Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Tylophorine
go back to main search page
Accession:CHEBI:9786 term browser browse the term
Definition:An organic heteropentacyclic compound that has formula C24H27NO4.
Synonyms:related_synonym: Formula=C24H27NO4;   InChI=1S/C24H27NO4/c1-26-21-9-16-15-8-14-6-5-7-25(14)13-20(15)19-12-24(29-4)23(28-3)11-18(19)17(16)10-22(21)27-2/h9-12,14H,5-8,13H2,1-4H3/t14-/m0/s1;   InChIKey=SSEUDFYBEOIWGF-AWEZNQCLSA-N;   SMILES=COc1cc2c3C[C@@H]4CCCN4Cc3c3cc(OC)c(OC)cc3c2cc1OC
 xref: CAS:482-20-2;   KEGG:C10623;   KNApSAcK:C00002367
 xref_mesh: MESH:C004218



show annotations for term's descendants           Sort by:
 
Tylophorine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO tylophorine analog inhibits the reaction [TNF results in increased activity of AKT1 protein]; tylophorine analog results in decreased phosphorylation of and results in decreased expression of AKT1 CTD PMID:19284764 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO tylophorine analog results in increased expression of BCL2L1 mRNA CTD PMID:19284764 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO tylophorine analog results in decreased expression of CCNA2 CTD PMID:19284764 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO tylophorine analog results in increased expression of CCNB1 protein CTD PMID:19284764 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO tylophorine analog results in increased expression of CCND1 protein CTD PMID:19284764 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO tylophorine analog results in increased expression of CDC25A CTD PMID:19284764 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator increases expression ISO tylophorine analog results in increased expression of CFLAR mRNA CTD PMID:19284764 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex increases activity ISO tylophorine analog results in increased activity of CHUK protein CTD PMID:19284764 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 increases expression ISO tylophorine analog results in increased expression of IRAK1 mRNA CTD PMID:19284764 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521
JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 increases expression ISO tylophorine analog results in increased expression of MAP3K14 mRNA CTD PMID:19284764 NCBI chr10:88,165,349...88,215,558
Ensembl chr10:88,165,351...88,215,523
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO tylophorine analog results in increased expression of NFKBIA mRNA CTD PMID:19284764 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta increases expression ISO tylophorine analog results in increased expression of PIK3CD mRNA CTD PMID:19284764 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha increases expression ISO tylophorine analog results in increased expression of PPP3CA mRNA CTD PMID:19284764 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha increases expression ISO tylophorine analog results in increased expression of PRKACA mRNA CTD PMID:19284764 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO tylophorine analog inhibits the reaction [TNF results in increased expression of PTGS2 protein] CTD PMID:19284764 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [tylophorine analog co-treated with TNF] results in decreased expression of RELA protein CTD PMID:19284764 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [tylophorine analog co-treated with TNF] results in decreased expression of RELA protein; tylophorine analog inhibits the reaction [TNF results in increased activity of AKT1 protein]; tylophorine analog inhibits the reaction [TNF results in increased expression of PTGS2 protein] CTD PMID:19284764 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    chemical entity 19795
      atom 19794
        nonmetal atom 19681
          nitrogen atom 18762
            nitrogen molecular entity 18762
              organonitrogen compound 18540
                organonitrogen heterocyclic compound 17659
                  Tylophorine 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            organic molecule 19545
                              organic cyclic compound 19339
                                organic heterocyclic compound 18579
                                  organic heteropolycyclic compound 18039
                                    organic heteropentacyclic compound 13307
                                      Tylophorine 17
paths to the root