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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:valsartan
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Accession:CHEBI:9927 term browser browse the term
Definition:A monocarboxylic acid amide consisting of L-valine in which the amino hydrogens have been replaced by a pentanoyl and a [2'-(1H-tetrazol-5-yl)biphenyl]-4-yl]methyl group. It exhibits antihypertensive activity.
Synonyms:exact_synonym: N-pentanoyl-N-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-L-valine
 related_synonym: (S)-N-valeryl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl}-valine;   Diovan;   Formula=C24H29N5O3;   InChI=1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1;   InChIKey=ACWBQPMHZXGDFX-QFIPXVFZSA-N;   N-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)-N-valeryl-L-valine;   N-pentanoyl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-L-valine;   SMILES=CCCCC(=O)N(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)[C@@H](C(C)C)C(O)=O
 xref: Beilstein:7754038;   CAS:137862-53-4;   DrugBank:DB00177;   Drug_Central:2806;   HMDB:HMDB0014323;   KEGG:D00400;   LINCS:LSM-2993
 xref_mesh: MESH:C081489
 xref: Patent:EP443983;   Patent:US5399578;   Reaxys:7754038;   Wikipedia:Valsartan



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valsartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme multiple interactions
decreases expression
EXP Valsartan inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of ACE protein]
Valsartan results in decreased expression of ACE mRNA
CTD PMID:23733546 PMID:31023080 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ace2 angiotensin I converting enzyme 2 multiple interactions EXP Valsartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA] CTD PMID:16176966 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of ADAMTS1 mRNA] CTD PMID:19225232 NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
JBrowse link
G Agt angiotensinogen multiple interactions
increases expression
ISO
EXP
[benazepril co-treated with Valsartan] results in decreased expression of AGT protein modified form; [Valsartan co-treated with benidipine] inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; [Valsartan co-treated with Simvastatin] inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]; [Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; [Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]; Valsartan inhibits the reaction [AGT protein affects the localization of STAT1 protein]; Valsartan inhibits the reaction [AGT protein affects the localization of STAT3 protein]; Valsartan inhibits the reaction [AGT protein results in decreased expression of APOE protein]; Valsartan inhibits the reaction [AGT protein results in decreased expression of BMP4 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of CDKN1B mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of FZD2 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of ID2 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of IER2 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of MN1 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of PPP1R3C mRNA]; Valsartan inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; Valsartan inhibits the reaction [AGT protein results in increased activity of STAT1 protein]; Valsartan inhibits the reaction [AGT protein results in increased activity of STAT3 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of ADAMTS1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CCL2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of CYBB mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CYBB protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of DUSP5 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of DYRK2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of EGR1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of FGF5 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of FILIP1L mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of FOSL1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of HBEGF mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of HDAC9 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of HIVEP1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of IER3 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of INHBA mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of KDR mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of KLF9 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of LIF mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of MAFF mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of NFIL3 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of NUP98 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of PLAUR mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of PTGS2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of RCAN1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of RGS3 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SLC25A32 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SNN mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SPRY2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of TGIF1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of TIMP1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of TIMP1 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of STAT1 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of STAT3 protein]; Valsartan inhibits the reaction [AGT protein results in increased secretion of SERPINE1 protein]; Valsartan inhibits the reaction [benazepril results in decreased expression of AGT protein]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of EGR1 mRNA]]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of KLF10 mRNA]]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]
Valsartan results in increased expression of AGT protein; Valsartan results in increased expression of AGT protein modified form
Dactinomycin promotes the reaction [Valsartan inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Valsartan inhibits the reaction [AGT protein affects the localization of ELAVL1 protein]; Valsartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; Valsartan inhibits the reaction [AGT protein results in decreased export of Sodium]; Valsartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of SYP protein]; Valsartan inhibits the reaction [AGT protein results in increased abundance of Nitric Oxide]; Valsartan inhibits the reaction [AGT protein results in increased abundance of Oxygen]; Valsartan inhibits the reaction [AGT protein results in increased abundance of Prostaglandins E]; Valsartan inhibits the reaction [AGT protein results in increased activity of SERPINE1 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of AGTR2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of AGTR2 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT1 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of ENG protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of KDR mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of SPP1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SPP1 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of TEK mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of VEGFA mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of VEGFA protein]; Valsartan inhibits the reaction [AGT protein results in increased secretion of Nitric Oxide]; Valsartan inhibits the reaction [AGT protein results in increased ubiquitination of SYP protein]; Valsartan inhibits the reaction [Dimethylnitrosamine results in increased expression of AGT protein]; Valsartan inhibits the reaction [Oxygen deficiency promotes the reaction [AGT protein results in increased expression of NOS3 protein]]; Valsartan inhibits the reaction [Oxygen deficiency promotes the reaction [AGT protein results in increased expression of VEGFA protein]]; Valsartan promotes the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]]; Valsartan promotes the reaction [AGT protein results in increased expression of FOS mRNA]; Valsartan promotes the reaction [AGT protein results in increased expression of JUN mRNA]; Valsartan promotes the reaction [AGT protein results in increased expression of MAP2 protein]; Valsartan promotes the reaction [AGT protein results in increased expression of TUBB3 protein]; Valsartan promotes the reaction [AGT protein results in increased expression of UBE2V2 protein]; Valsartan promotes the reaction [Glucose results in increased expression of AGT protein]; Valsartan promotes the reaction [Particulate Matter results in increased expression of AGT protein modified form]
[Valsartan co-treated with AGT protein] results in increased activity of LPL protein; Valsartan inhibits the reaction [AGT protein results in increased activity of ALOX15 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of CXCL10 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CXCL10 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of OSR1 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of SLC12A3 protein]; Valsartan promotes the reaction [AGT protein results in increased expression of UBE2V2 mRNA]; Valsartan promotes the reaction [AGT protein results in increased expression of UBE2V2 protein]
CTD PMID:9261183 PMID:10082498 PMID:11115077 PMID:11244025 PMID:11403356 More... NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression
multiple interactions
EXP
ISO
Valsartan results in decreased expression of AGTR1A mRNA
Valsartan binds to and results in decreased activity of AGTR1 protein
CTD PMID:18403896 PMID:28973481 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Agtr2 angiotensin II receptor, type 2 affects response to substance
increases expression
decreases expression
multiple interactions
ISO
EXP
AGTR2 affects the susceptibility to Valsartan
Valsartan results in increased expression of AGTR2 protein
Valsartan results in decreased expression of AGTR2 mRNA
[PD 123319 results in decreased activity of AGTR2 protein] inhibits the reaction [Valsartan results in increased abundance of Cyclic GMP]; [PD 123319 results in decreased activity of AGTR2 protein] which results in decreased susceptibility to Valsartan; Valsartan inhibits the reaction [AGT protein results in increased expression of AGTR2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of AGTR2 protein]
CTD PMID:11403356 PMID:12215461 PMID:16982965 PMID:18403896 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO
EXP
Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein] CTD PMID:31009642 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alb albumin multiple interactions
decreases export
EXP
ISO
Valsartan inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein]
Valsartan results in decreased export of ALB protein
CTD PMID:16872305 PMID:17664856 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Alox15 arachidonate 15-lipoxygenase multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased activity of ALOX15 protein] CTD PMID:9261183 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
JBrowse link
G Ang angiogenin decreases expression ISO Valsartan results in decreased expression of ANG mRNA CTD PMID:22768174 NCBI chr15:24,317,733...24,323,361 JBrowse link
G Angpt1 angiopoietin 1 multiple interactions EXP Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT1 protein] CTD PMID:14638905 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067
JBrowse link
G Angpt2 angiopoietin 2 multiple interactions EXP Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT2 mRNA] CTD PMID:14638905 NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804
JBrowse link
G Apcs amyloid P component, serum decreases expression ISO Valsartan results in decreased expression of APCS protein CTD PMID:16129801 NCBI chr13:85,373,338...85,374,134
Ensembl chr13:85,373,220...85,374,298
JBrowse link
G Apob apolipoprotein B multiple interactions ISO [Valsartan co-treated with benazepril] results in decreased expression of APOB protein; fluvastatin promotes the reaction [[Valsartan co-treated with benazepril] results in decreased expression of APOB protein] CTD PMID:20671225 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Apoe apolipoprotein E multiple interactions ISO [Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with Atorvastatin co-treated with Valsartan] results in decreased expression of APOE protein; Valsartan inhibits the reaction [AGT protein results in decreased expression of APOE protein] CTD PMID:17785354 PMID:19603250 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Aqp1 aquaporin 1 multiple interactions EXP Valsartan inhibits the reaction [Glucose results in increased expression of AQP1 mRNA] CTD PMID:11510275 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
JBrowse link
G Aqp4 aquaporin 4 multiple interactions EXP Valsartan inhibits the reaction [Glucose results in increased expression of AQP4 mRNA] CTD PMID:11510275 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
JBrowse link
G Atp6ap2 ATPase H+ transporting accessory protein 2 multiple interactions EXP Valsartan inhibits the reaction [Streptozocin results in increased expression of ATP6AP2 mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of ATP6AP2 protein] CTD PMID:18192338 NCBI chr  X:10,183,983...10,210,948
Ensembl chr  X:10,183,068...10,210,918
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BAX protein] CTD PMID:32197949 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BBC3 mRNA] CTD PMID:32197949 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 protein] CTD PMID:32197949 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BCL2L11 mRNA] CTD PMID:32197949 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Bdkrb1 bradykinin receptor B1 multiple interactions EXP [bradykinin, Leu(8)-des-Arg(9)- results in decreased activity of BDKRB1 protein] inhibits the reaction [Valsartan results in increased abundance of Cyclic GMP]; [bradykinin, Leu(8)-des-Arg(9)- results in decreased activity of BDKRB1 protein] which results in decreased susceptibility to Valsartan CTD PMID:16982965 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
JBrowse link
G Bdkrb2 bradykinin receptor B2 multiple interactions EXP [icatibant results in decreased activity of BDKRB2 protein] inhibits the reaction [Valsartan results in increased abundance of Cyclic GMP]; [icatibant results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to Valsartan CTD PMID:16982965 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
JBrowse link
G Bmp4 bone morphogenetic protein 4 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in decreased expression of BMP4 mRNA] CTD PMID:19225232 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Bmp7 bone morphogenetic protein 7 multiple interactions EXP Valsartan inhibits the reaction [Tacrolimus results in decreased expression of BMP7 protein] CTD PMID:17703430 NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Valsartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; Valsartan inhibits the reaction [Cyclophosphamide results in increased activity of CASP3 protein] CTD PMID:23300732 PMID:32197949 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp4 caspase 4 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased cleavage of CASP4 protein] CTD PMID:32197949 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP
[Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; Valsartan inhibits the reaction [AGT protein results in increased expression of CCL2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; Valsartan inhibits the reaction [sodium arsenite results in increased secretion of CCL2 protein]
Valsartan inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]
Valsartan inhibits the reaction [Oxygen deficiency results in increased expression of CCL2 mRNA]
CTD PMID:15284299 PMID:16705055 PMID:17624267 PMID:18436887 PMID:19225232 More... NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cd163 CD163 molecule decreases expression ISO Valsartan results in decreased expression of CD163 mRNA CTD PMID:22768174 NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878
JBrowse link
G Cd34 CD34 molecule decreases expression ISO Valsartan results in decreased expression of CD34 mRNA CTD PMID:22768174 NCBI chr13:106,480,074...106,499,462
Ensembl chr13:106,480,043...106,499,832
JBrowse link
G Cd68 Cd68 molecule decreases expression ISO Valsartan results in decreased expression of CD68 mRNA CTD PMID:22768174 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in decreased expression of CDKN1B mRNA] CTD PMID:19225232 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression ISO Valsartan results in decreased expression of CEBPA mRNA CTD PMID:22768174 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL1A1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL1A1 protein] CTD PMID:31009642 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL3A1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL3A1 protein] CTD PMID:31009642 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Col4a4 collagen type IV alpha 4 chain multiple interactions ISO Valsartan inhibits the reaction [Streptozocin results in increased expression of COL4A4 mRNA] CTD PMID:33631230 NCBI chr 9:83,833,173...83,875,436
Ensembl chr 9:83,755,515...83,875,876
JBrowse link
G Crem cAMP responsive element modulator decreases expression EXP Valsartan results in decreased expression of CREM mRNA CTD PMID:19027736 NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
JBrowse link
G Ctf1 cardiotrophin 1 multiple interactions EXP Dactinomycin promotes the reaction [Valsartan inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Valsartan inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of CTF1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of CTF1 protein] CTD PMID:23288202 NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335
JBrowse link
G Ctss cathepsin S decreases expression ISO Valsartan results in decreased expression of CTSS mRNA CTD PMID:22768174 NCBI chr 2:183,089,192...183,114,483
Ensembl chr 2:183,086,437...183,114,483
JBrowse link
G Cxadr CXADR, Ig-like cell adhesion molecule decreases expression ISO Valsartan results in decreased expression of CXADR mRNA; Valsartan results in decreased expression of CXADR protein CTD PMID:20392896 NCBI chr11:16,982,752...17,030,078
Ensembl chr11:16,982,860...17,030,046
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of CXCL10 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CXCL10 protein] CTD PMID:18716376 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of CYBB mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CYBB protein] CTD PMID:15643130 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 decreases expression EXP Valsartan results in decreased expression of CYP11B2 mRNA; Valsartan results in decreased expression of CYP11B2 protein CTD PMID:16043663 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects response to substance ISO CYP3A5 gene affects the susceptibility to Valsartan CTD PMID:22149319 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of DDIT3 mRNA]; Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of DDIT3 protein] CTD PMID:32197949 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Des desmin multiple interactions EXP Valsartan inhibits the reaction [Streptozocin results in increased expression of DES protein] CTD PMID:17624267 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
JBrowse link
G Dusp5 dual specificity phosphatase 5 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of DUSP5 mRNA] CTD PMID:19225232 NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
JBrowse link
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of DYRK2 mRNA] CTD PMID:19225232 NCBI chr 7:54,348,724...54,381,363
Ensembl chr 7:54,349,610...54,380,106
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP [Valsartan co-treated with benazepril] results in decreased expression of EDN1 protein CTD PMID:11136700 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Ednra endothelin receptor type A decreases expression EXP Valsartan results in decreased expression of EDNRA mRNA CTD PMID:28951255 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of EGR1 mRNA]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of EGR1 mRNA]] CTD PMID:19225232 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased phosphorylation of EIF2AK3 protein] CTD PMID:32197949 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Elavl1 ELAV like RNA binding protein 1 multiple interactions EXP Valsartan inhibits the reaction [AGT protein affects the localization of ELAVL1 protein] CTD PMID:19246637 NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784
JBrowse link
G Eng endoglin multiple interactions EXP Valsartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of ENG protein] CTD PMID:15539634 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased phosphorylation of ERN1 protein] CTD PMID:32197949 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO Valsartan results in decreased expression of FABP4 mRNA CTD PMID:22768174 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP benazepril promotes the reaction [Valsartan inhibits the reaction [Doxorubicin results in increased expression of FAS protein]]; Valsartan inhibits the reaction [Doxorubicin results in increased expression of FAS protein]; Valsartan promotes the reaction [benazepril inhibits the reaction [Doxorubicin results in increased expression of FAS protein]] CTD PMID:15315341 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand multiple interactions EXP benazepril promotes the reaction [Valsartan inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]]; Valsartan inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]; Valsartan promotes the reaction [benazepril inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]] CTD PMID:15315341 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fgf5 fibroblast growth factor 5 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of FGF5 mRNA] CTD PMID:19225232 NCBI chr14:11,325,334...11,346,570
Ensembl chr14:11,325,334...11,345,997
JBrowse link
G Filip1l filamin A interacting protein 1-like multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of FILIP1L mRNA] CTD PMID:19225232 NCBI chr11:42,937,353...43,177,085
Ensembl chr11:42,940,467...43,177,415
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Valsartan promotes the reaction [AGT protein results in increased expression of FOS mRNA] CTD PMID:18619357 PMID:18846332 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of FOSL1 mRNA] CTD PMID:19225232 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in decreased secretion of FSHB protein] CTD PMID:32197949 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Fzd2 frizzled class receptor 2 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in decreased expression of FZD2 mRNA] CTD PMID:19225232 NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP
ISO
Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein] CTD PMID:31009642 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of HBEGF mRNA] CTD PMID:19225232 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
JBrowse link
G Hdac2 histone deacetylase 2 multiple interactions EXP
ISO
Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of HDAC2 protein] CTD PMID:31009642 NCBI chr20:40,548,250...40,571,609
Ensembl chr20:40,548,250...40,571,609
JBrowse link
G Hdac9 histone deacetylase 9 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of HDAC9 mRNA] CTD PMID:19225232 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333
JBrowse link
G Hgf hepatocyte growth factor multiple interactions EXP Valsartan inhibits the reaction [Bleomycin results in decreased expression of HGF mRNA]; Valsartan inhibits the reaction [Bleomycin results in decreased expression of HGF protein] CTD PMID:16115399 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Hivep1 HIVEP zinc finger 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of HIVEP1 mRNA] CTD PMID:19225232 NCBI chr17:22,585,016...22,714,517
Ensembl chr17:22,585,016...22,711,956
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 protein] CTD PMID:32197949 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Valsartan inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]
Valsartan inhibits the reaction [sodium arsenite results in increased secretion of ICAM1 protein modified form]
CTD PMID:17724226 PMID:28973481 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Id2 inhibitor of DNA binding 2 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in decreased expression of ID2 mRNA] CTD PMID:19225232 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Ier2 immediate early response 2 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in decreased expression of IER2 mRNA] CTD PMID:19225232 NCBI chr19:23,494,551...23,496,075
Ensembl chr19:23,494,184...23,499,211
JBrowse link
G Ier3 immediate early response 3 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of IER3 mRNA] CTD PMID:19225232 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583
JBrowse link
G Il1b interleukin 1 beta decreases expression EXP Valsartan results in decreased expression of IL1B mRNA CTD PMID:28951255 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Tacrolimus co-treated with Valsartan] results in decreased expression of IL6 protein; [Tacrolimus co-treated with Valsartan] results in increased expression of IL6 protein CTD PMID:16549154 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Inhba inhibin subunit beta A multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of INHBA mRNA] CTD PMID:19225232 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]] CTD PMID:15677497 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Valsartan promotes the reaction [AGT protein results in increased expression of JUN mRNA] CTD PMID:18619357 PMID:18846332 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO
EXP
Valsartan inhibits the reaction [AGT protein results in increased expression of KDR mRNA] CTD PMID:14638905 PMID:15005273 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Kl Klotho increases expression EXP Valsartan results in increased expression of KL mRNA; Valsartan results in increased expression of KL protein CTD PMID:21051829 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080
JBrowse link
G Klf10 Kruppel-like factor 10 multiple interactions ISO [Valsartan co-treated with Simvastatin] inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of KLF10 mRNA]] CTD PMID:19225232 NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994
JBrowse link
G Klf9 Kruppel-like factor 9 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of KLF9 mRNA] CTD PMID:19225232 NCBI chr 1:220,700,108...220,725,029
Ensembl chr 1:220,700,108...220,725,037
JBrowse link
G Kng2 kininogen 2 multiple interactions
increases expression
EXP benazepril promotes the reaction [Valsartan results in increased expression of KNG1 protein modified form]; PD 123319 inhibits the reaction [benazepril promotes the reaction [Valsartan results in increased expression of KNG1 protein modified form]]; PD 123319 inhibits the reaction [Valsartan promotes the reaction [benazepril results in increased expression of KNG1 protein modified form]]; Valsartan promotes the reaction [benazepril results in increased expression of KNG1 protein modified form] CTD PMID:11509473 NCBI chr11:77,913,876...77,936,247 JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in decreased secretion of LHB protein] CTD PMID:32197949 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lif LIF, interleukin 6 family cytokine multiple interactions ISO [Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]; Valsartan inhibits the reaction [AGT protein results in increased expression of LIF mRNA]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]] CTD PMID:19225232 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
JBrowse link
G Lpl lipoprotein lipase multiple interactions
increases activity
ISO [Valsartan co-treated with AGT protein] results in increased activity of LPL protein
Valsartan results in increased activity of LPL protein
CTD PMID:18640387 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Maff MAF bZIP transcription factor F multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of MAFF mRNA] CTD PMID:19225232 NCBI chr 7:110,912,499...110,923,851
Ensembl chr 7:110,912,499...110,923,851
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions EXP Valsartan promotes the reaction [AGT protein results in increased expression of MAP2 protein] CTD PMID:17068200 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein] CTD PMID:19041135 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein] CTD PMID:19041135 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
EXP [Valsartan co-treated with Fosinopril] results in decreased expression of MMP9 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of MMP9 protein
Valsartan results in decreased expression of MMP9 mRNA; Valsartan results in decreased expression of MMP9 protein
CTD PMID:21051829 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mn1 MN1 proto-oncogene, transcriptional regulator multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in decreased expression of MN1 mRNA] CTD PMID:19225232 NCBI chr12:45,184,060...45,220,102
Ensembl chr12:45,183,085...45,221,651
JBrowse link
G Mrc1 mannose receptor, C type 1 decreases expression ISO Valsartan results in decreased expression of MRC1 mRNA CTD PMID:22768174 NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
JBrowse link
G Mtus1 microtubule associated scaffold protein 1 multiple interactions EXP Valsartan promotes the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]] CTD PMID:17068200 NCBI chr16:51,202,497...51,347,791
Ensembl chr16:51,253,562...51,347,793
JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions
increases expression
EXP
ISO
[Valsartan co-treated with benazepril] results in increased expression of MYH6 mRNA
Valsartan inhibits the reaction [Isoproterenol results in increased expression of MYH6 protein]
Valsartan results in increased expression of MYH6 mRNA
CTD PMID:11136700 PMID:31009642 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions ISO Valsartan inhibits the reaction [Isoproterenol results in increased expression of MYH7 mRNA] CTD PMID:31009642 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of NFIL3 mRNA] CTD PMID:19225232 NCBI chr17:12,280,499...12,295,728
Ensembl chr17:12,280,484...12,295,858
JBrowse link
G Nos1 nitric oxide synthase 1 decreases expression EXP Valsartan results in decreased expression of NOS1 protein CTD PMID:31023080 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein] CTD PMID:32197949 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases expression
EXP
ISO
[fluvastatin co-treated with Valsartan] results in increased expression of NOS3 mRNA; Valsartan inhibits the reaction [Oxygen deficiency promotes the reaction [AGT protein results in increased expression of NOS3 protein]]
Valsartan results in decreased expression of NOS3 protein
Valsartan inhibits the reaction [Oxygen deficiency results in increased phosphorylation of NOS3 protein]
CTD PMID:11897773 PMID:18436887 PMID:28951255 PMID:31023080 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP Valsartan inhibits reaction [streptozotocin decreases expression of Nphs1 mRNA and protein in kidney] RGD PMID:17624267 RGD:38596322 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078
JBrowse link
G Nppa natriuretic peptide A multiple interactions
decreases expression
EXP
ISO
[Valsartan co-treated with benazepril] results in decreased expression of NPPA mRNA; Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]
Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPA protein]
Valsartan results in decreased expression of NPPA mRNA
CTD PMID:11136700 PMID:23288202 PMID:31009642 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nppb natriuretic peptide B multiple interactions
decreases expression
ISO
EXP
Valsartan inhibits the reaction [CHOP protocol results in increased expression of NPPB protein]
Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]
Valsartan results in decreased expression of NPPB mRNA
[Valsartan co-treated with benazepril] results in decreased expression of NPPB mRNA
Valsartan results in decreased expression of NPPB protein
CTD PMID:11136700 PMID:12417542 PMID:16247790 PMID:31009642 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of NQO1 protein] CTD PMID:32197949 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nup98 nucleoporin 98 and 96 precursor multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of NUP98 mRNA] CTD PMID:19225232 NCBI chr 1:156,494,423...156,591,415
Ensembl chr 1:156,494,423...156,591,415
JBrowse link
G Osr1 odd-skipped related transcription factor 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of OSR1 protein] CTD PMID:20175999 NCBI chr 6:32,369,561...32,380,822
Ensembl chr 6:32,373,816...32,380,817
JBrowse link
G Pde3a phosphodiesterase 3A increases expression EXP Valsartan results in increased expression of PDE3A mRNA CTD PMID:19027736 NCBI chr 4:174,172,804...174,443,944
Ensembl chr 4:174,172,868...174,438,274
JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of PLAUR mRNA] CTD PMID:19225232 NCBI chr 1:80,053,441...80,068,384
Ensembl chr 1:80,050,324...80,068,595
JBrowse link
G Postn periostin multiple interactions EXP Valsartan inhibits the reaction [AGT protein results in increased expression of POSTN mRNA] CTD PMID:17485602 NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO Valsartan results in decreased expression of PPARG mRNA CTD PMID:22768174 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in decreased expression of PPP1R3C mRNA] CTD PMID:19225232 NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
Valsartan inhibits the reaction [AGT protein results in increased expression of PTGS2 mRNA]
Valsartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]
CTD PMID:19145780 PMID:19225232 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 multiple interactions EXP Valsartan promotes the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]] CTD PMID:17068200 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984
JBrowse link
G Rcan1 regulator of calcineurin 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of RCAN1 mRNA] CTD PMID:19225232 NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased phosphorylation of RELA protein] CTD PMID:32197949 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ren renin multiple interactions
increases expression
increases activity
ISO
EXP
[benazepril co-treated with Valsartan] results in increased activity of REN protein
Valsartan results in increased expression of REN protein
Valsartan results in increased activity of REN protein
CTD PMID:8505092 PMID:10836730 PMID:11501062 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Rgs3 regulator of G-protein signaling 3 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of RGS3 mRNA] CTD PMID:19225232 NCBI chr 5:76,022,038...76,161,895
Ensembl chr 5:76,022,001...76,161,894
JBrowse link
G Sele selectin E multiple interactions ISO Valsartan inhibits the reaction [sodium arsenite results in increased expression of SELE protein] CTD PMID:28973481 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions
decreases expression
ISO
EXP
Valsartan inhibits the reaction [AGT protein results in increased secretion of SERPINE1 protein]
Valsartan results in decreased expression of SERPINE1 mRNA; Valsartan results in decreased expression of SERPINE1 protein
[Valsartan co-treated with Fosinopril] results in decreased expression of SERPINE1 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of SERPINE1 protein; Valsartan inhibits the reaction [AGT protein results in increased activity of SERPINE1 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 protein]
CTD PMID:11244025 PMID:21051829 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Slc12a3 solute carrier family 12 member 3 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of SLC12A3 protein] CTD PMID:20175999 NCBI chr19:10,630,649...10,679,250
Ensembl chr19:10,631,393...10,669,091
JBrowse link
G Slc22a25 solute carrier family 22, member 25 multiple interactions ISO Valsartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate] CTD PMID:17132213 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085
JBrowse link
G Slc25a32 solute carrier family 25 member 32 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of SLC25A32 mRNA] CTD PMID:19225232 NCBI chr 7:70,142,958...70,160,726
Ensembl chr 7:70,142,964...70,160,770
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP naloxonazine inhibits the reaction [Valsartan inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]]; naloxonazine inhibits the reaction [Valsartan inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Valsartan inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Valsartan inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] CTD PMID:12658023 PMID:17199717 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Smad3 SMAD family member 3 multiple interactions
decreases expression
EXP Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein]
Valsartan results in decreased expression of SMAD3 protein
CTD PMID:15619341 PMID:16872305 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Smad7 SMAD family member 7 multiple interactions
increases expression
EXP Valsartan inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMAD7 protein]
Valsartan results in increased expression of SMAD7 protein
CTD PMID:15619341 PMID:16872305 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765
JBrowse link
G Snn stannin multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of SNN mRNA] CTD PMID:19225232 NCBI chr10:4,572,933...4,581,606
Ensembl chr10:4,572,376...4,584,021
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [benazepril co-treated with Valsartan] results in increased expression of SOD1 protein CTD PMID:20445533 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP Valsartan inhibits the reaction [AGT protein results in increased expression of SPP1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SPP1 protein] CTD PMID:11115077 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of SPRY2 mRNA] CTD PMID:19225232 NCBI chr15:82,692,312...82,697,408
Ensembl chr15:82,692,143...82,698,009
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein affects the localization of STAT1 protein]; Valsartan inhibits the reaction [AGT protein results in increased activity of STAT1 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of STAT1 protein] CTD PMID:12846741 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Valsartan inhibits the reaction [AGT protein affects the localization of STAT3 protein]; Valsartan inhibits the reaction [AGT protein results in increased activity of STAT3 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of STAT3 protein] CTD PMID:12846741 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Syp synaptophysin multiple interactions ISO
EXP
Valsartan inhibits the reaction [Streptozocin results in decreased expression of SYP protein]
Valsartan inhibits the reaction [AGT protein results in decreased expression of SYP protein]; Valsartan inhibits the reaction [AGT protein results in increased ubiquitination of SYP protein]
CTD PMID:18487452 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745
JBrowse link
G Tek TEK receptor tyrosine kinase multiple interactions EXP Valsartan inhibits the reaction [AGT protein results in increased expression of TEK mRNA] CTD PMID:14638905 NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
ISO
EXP
[benazepril co-treated with Valsartan] results in decreased expression of TGFB1 protein
Valsartan inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]
Valsartan results in decreased expression of TGFB1 protein
[Tacrolimus co-treated with Valsartan] results in increased expression of TGFB1 protein; Valsartan inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Ovalbumin results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Tacrolimus results in increased expression of TGFB1 protein]
CTD PMID:11798641 PMID:15619341 PMID:16115399 PMID:16549154 PMID:16872305 More... NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 multiple interactions
decreases expression
EXP Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR2 mRNA]
Valsartan results in decreased expression of TGFBR2 mRNA
CTD PMID:15619341 PMID:16872305 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of TGIF1 mRNA] CTD PMID:19225232 NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
decreases expression
ISO
EXP
Valsartan inhibits the reaction [AGT protein results in increased expression of TIMP1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of TIMP1 protein]
Valsartan results in decreased expression of TIMP1 mRNA; Valsartan results in decreased expression of TIMP1 protein
[Valsartan co-treated with Fosinopril] results in decreased expression of TIMP1 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of TIMP1 protein; Valsartan inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 mRNA]
CTD PMID:12846741 PMID:15504291 PMID:21051829 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
[Metformin co-treated with rosiglitazone co-treated with Valsartan co-treated with Ezetimibe] inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; [Metformin co-treated with rosiglitazone co-treated with Valsartan] inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; Valsartan inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]
Valsartan inhibits the reaction [Oxygen deficiency results in increased expression of TNF mRNA]
CTD PMID:16865780 PMID:18436887 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of TP53 mRNA] CTD PMID:32197949 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tubb3 tubulin, beta 3 class III multiple interactions EXP Valsartan promotes the reaction [AGT protein results in increased expression of TUBB3 protein] CTD PMID:17068200 NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243
JBrowse link
G Tug1 taurine up-regulated 1 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of TUG1 mRNA] CTD PMID:32197949 NCBI chr14:78,519,894...78,526,927
Ensembl chr14:78,522,506...78,526,927
JBrowse link
G Ube2v2 ubiquitin conjugating enzyme E2 V2 multiple interactions ISO
EXP
Valsartan promotes the reaction [AGT protein results in increased expression of UBE2V2 mRNA]; Valsartan promotes the reaction [AGT protein results in increased expression of UBE2V2 protein]; Valsartan promotes the reaction [Oxygen deficiency results in increased expression of UBE2V2 mRNA] CTD PMID:16769992 PMID:17068200 NCBI chr11:85,304,528...85,338,430
Ensembl chr11:85,304,526...85,336,369
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions
ISO
EXP
Valsartan results in decreased expression of VEGFA mRNA
Valsartan inhibits the reaction [AGT protein results in increased expression of VEGFA mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of VEGFA protein]; Valsartan inhibits the reaction [Oxygen deficiency promotes the reaction [AGT protein results in increased expression of VEGFA protein]]; Valsartan inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]
CTD PMID:11897773 PMID:14638905 PMID:14718351 PMID:17724226 PMID:22768174 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        xenobiotic 18436
          valsartan 146
            Byvalson 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic acid 18346
                                        carboacyl group 17469
                                          univalent carboacyl group 17469
                                            carbamoyl group 17285
                                              carboxamide 17285
                                                monocarboxylic acid amide 15010
                                                  valsartan 146
                                                    Byvalson 0
paths to the root