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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Tryptanthrine
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Accession:CHEBI:9768 term browser browse the term
Definition:An alkaloid antibiotic that has formula C15H8N2O2.
Synonyms:related_synonym: Formula=C15H8N2O2;   InChI=1S/C15H8N2O2/c18-13-10-6-2-4-8-12(10)17-14(13)16-11-7-3-1-5-9(11)15(17)19/h1-8H;   InChIKey=VQQVWGVXDIPORV-UHFFFAOYSA-N;   SMILES=O=C1c2ccccc2-n2c1nc1ccccc1c2=O
 xref: CAS:13220-57-0;   KEGG:C10742;   KNApSAcK:C00002200
 xref_mesh: MESH:C046243



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Tryptanthrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects binding
decreases expression
ISO tryptanthrine binds to ABCB1 promoter
tryptanthrine results in decreased expression of ABCB1 mRNA; tryptanthrine results in decreased expression of ABCB1 protein
CTD PMID:17482571 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO tryptanthrine promotes the reaction [[AHR protein binds to ARNT protein] which binds to CCL20 promoter] CTD PMID:26259605 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO tryptanthrine results in decreased phosphorylation of AKT1 protein CTD PMID:26341616 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO tryptanthrine promotes the reaction [[AHR protein binds to ARNT protein] which binds to CCL20 promoter] CTD PMID:26259605 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
JBrowse link
G Calca calcitonin-related polypeptide alpha increases expression ISO tryptanthrine results in increased expression of CALCA mRNA CTD PMID:23500671 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 multiple interactions ISO tryptanthrine promotes the reaction [[AHR protein binds to ARNT protein] which binds to CCL20 promoter]
tryptanthrine inhibits the reaction [[IL17A protein co-treated with TNF protein] results in increased expression of CCL20 mRNA]
CTD PMID:26259605 PMID:32173427 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
JBrowse link
G Ccna1 cyclin A1 decreases expression ISO tryptanthrine results in decreased expression of CCNA1 mRNA; tryptanthrine results in decreased expression of CCNA1 protein CTD PMID:26341616 NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO tryptanthrine results in decreased expression of CCNB1 mRNA; tryptanthrine results in decreased expression of CCNB1 protein CTD PMID:26341616 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO tryptanthrine results in decreased expression of CCND1 protein CTD PMID:23500671 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO tryptanthrine results in decreased expression of CCND3 protein CTD PMID:23500671 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO tryptanthrine results in decreased expression of CDK2 mRNA; tryptanthrine results in decreased expression of CDK2 protein CTD PMID:26341616 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO tryptanthrine results in decreased expression of CDK4 protein CTD PMID:23500671 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO tryptanthrine results in decreased expression of CDK6 protein CTD PMID:23500671 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Gap43 growth associated protein 43 increases expression ISO tryptanthrine results in increased expression of GAP43 mRNA CTD PMID:23500671 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
JBrowse link
G Il17a interleukin 17A multiple interactions ISO tryptanthrine inhibits the reaction [[IL17A protein co-treated with TNF protein] results in increased expression of CCL20 mRNA]; tryptanthrine inhibits the reaction [[IL17A protein co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; tryptanthrine inhibits the reaction [[IL17A protein co-treated with TNF protein] results in increased expression of IL1B mRNA]; tryptanthrine inhibits the reaction [[IL17A protein co-treated with TNF protein] results in increased expression of IL6 mRNA]; tryptanthrine inhibits the reaction [[IL17A protein co-treated with TNF protein] results in increased expression of S100A9 mRNA]; tryptanthrine inhibits the reaction [[IL17A protein co-treated with TNF protein] results in increased expression of TNF mRNA]; tryptanthrine inhibits the reaction [RORC protein results in increased expression of IL17A mRNA] CTD PMID:32173427 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il17f interleukin 17F multiple interactions ISO tryptanthrine inhibits the reaction [RORC protein results in increased expression of IL17F mRNA] CTD PMID:32173427 NCBI chr 9:23,190,094...23,201,482
Ensembl chr 9:23,190,100...23,201,482
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO tryptanthrine inhibits the reaction [[IL17A protein co-treated with TNF protein] results in increased expression of IL1B mRNA] CTD PMID:32173427 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il22 interleukin 22 multiple interactions ISO tryptanthrine inhibits the reaction [RORC protein results in increased expression of IL22 mRNA] CTD PMID:32173427 NCBI chr 7:53,801,206...53,805,673
Ensembl chr 7:53,801,206...53,806,186
JBrowse link
G Il6 interleukin 6 multiple interactions ISO tryptanthrine inhibits the reaction [[IL17A protein co-treated with TNF protein] results in increased expression of IL6 mRNA] CTD PMID:32173427 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Map2 microtubule-associated protein 2 increases expression ISO tryptanthrine results in increased expression of MAP2 protein CTD PMID:23500671 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
JBrowse link
G Mapt microtubule-associated protein tau increases expression ISO tryptanthrine results in increased expression of MAPT mRNA CTD PMID:23500671 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mycn MYCN proto-oncogene, bHLH transcription factor decreases expression ISO tryptanthrine results in decreased expression of MYCN mRNA; tryptanthrine results in decreased expression of MYCN protein CTD PMID:23500671 NCBI chr 6:35,717,764...35,723,590
Ensembl chr 6:35,717,764...35,723,590
JBrowse link
G Nefh neurofilament heavy chain increases expression ISO tryptanthrine results in increased expression of NEFH protein CTD PMID:23500671 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO tryptanthrine results in decreased phosphorylation of PTK2 protein CTD PMID:26341616 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Rorc RAR-related orphan receptor C multiple interactions ISO tryptanthrine inhibits the reaction [RORC protein results in increased expression of IL17A mRNA]; tryptanthrine inhibits the reaction [RORC protein results in increased expression of IL17F mRNA]; tryptanthrine inhibits the reaction [RORC protein results in increased expression of IL22 mRNA] CTD PMID:32173427 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
JBrowse link
G S100a9 S100 calcium binding protein A9 multiple interactions ISO tryptanthrine inhibits the reaction [[IL17A protein co-treated with TNF protein] results in increased expression of S100A9 mRNA] CTD PMID:32173427 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G Sst somatostatin increases expression ISO tryptanthrine results in increased expression of SST mRNA CTD PMID:23500671 NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO tryptanthrine inhibits the reaction [[IL17A protein co-treated with TNF protein] results in increased expression of CCL20 mRNA]; tryptanthrine inhibits the reaction [[IL17A protein co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; tryptanthrine inhibits the reaction [[IL17A protein co-treated with TNF protein] results in increased expression of IL1B mRNA]; tryptanthrine inhibits the reaction [[IL17A protein co-treated with TNF protein] results in increased expression of IL6 mRNA]; tryptanthrine inhibits the reaction [[IL17A protein co-treated with TNF protein] results in increased expression of S100A9 mRNA]; tryptanthrine inhibits the reaction [[IL17A protein co-treated with TNF protein] results in increased expression of TNF mRNA] CTD PMID:32173427 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO tryptanthrine results in decreased expression of and results in increased degradation of TP53 protein CTD PMID:17482571 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

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  CHEBI ontology 19740
    role 19713
      biological role 19711
        antimicrobial agent 17880
          alkaloid antibiotic 296
            Tryptanthrine 29
Path 2
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  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic molecule 19587
                              organic cyclic compound 19393
                                organic heterocyclic compound 18766
                                  organic heteropolycyclic compound 18254
                                    organic heterotetracyclic compound 9181
                                      Tryptanthrine 29
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