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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Tryptanthrine
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Accession:CHEBI:9768 term browser browse the term
Definition:An alkaloid antibiotic that has formula C15H8N2O2.
Synonyms:related_synonym: Formula=C15H8N2O2;   InChI=1S/C15H8N2O2/c18-13-10-6-2-4-8-12(10)17-14(13)16-11-7-3-1-5-9(11)15(17)19/h1-8H;   InChIKey=VQQVWGVXDIPORV-UHFFFAOYSA-N;   SMILES=O=C1c2ccccc2-n2c1nc1ccccc1c2=O
 xref: CAS:13220-57-0;   KEGG:C10742;   KNApSAcK:C00002200
 xref_mesh: MESH:C046243


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Tryptanthrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects binding
decreases expression
ISO tryptanthrine binds to ABCB1 promoter
tryptanthrine results in decreased expression of ABCB1 mRNA; tryptanthrine results in decreased expression of ABCB1 protein
CTD PMID:17482571 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO tryptanthrine promotes the reaction [[AHR protein binds to ARNT protein] which binds to CCL20 promoter] CTD PMID:26259605 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO tryptanthrine promotes the reaction [[AHR protein binds to ARNT protein] which binds to CCL20 promoter] CTD PMID:26259605 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Calca calcitonin-related polypeptide alpha increases expression ISO tryptanthrine results in increased expression of CALCA mRNA CTD PMID:23500671 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 multiple interactions ISO tryptanthrine promotes the reaction [[AHR protein binds to ARNT protein] which binds to CCL20 promoter] CTD PMID:26259605 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO tryptanthrine results in decreased expression of CCND1 protein CTD PMID:23500671 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO tryptanthrine results in decreased expression of CCND3 protein CTD PMID:23500671 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO tryptanthrine results in decreased expression of CDK4 protein CTD PMID:23500671 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO tryptanthrine results in decreased expression of CDK6 protein CTD PMID:23500671 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Gap43 growth associated protein 43 increases expression ISO tryptanthrine results in increased expression of GAP43 mRNA CTD PMID:23500671 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Map2 microtubule-associated protein 2 increases expression ISO tryptanthrine results in increased expression of MAP2 protein CTD PMID:23500671 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
JBrowse link
G Mapt microtubule-associated protein tau increases expression ISO tryptanthrine results in increased expression of MAPT mRNA CTD PMID:23500671 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mycn MYCN proto-oncogene, bHLH transcription factor decreases expression ISO tryptanthrine results in decreased expression of MYCN mRNA; tryptanthrine results in decreased expression of MYCN protein CTD PMID:23500671 NCBI chr 6:38,222,554...38,228,419
Ensembl chr 6:38,222,555...38,228,379
JBrowse link
G Nefh neurofilament heavy increases expression ISO tryptanthrine results in increased expression of NEFH protein CTD PMID:23500671 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Sst somatostatin increases expression ISO tryptanthrine results in increased expression of SST mRNA CTD PMID:23500671 NCBI chr11:80,358,172...80,359,449
Ensembl chr11:80,358,211...80,359,444
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO tryptanthrine results in decreased expression of and results in increased degradation of TP53 protein CTD PMID:17482571 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        antimicrobial agent 17329
          alkaloid antibiotic 270
            Tryptanthrine 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic molecule 19514
                              organic cyclic compound 19311
                                organic heterocyclic compound 18425
                                  organic heteropolycyclic compound 17838
                                    organic heterotetracyclic compound 4656
                                      Tryptanthrine 16
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