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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tubocurarine
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Accession:CHEBI:9774 term browser browse the term
Definition:A benzylisoquinoline alkaloid muscle relaxant which constitutes the active component of curare.
Synonyms:exact_synonym: 7',12'-dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyltubocuraran-2'-ium
 related_synonym: 7',12'-dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyltubocuraranium;   Formula=C37H41N2O6;   InChI=1S/C37H40N2O6/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41)/p+1/t28-,29+/m0/s1;   InChIKey=JFJZZMVDLULRGK-URLMMPGGSA-O;   SMILES=[H][C@]12Cc3ccc(Oc4c(O)c(OC)cc5CC[N+](C)(C)[C@]([H])(Cc6ccc(O)c(Oc7cc1c(CCN2C)cc7OC)c6)c45)cc3;   Tubocurarin;   d-tubocurarine
 xref: Beilstein:3898737;   CAS:57-95-4;   DrugBank:DB01199;   Drug_Central:2781;   KEGG:C07547;   KNApSAcK:C00001927;   LINCS:LSM-4245
 xref_mesh: MESH:D014403
 xref: PDBeChem:TC9;   PMID:2215478;   PMID:6196640;   PMID:7911306;   PMID:8166227;   Reaxys:3898737;   Wikipedia:Tubocurarine_chloride


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tubocurarine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO Tubocurarine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Tubocurarine promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Tubocurarine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein] CTD PMID:10421444 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Tubocurarine inhibits the reaction [[Nicotine results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form]; Tubocurarine inhibits the reaction [Nicotine results in increased metabolism of APP protein] CTD PMID:29618714 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Tubocurarine inhibits the reaction [PTMA protein results in decreased expression of BCL2] CTD PMID:16644063 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of BGLAP] CTD PMID:19436947 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G C7 complement C7 multiple interactions
decreases expression
ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of C7 mRNA]
Tubocurarine results in decreased expression of C7 mRNA
CTD PMID:16949557 NCBI chr 2:54,707,621...54,781,624
Ensembl chr 2:54,709,138...54,777,729
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein] CTD PMID:15231866 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit multiple interactions ISO Tubocurarine inhibits the reaction [CHRNA1 protein binds to PLAU protein] CTD PMID:19690163 NCBI chr 3:60,445,657...60,460,724
Ensembl chr 3:60,445,666...60,460,724
JBrowse link
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions EXP Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]] CTD PMID:7808438 NCBI chr15:42,808,897...42,825,179
Ensembl chr15:42,808,897...42,825,179
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions ISO
EXP
Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]
Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]]; Tubocurarine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]
CTD PMID:7808438 PMID:9687574 PMID:16931985 NCBI chr 8:59,594,007...59,607,122
Ensembl chr 8:59,592,403...59,607,275
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]; Tubocurarine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]
CTD PMID:7756618 PMID:11711029 PMID:14645658 PMID:16931985 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions ISO Tubocurarine binds to and results in decreased activity of CHRNA7 protein; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Tubocurarine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein] CTD PMID:10082212 PMID:10216184 PMID:16931985 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO
EXP
Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]; Tubocurarine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]]
Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]
CTD PMID:7756618 PMID:7808438 PMID:11711029 PMID:14645658 PMID:16931985 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions ISO
EXP
Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]
Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]]; Tubocurarine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]
CTD PMID:7808438 PMID:9687574 PMID:16931985 NCBI chr 8:59,610,489...59,629,073
Ensembl chr 8:59,609,693...59,629,133
JBrowse link
G Cntn1 contactin 1 increases expression
decreases expression
multiple interactions
ISO Tubocurarine results in increased expression of CNTN1 mRNA
Tubocurarine results in decreased expression of CNTN1 mRNA
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA]
CTD PMID:12588870 PMID:16949557 NCBI chr 7:133,290,606...133,588,314
Ensembl chr 7:133,400,485...133,586,677
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased secretion of CSF2 protein] CTD PMID:9606035 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Dhfr dihydrofolate reductase multiple interactions
decreases expression
ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA]
Tubocurarine results in decreased expression of DHFR mRNA
CTD PMID:12588870 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453
JBrowse link
G Eml4 EMAP like 4 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of EML4 mRNA] CTD PMID:12588870 NCBI chr 6:6,618,370...6,674,550
Ensembl chr 6:6,619,076...6,674,554
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Tubocurarine inhibits the reaction [PTMA protein results in increased expression of FAS] CTD PMID:16644063 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fez1 fasciculation and elongation protein zeta 1 multiple interactions
decreases expression
ISO Tubocurarine promotes the reaction [Nicotine results in decreased expression of FEZ1 mRNA]
Tubocurarine results in decreased expression of FEZ1 mRNA
CTD PMID:12588870 NCBI chr 8:39,305,128...39,350,270
Ensembl chr 8:39,305,128...39,350,270
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of FOS] CTD PMID:11425648 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Golga4 golgin A4 decreases expression
multiple interactions
ISO Tubocurarine results in decreased expression of GOLGA4 mRNA
Tubocurarine inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA]
CTD PMID:16949557 NCBI chr 8:127,171,221...127,248,938
Ensembl chr 8:127,171,537...127,248,538
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 mRNA]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]] CTD PMID:22119045 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Kcnn1 potassium calcium-activated channel subfamily N member 1 decreases activity ISO Tubocurarine results in decreased activity of KCNN1 protein CTD PMID:10696100 NCBI chr16:20,325,270...20,349,163
Ensembl chr16:20,336,638...20,348,804
JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases activity ISO
EXP
Tubocurarine results in decreased activity of KCNN2 protein CTD PMID:10696100 PMID:10991935 NCBI chr18:39,331,894...39,479,574
Ensembl chr18:39,335,377...39,479,257
JBrowse link
G Kmt2c lysine methyltransferase 2C multiple interactions
decreases expression
ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA]
Tubocurarine results in decreased expression of KMT2C mRNA
CTD PMID:12588870 NCBI chr 4:82,506...109,986
NCBI chr 4:6,083,650...6,294,413
Ensembl chr 4:6,083,736...6,292,516
JBrowse link
G Litaf lipopolysaccharide-induced TNF factor multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of LITAF mRNA] CTD PMID:12588870 NCBI chr10:4,753,546...4,763,272
Ensembl chr10:4,719,713...4,763,510
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] CTD PMID:22119045 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] CTD PMID:22119045 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO Tubocurarine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 protein] CTD PMID:17151781 PMID:18986645 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Nin ninein multiple interactions
decreases expression
ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of NIN mRNA]
Tubocurarine results in decreased expression of NIN mRNA
CTD PMID:16949557 NCBI chr 6:92,423,412...92,527,776
Ensembl chr 6:92,433,381...92,527,711
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions ISO Tubocurarine inhibits the reaction [CHRNA1 protein binds to PLAU protein] CTD PMID:19690163 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression
multiple interactions
ISO Tubocurarine results in decreased expression of POU5F1 mRNA
Tubocurarine inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA]
CTD PMID:15612475 PMID:15749260 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase decreases expression ISO Tubocurarine results in decreased expression of PRKN mRNA CTD PMID:16949557 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Ptma prothymosin alpha multiple interactions ISO Tubocurarine inhibits the reaction [PTMA protein results in decreased expression of BCL2]; Tubocurarine inhibits the reaction [PTMA protein results in increased expression of FAS] CTD PMID:16644063 NCBI chr 9:93,545,396...93,549,436
Ensembl chr 9:93,545,396...93,549,436
JBrowse link
G Ptpra protein tyrosine phosphatase, receptor type, A multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of PTPRA mRNA] CTD PMID:12588870 NCBI chr 3:122,976,066...123,084,585
Ensembl chr 3:122,976,104...123,084,863
JBrowse link
G Rbbp6 RB binding protein 6, ubiquitin ligase multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA] CTD PMID:12588870 NCBI chr 1:192,933,264...192,965,160
Ensembl chr 1:192,933,540...192,965,158
JBrowse link
G Sftpa1 surfactant protein A1 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPA1 mRNA] CTD PMID:9458815 NCBI chr16:18,716,019...18,719,404
Ensembl chr16:18,716,019...18,719,403
JBrowse link
G Sftpc surfactant protein C multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPC mRNA] CTD PMID:9458815 NCBI chr15:52,211,538...52,214,480
Ensembl chr15:52,211,544...52,214,616
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 multiple interactions
decreases expression
ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of SOS1 mRNA]
Tubocurarine results in decreased expression of SOS1 mRNA
CTD PMID:16949557 NCBI chr 6:3,105,443...3,182,977
Ensembl chr 6:3,104,861...3,182,996
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of SPP1 protein] CTD PMID:11425648 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Stip1 stress-induced phosphoprotein 1 multiple interactions
decreases expression
ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of STIP1 mRNA]
Tubocurarine results in decreased expression of STIP1 mRNA
CTD PMID:16949557 NCBI chr 1:222,274,133...222,293,139
Ensembl chr 1:222,274,133...222,293,148
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C multiple interactions
decreases expression
ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE2C mRNA]
Tubocurarine results in decreased expression of UBE2C mRNA
CTD PMID:16949557 NCBI chr 3:161,236,971...161,239,371
Ensembl chr 3:161,236,898...161,241,159
JBrowse link
G Ube3a ubiquitin protein ligase E3A increases expression
multiple interactions
ISO Tubocurarine results in increased expression of UBE3A mRNA
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE3A mRNA]
CTD PMID:12588870 NCBI chr 1:116,586,901...116,678,161
Ensembl chr 1:116,587,815...116,679,973
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP Tubocurarine inhibits the reaction [Isoflurophate results in increased expression of XDH protein alternative form] CTD PMID:9789800 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link
G Zfp42 zinc finger protein 42 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of ZFP42 mRNA] CTD PMID:15749260 NCBI chr16:52,016,590...52,026,346 JBrowse link
G Zfr zinc finger RNA binding protein decreases expression
multiple interactions
ISO Tubocurarine results in decreased expression of ZFR mRNA
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA]
CTD PMID:12588870 NCBI chr 2:62,150,251...62,213,048
Ensembl chr 2:62,150,251...62,213,048
JBrowse link

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              tubocurarine 46
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                            organic molecule 19586
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                                organic heterocyclic compound 18511
                                  organonitrogen heterocyclic compound 17579
                                    isoquinolines 432
                                      benzyltetrahydroisoquinoline 75
                                        tubocuraran 46
                                          tubocurarine 46
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