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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:valsartan
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Accession:CHEBI:9927 term browser browse the term
Definition:A monocarboxylic acid amide consisting of L-valine in which the amino hydrogens have been replaced by a pentanoyl and a [2'-(1H-tetrazol-5-yl)biphenyl]-4-yl]methyl group. It exhibits antihypertensive activity.
Synonyms:exact_synonym: N-pentanoyl-N-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-L-valine
 related_synonym: (S)-N-valeryl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl}-valine;   Diovan;   Formula=C24H29N5O3;   InChI=1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1;   InChIKey=ACWBQPMHZXGDFX-QFIPXVFZSA-N;   N-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)-N-valeryl-L-valine;   N-pentanoyl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-L-valine;   SMILES=CCCCC(=O)N(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)[C@@H](C(C)C)C(O)=O
 xref: Beilstein:7754038;   CAS:137862-53-4;   DrugBank:DB00177;   Drug_Central:2806;   HMDB:HMDB0014323;   KEGG:D00400;   LINCS:LSM-2993
 xref_mesh: MESH:C081489
 xref: Patent:EP443983;   Patent:US5399578;   Reaxys:7754038;   Wikipedia:Valsartan


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valsartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme multiple interactions
decreases expression
EXP Valsartan inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of ACE protein]
Valsartan results in decreased expression of ACE mRNA
CTD PMID:23733546 PMID:31023080 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Ace2 angiotensin I converting enzyme 2 multiple interactions EXP Valsartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA] CTD PMID:16176966 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of ADAMTS1 mRNA] CTD PMID:19225232 NCBI chr11:25,342,119...25,350,938
Ensembl chr11:25,342,126...25,350,974
JBrowse link
G Agt angiotensinogen multiple interactions
increases expression
ISO
EXP
[benazepril co-treated with Valsartan] results in decreased expression of AGT protein modified form; [Valsartan co-treated with benidipine] inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; [Valsartan co-treated with Simvastatin] inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]; [Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; [Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]; Valsartan inhibits the reaction [AGT protein affects the localization of STAT1 protein]; Valsartan inhibits the reaction [AGT protein affects the localization of STAT3 protein]; Valsartan inhibits the reaction [AGT protein results in decreased expression of APOE protein]; Valsartan inhibits the reaction [AGT protein results in decreased expression of BMP4 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of CDKN1B mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of FZD2 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of ID2 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of IER2 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of MN1 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of PPP1R3C mRNA]; Valsartan inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; Valsartan inhibits the reaction [AGT protein results in increased activity of STAT1 protein]; Valsartan inhibits the reaction [AGT protein results in increased activity of STAT3 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of ADAMTS1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CCL2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of CYBB mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CYBB protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of DUSP5 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of DYRK2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of EGR1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of FGF5 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of FILIP1L mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of FOSL1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of HBEGF mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of HDAC9 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of HIVEP1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of IER3 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of INHBA mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of KDR mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of KLF9 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of LIF mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of MAFF mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of NFIL3 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of NUP98 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of PLAUR mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of PTGS2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of RCAN1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of RGS3 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SLC25A32 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SNN mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SPRY2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of TGIF1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of TIMP1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of TIMP1 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of STAT1 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of STAT3 protein]; Valsartan inhibits the reaction [AGT protein results in increased secretion of SERPINE1 protein]; Valsartan inhibits the reaction [benazepril results in decreased expression of AGT protein]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of EGR1 mRNA]]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of KLF10 mRNA]]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]
Valsartan results in increased expression of AGT protein; Valsartan results in increased expression of AGT protein modified form
Dactinomycin promotes the reaction [Valsartan inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Valsartan inhibits the reaction [AGT protein affects the localization of ELAVL1 protein]; Valsartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; Valsartan inhibits the reaction [AGT protein results in decreased export of Sodium]; Valsartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of SYP protein]; Valsartan inhibits the reaction [AGT protein results in increased abundance of Nitric Oxide]; Valsartan inhibits the reaction [AGT protein results in increased abundance of Oxygen]; Valsartan inhibits the reaction [AGT protein results in increased abundance of Prostaglandins E]; Valsartan inhibits the reaction [AGT protein results in increased activity of SERPINE1 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of AGTR2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of AGTR2 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT1 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of ENG protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of KDR mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of SPP1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SPP1 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of TEK mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of VEGFA mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of VEGFA protein]; Valsartan inhibits the reaction [AGT protein results in increased secretion of Nitric Oxide]; Valsartan inhibits the reaction [AGT protein results in increased ubiquitination of SYP protein]; Valsartan inhibits the reaction [Dimethylnitrosamine results in increased expression of AGT protein]; Valsartan inhibits the reaction [Oxygen deficiency promotes the reaction [AGT protein results in increased expression of NOS3 protein]]; Valsartan inhibits the reaction [Oxygen deficiency promotes the reaction [AGT protein results in increased expression of VEGFA protein]]; Valsartan promotes the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]]; Valsartan promotes the reaction [AGT protein results in increased expression of FOS mRNA]; Valsartan promotes the reaction [AGT protein results in increased expression of JUN mRNA]; Valsartan promotes the reaction [AGT protein results in increased expression of MAP2 protein]; Valsartan promotes the reaction [AGT protein results in increased expression of TUBB3 protein]; Valsartan promotes the reaction [AGT protein results in increased expression of UBE2V2 protein]; Valsartan promotes the reaction [Glucose results in increased expression of AGT protein]; Valsartan promotes the reaction [Particulate Matter results in increased expression of AGT protein modified form]
[Valsartan co-treated with AGT protein] results in increased activity of LPL protein; Valsartan inhibits the reaction [AGT protein results in increased activity of ALOX15 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of CXCL10 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CXCL10 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of OSR1 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of SLC12A3 protein]; Valsartan promotes the reaction [AGT protein results in increased expression of UBE2V2 mRNA]; Valsartan promotes the reaction [AGT protein results in increased expression of UBE2V2 protein]
CTD PMID:9261183 PMID:10082498 PMID:11115077 PMID:11244025 PMID:11403356 PMID:11501062 PMID:11897773 PMID:12676074 PMID:12846741 PMID:14597645 PMID:14597853 PMID:14620932 PMID:14638905 PMID:14718351 PMID:15005273 PMID:15504291 PMID:15539634 PMID:15643130 PMID:15677497 PMID:15831366 PMID:16176966 PMID:16705055 PMID:16769992 PMID:17068200 PMID:17485602 PMID:17785354 PMID:18331727 PMID:18390891 PMID:18487452 PMID:18619357 PMID:18640387 PMID:18716376 PMID:18846332 PMID:19041135 PMID:19145780 PMID:19225232 PMID:19246637 PMID:19861503 PMID:20175999 PMID:20718632 PMID:23288202 PMID:23300732 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression
multiple interactions
EXP
ISO
Valsartan results in decreased expression of AGTR1A mRNA
Valsartan binds to and results in decreased activity of AGTR1 protein
CTD PMID:18403896 PMID:28973481 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Agtr2 angiotensin II receptor, type 2 affects response to substance
increases expression
decreases expression
multiple interactions
ISO
EXP
AGTR2 affects the susceptibility to Valsartan
Valsartan results in increased expression of AGTR2 protein
Valsartan results in decreased expression of AGTR2 mRNA
[PD 123319 results in decreased activity of AGTR2 protein] inhibits the reaction [Valsartan results in increased abundance of Cyclic GMP]; [PD 123319 results in decreased activity of AGTR2 protein] which results in decreased susceptibility to Valsartan; Valsartan inhibits the reaction [AGT protein results in increased expression of AGTR2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of AGTR2 protein]
CTD PMID:11403356 PMID:12215461 PMID:16982965 PMID:18403896 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO
EXP
Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein] CTD PMID:31009642 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin multiple interactions
decreases export
EXP
ISO
Valsartan inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein]
Valsartan results in decreased export of ALB protein
CTD PMID:16872305 PMID:17664856 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Alox15 arachidonate 15-lipoxygenase multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased activity of ALOX15 protein] CTD PMID:9261183 NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161
JBrowse link
G Ang angiogenin decreases expression ISO Valsartan results in decreased expression of ANG mRNA CTD PMID:22768174 NCBI chr15:28,022,926...28,028,636 JBrowse link
G Angpt1 angiopoietin 1 multiple interactions EXP Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT1 protein] CTD PMID:14638905 NCBI chr 7:81,338,327...81,592,459
Ensembl chr 7:81,342,280...81,592,206
JBrowse link
G Angpt2 angiopoietin 2 multiple interactions EXP Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT2 mRNA] CTD PMID:14638905 NCBI chr16:75,966,480...76,016,147
Ensembl chr16:75,966,352...76,016,195
JBrowse link
G Apcs amyloid P component, serum decreases expression ISO Valsartan results in decreased expression of APCS protein CTD PMID:16129801 NCBI chr13:91,426,621...91,427,417
Ensembl chr13:91,426,479...91,427,575
JBrowse link
G Apob apolipoprotein B multiple interactions ISO [Valsartan co-treated with benazepril] results in decreased expression of APOB protein; fluvastatin promotes the reaction [[Valsartan co-treated with benazepril] results in decreased expression of APOB protein] CTD PMID:20671225 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
JBrowse link
G Apoe apolipoprotein E multiple interactions ISO [Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with Atorvastatin co-treated with Valsartan] results in decreased expression of APOE protein; Valsartan inhibits the reaction [AGT protein results in decreased expression of APOE protein] CTD PMID:17785354 PMID:19603250 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Aqp1 aquaporin 1 multiple interactions EXP Valsartan inhibits the reaction [Glucose results in increased expression of AQP1 mRNA] CTD PMID:11510275 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Aqp4 aquaporin 4 multiple interactions EXP Valsartan inhibits the reaction [Glucose results in increased expression of AQP4 mRNA] CTD PMID:11510275 NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996
JBrowse link
G Atp6ap2 ATPase H+ transporting accessory protein 2 multiple interactions EXP Valsartan inhibits the reaction [Streptozocin results in increased expression of ATP6AP2 mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of ATP6AP2 protein] CTD PMID:18192338 NCBI chr  X:11,137,889...11,164,854
Ensembl chr  X:11,136,939...11,164,915
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BAX protein] CTD PMID:32197949 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BBC3 mRNA] CTD PMID:32197949 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 protein] CTD PMID:32197949 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BCL2L11 mRNA] CTD PMID:32197949 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bdkrb1 bradykinin receptor B1 multiple interactions EXP [bradykinin, Leu(8)-des-Arg(9)- results in decreased activity of BDKRB1 protein] inhibits the reaction [Valsartan results in increased abundance of Cyclic GMP]; [bradykinin, Leu(8)-des-Arg(9)- results in decreased activity of BDKRB1 protein] which results in decreased susceptibility to Valsartan CTD PMID:16982965 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574
JBrowse link
G Bdkrb2 bradykinin receptor B2 multiple interactions EXP [icatibant results in decreased activity of BDKRB2 protein] inhibits the reaction [Valsartan results in increased abundance of Cyclic GMP]; [icatibant results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to Valsartan CTD PMID:16982965 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G Bmp4 bone morphogenetic protein 4 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in decreased expression of BMP4 mRNA] CTD PMID:19225232 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Bmp7 bone morphogenetic protein 7 multiple interactions EXP Valsartan inhibits the reaction [Tacrolimus results in decreased expression of BMP7 protein] CTD PMID:17703430 NCBI chr 3:170,879,972...170,955,820
Ensembl chr 3:170,879,973...170,955,399
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Valsartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; Valsartan inhibits the reaction [Cyclophosphamide results in increased activity of CASP3 protein] CTD PMID:23300732 PMID:32197949 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp4 caspase 4 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased cleavage of CASP4 protein] CTD PMID:32197949 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP
[Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; Valsartan inhibits the reaction [AGT protein results in increased expression of CCL2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; Valsartan inhibits the reaction [sodium arsenite results in increased secretion of CCL2 protein]
Valsartan inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]
Valsartan inhibits the reaction [Oxygen deficiency results in increased expression of CCL2 mRNA]
CTD PMID:15284299 PMID:16705055 PMID:17624267 PMID:18436887 PMID:19225232 PMID:28973481 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cd163 CD163 molecule decreases expression ISO Valsartan results in decreased expression of CD163 mRNA CTD PMID:22768174 NCBI chr 4:156,752,063...156,785,467
Ensembl chr 4:156,752,082...156,785,467
JBrowse link
G Cd34 CD34 molecule decreases expression ISO Valsartan results in decreased expression of CD34 mRNA CTD PMID:22768174 NCBI chr13:113,691,842...113,711,259
Ensembl chr13:113,691,932...113,711,647
JBrowse link
G Cd68 Cd68 molecule decreases expression ISO Valsartan results in decreased expression of CD68 mRNA CTD PMID:22768174 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in decreased expression of CDKN1B mRNA] CTD PMID:19225232 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression ISO Valsartan results in decreased expression of CEBPA mRNA CTD PMID:22768174 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL1A1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL1A1 protein] CTD PMID:31009642 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL3A1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL3A1 protein] CTD PMID:31009642 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Crem cAMP responsive element modulator decreases expression EXP Valsartan results in decreased expression of CREM mRNA CTD PMID:19027736 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888
JBrowse link
G Ctf1 cardiotrophin 1 multiple interactions EXP Dactinomycin promotes the reaction [Valsartan inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Valsartan inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of CTF1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of CTF1 protein] CTD PMID:23288202 NCBI chr 1:199,162,319...199,168,296
Ensembl chr 1:199,163,086...199,168,296
JBrowse link
G Ctss cathepsin S decreases expression ISO Valsartan results in decreased expression of CTSS mRNA CTD PMID:22768174 NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458
JBrowse link
G Cxadr CXADR, Ig-like cell adhesion molecule decreases expression ISO Valsartan results in decreased expression of CXADR mRNA; Valsartan results in decreased expression of CXADR protein CTD PMID:20392896 NCBI chr11:16,826,269...16,873,564
Ensembl chr11:16,826,399...16,873,562
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of CXCL10 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CXCL10 protein] CTD PMID:18716376 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of CYBB mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CYBB protein] CTD PMID:15643130 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 decreases expression EXP Valsartan results in decreased expression of CYP11B2 mRNA; Valsartan results in decreased expression of CYP11B2 protein CTD PMID:16043663 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects response to substance ISO CYP3A5 gene affects the susceptibility to Valsartan CTD PMID:22149319 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of DDIT3 mRNA]; Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of DDIT3 protein] CTD PMID:32197949 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Des desmin multiple interactions EXP Valsartan inhibits the reaction [Streptozocin results in increased expression of DES protein] CTD PMID:17624267 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294
JBrowse link
G Dusp5 dual specificity phosphatase 5 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of DUSP5 mRNA] CTD PMID:19225232 NCBI chr 1:274,245,184...274,258,595
Ensembl chr 1:274,245,184...274,258,595
JBrowse link
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of DYRK2 mRNA] CTD PMID:19225232 NCBI chr 7:61,785,423...61,816,775
Ensembl chr 7:61,786,309...61,798,729
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP [Valsartan co-treated with benazepril] results in decreased expression of EDN1 protein CTD PMID:11136700 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Ednra endothelin receptor type A decreases expression EXP Valsartan results in decreased expression of EDNRA mRNA CTD PMID:28951255 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of EGR1 mRNA]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of EGR1 mRNA]] CTD PMID:19225232 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased phosphorylation of EIF2AK3 protein] CTD PMID:32197949 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Elavl1 ELAV like RNA binding protein 1 multiple interactions EXP Valsartan inhibits the reaction [AGT protein affects the localization of ELAVL1 protein] CTD PMID:19246637 NCBI chr12:2,461,502...2,502,432
Ensembl chr12:2,461,502...2,502,432
JBrowse link
G Eng endoglin multiple interactions EXP Valsartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of ENG protein] CTD PMID:15539634 NCBI chr 3:11,679,530...11,717,486
Ensembl chr 3:11,679,530...11,717,485
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased phosphorylation of ERN1 protein] CTD PMID:32197949 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO Valsartan results in decreased expression of FABP4 mRNA CTD PMID:22768174 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP benazepril promotes the reaction [Valsartan inhibits the reaction [Doxorubicin results in increased expression of FAS protein]]; Valsartan inhibits the reaction [Doxorubicin results in increased expression of FAS protein]; Valsartan promotes the reaction [benazepril inhibits the reaction [Doxorubicin results in increased expression of FAS protein]] CTD PMID:15315341 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions EXP benazepril promotes the reaction [Valsartan inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]]; Valsartan inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]; Valsartan promotes the reaction [benazepril inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]] CTD PMID:15315341 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fgf5 fibroblast growth factor 5 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of FGF5 mRNA] CTD PMID:19225232 NCBI chr14:12,974,921...12,996,046
Ensembl chr14:12,974,921...12,995,584
JBrowse link
G Filip1l filamin A interacting protein 1-like multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of FILIP1L mRNA] CTD PMID:19225232 NCBI chr11:45,039,488...45,275,141
Ensembl chr11:45,039,461...45,124,423
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Valsartan promotes the reaction [AGT protein results in increased expression of FOS mRNA] CTD PMID:18619357 PMID:18846332 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of FOSL1 mRNA] CTD PMID:19225232 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in decreased secretion of FSHB protein] CTD PMID:32197949 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Fzd2 frizzled class receptor 2 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in decreased expression of FZD2 mRNA] CTD PMID:19225232 NCBI chr10:90,550,147...90,552,057
Ensembl chr10:90,550,147...90,552,057
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP
ISO
Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein] CTD PMID:31009642 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of HBEGF mRNA] CTD PMID:19225232 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
JBrowse link
G Hdac2 histone deacetylase 2 multiple interactions EXP
ISO
Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of HDAC2 protein] CTD PMID:31009642 NCBI chr20:43,084,870...43,108,198
Ensembl chr20:43,084,870...43,108,198
JBrowse link
G Hdac9 histone deacetylase 9 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of HDAC9 mRNA] CTD PMID:19225232 NCBI chr 6:53,487,367...54,358,694
Ensembl chr 6:53,488,883...54,059,119
JBrowse link
G Hgf hepatocyte growth factor multiple interactions EXP Valsartan inhibits the reaction [Bleomycin results in decreased expression of HGF mRNA]; Valsartan inhibits the reaction [Bleomycin results in decreased expression of HGF protein] CTD PMID:16115399 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hivep1 HIVEP zinc finger 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of HIVEP1 mRNA] CTD PMID:19225232 NCBI chr17:22,278,103...22,403,362
Ensembl chr17:22,278,798...22,311,392
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 protein] CTD PMID:32197949 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Valsartan inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]
Valsartan inhibits the reaction [sodium arsenite results in increased secretion of ICAM1 protein modified form]
CTD PMID:17724226 PMID:28973481 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Id2 inhibitor of DNA binding 2 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in decreased expression of ID2 mRNA] CTD PMID:19225232 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Ier2 immediate early response 2 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in decreased expression of IER2 mRNA] CTD PMID:19225232 NCBI chr19:25,774,146...25,775,670
Ensembl chr19:25,774,143...25,775,659
JBrowse link
G Ier3 immediate early response 3 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of IER3 mRNA] CTD PMID:19225232 NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769
JBrowse link
G Il1b interleukin 1 beta decreases expression EXP Valsartan results in decreased expression of IL1B mRNA CTD PMID:28951255 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Tacrolimus co-treated with Valsartan] results in decreased expression of IL6 protein; [Tacrolimus co-treated with Valsartan] results in increased expression of IL6 protein CTD PMID:16549154 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Inhba inhibin subunit beta A multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of INHBA mRNA] CTD PMID:19225232 NCBI chr17:51,894,869...51,919,998
Ensembl chr17:51,898,217...51,912,496
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]] CTD PMID:15677497 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Valsartan promotes the reaction [AGT protein results in increased expression of JUN mRNA] CTD PMID:18619357 PMID:18846332 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO
EXP
Valsartan inhibits the reaction [AGT protein results in increased expression of KDR mRNA] CTD PMID:14638905 PMID:15005273 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Kl Klotho increases expression EXP Valsartan results in increased expression of KL mRNA; Valsartan results in increased expression of KL protein CTD PMID:21051829 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
JBrowse link
G Klf10 Kruppel-like factor 10 multiple interactions ISO [Valsartan co-treated with Simvastatin] inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of KLF10 mRNA]] CTD PMID:19225232 NCBI chr 7:77,156,010...77,162,096
Ensembl chr 7:77,156,006...77,162,148
JBrowse link
G Klf9 Kruppel-like factor 9 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of KLF9 mRNA] CTD PMID:19225232 NCBI chr 1:240,908,483...240,933,198
Ensembl chr 1:240,908,483...240,933,198
JBrowse link
G Kng2 kininogen 2 multiple interactions
increases expression
EXP benazepril promotes the reaction [Valsartan results in increased expression of KNG1 protein modified form]; PD 123319 inhibits the reaction [benazepril promotes the reaction [Valsartan results in increased expression of KNG1 protein modified form]]; PD 123319 inhibits the reaction [Valsartan promotes the reaction [benazepril results in increased expression of KNG1 protein modified form]]; Valsartan promotes the reaction [benazepril results in increased expression of KNG1 protein modified form] CTD PMID:11509473 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in decreased secretion of LHB protein] CTD PMID:32197949 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Lif LIF, interleukin 6 family cytokine multiple interactions ISO [Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]; Valsartan inhibits the reaction [AGT protein results in increased expression of LIF mRNA]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]] CTD PMID:19225232 NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642
JBrowse link
G Lpl lipoprotein lipase multiple interactions
increases activity
ISO [Valsartan co-treated with AGT protein] results in increased activity of LPL protein
Valsartan results in increased activity of LPL protein
CTD PMID:18640387 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Maff MAF bZIP transcription factor F multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of MAFF mRNA] CTD PMID:19225232 NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions EXP Valsartan promotes the reaction [AGT protein results in increased expression of MAP2 protein] CTD PMID:17068200 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein] CTD PMID:19041135 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein] CTD PMID:19041135 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
EXP [Valsartan co-treated with Fosinopril] results in decreased expression of MMP9 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of MMP9 protein
Valsartan results in decreased expression of MMP9 mRNA; Valsartan results in decreased expression of MMP9 protein
CTD PMID:21051829 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mn1 MN1 proto-oncogene, transcriptional regulator multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in decreased expression of MN1 mRNA] CTD PMID:19225232 NCBI chr12:51,214,192...51,250,230
Ensembl chr12:51,214,192...51,250,230
JBrowse link
G Mrc1 mannose receptor, C type 1 decreases expression ISO Valsartan results in decreased expression of MRC1 mRNA CTD PMID:22768174 NCBI chr17:81,352,700...81,433,743
Ensembl chr17:81,352,700...81,433,743
JBrowse link
G Mtus1 microtubule associated scaffold protein 1 multiple interactions EXP Valsartan promotes the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]] CTD PMID:17068200 NCBI chr16:54,240,892...54,386,131
Ensembl chr16:54,291,251...54,386,129
JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions
increases expression
EXP
ISO
[Valsartan co-treated with benazepril] results in increased expression of MYH6 mRNA
Valsartan inhibits the reaction [Isoproterenol results in increased expression of MYH6 protein]
Valsartan results in increased expression of MYH6 mRNA
CTD PMID:11136700 PMID:31009642 NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699
JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions ISO Valsartan inhibits the reaction [Isoproterenol results in increased expression of MYH7 mRNA] CTD PMID:31009642 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of NFIL3 mRNA] CTD PMID:19225232 NCBI chr17:12,261,102...12,276,316
Ensembl chr17:12,261,102...12,276,315
JBrowse link
G Nos1 nitric oxide synthase 1 decreases expression EXP Valsartan results in decreased expression of NOS1 protein CTD PMID:31023080 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein] CTD PMID:32197949 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases expression
EXP
ISO
[fluvastatin co-treated with Valsartan] results in increased expression of NOS3 mRNA; Valsartan inhibits the reaction [Oxygen deficiency promotes the reaction [AGT protein results in increased expression of NOS3 protein]]
Valsartan results in decreased expression of NOS3 protein
Valsartan inhibits the reaction [Oxygen deficiency results in increased phosphorylation of NOS3 protein]
CTD PMID:11897773 PMID:18436887 PMID:28951255 PMID:31023080 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP Valsartan inhibits reaction [streptozotocin decreases expression of Nphs1 mRNA and protein in kidney]
Valsartan inhibits the reaction [Streptozocin results in decreased expression of NPHS1 mRNA]; Valsartan inhibits the reaction [Streptozocin results in decreased expression of NPHS1 protein]
CTD PMID:17624267, PMID:17624267 RGD:38596322 NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559
JBrowse link
G Nppa natriuretic peptide A multiple interactions
decreases expression
EXP
ISO
[Valsartan co-treated with benazepril] results in decreased expression of NPPA mRNA; Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]
Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPA protein]
Valsartan results in decreased expression of NPPA mRNA
CTD PMID:11136700 PMID:23288202 PMID:31009642 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppb natriuretic peptide B multiple interactions
decreases expression
ISO
EXP
Valsartan inhibits the reaction [CHOP protocol results in increased expression of NPPB protein]
Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]
Valsartan results in decreased expression of NPPB mRNA
[Valsartan co-treated with benazepril] results in decreased expression of NPPB mRNA
Valsartan results in decreased expression of NPPB protein
CTD PMID:11136700 PMID:12417542 PMID:16247790 PMID:31009642 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of NQO1 protein] CTD PMID:32197949 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nup98 nucleoporin 98 and 96 precursor multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of NUP98 mRNA] CTD PMID:19225232 NCBI chr 1:167,213,866...167,308,851
Ensembl chr 1:167,213,866...167,308,851
JBrowse link
G Osr1 odd-skipped related transcription factor 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of OSR1 protein] CTD PMID:20175999 NCBI chr 6:35,314,431...35,321,458
Ensembl chr 6:35,314,444...35,321,667
JBrowse link
G Pde3a phosphodiesterase 3A increases expression EXP Valsartan results in increased expression of PDE3A mRNA CTD PMID:19027736 NCBI chr 4:175,431,904...175,703,844
Ensembl chr 4:175,431,904...175,700,238
JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of PLAUR mRNA] CTD PMID:19225232 NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708
JBrowse link
G Postn periostin multiple interactions EXP Valsartan inhibits the reaction [AGT protein results in increased expression of POSTN mRNA] CTD PMID:17485602 NCBI chr 2:143,656,820...143,688,087
Ensembl chr 2:143,656,793...143,688,087
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO Valsartan results in decreased expression of PPARG mRNA CTD PMID:22768174 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in decreased expression of PPP1R3C mRNA] CTD PMID:19225232 NCBI chr 1:255,371,830...255,376,833
Ensembl chr 1:255,371,810...255,376,833
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
Valsartan inhibits the reaction [AGT protein results in increased expression of PTGS2 mRNA]
Valsartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]
CTD PMID:19145780 PMID:19225232 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 multiple interactions EXP Valsartan promotes the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]] CTD PMID:17068200 NCBI chr 4:157,239,141...157,263,890
Ensembl chr 4:157,239,142...157,263,890
JBrowse link
G Rcan1 regulator of calcineurin 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of RCAN1 mRNA] CTD PMID:19225232 NCBI chr11:32,539,689...32,620,274
Ensembl chr11:32,539,683...32,550,539
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased phosphorylation of RELA protein] CTD PMID:32197949 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ren renin multiple interactions
increases expression
increases activity
ISO
EXP
[benazepril co-treated with Valsartan] results in increased activity of REN protein
Valsartan results in increased expression of REN protein
Valsartan results in increased activity of REN protein
CTD PMID:8505092 PMID:10836730 PMID:11501062 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Rgs3 regulator of G-protein signaling 3 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of RGS3 mRNA] CTD PMID:19225232 NCBI chr 5:78,429,017...78,567,281
Ensembl chr 5:78,428,669...78,567,288
JBrowse link
G Sele selectin E multiple interactions ISO Valsartan inhibits the reaction [sodium arsenite results in increased expression of SELE protein] CTD PMID:28973481 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions
decreases expression
ISO
EXP
Valsartan inhibits the reaction [AGT protein results in increased secretion of SERPINE1 protein]
Valsartan results in decreased expression of SERPINE1 mRNA; Valsartan results in decreased expression of SERPINE1 protein
[Valsartan co-treated with Fosinopril] results in decreased expression of SERPINE1 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of SERPINE1 protein; Valsartan inhibits the reaction [AGT protein results in increased activity of SERPINE1 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 protein]
CTD PMID:11244025 PMID:21051829 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Slc12a3 solute carrier family 12 member 3 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of SLC12A3 protein] CTD PMID:20175999 NCBI chr19:11,106,033...11,144,674
Ensembl chr19:11,106,033...11,144,641
JBrowse link
G Slc22a25 solute carrier family 22, member 25 multiple interactions ISO Valsartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate] CTD PMID:17132213 NCBI chr 1:224,596,886...224,698,512
Ensembl chr 1:224,596,887...224,698,514
JBrowse link
G Slc25a32 solute carrier family 25 member 32 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of SLC25A32 mRNA] CTD PMID:19225232 NCBI chr 7:77,983,885...78,005,058
Ensembl chr 7:77,987,212...78,004,975
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP naloxonazine inhibits the reaction [Valsartan inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]]; naloxonazine inhibits the reaction [Valsartan inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Valsartan inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Valsartan inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] CTD PMID:12658023 PMID:17199717 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Smad3 SMAD family member 3 multiple interactions
decreases expression
EXP Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein]
Valsartan results in decreased expression of SMAD3 protein
CTD PMID:15619341 PMID:16872305 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Smad7 SMAD family member 7 multiple interactions
increases expression
EXP Valsartan inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMAD7 protein]
Valsartan results in increased expression of SMAD7 protein
CTD PMID:15619341 PMID:16872305 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
JBrowse link
G Snn stannin multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of SNN mRNA] CTD PMID:19225232 NCBI chr10:4,635,897...4,644,570
Ensembl chr10:4,635,898...4,644,570
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [benazepril co-treated with Valsartan] results in increased expression of SOD1 protein CTD PMID:20445533 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP Valsartan inhibits the reaction [AGT protein results in increased expression of SPP1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SPP1 protein] CTD PMID:11115077 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of SPRY2 mRNA] CTD PMID:19225232 NCBI chr15:90,172,769...90,177,823
Ensembl chr15:90,172,975...90,175,802
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein affects the localization of STAT1 protein]; Valsartan inhibits the reaction [AGT protein results in increased activity of STAT1 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of STAT1 protein] CTD PMID:12846741 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Valsartan inhibits the reaction [AGT protein affects the localization of STAT3 protein]; Valsartan inhibits the reaction [AGT protein results in increased activity of STAT3 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of STAT3 protein] CTD PMID:12846741 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Syp synaptophysin multiple interactions ISO
EXP
Valsartan inhibits the reaction [Streptozocin results in decreased expression of SYP protein]
Valsartan inhibits the reaction [AGT protein results in decreased expression of SYP protein]; Valsartan inhibits the reaction [AGT protein results in increased ubiquitination of SYP protein]
CTD PMID:18487452 NCBI chr  X:15,694,699...15,709,244
Ensembl chr  X:15,695,566...15,707,436
JBrowse link
G Tek TEK receptor tyrosine kinase multiple interactions EXP Valsartan inhibits the reaction [AGT protein results in increased expression of TEK mRNA] CTD PMID:14638905 NCBI chr 5:113,725,717...113,852,799
Ensembl chr 5:113,725,717...113,852,799
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
ISO
EXP
[benazepril co-treated with Valsartan] results in decreased expression of TGFB1 protein
Valsartan results in decreased expression of TGFB1 protein
[Tacrolimus co-treated with Valsartan] results in increased expression of TGFB1 protein; Valsartan inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Ovalbumin results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Tacrolimus results in increased expression of TGFB1 protein]
CTD PMID:11798641 PMID:15619341 PMID:16115399 PMID:16549154 PMID:16872305 PMID:16928621 PMID:17680535 PMID:17703430 PMID:18390891 PMID:19080339 PMID:23733546 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 multiple interactions
decreases expression
EXP Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR2 mRNA]
Valsartan results in decreased expression of TGFBR2 mRNA
CTD PMID:15619341 PMID:16872305 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of TGIF1 mRNA] CTD PMID:19225232 NCBI chr 9:119,181,079...119,190,698
Ensembl chr 9:119,181,083...119,190,698
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
decreases expression
ISO
EXP
Valsartan inhibits the reaction [AGT protein results in increased expression of TIMP1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of TIMP1 protein]
Valsartan results in decreased expression of TIMP1 mRNA; Valsartan results in decreased expression of TIMP1 protein
[Valsartan co-treated with Fosinopril] results in decreased expression of TIMP1 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of TIMP1 protein; Valsartan inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 mRNA]
CTD PMID:12846741 PMID:15504291 PMID:21051829 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
[Metformin co-treated with rosiglitazone co-treated with Valsartan co-treated with Ezetimibe] inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; [Metformin co-treated with rosiglitazone co-treated with Valsartan] inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; Valsartan inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]
Valsartan inhibits the reaction [Oxygen deficiency results in increased expression of TNF mRNA]
CTD PMID:16865780 PMID:18436887 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of TP53 mRNA] CTD PMID:32197949 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tubb3 tubulin, beta 3 class III multiple interactions EXP Valsartan promotes the reaction [AGT protein results in increased expression of TUBB3 protein] CTD PMID:17068200 NCBI chr19:56,220,759...56,229,813
Ensembl chr19:56,220,755...56,229,813
JBrowse link
G Tug1 taurine up-regulated 1 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of TUG1 mRNA] CTD PMID:32197949 NCBI chr14:83,878,757...83,885,791
Ensembl chr14:83,878,295...83,887,584
JBrowse link
G Ube2v2 ubiquitin conjugating enzyme E2 V2 multiple interactions ISO
EXP
Valsartan promotes the reaction [AGT protein results in increased expression of UBE2V2 mRNA]; Valsartan promotes the reaction [AGT protein results in increased expression of UBE2V2 protein]; Valsartan promotes the reaction [Oxygen deficiency results in increased expression of UBE2V2 mRNA] CTD PMID:16769992 PMID:17068200 NCBI chr11:89,557,273...89,591,175
Ensembl chr11:89,557,273...89,591,175
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions
ISO
EXP
Valsartan results in decreased expression of VEGFA mRNA
Valsartan inhibits the reaction [AGT protein results in increased expression of VEGFA mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of VEGFA protein]; Valsartan inhibits the reaction [Oxygen deficiency promotes the reaction [AGT protein results in increased expression of VEGFA protein]]; Valsartan inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]
CTD PMID:11897773 PMID:14638905 PMID:14718351 PMID:17724226 PMID:22768174 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19723
      biological role 19723
        xenobiotic 18396
          valsartan 145
            Byvalson 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    p-block element atom 19665
                      carbon group element atom 19583
                        carbon atom 19573
                          organic molecular entity 19573
                            organic group 18603
                              organic divalent group 18594
                                organodiyl group 18594
                                  carbonyl group 18507
                                    carbonyl compound 18507
                                      carboxylic acid 18159
                                        carboacyl group 17415
                                          univalent carboacyl group 17415
                                            carbamoyl group 17211
                                              carboxamide 17211
                                                monocarboxylic acid amide 14599
                                                  valsartan 145
                                                    Byvalson 0
paths to the root