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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ursodeoxycholic acid
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Accession:CHEBI:9907 term browser browse the term
Definition:A bile acid found in the bile of bears (Ursidae) as a conjugate with taurine. Used therapeutically, it prevents the synthesis and absorption of cholesterol and can lead to the dissolution of gallstones.
Synonyms:related_synonym: (3alpha,5beta,7beta)-3,7-dihydroxycholan-24-oic acid;   3alpha,7beta-Dihydroxy-5beta-cholan-24-oic acid;   Actigall;   Formula=C24H40O4;   InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20+,22+,23+,24-/m1/s1;   InChIKey=RUDATBOHQWOJDD-UZVSRGJWSA-N;   SMILES=[H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]1([H])CC[C@]3(C)[C@]([H])(CC[C@@]3([H])[C@]1([H])[C@@H](O)C2)[C@H](C)CCC(O)=O;   Ursodeoxycholate;   Ursodiol
 xref: Beilstein:3219888;   CAS:128-13-2;   DrugBank:DB01586;   Drug_Central:2797;   HMDB:HMDB0000946;   KEGG:C07880;   KEGG:D00734;   LINCS:LSM-6555;   LIPID_MAPS_instance:LMST04010033
 xref_mesh: MESH:D014580
 xref: PMID:14989050;   PMID:17489439;   PMID:24816727;   Reaxys:3219888;   Wikipedia:Ursodiol
 cyclic_relationship: is_conjugate_acid_of CHEBI:78604


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tauroursodeoxycholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF4 activating transcription factor 4 multiple interactions EXP ursodoxicoltaurine inhibits the reaction [Cadmium results in increased expression of ATF4 mRNA] CTD PMID:37207789 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368 		JBrowse link
G ATF6 activating transcription factor 6 multiple interactions EXP ursodoxicoltaurine inhibits the reaction [Cadmium results in increased expression of ATF6 mRNA] CTD PMID:37207789 NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304 		JBrowse link
G CAT catalase multiple interactions EXP ursodoxicoltaurine inhibits the reaction [Cadmium results in increased expression of CAT mRNA] CTD PMID:37207789 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions EXP ursodoxicoltaurine inhibits the reaction [Cadmium results in increased expression of DDIT3 mRNA] CTD PMID:37207789 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP ursodoxicoltaurine inhibits the reaction [Cadmium results in increased expression of HSPA5 mRNA] CTD PMID:37207789 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 multiple interactions EXP ursodoxicoltaurine inhibits the reaction [Cadmium results in decreased expression of PTGS1 mRNA] CTD PMID:37207789 NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP ursodoxicoltaurine inhibits the reaction [Cadmium results in decreased expression of PTGS2 mRNA] CTD PMID:37207789 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884 		JBrowse link
G PTX3 pentraxin 3 multiple interactions EXP ursodoxicoltaurine inhibits the reaction [Cadmium results in decreased expression of PTX3 mRNA] CTD PMID:37207789 NCBI chr13:97,273,594...97,279,570
Ensembl chr13:97,273,594...97,279,569 		JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions EXP ursodoxicoltaurine inhibits the reaction [Cadmium results in increased expression of SOD1 mRNA] CTD PMID:37207789 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729 		JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions EXP ursodoxicoltaurine affects the reaction [Cadmium results in increased expression of SOD2 mRNA] CTD PMID:37207789 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560 		JBrowse link
G TNFAIP6 TNF alpha induced protein 6 multiple interactions EXP [ursodoxicoltaurine co-treated with Cadmium] results in increased expression of TNFAIP6 mRNA; ursodoxicoltaurine inhibits the reaction [Cadmium results in decreased expression of TNFAIP6 mRNA] CTD PMID:37207789 NCBI chr15:862,013...881,352
Ensembl chr15:862,015...881,461 		JBrowse link
G XBP1 X-box binding protein 1 multiple interactions EXP ursodoxicoltaurine inhibits the reaction [Cadmium results in increased splicing of XBP1 mRNA] CTD PMID:37207789 NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,016,526 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5052
    chemical entity 5080
      molecular entity 5051
        polyatomic entity 5032
          heteroatomic molecular entity 5001
            hydroxides 4835
              organic hydroxy compound 4767
                hydroxy-5beta-cholanic acid 16
                  dihydroxy-5beta-cholanic acid 14
                    ursodeoxycholic acid 12
                      3alpha,7beta-dihydroxy-12-oxo-5beta-cholanic acid 0
                      glycoursodeoxycholic acid 0
                      tauroursodeoxycholic acid 12
                      ursodeoxycholoyl-CoA 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 5052
    subatomic particle 5043
      composite particle 5043
        hadron 5071
          baryon 5043
            nucleon 5043
              atomic nucleus 5043
                atom 5043
                  main group element atom 5013
                    p-block element atom 5010
                      carbon group element atom 4927
                        carbon atom 4954
                          organic molecular entity 4926
                            organic molecule 4874
                              organic cyclic compound 4812
                                organic polycyclic compound 167
                                  steroid 107
                                    steroid fundamental parent 85
                                      cholane 16
                                        cholanoid 16
                                          cholanic acids 16
                                            cholanic acid 16
                                              5beta-cholanic acid 16
                                                hydroxy-5beta-cholanic acid 16
                                                  dihydroxy-5beta-cholanic acid 14
                                                    ursodeoxycholic acid 12
                                                      3alpha,7beta-dihydroxy-12-oxo-5beta-cholanic acid 0
                                                      glycoursodeoxycholic acid 0
                                                      tauroursodeoxycholic acid 12
                                                      ursodeoxycholoyl-CoA 0
paths to the root