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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Tryptanthrine
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Accession:CHEBI:9768 term browser browse the term
Definition:An alkaloid antibiotic that has formula C15H8N2O2.
Synonyms:related_synonym: Formula=C15H8N2O2;   InChI=1S/C15H8N2O2/c18-13-10-6-2-4-8-12(10)17-14(13)16-11-7-3-1-5-9(11)15(17)19/h1-8H;   InChIKey=VQQVWGVXDIPORV-UHFFFAOYSA-N;   SMILES=O=C1c2ccccc2-n2c1nc1ccccc1c2=O
 xref: CAS:13220-57-0;   KEGG:C10742;   KNApSAcK:C00002200
 xref_mesh: MESH:C046243



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Tryptanthrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects binding
decreases expression
ISO tryptanthrine binds to ABCB1 promoter
tryptanthrine results in decreased expression of ABCB1 mRNA; tryptanthrine results in decreased expression of ABCB1 protein
CTD PMID:17482571 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO tryptanthrine promotes the reaction [[AHR protein binds to ARNT protein] which binds to CCL20 promoter] CTD PMID:26259605 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO tryptanthrine promotes the reaction [[AHR protein binds to ARNT protein] which binds to CCL20 promoter] CTD PMID:26259605 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
JBrowse link
G Calca calcitonin-related polypeptide alpha increases expression ISO tryptanthrine results in increased expression of CALCA mRNA CTD PMID:23500671 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 multiple interactions ISO tryptanthrine promotes the reaction [[AHR protein binds to ARNT protein] which binds to CCL20 promoter] CTD PMID:26259605 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO tryptanthrine results in decreased expression of CCND1 protein CTD PMID:23500671 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO tryptanthrine results in decreased expression of CCND3 protein CTD PMID:23500671 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO tryptanthrine results in decreased expression of CDK4 protein CTD PMID:23500671 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO tryptanthrine results in decreased expression of CDK6 protein CTD PMID:23500671 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Gap43 growth associated protein 43 increases expression ISO tryptanthrine results in increased expression of GAP43 mRNA CTD PMID:23500671 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
JBrowse link
G Map2 microtubule-associated protein 2 increases expression ISO tryptanthrine results in increased expression of MAP2 protein CTD PMID:23500671 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
JBrowse link
G Mapt microtubule-associated protein tau increases expression ISO tryptanthrine results in increased expression of MAPT mRNA CTD PMID:23500671 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mycn MYCN proto-oncogene, bHLH transcription factor decreases expression ISO tryptanthrine results in decreased expression of MYCN mRNA; tryptanthrine results in decreased expression of MYCN protein CTD PMID:23500671 NCBI chr 6:35,717,764...35,723,590
Ensembl chr 6:35,717,764...35,723,590
JBrowse link
G Nefh neurofilament heavy chain increases expression ISO tryptanthrine results in increased expression of NEFH protein CTD PMID:23500671 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
JBrowse link
G Sst somatostatin increases expression ISO tryptanthrine results in increased expression of SST mRNA CTD PMID:23500671 NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO tryptanthrine results in decreased expression of and results in increased degradation of TP53 protein CTD PMID:17482571 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        antimicrobial agent 17472
          alkaloid antibiotic 275
            Tryptanthrine 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  organic heteropolycyclic compound 18043
                                    organic heterotetracyclic compound 9073
                                      Tryptanthrine 16
paths to the root