NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
EXP |
Verapamil inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased expression of STAT3 protein]; Verapamil inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased expression of STAT3 protein] |
CTD |
PMID:19299911 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP ISO |
Verapamil inhibits the reaction [[Carbon Tetrachloride co-treated with lard co-treated with Ethanol] results in increased expression of TGFB1 protein] Verapamil inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; Verapamil inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 protein]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; Verapamil inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; Verapamil inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] |
CTD |
PMID:17223571 PMID:34217686 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
affects expression multiple interactions |
ISO EXP |
Verapamil affects the expression of TIMP1 protein Verapamil inhibits the reaction [ferrous sulfate results in increased expression of TIMP1 protein] |
CTD |
PMID:12388792 PMID:27095094 |
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NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO EXP |
Verapamil affects the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Verapamil inhibits the reaction [Particulate Matter results in increased secretion of TNF protein] Verapamil inhibits the reaction [tert-Butylhydroperoxide results in increased secretion of TNF protein] Verapamil inhibits the reaction [Diethylhexyl Phthalate results in increased secretion of TNF protein] |
CTD |
PMID:15613243 PMID:17092623 PMID:17129690 PMID:17369293 PMID:35460826 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Trh |
thyrotropin releasing hormone |
multiple interactions |
ISO |
Verapamil inhibits the reaction [TRH protein results in increased secretion of TSHB protein]; Verapamil promotes the reaction [TRH protein results in increased secretion of PRL protein] |
CTD |
PMID:7851873 |
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NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637
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G |
Tshb |
thyroid stimulating hormone subunit beta |
multiple interactions |
ISO |
Verapamil inhibits the reaction [TRH protein results in increased secretion of TSHB protein] |
CTD |
PMID:7851873 |
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NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
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G |
Txnip |
thioredoxin interacting protein |
multiple interactions |
EXP |
Verapamil inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TXNIP mRNA]; Verapamil inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TXNIP protein] |
CTD |
PMID:35460826 |
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NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
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G |
Vim |
vimentin |
multiple interactions |
EXP ISO |
Verapamil inhibits the reaction [diphenylditelluride results in decreased phosphorylation of VIM protein]; Verapamil inhibits the reaction [diphenylditelluride results in increased phosphorylation of VIM protein] Verapamil inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] |
CTD |
PMID:21863293 PMID:21879721 PMID:34217686 |
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NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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