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ONTOLOGY REPORT - ANNOTATIONS


Term:tubocurarine
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Accession:CHEBI:9774 term browser browse the term
Definition:A benzylisoquinoline alkaloid muscle relaxant which constitutes the active component of curare.
Synonyms:exact_synonym: 7',12'-dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyltubocuraran-2'-ium
 related_synonym: 7',12'-dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyltubocuraranium;   Formula=C37H41N2O6;   InChI=1S/C37H40N2O6/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41)/p+1/t28-,29+/m0/s1;   InChIKey=JFJZZMVDLULRGK-URLMMPGGSA-O;   SMILES=[H][C@]12Cc3ccc(Oc4c(O)c(OC)cc5CC[N+](C)(C)[C@]([H])(Cc6ccc(O)c(Oc7cc1c(CCN2C)cc7OC)c6)c45)cc3;   Tubocurarin;   d-tubocurarine
 xref: Beilstein:3898737 "Beilstein";   CAS:57-95-4 "ChemIDplus";   DrugBank:DB01199;   Drug_Central:2781 "DrugCentral";   KEGG:C07547;   KNApSAcK:C00001927;   LINCS:LSM-4245
 xref_mesh: MESH:D014403
 xref: PDBeChem:TC9;   PMID:2215478 "Europe PMC";   PMID:6196640 "Europe PMC";   PMID:7911306 "Europe PMC";   PMID:8166227 "Europe PMC";   Reaxys:3898737 "Reaxys";   Wikipedia:Tubocurarine_chloride


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tubocurarine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ache acetylcholinesterase JBrowse link 12 22,472,358 22,477,052 RGD:6480464
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bglap bone gamma-carboxyglutamate protein JBrowse link 2 187,741,770 187,748,445 RGD:6480464
G C7 complement C7 JBrowse link 2 54,707,621 54,781,624 RGD:6480464
G Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:6480464
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit JBrowse link 3 60,445,657 60,460,724 RGD:6480464
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit JBrowse link 15 42,808,897 42,825,179 RGD:6480464
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit JBrowse link 8 59,594,007 59,607,122 RGD:6480464
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit JBrowse link 3 176,533,182 176,547,965 RGD:6480464
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit JBrowse link 1 123,897,341 124,039,263 RGD:6480464
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit JBrowse link 2 189,088,570 189,096,785 RGD:6480464
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit JBrowse link 8 59,610,489 59,629,073 RGD:6480464
G Cntn1 contactin 1 JBrowse link 7 133,290,606 133,588,314 RGD:6480464
G Csf2 colony stimulating factor 2 JBrowse link 10 39,602,089 39,604,070 RGD:6480464
G Dhfr dihydrofolate reductase JBrowse link 2 21,931,887 21,958,927 RGD:6480464
G Eml4 EMAP like 4 JBrowse link 6 6,618,370 6,674,550 RGD:6480464
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:6480464
G Fez1 fasciculation and elongation protein zeta 1 JBrowse link 8 39,305,128 39,350,270 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Golga4 golgin A4 JBrowse link 8 127,171,221 127,248,938 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Kcnn1 potassium calcium-activated channel subfamily N member 1 JBrowse link 16 20,325,270 20,349,163 RGD:6480464
G Kcnn2 potassium calcium-activated channel subfamily N member 2 JBrowse link 18 39,331,894 39,479,574 RGD:6480464
G Kmt2c lysine methyltransferase 2C JBrowse link 4
4
82,506
6,083,650
109,986
6,294,413
RGD:6480464
G Litaf lipopolysaccharide-induced TNF factor JBrowse link 10 4,753,546 4,763,272 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mmp1 matrix metallopeptidase 1 JBrowse link 8 5,703,206 5,723,593 RGD:6480464
G Nin ninein JBrowse link 6 92,423,412 92,527,776 RGD:6480464
G Plau plasminogen activator, urokinase JBrowse link 15 3,644,296 3,650,765 RGD:6480464
G Pou5f1 POU class 5 homeobox 1 JBrowse link 20 3,747,231 3,751,994 RGD:6480464
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:6480464
G Ptma prothymosin alpha JBrowse link 9 93,545,396 93,549,436 RGD:6480464
G Ptpra protein tyrosine phosphatase, receptor type, A JBrowse link 3 122,976,066 123,084,585 RGD:6480464
G Rbbp6 RB binding protein 6, ubiquitin ligase JBrowse link 1 192,933,264 192,965,160 RGD:6480464
G Sftpa1 surfactant protein A1 JBrowse link 16 18,716,019 18,719,404 RGD:6480464
G Sftpc surfactant protein C JBrowse link 15 52,211,538 52,214,480 RGD:6480464
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:6480464
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:6480464
G Stip1 stress-induced phosphoprotein 1 JBrowse link 1 222,274,133 222,293,139 RGD:6480464
G Ube2c ubiquitin-conjugating enzyme E2C JBrowse link 3 161,236,971 161,239,371 RGD:6480464
G Ube3a ubiquitin protein ligase E3A JBrowse link 1 116,586,901 116,678,161 RGD:6480464
G Xdh xanthine dehydrogenase JBrowse link 6 25,149,570 25,211,273 RGD:6480464
G Zfp42 zinc finger protein 42 JBrowse link 16 52,016,590 52,026,346 RGD:6480464
G Zfr zinc finger RNA binding protein JBrowse link 2 62,150,251 62,213,048 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      application 19220
        pharmaceutical 19081
          drug 19081
            drug allergen 9747
              tubocurarine 46
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    p-block element atom 19531
                      carbon group element atom 19413
                        carbon atom 19405
                          organic molecular entity 19405
                            organic molecule 19327
                              organic cyclic compound 19076
                                organic heterocyclic compound 18151
                                  organonitrogen heterocyclic compound 16960
                                    isoquinolines 429
                                      benzyltetrahydroisoquinoline 76
                                        tubocuraran 46
                                          tubocurarine 46
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.