Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Tylophorine
go back to main search page
Accession:CHEBI:9786 term browser browse the term
Definition:An organic heteropentacyclic compound that has formula C24H27NO4.
Synonyms:related_synonym: Formula=C24H27NO4;   InChI=1S/C24H27NO4/c1-26-21-9-16-15-8-14-6-5-7-25(14)13-20(15)19-12-24(29-4)23(28-3)11-18(19)17(16)10-22(21)27-2/h9-12,14H,5-8,13H2,1-4H3/t14-/m0/s1;   InChIKey=SSEUDFYBEOIWGF-AWEZNQCLSA-N;   SMILES=COc1cc2c3C[C@@H]4CCCN4Cc3c3cc(OC)c(OC)cc3c2cc1OC
 xref: CAS:482-20-2;   KEGG:C10623;   KNApSAcK:C00002367
 xref_mesh: MESH:C004218


show annotations for term's descendants           Sort by:
 
Tylophorine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO tylophorine analog inhibits the reaction [TNF results in increased activity of AKT1 protein]; tylophorine analog results in decreased phosphorylation of and results in decreased expression of AKT1 CTD PMID:19284764 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO tylophorine analog results in increased expression of BCL2L1 mRNA CTD PMID:19284764 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO tylophorine analog results in decreased expression of CCNA2 CTD PMID:19284764 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO tylophorine analog results in increased expression of CCNB1 protein CTD PMID:19284764 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO tylophorine analog results in increased expression of CCND1 protein CTD PMID:19284764 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO tylophorine analog results in increased expression of CDC25A CTD PMID:19284764 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator increases expression ISO tylophorine analog results in increased expression of CFLAR mRNA CTD PMID:19284764 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex increases activity ISO tylophorine analog results in increased activity of CHUK protein CTD PMID:19284764 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 increases expression ISO tylophorine analog results in increased expression of IRAK1 mRNA CTD PMID:19284764 NCBI chr  X:156,716,469...156,726,367
Ensembl chr  X:156,716,604...156,725,977
JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 increases expression ISO tylophorine analog results in increased expression of MAP3K14 mRNA CTD PMID:19284764 NCBI chr10:91,303,428...91,353,601
Ensembl chr10:91,303,428...91,353,601
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO tylophorine analog results in increased expression of NFKBIA mRNA CTD PMID:19284764 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta increases expression ISO tylophorine analog results in increased expression of PIK3CD mRNA CTD PMID:19284764 NCBI chr 5:166,602,053...166,628,028
Ensembl chr 5:166,602,053...166,628,028
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha increases expression ISO tylophorine analog results in increased expression of PPP3CA mRNA CTD PMID:19284764 NCBI chr 2:241,909,332...242,186,861
Ensembl chr 2:241,909,832...242,184,854
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha increases expression ISO tylophorine analog results in increased expression of PRKACA mRNA CTD PMID:19284764 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO tylophorine analog inhibits the reaction [TNF results in increased expression of PTGS2 protein] CTD PMID:19284764 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [tylophorine analog co-treated with TNF] results in decreased expression of RELA protein CTD PMID:19284764 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [tylophorine analog co-treated with TNF] results in decreased expression of RELA protein; tylophorine analog inhibits the reaction [TNF results in increased activity of AKT1 protein]; tylophorine analog inhibits the reaction [TNF results in increased expression of PTGS2 protein] CTD PMID:19284764 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      atom 19808
        nonmetal atom 19683
          nitrogen atom 18565
            nitrogen molecular entity 18565
              organonitrogen compound 18335
                organonitrogen heterocyclic compound 17481
                  Tylophorine 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic molecule 19514
                              organic cyclic compound 19311
                                organic heterocyclic compound 18425
                                  organic heteropolycyclic compound 17838
                                    organic heteropentacyclic compound 13227
                                      Tylophorine 17
paths to the root