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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tubocurarine
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Accession:CHEBI:9774 term browser browse the term
Definition:A benzylisoquinoline alkaloid muscle relaxant which constitutes the active component of curare.
Synonyms:exact_synonym: 7',12'-dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyltubocuraran-2'-ium
 related_synonym: 7',12'-dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyltubocuraranium;   Formula=C37H41N2O6;   InChI=1S/C37H40N2O6/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41)/p+1/t28-,29+/m0/s1;   InChIKey=JFJZZMVDLULRGK-URLMMPGGSA-O;   SMILES=[H][C@]12Cc3ccc(Oc4c(O)c(OC)cc5CC[N+](C)(C)[C@]([H])(Cc6ccc(O)c(Oc7cc1c(CCN2C)cc7OC)c6)c45)cc3;   Tubocurarin;   d-tubocurarine
 xref: Beilstein:3898737;   CAS:57-95-4;   DrugBank:DB01199;   Drug_Central:2781;   KEGG:C07547;   KNApSAcK:C00001927;   LINCS:LSM-4245
 xref_mesh: MESH:D014403
 xref: PDBeChem:TC9;   PMID:2215478;   PMID:6196640;   PMID:7911306;   PMID:8166227;   Reaxys:3898737;   Wikipedia:Tubocurarine_chloride

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tubocurarine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO Tubocurarine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Tubocurarine promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Tubocurarine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein] CTD PMID:10421444 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Tubocurarine inhibits the reaction [[Nicotine results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form]; Tubocurarine inhibits the reaction [Nicotine results in increased metabolism of APP protein] CTD PMID:29618714 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Tubocurarine inhibits the reaction [PTMA protein results in decreased expression of BCL2] CTD PMID:16644063 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of BGLAP] CTD PMID:19436947 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747 		JBrowse link
G C7 complement C7 multiple interactions
decreases expression		 ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of C7 mRNA]
Tubocurarine results in decreased expression of C7 mRNA		 CTD PMID:16949557 NCBI chr 2:54,707,621...54,781,624
Ensembl chr 2:54,709,138...54,777,729 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein] CTD PMID:15231866 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418 		JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit multiple interactions ISO Tubocurarine inhibits the reaction [CHRNA1 protein binds to PLAU protein] CTD PMID:19690163 NCBI chr 3:60,445,657...60,460,724
Ensembl chr 3:60,445,666...60,460,724 		JBrowse link
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions EXP Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]] CTD PMID:7808438 NCBI chr15:42,808,897...42,825,179
Ensembl chr15:42,808,897...42,825,179 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions ISO
EXP		 Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]
Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]]; Tubocurarine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]		 CTD PMID:7808438 PMID:9687574 PMID:16931985 NCBI chr 8:59,594,007...59,607,122
Ensembl chr 8:59,592,403...59,607,275 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]; Tubocurarine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]		 CTD PMID:7756618 PMID:11711029 PMID:14645658 PMID:16931985 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions ISO Tubocurarine binds to and results in decreased activity of CHRNA7 protein; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Tubocurarine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein] CTD PMID:10082212 PMID:10216184 PMID:16931985 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO
EXP		 Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]; Tubocurarine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]]
Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]		 CTD PMID:7756618 PMID:7808438 PMID:11711029 PMID:14645658 PMID:16931985 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions ISO
EXP		 Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]
Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]]; Tubocurarine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]		 CTD PMID:7808438 PMID:9687574 PMID:16931985 NCBI chr 8:59,610,489...59,629,073
Ensembl chr 8:59,609,693...59,629,133 		JBrowse link
G Cntn1 contactin 1 increases expression
decreases expression
multiple interactions		 ISO Tubocurarine results in increased expression of CNTN1 mRNA
Tubocurarine results in decreased expression of CNTN1 mRNA
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA]		 CTD PMID:12588870 PMID:16949557 NCBI chr 7:133,290,606...133,588,314
Ensembl chr 7:133,400,485...133,586,677 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased secretion of CSF2 protein] CTD PMID:9606035 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070 		JBrowse link
G Dhfr dihydrofolate reductase multiple interactions
decreases expression		 ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA]
Tubocurarine results in decreased expression of DHFR mRNA		 CTD PMID:12588870 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453 		JBrowse link
G Eml4 EMAP like 4 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of EML4 mRNA] CTD PMID:12588870 NCBI chr 6:6,618,370...6,674,550
Ensembl chr 6:6,619,076...6,674,554 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Tubocurarine inhibits the reaction [PTMA protein results in increased expression of FAS] CTD PMID:16644063 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Fez1 fasciculation and elongation protein zeta 1 multiple interactions
decreases expression		 ISO Tubocurarine promotes the reaction [Nicotine results in decreased expression of FEZ1 mRNA]
Tubocurarine results in decreased expression of FEZ1 mRNA		 CTD PMID:12588870 NCBI chr 8:39,305,128...39,350,270
Ensembl chr 8:39,305,128...39,350,270 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of FOS] CTD PMID:11425648 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Golga4 golgin A4 decreases expression
multiple interactions		 ISO Tubocurarine results in decreased expression of GOLGA4 mRNA
Tubocurarine inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA]		 CTD PMID:16949557 NCBI chr 8:127,171,221...127,248,938
Ensembl chr 8:127,171,537...127,248,538 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 mRNA]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]] CTD PMID:22119045 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Kcnn1 potassium calcium-activated channel subfamily N member 1 decreases activity ISO Tubocurarine results in decreased activity of KCNN1 protein CTD PMID:10696100 NCBI chr16:20,325,270...20,349,163
Ensembl chr16:20,336,638...20,348,804 		JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases activity ISO
EXP		 Tubocurarine results in decreased activity of KCNN2 protein CTD PMID:10696100 PMID:10991935 NCBI chr18:39,331,894...39,479,574
Ensembl chr18:39,335,377...39,479,257 		JBrowse link
G Kmt2c lysine methyltransferase 2C multiple interactions
decreases expression		 ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA]
Tubocurarine results in decreased expression of KMT2C mRNA		 CTD PMID:12588870 NCBI chr 4:82,506...109,986
NCBI chr 4:6,083,650...6,294,413
Ensembl chr 4:6,083,736...6,292,516 		JBrowse link
G Litaf lipopolysaccharide-induced TNF factor multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of LITAF mRNA] CTD PMID:12588870 NCBI chr10:4,753,546...4,763,272
Ensembl chr10:4,719,713...4,763,510 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] CTD PMID:22119045 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] CTD PMID:22119045 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO Tubocurarine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 protein] CTD PMID:17151781 PMID:18986645 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591 		JBrowse link
G Nin ninein multiple interactions
decreases expression		 ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of NIN mRNA]
Tubocurarine results in decreased expression of NIN mRNA		 CTD PMID:16949557 NCBI chr 6:92,423,412...92,527,776
Ensembl chr 6:92,433,381...92,527,711 		JBrowse link
G Plau plasminogen activator, urokinase multiple interactions ISO Tubocurarine inhibits the reaction [CHRNA1 protein binds to PLAU protein] CTD PMID:19690163 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression
multiple interactions		 ISO Tubocurarine results in decreased expression of POU5F1 mRNA
Tubocurarine inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA]		 CTD PMID:15612475 PMID:15749260 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase decreases expression ISO Tubocurarine results in decreased expression of PRKN mRNA CTD PMID:16949557 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Ptma prothymosin alpha multiple interactions ISO Tubocurarine inhibits the reaction [PTMA protein results in decreased expression of BCL2]; Tubocurarine inhibits the reaction [PTMA protein results in increased expression of FAS] CTD PMID:16644063 NCBI chr 9:93,545,396...93,549,436
Ensembl chr 9:93,545,396...93,549,436 		JBrowse link
G Ptpra protein tyrosine phosphatase, receptor type, A multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of PTPRA mRNA] CTD PMID:12588870 NCBI chr 3:122,976,066...123,084,585
Ensembl chr 3:122,976,104...123,084,863 		JBrowse link
G Rbbp6 RB binding protein 6, ubiquitin ligase multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA] CTD PMID:12588870 NCBI chr 1:192,933,264...192,965,160
Ensembl chr 1:192,933,540...192,965,158 		JBrowse link
G Sftpa1 surfactant protein A1 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPA1 mRNA] CTD PMID:9458815 NCBI chr16:18,716,019...18,719,404
Ensembl chr16:18,716,019...18,719,403 		JBrowse link
G Sftpc surfactant protein C multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPC mRNA] CTD PMID:9458815 NCBI chr15:52,211,538...52,214,480
Ensembl chr15:52,211,544...52,214,616 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 multiple interactions
decreases expression		 ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of SOS1 mRNA]
Tubocurarine results in decreased expression of SOS1 mRNA		 CTD PMID:16949557 NCBI chr 6:3,105,443...3,182,977
Ensembl chr 6:3,104,861...3,182,996 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of SPP1 protein] CTD PMID:11425648 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901 		JBrowse link
G Stip1 stress-induced phosphoprotein 1 multiple interactions
decreases expression		 ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of STIP1 mRNA]
Tubocurarine results in decreased expression of STIP1 mRNA		 CTD PMID:16949557 NCBI chr 1:222,274,133...222,293,139
Ensembl chr 1:222,274,133...222,293,148 		JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C multiple interactions
decreases expression		 ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE2C mRNA]
Tubocurarine results in decreased expression of UBE2C mRNA		 CTD PMID:16949557 NCBI chr 3:161,236,971...161,239,371
Ensembl chr 3:161,236,898...161,241,159 		JBrowse link
G Ube3a ubiquitin protein ligase E3A increases expression
multiple interactions		 ISO Tubocurarine results in increased expression of UBE3A mRNA
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE3A mRNA]		 CTD PMID:12588870 NCBI chr 1:116,586,901...116,678,161
Ensembl chr 1:116,587,815...116,679,973 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP Tubocurarine inhibits the reaction [Isoflurophate results in increased expression of XDH protein alternative form] CTD PMID:9789800 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494 		JBrowse link
G Zfp42 zinc finger protein 42 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of ZFP42 mRNA] CTD PMID:15749260 NCBI chr16:52,016,590...52,026,346 JBrowse link
G Zfr zinc finger RNA binding protein decreases expression
multiple interactions		 ISO Tubocurarine results in decreased expression of ZFR mRNA
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA]		 CTD PMID:12588870 NCBI chr 2:62,150,251...62,213,048
Ensembl chr 2:62,150,251...62,213,048 		JBrowse link
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  CHEBI ontology 19875
    role 19825
      application 19494
        pharmaceutical 19364
          drug 19364
            drug allergen 9938
              tubocurarine 46
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  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
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              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic molecule 19586
                              organic cyclic compound 19395
                                organic heterocyclic compound 18511
                                  organonitrogen heterocyclic compound 17579
                                    isoquinolines 432
                                      benzyltetrahydroisoquinoline 75
                                        tubocuraran 46
                                          tubocurarine 46
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