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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:trovafloxacin
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Accession:CHEBI:9763 term browser browse the term
Definition:A 1,8-naphthyridine derivative that is 4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid bearing additional 2,4-difluorophenyl, fluoro and 6-amino-3-azabicyclo[3.1.0]hex-3-yl substituents at positions 1, 6 and 7 respectively. A broad-spectrum antibiotic that was withdrawn from the market due to risk of liver failure.
Synonyms:exact_synonym: 7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
 related_synonym: Formula=C20H15F3N4O3;   InChI=1S/C20H15F3N4O3/c21-8-1-2-15(13(22)3-8)27-7-12(20(29)30)17(28)9-4-14(23)19(25-18(9)27)26-5-10-11(6-26)16(10)24/h1-4,7,10-11,16H,5-6,24H2,(H,29,30)/t10-,11+,16+;   InChIKey=WVPSKSLAZQPAKQ-CDMJZVDBSA-N;   SMILES=N[C@H]1[C@@H]2CN(C[C@H]12)c1nc2n(cc(C(O)=O)c(=O)c2cc1F)-c1ccc(F)cc1F;   trovafloxacine;   trovafloxacino;   trovafloxacinum
 xref: CAS:147059-72-1;   DrugBank:DB00685;   Drug_Central:2777;   HMDB:HMDB0014823;   KEGG:C07664;   KEGG:D08654
 xref_mesh: MESH:C080163
 xref: PMID:20022474;   PMID:20462743;   PMID:20538741;   PMID:20655887;   PMID:21151465;   PMID:22305082;   PMID:23727874;   PMID:24097668;   PMID:24525298;   Reaxys:8172628;   Wikipedia:Trovafloxacin
 cyclic_relationship: is_conjugate_base_of CHEBI:77569



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trovafloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha decreases expression EXP trovafloxacin results in decreased expression of ACACA mRNA CTD PMID:24136188 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acsf2 acyl-CoA synthetase family member 2 decreases expression EXP trovafloxacin results in decreased expression of ACSF2 mRNA CTD PMID:24136188 NCBI chr10:79,504,510...79,546,714
Ensembl chr10:79,504,511...79,546,673
JBrowse link
G Actb actin, beta decreases expression EXP trovafloxacin results in decreased expression of ACTB mRNA CTD PMID:24136188 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
JBrowse link
G Actg1 actin, gamma 1 decreases expression EXP trovafloxacin results in decreased expression of ACTG1 mRNA CTD PMID:24136188 NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
JBrowse link
G Acy1 aminoacylase 1 decreases expression EXP trovafloxacin results in decreased expression of ACY1 mRNA CTD PMID:24136188 NCBI chr 8:107,072,354...107,077,756
Ensembl chr 8:107,072,358...107,077,682
JBrowse link
G Adap2 ArfGAP with dual PH domains 2 increases expression EXP trovafloxacin results in increased expression of ADAP2 mRNA CTD PMID:24136188 NCBI chr10:65,138,006...65,166,147
Ensembl chr10:65,138,020...65,165,604
JBrowse link
G Adipor2 adiponectin receptor 2 decreases expression EXP trovafloxacin results in decreased expression of ADIPOR2 mRNA CTD PMID:24136188 NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ADRB2 mRNA CTD PMID:18930950 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 decreases expression EXP trovafloxacin results in decreased expression of AKR7A3 mRNA CTD PMID:24136188 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO trovafloxacin results in increased phosphorylation of AKT1 protein
TNF protein promotes the reaction [trovafloxacin results in increased phosphorylation of AKT1 protein]
CTD PMID:33609687 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression EXP trovafloxacin results in decreased expression of ALDH1A1 mRNA CTD PMID:24136188 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 decreases expression EXP trovafloxacin results in decreased expression of ALDH1B1 mRNA CTD PMID:24136188 NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378
JBrowse link
G Amd1 adenosylmethionine decarboxylase 1 decreases expression EXP trovafloxacin results in decreased expression of AMD1 mRNA CTD PMID:24136188 NCBI chr20:43,695,783...43,711,476
Ensembl chr20:43,697,237...43,711,476
JBrowse link
G Ammecr1l AMMECR1 like increases expression EXP trovafloxacin results in increased expression of AMMECR1L mRNA CTD PMID:24136188 NCBI chr18:23,386,114...23,411,177
Ensembl chr18:23,386,903...23,410,920
JBrowse link
G Angptl4 angiopoietin-like 4 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ANGPTL4 mRNA CTD PMID:18930950 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
JBrowse link
G Ankhd1 ankyrin repeat and KH domain containing 1 increases expression EXP trovafloxacin results in increased expression of ANKHD1-EIF4EBP3 mRNA CTD PMID:24136188 NCBI chr18:28,161,882...28,260,917 JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression EXP trovafloxacin results in decreased expression of AP1S1 mRNA CTD PMID:24136188 NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of APEX1 mRNA CTD PMID:18930950 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
JBrowse link
G Apoa5 apolipoprotein A5 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of APOA5 mRNA CTD PMID:18930950 NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816
JBrowse link
G Arhgap24 Rho GTPase activating protein 24 decreases expression EXP trovafloxacin results in decreased expression of ARHGAP24 mRNA CTD PMID:24136188 NCBI chr14:6,800,631...7,184,001
Ensembl chr14:6,800,631...7,183,823
JBrowse link
G Arid5b AT-rich interaction domain 5B multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ARID5B mRNA CTD PMID:18930950 NCBI chr20:20,307,731...20,490,746
Ensembl chr20:20,307,731...20,487,433
JBrowse link
G Armt1 acidic residue methyltransferase 1 decreases expression EXP trovafloxacin results in decreased expression of ARMT1 mRNA CTD PMID:24136188 NCBI chr 1:40,894,558...40,918,302
Ensembl chr 1:40,894,550...40,918,302
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions
increases phosphorylation
ISO pyrazolanthrone inhibits the reaction [trovafloxacin results in increased phosphorylation of ATF2 protein] CTD PMID:24525298 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
JBrowse link
G Atg10 autophagy related 10 multiple interactions ISO [trovafloxacin co-treated with TNF protein] results in increased expression of ATG10 mRNA CTD PMID:33609687 NCBI chr 2:22,109,304...22,398,313
Ensembl chr 2:22,108,426...22,398,233
JBrowse link
G Atg101 autophagy related 101 increases expression ISO trovafloxacin results in increased expression of ATG101 mRNA CTD PMID:33609687 NCBI chr 7:132,398,477...132,407,643
Ensembl chr 7:132,398,483...132,407,633
JBrowse link
G Atg12 autophagy related 12 increases expression ISO trovafloxacin results in increased expression of ATG12 mRNA CTD PMID:33609687 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
JBrowse link
G Atg14 autophagy related 14 increases expression
multiple interactions
ISO trovafloxacin results in increased expression of ATG14 mRNA
TNF protein inhibits the reaction [trovafloxacin results in increased expression of ATG14 mRNA]
CTD PMID:33609687 NCBI chr15:20,795,750...20,827,113
Ensembl chr15:20,795,750...20,827,113
JBrowse link
G Atg16l1 autophagy related 16-like 1 increases expression
multiple interactions
ISO trovafloxacin results in increased expression of ATG16L1 mRNA
[trovafloxacin co-treated with TNF protein] results in increased expression of ATG16L1 mRNA
CTD PMID:33609687 NCBI chr 9:88,420,737...88,457,530
Ensembl chr 9:88,422,038...88,457,529
JBrowse link
G Atg16l2 autophagy related 16-like 2 decreases expression ISO trovafloxacin results in decreased expression of ATG16L2 mRNA CTD PMID:33609687 NCBI chr 1:155,687,386...155,703,419
Ensembl chr 1:155,684,564...155,703,420
JBrowse link
G Atg2a autophagy related 2A multiple interactions ISO [trovafloxacin co-treated with TNF protein] results in increased expression of ATG2A mRNA CTD PMID:33609687 NCBI chr 1:203,542,559...203,562,242
Ensembl chr 1:203,542,559...203,562,242
JBrowse link
G Atg2b autophagy related 2B increases expression ISO trovafloxacin results in increased expression of ATG2B mRNA CTD PMID:33609687 NCBI chr 6:124,522,283...124,592,412
Ensembl chr 6:124,525,523...124,592,015
JBrowse link
G Atg3 autophagy related 3 increases expression
multiple interactions
ISO trovafloxacin results in increased expression of ATG3 mRNA
[trovafloxacin co-treated with TNF protein] results in increased expression of ATG3 mRNA
CTD PMID:33609687 NCBI chr11:55,624,928...55,653,212
Ensembl chr11:55,624,917...55,653,224
JBrowse link
G Atg4a autophagy related 4A, cysteine peptidase increases expression
multiple interactions
ISO trovafloxacin results in increased expression of ATG4A mRNA
[trovafloxacin co-treated with TNF protein] results in increased expression of ATG4A mRNA
CTD PMID:33609687 NCBI chr  X:104,665,345...104,765,271 JBrowse link
G Atg4c autophagy related 4C, cysteine peptidase multiple interactions ISO [trovafloxacin co-treated with TNF protein] results in decreased expression of ATG4C mRNA CTD PMID:33609687 NCBI chr 5:113,867,218...113,935,534
Ensembl chr 5:113,867,092...113,934,830
JBrowse link
G Atg5 autophagy related 5 affects response to substance
increases expression
multiple interactions
ISO ATG5 protein affects the susceptibility to trovafloxacin
trovafloxacin results in increased expression of ATG5 mRNA
ATG5 protein affects the reaction [trovafloxacin results in increased cleavage of CASP3 protein]; ATG5 protein affects the reaction [trovafloxacin results in increased cleavage of PARP1 protein]; ATG5 protein affects the reaction [trovafloxacin results in increased phosphorylation of MAPK1 protein]; ATG5 protein affects the reaction [trovafloxacin results in increased phosphorylation of MAPK3 protein]; ATG5 protein affects the reaction [trovafloxacin results in increased phosphorylation of MAPK8 protein]; TNF protein inhibits the reaction [trovafloxacin results in increased expression of ATG5 mRNA]
CTD PMID:33609687 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Atg9b autophagy related 9B increases expression
multiple interactions
ISO trovafloxacin results in increased expression of ATG9B mRNA
TNF protein promotes the reaction [trovafloxacin results in increased expression of ATG9B mRNA]; trovafloxacin promotes the reaction [TNF protein results in increased expression of ATG9B mRNA]
CTD PMID:33609687 NCBI chr 4:10,784,934...10,793,832
Ensembl chr 4:10,786,114...10,793,651
JBrowse link
G Atp6v0e2 ATPase, H+ transporting V0 subunit e2 decreases expression EXP trovafloxacin results in decreased expression of ATP6V0E2 mRNA CTD PMID:24136188 NCBI chr 4:77,484,868...77,488,016
Ensembl chr 4:77,482,226...77,488,777
JBrowse link
G Atr ATR serine/threonine kinase multiple interactions ISO 4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine inhibits the reaction [[trovafloxacin co-treated with TNF protein] results in increased phosphorylation of ATR protein]; 4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine inhibits the reaction [trovafloxacin results in increased phosphorylation of ATR protein]; [trovafloxacin co-treated with TNF protein] results in increased phosphorylation of and results in increased activity of ATR protein; trovafloxacin results in increased phosphorylation of and results in increased activity of ATR protein; U 0126 inhibits the reaction [trovafloxacin results in increased activity of ATR protein] CTD PMID:25748550 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
JBrowse link
G Atrn attractin increases expression EXP trovafloxacin results in increased expression of ATRN mRNA CTD PMID:24136188 NCBI chr 3:118,110,320...118,244,326
Ensembl chr 3:118,110,229...118,244,322
JBrowse link
G B2m beta-2 microglobulin multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of B2M mRNA CTD PMID:18930950 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of BHLHE40 mRNA CTD PMID:18930950 NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions
decreases expression
ISO trovafloxacin inhibits the reaction [TNF protein results in increased expression of BIRC2 mRNA]
trovafloxacin results in decreased expression of BIRC2 protein
[trovafloxacin co-treated with TNF protein] results in decreased expression of BIRC2 mRNA
trovafloxacin results in decreased expression of BIRC2 mRNA
CTD PMID:32035082 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions
decreases expression
ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of BIRC3 mRNA
[trovafloxacin co-treated with TNF protein] results in increased expression of BIRC3 mRNA
trovafloxacin results in decreased expression of BIRC3 mRNA
CTD PMID:18930950 PMID:32035082 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Bpnt1 3'(2'), 5'-bisphosphate nucleotidase 1 decreases expression EXP trovafloxacin results in decreased expression of BPNT1 mRNA CTD PMID:24136188 NCBI chr13:96,865,634...96,893,506
Ensembl chr13:96,868,580...96,893,503
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 decreases expression EXP trovafloxacin results in decreased expression of BST2 mRNA CTD PMID:24136188 NCBI chr16:18,217,404...18,220,979
Ensembl chr16:18,217,407...18,220,979
JBrowse link
G Caprin1 cell cycle associated protein 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CAPRIN1 mRNA CTD PMID:18930950 NCBI chr 3:90,152,305...90,230,447
Ensembl chr 3:90,153,620...90,230,502
JBrowse link
G Casd1 CAS1 domain containing 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CASD1 mRNA CTD PMID:18930950 NCBI chr 4:32,658,888...32,739,224
Ensembl chr 4:32,658,748...32,739,202
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
ISO [TNF protein co-treated with IL6 protein co-treated with IL1B protein] promotes the reaction [trovafloxacin results in increased activity of CASP3 protein]; [TNF protein co-treated with trovafloxacin] results in increased activity of CASP3 protein; [trovafloxacin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [trovafloxacin co-treated with IL1B protein] results in increased activity of CASP3 protein; [trovafloxacin co-treated with IL6 protein] results in increased activity of CASP3 protein; [trovafloxacin co-treated with TNF protein] results in increased activity of CASP3 protein; ATG5 protein affects the reaction [trovafloxacin results in increased cleavage of CASP3 protein]; U 0126 inhibits the reaction [[TNF protein co-treated with trovafloxacin] results in increased activity of CASP3 protein]
[TNF protein co-treated with trovafloxacin] results in increased cleavage of CASP3 protein
CTD PMID:19638433 PMID:24097668 PMID:25748550 PMID:30876886 PMID:33609687 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp6 caspase 6 increases expression EXP trovafloxacin results in increased expression of CASP6 mRNA CTD PMID:24136188 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Casp7 caspase 7 decreases expression EXP trovafloxacin results in decreased expression of CASP7 mRNA CTD PMID:24136188 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [trovafloxacin co-treated with TNF protein] results in increased activity of CASP8 protein CTD PMID:24097668 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [trovafloxacin co-treated with TNF protein] results in increased activity of CASP9 protein CTD PMID:24097668 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccdc6 coiled-coil domain containing 6 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CCDC6 mRNA CTD PMID:18930950 NCBI chr20:18,432,177...18,528,186
Ensembl chr20:18,433,695...18,528,658
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO trovafloxacin promotes the reaction [TNF protein results in increased expression of CCL2 protein] CTD PMID:19638433 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccnb2 cyclin B2 decreases expression EXP trovafloxacin results in decreased expression of CCNB2 mRNA CTD PMID:24136188 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP trovafloxacin results in decreased expression of CCND1 mRNA CTD PMID:24136188 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cd36 CD36 molecule decreases expression EXP trovafloxacin results in decreased expression of CD36 mRNA CTD PMID:24136188 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cd8b CD8b molecule multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CD8B mRNA CTD PMID:18930950 NCBI chr 4:103,312,596...103,328,523
Ensembl chr 4:103,312,578...103,328,553
JBrowse link
G Cdc20 cell division cycle 20 decreases expression EXP trovafloxacin results in decreased expression of CDC20 mRNA CTD PMID:24136188 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
JBrowse link
G Cdc42ep4 CDC42 effector protein 4 increases expression EXP trovafloxacin results in increased expression of CDC42EP4 mRNA CTD PMID:24136188 NCBI chr10:98,772,613...98,797,924
Ensembl chr10:98,772,495...98,797,695
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression EXP trovafloxacin results in decreased expression of CDK1 mRNA CTD PMID:24136188 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk16 cyclin-dependent kinase 16 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CDK16 mRNA CTD PMID:18930950 NCBI chr  X:1,492,814...1,504,309
Ensembl chr  X:1,492,814...1,504,148
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CDKN1A mRNA
trovafloxacin results in increased expression of CDKN1A mRNA
CTD PMID:18930950 PMID:25748550 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression EXP trovafloxacin results in decreased expression of CDKN3 mRNA CTD PMID:24136188 NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CEBPA mRNA CTD PMID:18930950 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Chfr checkpoint with forkhead and ring finger domains multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CHFR mRNA CTD PMID:18930950 NCBI chr12:46,504,497...46,538,104
Ensembl chr12:46,504,497...46,538,014
JBrowse link
G Chka choline kinase alpha multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CHKA mRNA CTD PMID:18930950 NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 decreases expression EXP trovafloxacin results in decreased expression of CKS2 mRNA CTD PMID:24136188 NCBI chr17:13,570,611...13,575,770 JBrowse link
G Cldn14 claudin 14 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CLDN14 mRNA CTD PMID:18930950 NCBI chr11:33,232,281...33,329,440
Ensembl chr11:33,232,220...33,329,171
JBrowse link
G Clint1 clathrin interactor 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CLINT1 mRNA CTD PMID:18930950 NCBI chr10:30,298,618...30,353,185
Ensembl chr10:30,298,704...30,353,063
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of COMT mRNA CTD PMID:18930950 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Copg1 COPI coat complex subunit gamma 1 decreases expression EXP trovafloxacin results in decreased expression of COPG1 mRNA CTD PMID:24136188 NCBI chr 4:120,366,540...120,392,502 JBrowse link
G Cpox coproporphyrinogen oxidase decreases expression EXP trovafloxacin results in decreased expression of CPOX mRNA CTD PMID:24136188 NCBI chr11:41,936,585...41,946,568
Ensembl chr11:41,936,591...41,946,746
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression EXP trovafloxacin results in increased expression of CPT1A mRNA CTD PMID:24136188 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Crk CRK proto-oncogene, adaptor protein multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CRK mRNA CTD PMID:18930950 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406
JBrowse link
G Cs citrate synthase decreases expression EXP trovafloxacin results in decreased expression of CS mRNA CTD PMID:24136188 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CXCL2 mRNA; trovafloxacin promotes the reaction [TNF protein results in increased expression of CXCL2 protein] CTD PMID:18930950 PMID:19638433 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CXCL3 mRNA; trovafloxacin promotes the reaction [TNF protein results in increased expression of CXCL1 protein] CTD PMID:18930950 PMID:19638433 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO trovafloxacin results in decreased activity of CYP19A1 protein CTD PMID:26141389 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp2b12 cytochrome P450, family 2, subfamily b, polypeptide 12 decreases expression EXP trovafloxacin results in decreased expression of CYP2B12 mRNA CTD PMID:24136188 NCBI chr 1:82,007,609...82,019,409
Ensembl chr 1:82,007,609...82,080,480
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CYP7A1 mRNA CTD PMID:18930950 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 increases expression EXP trovafloxacin results in increased expression of CYP8B1 mRNA CTD PMID:24136188 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Dapk1 death associated protein kinase 1 decreases expression EXP trovafloxacin results in decreased expression of DAPK1 mRNA CTD PMID:24136188 NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 decreases expression ISO trovafloxacin results in decreased expression of DDIT3 mRNA CTD PMID:24136188 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ddx1 DEAD-box helicase 1 decreases expression EXP trovafloxacin results in decreased expression of DDX1 mRNA CTD PMID:24136188 NCBI chr 6:35,996,469...36,027,340
Ensembl chr 6:35,996,469...36,027,365
JBrowse link
G Ddx17 DEAD-box helicase 17 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of DDX17 mRNA CTD PMID:18930950 NCBI chr 7:111,091,127...111,109,353
Ensembl chr 7:111,089,445...111,109,193
JBrowse link
G Derl2 derlin 2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of DERL2 mRNA CTD PMID:18930950 NCBI chr10:55,727,764...55,739,462
Ensembl chr10:55,727,643...55,739,518
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 decreases expression EXP trovafloxacin results in decreased expression of DGAT2 mRNA CTD PMID:24136188 NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase decreases expression EXP trovafloxacin results in decreased expression of DLST mRNA CTD PMID:24136188 NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296
JBrowse link
G Dnajb2 DnaJ heat shock protein family (Hsp40) member B2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of DNAJB2 mRNA CTD PMID:18930950 NCBI chr 9:76,731,060...76,739,278
Ensembl chr 9:76,731,065...76,739,277
JBrowse link
G Dnph1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 decreases expression EXP trovafloxacin results in decreased expression of DNPH1 mRNA CTD PMID:24136188 NCBI chr 9:14,481,296...14,484,034
Ensembl chr 9:14,481,066...14,484,022
JBrowse link
G Dtymk deoxythymidylate kinase decreases expression EXP trovafloxacin results in decreased expression of DTYMK mRNA CTD PMID:24136188 NCBI chr 9:94,315,552...94,324,386
Ensembl chr 9:94,315,552...94,324,870
JBrowse link
G Dusp16 dual specificity phosphatase 16 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of DUSP16 mRNA CTD PMID:18930950 NCBI chr 4:167,546,780...167,629,949
Ensembl chr 4:167,548,155...167,629,980
JBrowse link
G Dusp8 dual specificity phosphatase 8 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of DUSP8 mRNA CTD PMID:18930950 NCBI chr 1:197,167,392...197,184,285
Ensembl chr 1:197,169,422...197,182,921
JBrowse link
G Dut deoxyuridine triphosphatase decreases expression EXP trovafloxacin results in decreased expression of DUT mRNA CTD PMID:24136188 NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of EGFR mRNA CTD PMID:18930950 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha decreases expression EXP trovafloxacin results in decreased expression of EIF2S1 mRNA CTD PMID:24136188 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Eif2s2 eukaryotic translation initiation factor 2 subunit beta multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of EIF2S2 mRNA CTD PMID:18930950 NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432
JBrowse link
G Eif3a eukaryotic translation initiation factor 3, subunit A multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of EIF3A mRNA CTD PMID:18930950 NCBI chr 1:259,902,767...259,932,976
Ensembl chr 1:259,902,680...259,932,976
JBrowse link
G Eif3c eukaryotic translation initiation factor 3, subunit C decreases expression EXP trovafloxacin results in decreased expression of EIF3C mRNA CTD PMID:24136188 NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493
JBrowse link
G Eif3l eukaryotic translation initiation factor 3, subunit L decreases expression EXP trovafloxacin results in decreased expression of EIF3L mRNA CTD PMID:24136188 NCBI chr 7:110,652,565...110,663,614
Ensembl chr 7:110,627,107...110,663,614
JBrowse link
G Eif4a2 eukaryotic translation initiation factor 4A2 increases expression EXP trovafloxacin results in increased expression of EIF4A2 mRNA CTD PMID:24136188 NCBI chr11:77,764,126...77,770,810
Ensembl chr11:77,764,124...77,770,781
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [trovafloxacin co-treated with TNF protein] results in increased phosphorylation of EIF4EBP1 protein; Sirolimus inhibits the reaction [[trovafloxacin co-treated with TNF protein] results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:33609687 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Eif6 eukaryotic translation initiation factor 6 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of EIF6 mRNA CTD PMID:18930950 NCBI chr 3:144,325,038...144,331,396
Ensembl chr 3:144,325,036...144,331,401
JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 decreases expression EXP trovafloxacin results in decreased expression of ELOVL6 mRNA CTD PMID:24136188 NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186
JBrowse link
G Emc1 ER membrane protein complex subunit 1 decreases expression EXP trovafloxacin results in decreased expression of EMC1 mRNA CTD PMID:24136188 NCBI chr 5:151,608,557...151,633,888
Ensembl chr 5:151,608,568...151,633,888
JBrowse link
G Ephx1 epoxide hydrolase 1 decreases expression EXP trovafloxacin results in decreased expression of EPHX1 mRNA CTD PMID:24136188 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Ergic1 endoplasmic reticulum-golgi intermediate compartment 1 decreases expression EXP trovafloxacin results in decreased expression of ERGIC1 mRNA CTD PMID:24136188 NCBI chr10:16,531,192...16,627,183
Ensembl chr10:16,531,194...16,626,957
JBrowse link
G Erp29 endoplasmic reticulum protein 29 decreases expression EXP trovafloxacin results in decreased expression of ERP29 mRNA CTD PMID:24136188 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ERRFI1 mRNA CTD PMID:18930950 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282
JBrowse link
G Ets2 ETS proto-oncogene 2, transcription factor multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ETS2 mRNA CTD PMID:18930950 NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319
JBrowse link
G F2 coagulation factor II multiple interactions ISO [Lipopolysaccharides co-treated with trovafloxacin] results in increased activity of F2 protein CTD PMID:19367693 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G Fam98a family with sequence similarity 98, member A decreases expression EXP trovafloxacin results in decreased expression of FAM98A mRNA CTD PMID:24136188 NCBI chr 6:19,874,082...19,888,744
Ensembl chr 6:19,874,071...19,888,742
JBrowse link
G Fasn fatty acid synthase multiple interactions
decreases expression
ISO
EXP
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of FASN mRNA
trovafloxacin results in decreased expression of FASN mRNA
CTD PMID:18930950 PMID:24136188 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fbxo9 f-box protein 9 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of FBXO9 mRNA CTD PMID:18930950 NCBI chr 8:78,958,482...78,984,015
Ensembl chr 8:78,958,483...78,983,949
JBrowse link
G Fga fibrinogen alpha chain multiple interactions ISO [Lipopolysaccharides co-treated with trovafloxacin] results in increased expression of FGA protein CTD PMID:19367693 NCBI chr 2:168,365,364...168,381,533
Ensembl chr 2:168,374,120...168,381,528
JBrowse link
G Fkbp4 FKBP prolyl isomerase 4 decreases expression EXP trovafloxacin results in decreased expression of FKBP4 mRNA CTD PMID:24136188 NCBI chr 4:161,703,379...161,711,833
Ensembl chr 4:161,703,379...161,711,833
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases expression EXP trovafloxacin results in increased expression of FMO3 mRNA CTD PMID:24136188 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of FOS mRNA CTD PMID:18930950 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fzd7 frizzled class receptor 7 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of FZD7 mRNA CTD PMID:18930950 NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of G6PC mRNA CTD PMID:18930950 NCBI chr10:86,307,400...86,318,766 JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases expression EXP trovafloxacin results in decreased expression of G6PD mRNA CTD PMID:24136188 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gabarapl1 GABA type A receptor associated protein like 1 multiple interactions
increases expression
ISO [trovafloxacin co-treated with TNF protein] results in increased expression of GABARAPL1 mRNA
trovafloxacin results in increased expression of GABARAPL1 mRNA
CTD PMID:33609687 NCBI chr 4:162,980,309...162,989,452
Ensembl chr 4:162,980,249...162,989,450
JBrowse link
G Gabarapl2 GABA type A receptor associated protein like 2 multiple interactions
increases expression
ISO TNF protein inhibits the reaction [trovafloxacin results in increased expression of GABARAPL2 mRNA] CTD PMID:33609687 NCBI chr19:39,910,572...39,921,408
Ensembl chr19:39,910,534...39,924,628
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma decreases expression EXP trovafloxacin results in decreased expression of GADD45G mRNA CTD PMID:24136188 NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase decreases expression EXP trovafloxacin results in decreased expression of GAPDH mRNA CTD PMID:24136188 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gcgr glucagon receptor multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of GCGR mRNA CTD PMID:18930950 NCBI chr10:105,808,474...105,816,641
Ensembl chr10:105,808,473...105,816,640
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression
multiple interactions
EXP
ISO
trovafloxacin results in decreased expression of GCLC mRNA
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of GCLC mRNA
CTD PMID:18930950 PMID:24136188 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gfm1 G elongation factor, mitochondrial 1 decreases expression EXP trovafloxacin results in decreased expression of GFM1 mRNA CTD PMID:24136188 NCBI chr 2:151,700,573...151,745,477
Ensembl chr 2:151,700,564...151,745,471
JBrowse link
G Ggcx gamma-glutamyl carboxylase decreases expression EXP trovafloxacin results in decreased expression of GGCX mRNA CTD PMID:24136188 NCBI chr 4:104,469,737...104,485,631
Ensembl chr 4:104,469,765...104,487,063
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GJA1 mRNA CTD PMID:18930950 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Glrx3 glutaredoxin 3 decreases expression EXP trovafloxacin results in decreased expression of GLRX3 mRNA CTD PMID:24136188 NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010
JBrowse link
G Glyat glycine-N-acyltransferase increases expression EXP trovafloxacin results in increased expression of GLYAT mRNA CTD PMID:24136188 NCBI chr 1:209,704,178...209,724,949
Ensembl chr 1:209,704,268...209,724,942
JBrowse link
G Gnl3 G protein nucleolar 3 increases expression EXP trovafloxacin results in increased expression of GNL3 mRNA CTD PMID:24136188 NCBI chr16:6,207,402...6,213,491
Ensembl chr16:6,207,402...6,213,392
JBrowse link
G Gnpnat1 glucosamine-phosphate N-acetyltransferase 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of GNPNAT1 mRNA CTD PMID:18930950 NCBI chr15:18,596,180...18,608,854
Ensembl chr15:18,596,442...18,608,739
JBrowse link
G Golga2 golgin A2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of GOLGA2 mRNA CTD PMID:18930950 NCBI chr 3:15,583,862...15,604,279
Ensembl chr 3:15,584,039...15,604,279
JBrowse link
G Golga4 golgin A4 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of GOLGA4 mRNA CTD PMID:18930950 NCBI chr 8:118,208,200...118,285,003 JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial decreases expression EXP trovafloxacin results in decreased expression of GPAM mRNA CTD PMID:24136188 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
JBrowse link
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 increases expression EXP trovafloxacin results in increased expression of GPLD1 mRNA CTD PMID:24136188 NCBI chr17:40,084,427...40,132,035
Ensembl chr17:40,084,617...40,126,939
JBrowse link
G Gsr glutathione-disulfide reductase decreases expression EXP trovafloxacin results in decreased expression of GSR mRNA CTD PMID:24136188 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gss glutathione synthetase decreases expression EXP trovafloxacin results in decreased expression of GSS mRNA CTD PMID:24136188 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases expression EXP trovafloxacin results in decreased expression of GSTA3 mRNA CTD PMID:24136188 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases phosphorylation
increases expression
ISO [TNF protein co-treated with trovafloxacin] results in increased expression of H2AX protein modified form; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[TNF protein co-treated with trovafloxacin] results in increased expression of H2AX protein modified form]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [trovafloxacin results in increased expression of H2AX protein modified form]; TNF protein promotes the reaction [trovafloxacin results in increased expression of H2AX protein modified form]
trovafloxacin results in increased phosphorylation of H2AX protein
CTD PMID:24817034 PMID:25748550 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hacd3 3-hydroxyacyl-CoA dehydratase 3 decreases expression EXP trovafloxacin results in decreased expression of HACD3 mRNA CTD PMID:24136188 NCBI chr 8:65,501,240...65,538,507
Ensembl chr 8:65,501,240...65,538,507
JBrowse link
G Hacl1 2-hydroxyacyl-CoA lyase 1 increases expression EXP trovafloxacin results in increased expression of HACL1 mRNA CTD PMID:24136188 NCBI chr16:6,826,881...6,863,027
Ensembl chr16:6,824,906...6,863,027
JBrowse link
G Hao2 hydroxyacid oxidase 2 increases expression EXP trovafloxacin results in increased expression of HAO2 mRNA CTD PMID:24136188 NCBI chr 2:186,200,137...186,232,997
Ensembl chr 2:186,200,504...186,224,425
JBrowse link
G Hmgn3 high mobility group nucleosomal binding domain 3 decreases expression EXP trovafloxacin results in decreased expression of HMGN3 mRNA CTD PMID:24136188 NCBI chr 8:84,022,493...84,059,329
Ensembl chr 8:84,022,495...84,062,976
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of HMOX1 mRNA CTD PMID:18930950 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnrnpf heterogeneous nuclear ribonucleoprotein F multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of HNRNPF mRNA CTD PMID:18930950 NCBI chr 4:151,083,262...151,104,464
Ensembl chr 4:151,083,062...151,109,038
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 decreases expression EXP trovafloxacin results in decreased expression of HSPH1 mRNA CTD PMID:24136188 NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 decreases expression EXP trovafloxacin results in decreased expression of HTATIP2 mRNA CTD PMID:24136188 NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ICAM1 mRNA; trovafloxacin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
[trovafloxacin co-treated with TNF protein] results in increased expression of ICAM1 mRNA
trovafloxacin results in decreased expression of ICAM1 mRNA
CTD PMID:18930950 PMID:32035082 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Id2 inhibitor of DNA binding 2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of ID2 mRNA CTD PMID:18930950 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Ide insulin degrading enzyme decreases expression EXP trovafloxacin results in decreased expression of IDE mRNA CTD PMID:24136188 NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 decreases expression EXP trovafloxacin results in decreased expression of IDH2 mRNA CTD PMID:24136188 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP
IFNG protein promotes the reaction [[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TNF protein]; IFNG protein results in increased susceptibility to [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5]; trovafloxacin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG protein]; trovafloxacin promotes the reaction [TNF protein results in increased expression of IFNG protein]
[IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to trovafloxacin
CTD PMID:18930950 PMID:19362101 PMID:19638433 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 increases expression
multiple interactions
EXP
ISO
trovafloxacin results in increased expression of IFRD1 mRNA
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IFRD1 mRNA
CTD PMID:18930950 PMID:24136188 NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IGFBP1 mRNA CTD PMID:18930950 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
JBrowse link
G Il17ra interleukin 17 receptor A multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL17RA mRNA CTD PMID:18930950 NCBI chr 4:153,667,534...153,690,174
Ensembl chr 4:153,667,534...153,690,174
JBrowse link
G Il18 interleukin 18 multiple interactions ISO IL18 protein results in increased susceptibility to [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5]; trovafloxacin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL18 protein]; trovafloxacin promotes the reaction [TNF protein results in increased expression of IL18 protein] CTD PMID:18930950 PMID:19638433 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO
EXP
[IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to trovafloxacin; [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to trovafloxacin CTD PMID:19362101 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [TNF protein co-treated with IL6 protein co-treated with IL1B protein] promotes the reaction [trovafloxacin results in increased activity of CASP3 protein]; [trovafloxacin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [trovafloxacin co-treated with IL1B protein] affects the localization of SELE protein; [trovafloxacin co-treated with IL1B protein] results in increased activity of CASP3 protein; [trovafloxacin co-treated with IL1B protein] results in increased expression of SELE mRNA; trovafloxacin promotes the reaction [IL1B protein results in increased secretion of SELE protein]
trovafloxacin promotes the reaction [TNF protein results in increased expression of IL1B protein]
CTD PMID:10822086 PMID:19638433 PMID:30876886 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to trovafloxacin; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] promotes the reaction [trovafloxacin results in increased activity of CASP3 protein]; [trovafloxacin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [trovafloxacin co-treated with IL6 protein] results in increased activity of CASP3 protein
trovafloxacin promotes the reaction [TNF protein results in increased expression of IL6 protein]
CTD PMID:19362101 PMID:19638433 PMID:30876886 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ip6k2 inositol hexakisphosphate kinase 2 increases expression EXP trovafloxacin results in increased expression of IP6K2 mRNA CTD PMID:24136188 NCBI chr 8:109,483,843...109,510,172
Ensembl chr 8:109,484,310...109,510,166
JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions
decreases expression
ISO
EXP
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IRF1 mRNA
trovafloxacin results in decreased expression of IRF1 mRNA
CTD PMID:18930950 PMID:24136188 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ISG20 mRNA CTD PMID:18930950 NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027
JBrowse link
G Ist1 IST1 factor associated with ESCRT-III increases expression EXP trovafloxacin results in increased expression of IST1 mRNA CTD PMID:24136188 NCBI chr19:37,648,840...37,671,019
Ensembl chr19:37,648,095...37,670,956
JBrowse link
G Ivns1abp influenza virus NS1A binding protein multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IVNS1ABP mRNA CTD PMID:18930950 NCBI chr13:63,427,040...63,446,701
Ensembl chr13:63,427,041...63,446,701
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of JUNB mRNA CTD PMID:18930950 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Klf9 Kruppel-like factor 9 increases expression EXP trovafloxacin results in increased expression of KLF9 mRNA CTD PMID:24136188 NCBI chr 1:220,700,108...220,725,029
Ensembl chr 1:220,700,108...220,725,037
JBrowse link
G Klhl24 kelch-like family member 24 increases expression EXP trovafloxacin results in increased expression of KLHL24 mRNA CTD PMID:24136188 NCBI chr11:80,843,621...80,877,693
Ensembl chr11:80,846,755...80,877,636
JBrowse link
G Kpna2 karyopherin subunit alpha 2 decreases expression EXP trovafloxacin results in decreased expression of KPNA2 mRNA CTD PMID:24136188 NCBI chr10:91,933,951...91,946,115
Ensembl chr10:91,933,951...91,946,150
JBrowse link
G Kpnb1 karyopherin subunit beta 1 decreases expression EXP trovafloxacin results in decreased expression of KPNB1 mRNA CTD PMID:24136188 NCBI chr10:82,145,662...82,174,437
Ensembl chr10:82,145,420...82,174,605
JBrowse link
G Krt18 keratin 18 decreases expression EXP trovafloxacin results in decreased expression of KRT18 mRNA CTD PMID:24136188 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
JBrowse link
G Laptm4b lysosomal protein transmembrane 4 beta decreases expression EXP trovafloxacin results in decreased expression of LAPTM4B mRNA CTD PMID:24136188 NCBI chr 7:65,434,525...65,477,386
Ensembl chr 7:65,434,394...65,477,383
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of LDLR mRNA CTD PMID:18930950 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Letm1 leucine zipper and EF-hand containing transmembrane protein 1 decreases expression EXP trovafloxacin results in decreased expression of LETM1 mRNA CTD PMID:24136188 NCBI chr14:76,942,647...76,982,220
Ensembl chr14:76,942,729...76,984,904
JBrowse link
G Lgalsl galectin-like decreases expression EXP trovafloxacin results in decreased expression of LGALSL mRNA CTD PMID:24136188 NCBI chr14:94,996,991...95,004,499
Ensembl chr14:94,996,990...95,004,980
JBrowse link
G Litaf lipopolysaccharide-induced TNF factor multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of LITAF mRNA CTD PMID:18930950 NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763
JBrowse link
G Lmna lamin A/C decreases expression EXP trovafloxacin results in decreased expression of LMNA mRNA CTD PMID:24136188 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
JBrowse link
G Lpin1 lipin 1 increases expression EXP trovafloxacin results in increased expression of LPIN1 mRNA CTD PMID:24136188 NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097
JBrowse link
G Lrp6 LDL receptor related protein 6 increases expression EXP trovafloxacin results in increased expression of LRP6 mRNA CTD PMID:24136188 NCBI chr 4:167,266,581...167,400,155
Ensembl chr 4:167,270,353...167,400,497
JBrowse link
G Lsm4 LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated decreases expression EXP trovafloxacin results in decreased expression of LSM4 mRNA CTD PMID:24136188 NCBI chr16:18,755,481...18,761,106
Ensembl chr16:18,755,484...18,760,926
JBrowse link
G Lta4h leukotriene A4 hydrolase decreases expression EXP trovafloxacin results in decreased expression of LTA4H mRNA CTD PMID:24136188 NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600
JBrowse link
G Lyz2 lysozyme 2 decreases expression EXP trovafloxacin results in decreased expression of LYZ2 mRNA CTD PMID:24136188 NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
JBrowse link
G Mal2 mal, T-cell differentiation protein 2 decreases expression EXP trovafloxacin results in decreased expression of MAL2 mRNA CTD PMID:24136188 NCBI chr 7:85,900,453...85,933,433
Ensembl chr 7:85,900,453...85,933,429
JBrowse link
G Manf mesencephalic astrocyte-derived neurotrophic factor multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of MANF mRNA CTD PMID:18930950 NCBI chr 8:107,500,856...107,551,595
Ensembl chr 8:107,548,352...107,551,438
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha multiple interactions
increases expression
ISO TNF protein inhibits the reaction [trovafloxacin results in increased expression of MAP1LC3A mRNA] CTD PMID:33609687 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression
ISO [trovafloxacin co-treated with TNF protein] results in increased expression of MAP1LC3B mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [trovafloxacin results in increased expression of and results in increased lipidation of MAP1LC3B protein]; TNF protein inhibits the reaction [trovafloxacin results in increased expression of and results in increased lipidation of MAP1LC3B protein]; trovafloxacin results in increased expression of and results in increased lipidation of MAP1LC3B protein
trovafloxacin results in increased expression of MAP1LC3B mRNA
CTD PMID:33609687 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of MAP2K7 mRNA CTD PMID:18930950 NCBI chr12:2,591,312...2,604,211
Ensembl chr12:2,591,219...2,604,222
JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of MAP3K8 mRNA CTD PMID:18930950 NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity
increases phosphorylation
multiple interactions
ISO trovafloxacin results in increased activity of MAPK1 protein
trovafloxacin results in increased phosphorylation of MAPK1 protein
[trovafloxacin co-treated with TNF protein] results in increased phosphorylation of MAPK1 protein; ATG5 protein affects the reaction [trovafloxacin results in increased phosphorylation of MAPK1 protein]
U 0126 inhibits the reaction [trovafloxacin results in increased activity of MAPK1 protein]
CTD PMID:24525298 PMID:32035082 PMID:33609687 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity
increases phosphorylation
multiple interactions
ISO trovafloxacin results in increased activity of MAPK3 protein
trovafloxacin results in increased phosphorylation of MAPK3 protein
[trovafloxacin co-treated with TNF protein] results in increased phosphorylation of MAPK3 protein; ATG5 protein affects the reaction [trovafloxacin results in increased phosphorylation of MAPK3 protein]
U 0126 inhibits the reaction [trovafloxacin results in increased activity of MAPK3 protein]
CTD PMID:24525298 PMID:32035082 PMID:33609687 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
ISO trovafloxacin results in increased phosphorylation of MAPK8 protein
ATG5 protein affects the reaction [trovafloxacin results in increased phosphorylation of MAPK8 protein]
CTD PMID:33609687 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 multiple interactions
increases phosphorylation
ISO SB 203580 inhibits the reaction [trovafloxacin results in increased phosphorylation of MAPKAPK2 protein] CTD PMID:24525298 NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457
JBrowse link
G Mavs mitochondrial antiviral signaling protein multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of MAVS mRNA CTD PMID:18930950 NCBI chr 3:118,451,650...118,466,094
Ensembl chr 3:118,451,743...118,466,094
JBrowse link
G Mdh2 malate dehydrogenase 2 decreases expression EXP trovafloxacin results in decreased expression of MDH2 mRNA CTD PMID:24136188 NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of MDM2 mRNA CTD PMID:18930950 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Me1 malic enzyme 1 decreases expression EXP trovafloxacin results in decreased expression of ME1 mRNA CTD PMID:24136188 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Med20 mediator complex subunit 20 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of MED20 mRNA CTD PMID:18930950 NCBI chr 9:13,370,146...13,382,756
Ensembl chr 9:13,370,146...13,382,476
JBrowse link
G Memo1 mediator of cell motility 1 decreases expression EXP trovafloxacin results in decreased expression of MEMO1 mRNA CTD PMID:24136188 NCBI chr 6:21,144,525...21,234,363
Ensembl chr 6:21,125,639...21,234,561
JBrowse link
G Mgll monoglyceride lipase decreases expression EXP trovafloxacin results in decreased expression of MGLL mRNA CTD PMID:24136188 NCBI chr 4:121,192,187...121,294,187
Ensembl chr 4:121,192,195...121,294,179
JBrowse link
G Mir877 microRNA 877 increases expression ISO trovafloxacin results in increased expression of MIR877 mRNA CTD PMID:27713024 NCBI chr20:2,811,476...2,811,560
Ensembl chr20:2,811,476...2,811,560
JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of MLXIPL mRNA CTD PMID:18930950 NCBI chr12:21,542,964...21,577,120
Ensembl chr12:21,543,576...21,577,112
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of MMP13 mRNA CTD PMID:18930950 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mogs mannosyl-oligosaccharide glucosidase multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of MOGS mRNA CTD PMID:18930950 NCBI chr 4:115,621,623...115,625,026
Ensembl chr 4:115,621,623...115,625,032
JBrowse link
G Mphosph8 M-phase phosphoprotein 8 increases expression EXP trovafloxacin results in increased expression of MPHOSPH8 mRNA CTD PMID:24136188 NCBI chr15:30,800,546...30,828,415 JBrowse link
G Mrpl12 mitochondrial ribosomal protein L12 decreases expression EXP trovafloxacin results in decreased expression of MRPL12 mRNA CTD PMID:24136188 NCBI chr10:105,758,410...105,762,913
Ensembl chr10:105,758,410...105,762,913
JBrowse link
G Mrps18b mitochondrial ribosomal protein S18B decreases expression EXP trovafloxacin results in decreased expression of MRPS18B mRNA CTD PMID:24136188 NCBI chr20:2,838,174...2,844,260
Ensembl chr20:2,838,030...2,844,260
JBrowse link
G Mt1 metallothionein 1 increases expression
multiple interactions
EXP
ISO
trovafloxacin results in increased expression of MT1A mRNA
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of MT1E mRNA
CTD PMID:18930950 PMID:24136188 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mttp microsomal triglyceride transfer protein decreases expression EXP trovafloxacin results in decreased expression of MTTP mRNA CTD PMID:24136188 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of MYD88 mRNA CTD PMID:18930950 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Naa15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit decreases expression EXP trovafloxacin results in decreased expression of NAA15 mRNA CTD PMID:24136188 NCBI chr 2:135,458,018...135,520,756
Ensembl chr 2:135,457,948...135,520,756
JBrowse link
G Ndufaf4 NADH:ubiquinone oxidoreductase complex assembly factor 4 decreases expression EXP trovafloxacin results in decreased expression of NDUFAF4 mRNA CTD PMID:24136188 NCBI chr 5:38,605,169...38,610,341
Ensembl chr 5:38,605,153...38,610,336
JBrowse link
G Nedd4l NEDD4 like E3 ubiquitin protein ligase multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NEDD4L mRNA CTD PMID:18930950 NCBI chr18:58,393,759...58,726,709
Ensembl chr18:58,393,509...58,723,137
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NEDD9 mRNA CTD PMID:18930950 NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases expression
ISO [Lipopolysaccharides co-treated with trovafloxacin] results in increased expression of NFKBIA mRNA; [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NFKBIA mRNA; [trovafloxacin co-treated with TNF protein] results in decreased expression of NFKBIA protein; trovafloxacin promotes the reaction [TNF protein results in increased expression of NFKBIA mRNA]
[trovafloxacin co-treated with TNF protein] results in increased expression of NFKBIA mRNA
trovafloxacin results in increased expression of NFKBIA mRNA; trovafloxacin results in increased expression of NFKBIA protein
CTD PMID:18930950 PMID:32035082 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nfkbiz NFKB inhibitor zeta multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NFKBIZ mRNA CTD PMID:18930950 NCBI chr11:44,782,676...44,810,723
Ensembl chr11:44,782,676...44,810,723
JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 decreases expression EXP trovafloxacin results in decreased expression of NME1 mRNA CTD PMID:24136188 NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408
JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 decreases expression EXP trovafloxacin results in decreased expression of NME2 mRNA CTD PMID:24136188 NCBI chr10:78,898,097...78,903,600
Ensembl chr10:78,897,770...78,903,538
JBrowse link
G Noct nocturnin multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NOCT mRNA CTD PMID:18930950 NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400
JBrowse link
G Notch2 notch receptor 2 decreases expression EXP trovafloxacin results in decreased expression of NOTCH2 mRNA CTD PMID:24136188 NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088
JBrowse link
G Nr2f6 nuclear receptor subfamily 2, group F, member 6 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of NR2F6 mRNA CTD PMID:18930950 NCBI chr16:18,046,012...18,053,914
Ensembl chr16:18,046,013...18,053,459
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression EXP trovafloxacin results in increased expression of NR3C1 mRNA CTD PMID:24136188 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nudt7 nudix hydrolase 7 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of NUDT7 mRNA CTD PMID:18930950 NCBI chr19:42,125,679...42,151,198
Ensembl chr19:42,125,711...42,151,081
JBrowse link
G Nup98 nucleoporin 98 and 96 precursor increases expression EXP trovafloxacin results in increased expression of NUP98 mRNA CTD PMID:24136188 NCBI chr 1:156,494,423...156,591,415
Ensembl chr 1:156,494,423...156,591,415
JBrowse link
G Obp3 alpha-2u globulin PGCL4 increases expression EXP trovafloxacin results in increased expression of OBP3 mRNA CTD PMID:24136188 NCBI chr 5:74,842,316...74,845,858
Ensembl chr 5:74,842,316...74,845,757
JBrowse link
G P2ry2 purinergic receptor P2Y2 decreases expression EXP trovafloxacin results in decreased expression of P2RY2 mRNA CTD PMID:24136188 NCBI chr 1:155,352,050...155,367,423
Ensembl chr 1:155,351,165...155,367,632
JBrowse link
G Pacsin2 protein kinase C and casein kinase substrate in neurons 2 decreases expression EXP trovafloxacin results in decreased expression of PACSIN2 mRNA CTD PMID:24136188 NCBI chr 7:114,505,525...114,599,087
Ensembl chr 7:114,505,152...114,598,546
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO trovafloxacin results in increased cleavage of PARP1 protein
ATG5 protein affects the reaction [trovafloxacin results in increased cleavage of PARP1 protein]
CTD PMID:33609687 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pbld1 phenazine biosynthesis-like protein domain containing 1 increases expression EXP trovafloxacin results in increased expression of PBLD1 mRNA CTD PMID:24136188 NCBI chr20:25,551,274...25,566,543
Ensembl chr20:25,551,275...25,565,614
JBrowse link
G Pcsk6 proprotein convertase subtilisin/kexin type 6 decreases expression EXP trovafloxacin results in decreased expression of PCSK6 mRNA CTD PMID:24136188 NCBI chr 1:119,428,978...119,627,626
Ensembl chr 1:119,429,265...119,627,596
JBrowse link
G Pctp phosphatidylcholine transfer protein decreases expression EXP trovafloxacin results in decreased expression of PCTP mRNA CTD PMID:24136188 NCBI chr10:74,808,887...74,856,260
Ensembl chr10:74,808,887...74,849,867
JBrowse link
G Pde4b phosphodiesterase 4B decreases expression
multiple interactions
EXP
ISO
trovafloxacin results in decreased expression of PDE4B mRNA
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PDE4B mRNA
CTD PMID:18930950 PMID:24136188 NCBI chr 5:116,799,827...117,367,707
Ensembl chr 5:116,799,971...117,367,696
JBrowse link
G Pdhx pyruvate dehydrogenase complex, component X decreases expression EXP trovafloxacin results in decreased expression of PDHX mRNA CTD PMID:24136188 NCBI chr 3:89,372,472...89,396,759
Ensembl chr 3:89,371,497...89,431,773
JBrowse link
G Pdlim1 PDZ and LIM domain 1 decreases expression EXP trovafloxacin results in decreased expression of PDLIM1 mRNA CTD PMID:24136188 NCBI chr 1:239,042,372...239,091,074
Ensembl chr 1:239,042,385...239,091,076
JBrowse link
G Perp p53 apoptosis effector related to PMP22 decreases expression EXP trovafloxacin results in decreased expression of PERP mRNA CTD PMID:24136188 NCBI chr 1:13,542,067...13,554,514
Ensembl chr 1:13,542,067...13,554,511
JBrowse link
G Pex2 peroxisomal biogenesis factor 2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PEX2 mRNA CTD PMID:18930950 NCBI chr 2:96,050,380...96,072,928
Ensembl chr 2:96,045,958...96,073,404
JBrowse link
G Pgk1 phosphoglycerate kinase 1 decreases expression EXP trovafloxacin results in decreased expression of PGK1 mRNA CTD PMID:24136188 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418
JBrowse link
G Pgm1 phosphoglucomutase 1 decreases expression EXP trovafloxacin results in decreased expression of PGM1 mRNA CTD PMID:24136188 NCBI chr 5:114,595,298...114,654,728
Ensembl chr 5:114,595,293...114,654,728
JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PHLDA1 mRNA CTD PMID:18930950 NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861
JBrowse link
G Pink1 PTEN induced kinase 1 increases expression EXP trovafloxacin results in increased expression of PINK1 mRNA CTD PMID:24136188 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Pip5k1a phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PIP5K1A mRNA CTD PMID:18930950 NCBI chr 2:182,628,299...182,671,584
Ensembl chr 2:182,628,300...182,671,598
JBrowse link
G Pisd phosphatidylserine decarboxylase multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PISD mRNA CTD PMID:18930950 NCBI chr14:77,941,927...77,991,021
Ensembl chr14:77,941,948...77,991,003
JBrowse link
G Plbd1 phospholipase B domain containing 1 decreases expression EXP trovafloxacin results in decreased expression of PLBD1 mRNA CTD PMID:24136188 NCBI chr 4:169,472,983...169,529,277
Ensembl chr 4:169,472,983...169,529,277
JBrowse link
G Plin2 perilipin 2 decreases expression EXP trovafloxacin results in decreased expression of PLIN2 mRNA CTD PMID:24136188 NCBI chr 5:101,156,643...101,211,738
Ensembl chr 5:101,154,411...101,242,319
JBrowse link
G Plin3 perilipin 3 decreases expression EXP trovafloxacin results in decreased expression of PLIN3 mRNA CTD PMID:24136188 NCBI chr 9:1,111,178...1,123,117 JBrowse link
G Plk3 polo-like kinase 3 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PLK3 mRNA CTD PMID:18930950 NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317
JBrowse link
G Plpp3 phospholipid phosphatase 3 increases expression EXP trovafloxacin results in increased expression of PLPP3 mRNA CTD PMID:24136188 NCBI chr 5:119,927,085...120,002,206
Ensembl chr 5:119,927,085...120,002,205
JBrowse link
G Pnp purine nucleoside phosphorylase multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PNP2 mRNA CTD PMID:18930950 NCBI chr15:24,170,456...24,178,274
Ensembl chr15:24,170,602...24,203,986
JBrowse link
G Polrmt RNA polymerase mitochondrial multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of POLRMT mRNA CTD PMID:18930950 NCBI chr 7:9,959,532...9,969,791
Ensembl chr 7:9,959,576...9,969,791
JBrowse link
G Ppa1 inorganic pyrophosphatase 1 decreases expression EXP trovafloxacin results in decreased expression of PPA1 mRNA CTD PMID:24136188 NCBI chr20:29,590,733...29,617,711
Ensembl chr20:29,590,707...29,619,215
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO trovafloxacin results in decreased expression of PPARA mRNA CTD PMID:25689681 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppox protoporphyrinogen oxidase decreases expression EXP trovafloxacin results in decreased expression of PPOX mRNA CTD PMID:24136188 NCBI chr13:83,697,661...83,701,998
Ensembl chr13:83,664,891...83,701,805
JBrowse link
G Ppp1r14a protein phosphatase 1, regulatory (inhibitor) subunit 14A decreases expression EXP trovafloxacin results in decreased expression of PPP1R14A mRNA CTD PMID:24136188 NCBI chr 1:84,583,127...84,590,743
Ensembl chr 1:84,586,627...84,590,671
JBrowse link
G Ppp1r14b protein phosphatase 1, regulatory (inhibitor) subunit 14B decreases expression EXP trovafloxacin results in decreased expression of PPP1R14B mRNA CTD PMID:24136188 NCBI chr 1:204,165,210...204,167,320
Ensembl chr 1:204,163,299...204,167,319
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PPP1R15A mRNA CTD PMID:18930950 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Preb prolactin regulatory element binding multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PREB mRNA CTD PMID:18930950 NCBI chr 6:25,418,805...25,422,594
Ensembl chr 6:25,418,776...25,422,590
JBrowse link
G Proser2 proline and serine rich 2 increases expression EXP trovafloxacin results in increased expression of PROSER2 mRNA CTD PMID:24136188 NCBI chr17:72,151,961...72,187,524
Ensembl chr17:72,151,872...72,185,825
JBrowse link
G Prss23 serine protease 23 decreases expression EXP trovafloxacin results in decreased expression of PRSS23 mRNA CTD PMID:24136188 NCBI chr 1:143,402,725...143,422,182
Ensembl chr 1:143,401,396...143,422,091
JBrowse link
G Psma5 proteasome 20S subunit alpha 5 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PSMA5 mRNA CTD PMID:18930950 NCBI chr 2:195,896,369...195,919,733
Ensembl chr 2:195,896,365...195,919,731
JBrowse link
G Psmb10 proteasome 20S subunit beta 10 decreases expression EXP trovafloxacin results in decreased expression of PSMB10 mRNA CTD PMID:24136188 NCBI chr19:33,830,958...33,833,442 JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PTEN mRNA CTD PMID:18930950 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptgr2 prostaglandin reductase 2 decreases expression EXP trovafloxacin results in decreased expression of PTGR2 mRNA CTD PMID:24136188 NCBI chr 6:103,931,367...103,963,113
Ensembl chr 6:103,931,409...103,963,111
JBrowse link
G Ptma prothymosin alpha decreases expression EXP trovafloxacin results in decreased expression of PTMA mRNA CTD PMID:24136188 NCBI chr 9:87,176,251...87,180,333
Ensembl chr 9:87,176,230...87,180,333
JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4A1 increases expression
multiple interactions
EXP
ISO
trovafloxacin results in increased expression of PTP4A1 mRNA
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PTP4A1 mRNA
CTD PMID:18930950 PMID:24136188 NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PTPN2 mRNA CTD PMID:18930950 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627
JBrowse link
G Ptpn21 protein tyrosine phosphatase, non-receptor type 21 decreases expression EXP trovafloxacin results in decreased expression of PTPN21 mRNA CTD PMID:24136188 NCBI chr 6:117,933,066...117,998,095
Ensembl chr 6:117,933,066...117,998,095
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin decreases expression EXP trovafloxacin results in decreased expression of PTTG1 mRNA CTD PMID:24136188 NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837
JBrowse link
G Ran RAN, member RAS oncogene family decreases expression EXP trovafloxacin results in decreased expression of RAN mRNA CTD PMID:24136188 NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276
JBrowse link
G Rangap1 RAN GTPase activating protein 1 decreases expression EXP trovafloxacin results in decreased expression of RANGAP1 mRNA CTD PMID:24136188 NCBI chr 7:113,224,695...113,250,441
Ensembl chr 7:113,224,703...113,250,438
JBrowse link
G Rarb retinoic acid receptor, beta decreases expression EXP trovafloxacin results in decreased expression of RARB mRNA CTD PMID:24136188 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression EXP trovafloxacin results in decreased expression of RB1 mRNA CTD PMID:24136188 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rb1cc1 RB1-inducible coiled-coil 1 multiple interactions
increases expression
ISO TNF protein inhibits the reaction [trovafloxacin results in increased expression of RB1CC1 mRNA] CTD PMID:33609687 NCBI chr 5:13,161,648...13,225,560
Ensembl chr 5:13,161,648...13,225,560
JBrowse link
G Rcan1 regulator of calcineurin 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of RCAN1 mRNA CTD PMID:18930950 NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045
JBrowse link
G Rdx radixin multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of RDX mRNA CTD PMID:18930950 NCBI chr 8:52,379,494...52,437,673
Ensembl chr 8:52,379,494...52,437,678
JBrowse link
G Reep6 receptor accessory protein 6 decreases expression EXP trovafloxacin results in decreased expression of REEP6 mRNA CTD PMID:24136188 NCBI chr 7:9,373,927...9,380,845
Ensembl chr 7:9,373,927...9,380,597
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of REL mRNA CTD PMID:18930950 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
ISO trovafloxacin affects the reaction [TNF protein affects the localization of RELA protein modified form]; trovafloxacin affects the reaction [TNF protein results in increased phosphorylation of RELA protein]
trovafloxacin affects the localization of RELA protein
trovafloxacin affects the reaction [Lipopolysaccharides affects the localization of RELA protein]
CTD PMID:32035082 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G RGD1308742 similar to Complement C5 precursor increases expression EXP trovafloxacin results in increased expression of RGD1308742 mRNA CTD PMID:24136188 NCBI chr 3:18,401,716...18,420,064
Ensembl chr 3:18,404,899...18,420,054
JBrowse link
G RGD1309534 similar to RIKEN cDNA 4931406C07 decreases expression EXP trovafloxacin results in decreased expression of RGD1309534 mRNA CTD PMID:24136188 NCBI chr 8:12,123,839...12,146,412
Ensembl chr 8:12,123,823...12,146,473
JBrowse link
G RGD1564804 similar to chromosome 1 open reading frame 50 increases expression EXP trovafloxacin results in increased expression of RGD1564804 mRNA CTD PMID:24136188 NCBI chr 5:132,837,135...132,841,744
Ensembl chr 5:132,836,506...132,841,762
JBrowse link
G Rmdn2 regulator of microtubule dynamics 2 decreases expression EXP trovafloxacin results in decreased expression of RMDN2 mRNA CTD PMID:24136188 NCBI chr 6:15,372,569...15,443,000
Ensembl chr 6:15,375,496...15,441,480
JBrowse link
G Rnd3 Rho family GTPase 3 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of RND3 mRNA CTD PMID:18930950 NCBI chr 3:35,571,929...35,589,283
Ensembl chr 3:35,571,143...35,589,327
JBrowse link
G Rnf26 ring finger protein 26 decreases expression EXP trovafloxacin results in decreased expression of RNF26 mRNA CTD PMID:24136188 NCBI chr 8:44,454,551...44,456,745
Ensembl chr 8:44,454,292...44,457,331
JBrowse link
G Rnf39 ring finger protein 39 increases expression EXP trovafloxacin results in increased expression of RNF39 mRNA CTD PMID:24136188 NCBI chr20:1,604,794...1,610,283
Ensembl chr20:1,604,794...1,610,283
JBrowse link
G Rnf6 ring finger protein 6 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of RNF6 mRNA CTD PMID:18930950 NCBI chr12:8,816,777...8,826,870
Ensembl chr12:8,816,833...8,826,847
JBrowse link
G Rpa1 replication protein A1 decreases expression EXP trovafloxacin results in decreased expression of RPA1 mRNA CTD PMID:24136188 NCBI chr10:60,148,869...60,199,999
Ensembl chr10:60,148,793...60,199,949
JBrowse link
G Rpl7l1 ribosomal protein L7-like 1 decreases expression EXP trovafloxacin results in decreased expression of RPL7L1 mRNA CTD PMID:24136188 NCBI chr 9:14,198,101...14,206,119
Ensembl chr 9:14,198,092...14,206,110
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO [trovafloxacin co-treated with TNF protein] results in increased phosphorylation of RPS6KB1 protein CTD PMID:33609687 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression EXP trovafloxacin results in decreased expression of RRM2 mRNA CTD PMID:24136188 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
JBrowse link
G Rsrp1 arginine and serine rich protein 1 increases expression EXP trovafloxacin results in increased expression of RSRP1 mRNA CTD PMID:24136188 NCBI chr 5:147,147,774...147,151,523
Ensembl chr 5:147,147,784...147,151,523
JBrowse link
G S100a11 S100 calcium binding protein A11 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of S100A11 mRNA CTD PMID:18930950 NCBI chr 2:179,191,504...179,197,098
Ensembl chr 2:179,191,715...179,197,044
JBrowse link
G Sae1 SUMO1 activating enzyme subunit 1 decreases expression EXP trovafloxacin results in decreased expression of SAE1 mRNA CTD PMID:24136188 NCBI chr 1:77,030,961...77,086,937
Ensembl chr 1:77,030,965...77,086,986
JBrowse link
G Sarnp SAP domain containing ribonucleoprotein decreases expression EXP trovafloxacin results in decreased expression of SARNP mRNA CTD PMID:24136188 NCBI chr 7:1,251,096...1,305,335
Ensembl chr 7:1,251,098...1,305,332
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases expression EXP trovafloxacin results in increased expression of SAT1 mRNA CTD PMID:24136188 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP trovafloxacin results in decreased expression of SCD1 mRNA CTD PMID:24136188 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Sds serine dehydratase increases expression EXP trovafloxacin results in increased expression of SDS mRNA CTD PMID:24136188 NCBI chr12:36,083,226...36,090,540
Ensembl chr12:36,083,229...36,088,203
JBrowse link
G Sec24d SEC24 homolog D, COPII coat complex component decreases expression EXP trovafloxacin results in decreased expression of SEC24D mRNA CTD PMID:24136188 NCBI chr 2:211,418,557...211,526,588
Ensembl chr 2:211,418,623...211,526,587
JBrowse link
G Sele selectin E multiple interactions ISO [trovafloxacin co-treated with IL1B protein] affects the localization of SELE protein; [trovafloxacin co-treated with IL1B protein] results in increased expression of SELE mRNA; trovafloxacin promotes the reaction [IL1B protein results in increased secretion of SELE protein]
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SELE mRNA
CTD PMID:10822086 PMID:18930950 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Senp2 SUMO specific peptidase 2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of SENP2 mRNA CTD PMID:18930950 NCBI chr11:78,981,429...79,018,274
Ensembl chr11:78,981,432...79,018,238
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SERPINE1 mRNA; SERPINE1 protein results in increased susceptibility to [trovafloxacin co-treated with Lipopolysaccharides]; trovafloxacin promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein] CTD PMID:18930950 PMID:19367693 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Sf3a3 splicing factor 3a, subunit 3 decreases expression EXP trovafloxacin results in decreased expression of SF3A3 mRNA CTD PMID:24136188 NCBI chr 5:136,967,713...136,987,345
Ensembl chr 5:136,967,691...136,987,361
JBrowse link
G Sfpq splicing factor proline and glutamine rich decreases expression EXP trovafloxacin results in decreased expression of SFPQ mRNA CTD PMID:24136188 NCBI chr 5:139,338,034...139,353,476
Ensembl chr 5:139,338,075...139,353,472
JBrowse link
G Sh3bp5 SH3-domain binding protein 5 increases expression EXP trovafloxacin results in increased expression of SH3BP5 mRNA CTD PMID:24136188 NCBI chr16:6,583,462...6,678,344
Ensembl chr16:6,583,465...6,698,975
JBrowse link
G Skil SKI-like proto-oncogene multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SKIL mRNA CTD PMID:18930950 NCBI chr 2:112,247,047...112,275,176
Ensembl chr 2:112,247,051...112,275,080
JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SLC11A2 mRNA CTD PMID:18930950 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145
JBrowse link
G Slc17a2 solute carrier family 17, member 2 increases expression EXP trovafloxacin results in increased expression of SLC17A2 mRNA CTD PMID:24136188 NCBI chr17:41,318,312...41,339,012
Ensembl chr17:41,319,701...41,336,325
JBrowse link
G Slc17a3 solute carrier family 17 member 3 decreases expression
multiple interactions
EXP
ISO
trovafloxacin results in decreased expression of SLC17A3 mRNA
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of SLC17A3 mRNA
CTD PMID:18930950 PMID:24136188 NCBI chr17:41,270,804...41,300,132
Ensembl chr17:41,270,812...41,295,256
JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases expression EXP trovafloxacin results in decreased expression of SLC22A1 mRNA CTD PMID:24136188 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc34a2 solute carrier family 34 member 2 decreases expression EXP trovafloxacin results in decreased expression of SLC34A2 mRNA CTD PMID:24136188 NCBI chr14:57,910,931...57,930,236
Ensembl chr14:57,910,480...57,930,436
JBrowse link
G Slc35e3 solute carrier family 35, member E3 decreases expression EXP trovafloxacin results in decreased expression of SLC35E3 mRNA CTD PMID:24136188 NCBI chr 7:53,337,091...53,350,152
Ensembl chr 7:53,337,095...53,350,165
JBrowse link
G Slc39a14 solute carrier family 39 member 14 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SLC39A14 mRNA CTD PMID:18930950 NCBI chr15:45,376,806...45,423,549
Ensembl chr15:45,376,917...45,423,524
JBrowse link
G Slc41a2 solute carrier family 41 member 2 decreases expression EXP trovafloxacin results in decreased expression of SLC41A2 mRNA CTD PMID:24136188 NCBI chr 7:20,383,714...20,491,178
Ensembl chr 7:20,383,757...20,491,166
JBrowse link
G Slc46a1 solute carrier family 46 member 1 increases expression EXP trovafloxacin results in increased expression of SLC46A1 mRNA CTD PMID:24136188 NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848
JBrowse link
G Slc7a2 solute carrier family 7 member 2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SLC7A2 mRNA CTD PMID:18930950 NCBI chr16:51,417,478...51,470,784
Ensembl chr16:51,417,493...51,470,784
JBrowse link
G Slc9a3r1 SLC9A3 regulator 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SLC9A3R1 mRNA CTD PMID:18930950 NCBI chr10:100,403,189...100,420,290
Ensembl chr10:100,403,069...100,420,598
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases expression EXP trovafloxacin results in increased expression of SLCO1A2 mRNA CTD PMID:24136188 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of SLCO1B3 mRNA CTD PMID:18930950 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Smarcd2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of SMARCD2 mRNA CTD PMID:18930950 NCBI chr10:91,193,752...91,202,817
Ensembl chr10:91,193,752...91,204,341
JBrowse link
G Smndc1 survival motor neuron domain containing 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SMNDC1 mRNA CTD PMID:18930950 NCBI chr 1:252,389,675...252,400,749
Ensembl chr 1:252,389,673...252,401,616
JBrowse link
G Snd1 staphylococcal nuclease and tudor domain containing 1 decreases expression EXP trovafloxacin results in decreased expression of SND1 mRNA CTD PMID:24136188 NCBI chr 4:57,095,205...57,494,501
Ensembl chr 4:57,095,208...57,530,843
JBrowse link
G Snx4 sorting nexin 4 multiple interactions ISO [trovafloxacin co-treated with TNF protein] results in decreased expression of SNX4 mRNA CTD PMID:33609687 NCBI chr11:67,460,872...67,518,143
Ensembl chr11:67,460,870...67,518,174
JBrowse link
G Socs2 suppressor of cytokine signaling 2 increases expression
multiple interactions
EXP
ISO
trovafloxacin results in increased expression of SOCS2 mRNA
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SOCS2 mRNA
CTD PMID:18930950 PMID:24136188 NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SOCS3 mRNA CTD PMID:18930950 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SOD2 mRNA CTD PMID:18930950 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Spart spartin decreases expression EXP trovafloxacin results in decreased expression of SPG20 mRNA CTD PMID:24136188 NCBI chr 2:139,292,630...139,319,248
Ensembl chr 2:139,292,355...139,319,248
JBrowse link
G Spred2 sprouty-related, EVH1 domain containing 2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SPRED2 mRNA CTD PMID:18930950 NCBI chr14:94,226,312...94,248,162
Ensembl chr14:94,148,837...94,249,162
JBrowse link
G Sptssa serine palmitoyltransferase, small subunit A increases expression EXP trovafloxacin results in increased expression of SPTSSA mRNA CTD PMID:24136188 NCBI chr 6:72,144,714...72,156,130
Ensembl chr 6:72,144,714...72,156,214
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression EXP trovafloxacin results in decreased expression of SREBF1 mRNA CTD PMID:24136188 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Srm spermidine synthase decreases expression EXP trovafloxacin results in decreased expression of SRM mRNA CTD PMID:24136188 NCBI chr 5:159,025,919...159,029,076
Ensembl chr 5:159,025,873...159,029,405
JBrowse link
G Srp72 signal recognition particle 72 decreases expression EXP trovafloxacin results in decreased expression of SRP72 mRNA CTD PMID:24136188 NCBI chr14:31,168,175...31,195,717 JBrowse link
G Srrm2 serine/arginine repetitive matrix 2 increases expression EXP trovafloxacin results in increased expression of SRRM2 mRNA CTD PMID:24136188 NCBI chr10:12,815,471...12,848,750
Ensembl chr10:12,815,471...12,848,751
JBrowse link
G Srsf1 serine and arginine rich splicing factor 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of SRSF1 mRNA CTD PMID:18930950 NCBI chr10:72,838,926...72,859,066
Ensembl chr10:72,839,274...72,845,336
JBrowse link
G Srsf2 serine and arginine rich splicing factor 2 decreases expression
multiple interactions
EXP
ISO
trovafloxacin results in decreased expression of SRSF2 mRNA
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SRSF2 mRNA
CTD PMID:18930950 PMID:24136188 NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338
JBrowse link
G Srsf3 serine and arginine rich splicing factor 3 decreases expression EXP trovafloxacin results in decreased expression of SRSF3 mRNA CTD PMID:24136188 NCBI chr20:7,091,928...7,101,860
Ensembl chr20:7,091,910...7,101,078
JBrowse link
G Srsf4 serine and arginine rich splicing factor 4 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SRSF4 mRNA CTD PMID:18930950 NCBI chr 5:144,060,981...144,090,798
Ensembl chr 5:144,061,463...144,089,229
JBrowse link
G Srsf5 serine and arginine rich splicing factor 5 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of SRSF5 mRNA CTD PMID:18930950 NCBI chr 6:100,605,165...100,610,192
Ensembl chr 6:100,605,456...100,610,177
JBrowse link
G Ssx2ip SSX family member 2 interacting protein decreases expression EXP trovafloxacin results in decreased expression of SSX2IP mRNA CTD PMID:24136188 NCBI chr 2:235,298,012...235,330,750
Ensembl chr 2:235,298,088...235,330,745
JBrowse link
G Stag2 stromal antigen 2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of STAG2 mRNA CTD PMID:18930950 NCBI chr  X:120,974,687...121,105,677
Ensembl chr  X:120,974,857...121,105,677
JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 increases expression EXP trovafloxacin results in increased expression of STARD4 mRNA CTD PMID:24136188 NCBI chr18:24,814,683...24,830,024
Ensembl chr18:24,817,107...24,830,024
JBrowse link
G Stard5 StAR-related lipid transfer domain containing 5 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of STARD5 mRNA CTD PMID:18930950 NCBI chr 1:137,606,151...137,616,017
Ensembl chr 1:137,606,177...137,616,469
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of STAT3 mRNA CTD PMID:18930950 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Stbd1 starch binding domain 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of STBD1 mRNA CTD PMID:18930950 NCBI chr14:15,470,452...15,473,857
Ensembl chr14:15,469,582...15,477,443
JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases expression EXP trovafloxacin results in decreased expression of STIP1 mRNA CTD PMID:24136188 NCBI chr 1:204,209,434...204,228,452
Ensembl chr 1:204,178,932...204,228,476
JBrowse link
G Stmn1 stathmin 1 decreases expression EXP trovafloxacin results in decreased expression of STMN1 mRNA CTD PMID:24136188 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
JBrowse link
G Sts steroid sulfatase increases expression EXP trovafloxacin results in increased expression of STS mRNA CTD PMID:24136188 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402
JBrowse link
G Sumo2 small ubiquitin-like modifier 2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of SUMO2 mRNA CTD PMID:18930950 NCBI chr10:100,771,941...100,784,503 JBrowse link
G Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SYNCRIP mRNA CTD PMID:18930950 NCBI chr 8:89,402,487...89,435,517
Ensembl chr 8:89,402,866...89,435,515
JBrowse link
G Synrg synergin, gamma increases expression EXP trovafloxacin results in increased expression of SYNRG mRNA CTD PMID:24136188 NCBI chr10:68,848,828...68,931,252 JBrowse link
G Tat tyrosine aminotransferase multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TAT mRNA CTD PMID:18930950 NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031
JBrowse link
G Tbc1d14 TBC1 domain family, member 14 increases expression EXP trovafloxacin results in increased expression of TBC1D14 mRNA CTD PMID:24136188 NCBI chr14:74,172,652...74,272,182
Ensembl chr14:74,172,664...74,272,183
JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 decreases expression EXP trovafloxacin results in decreased expression of TCIRG1 mRNA CTD PMID:24136188 NCBI chr 1:201,127,034...201,138,787
Ensembl chr 1:201,127,034...201,138,742
JBrowse link
G Tent2 terminal nucleotidyltransferase 2 decreases expression EXP trovafloxacin results in decreased expression of TENT2 mRNA CTD PMID:24136188 NCBI chr 2:24,380,135...24,432,099
Ensembl chr 2:24,380,225...24,432,099
JBrowse link
G Tfdp1 transcription factor Dp-1 decreases expression EXP trovafloxacin results in decreased expression of TFDP1 mRNA CTD PMID:24136188 NCBI chr16:76,162,040...76,200,871
Ensembl chr16:76,162,043...76,200,817
JBrowse link
G Tfg trafficking from ER to golgi regulator multiple interactions
decreases expression
ISO
EXP
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of TFG mRNA
trovafloxacin results in decreased expression of TFG mRNA
CTD PMID:18930950 PMID:24136188 NCBI chr11:43,885,542...43,911,976
Ensembl chr11:43,885,661...43,911,976
JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TGIF1 mRNA CTD PMID:18930950 NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802
JBrowse link
G Tgm2 transglutaminase 2 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TGM2 mRNA CTD PMID:18930950 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
JBrowse link
G Thbs1 thrombospondin 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of THBS1 mRNA CTD PMID:18930950 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Thrap3 thyroid hormone receptor associated protein 3 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of THRAP3 mRNA CTD PMID:18930950 NCBI chr 5:138,445,284...138,487,544
Ensembl chr 5:138,445,295...138,487,477
JBrowse link
G Thrsp thyroid hormone responsive decreases expression EXP trovafloxacin results in decreased expression of THRSP mRNA CTD PMID:24136188 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
JBrowse link
G Tkfc triokinase and FMN cyclase decreases expression EXP trovafloxacin results in decreased expression of TKFC mRNA CTD PMID:24136188 NCBI chr 1:207,238,230...207,253,035
Ensembl chr 1:207,236,557...207,252,737
JBrowse link
G Tkt transketolase decreases expression EXP trovafloxacin results in decreased expression of TKT mRNA CTD PMID:24136188 NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698
JBrowse link
G Tle1 TLE family member 1, transcriptional corepressor increases expression EXP trovafloxacin results in increased expression of TLE1 mRNA CTD PMID:24136188 NCBI chr 5:85,851,827...85,934,806
Ensembl chr 5:85,851,827...85,934,774
JBrowse link
G Tmem106b transmembrane protein 106B increases expression EXP trovafloxacin results in increased expression of TMEM106B mRNA CTD PMID:24136188 NCBI chr 4:41,328,125...41,347,315
Ensembl chr 4:41,327,994...41,345,619
JBrowse link
G Tmem41a transmembrane protein 41a decreases expression EXP trovafloxacin results in decreased expression of TMEM41A mRNA CTD PMID:24136188 NCBI chr11:79,084,005...79,090,613
Ensembl chr11:79,084,001...79,090,613
JBrowse link
G Tmpo thymopoietin decreases expression EXP trovafloxacin results in decreased expression of TMPO mRNA CTD PMID:24136188 NCBI chr 7:25,642,752...25,667,756
Ensembl chr 7:25,586,725...25,667,727
JBrowse link
G Tmx2 thioredoxin-related transmembrane protein 2 decreases expression EXP trovafloxacin results in decreased expression of TMX2 mRNA CTD PMID:24136188 NCBI chr 3:69,754,937...69,762,587
Ensembl chr 3:69,754,939...69,762,587
JBrowse link
G Tmx4 thioredoxin-related transmembrane protein 4 increases expression EXP trovafloxacin results in increased expression of TMX4 mRNA CTD PMID:24136188 NCBI chr 3:121,856,237...121,899,680
Ensembl chr 3:121,856,261...121,899,641
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases uptake
decreases expression
increases expression
increases response to substance
increases secretion
ISO
EXP
4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine inhibits the reaction [[trovafloxacin co-treated with TNF protein] results in increased phosphorylation of ATR protein]; [IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to trovafloxacin; [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to trovafloxacin; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] promotes the reaction [trovafloxacin results in increased activity of CASP3 protein]; [TNF protein co-treated with trovafloxacin] results in increased activity of CASP3 protein; [TNF protein co-treated with trovafloxacin] results in increased expression of H2AX protein modified form; [trovafloxacin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [trovafloxacin co-treated with TNF protein] results in decreased expression of ATG4C mRNA; [trovafloxacin co-treated with TNF protein] results in decreased expression of BIRC2 mRNA; [trovafloxacin co-treated with TNF protein] results in decreased expression of SNX4 mRNA; [trovafloxacin co-treated with TNF protein] results in decreased expression of XIAP mRNA; [trovafloxacin co-treated with TNF protein] results in increased activity of CASP3 protein; [trovafloxacin co-treated with TNF protein] results in increased activity of CASP8 protein; [trovafloxacin co-treated with TNF protein] results in increased activity of CASP9 protein; [trovafloxacin co-treated with TNF protein] results in increased expression of ATG10 mRNA; [trovafloxacin co-treated with TNF protein] results in increased expression of ATG16L1 mRNA; [trovafloxacin co-treated with TNF protein] results in increased expression of ATG2A mRNA; [trovafloxacin co-treated with TNF protein] results in increased expression of ATG3 mRNA; [trovafloxacin co-treated with TNF protein] results in increased expression of ATG4A mRNA; [trovafloxacin co-treated with TNF protein] results in increased expression of BIRC3 mRNA; [trovafloxacin co-treated with TNF protein] results in increased expression of GABARAPL1 mRNA; [trovafloxacin co-treated with TNF protein] results in increased expression of ICAM1 mRNA; [trovafloxacin co-treated with TNF protein] results in increased expression of MAP1LC3B mRNA; [trovafloxacin co-treated with TNF protein] results in increased expression of NFKBIA mRNA; [trovafloxacin co-treated with TNF protein] results in increased expression of TNFAIP3 mRNA; [trovafloxacin co-treated with TNF protein] results in increased expression of TNFAIP3 protein; [trovafloxacin co-treated with TNF protein] results in increased expression of ULK2 mRNA; [trovafloxacin co-treated with TNF protein] results in increased phosphorylation of and results in increased activity of ATR protein; [trovafloxacin co-treated with TNF protein] results in increased phosphorylation of EIF4EBP1 protein; [trovafloxacin co-treated with TNF protein] results in increased phosphorylation of MAPK1 protein; [trovafloxacin co-treated with TNF protein] results in increased phosphorylation of MAPK3 protein; [trovafloxacin co-treated with TNF protein] results in increased phosphorylation of RPS6KB1 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[TNF protein co-treated with trovafloxacin] results in increased expression of H2AX protein modified form]; Sirolimus inhibits the reaction [[trovafloxacin co-treated with TNF protein] results in increased phosphorylation of EIF4EBP1 protein]; TNF protein inhibits the reaction [trovafloxacin results in increased expression of and results in increased lipidation of MAP1LC3B protein]; TNF protein inhibits the reaction [trovafloxacin results in increased expression of ATG14 mRNA]; TNF protein inhibits the reaction [trovafloxacin results in increased expression of ATG5 mRNA]; TNF protein inhibits the reaction [trovafloxacin results in increased expression of GABARAPL2 mRNA]; TNF protein inhibits the reaction [trovafloxacin results in increased expression of MAP1LC3A mRNA]; TNF protein inhibits the reaction [trovafloxacin results in increased expression of MAP1LC3B2 mRNA]; TNF protein inhibits the reaction [trovafloxacin results in increased expression of MAP1LC3C mRNA]; TNF protein inhibits the reaction [trovafloxacin results in increased expression of RB1CC1 mRNA]; TNF protein promotes the reaction [trovafloxacin results in increased expression of ATG9B mRNA]; TNF protein promotes the reaction [trovafloxacin results in increased expression of H2AX protein modified form]; TNF protein promotes the reaction [trovafloxacin results in increased phosphorylation of AKT1 protein]; trovafloxacin affects the reaction [TNF protein affects the localization of RELA protein modified form]; trovafloxacin affects the reaction [TNF protein results in increased phosphorylation of RELA protein]; trovafloxacin promotes the reaction [TNF protein results in increased expression of ATG9B mRNA]; U 0126 inhibits the reaction [[TNF protein co-treated with trovafloxacin] results in increased activity of CASP3 protein]
trovafloxacin results in decreased uptake of TNF protein
trovafloxacin results in decreased expression of TNF
trovafloxacin results in increased expression of TNF mRNA; trovafloxacin results in increased expression of TNF protein
trovafloxacin results in increased susceptibility to TNF protein
trovafloxacin results in increased secretion of TNF protein
4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine inhibits the reaction [trovafloxacin promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; 4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine inhibits the reaction [trovafloxacin results in increased expression of and results in increased stability of TNF mRNA]; 4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine inhibits the reaction [trovafloxacin results in increased expression of TNF protein]; [Lipopolysaccharides co-treated with trovafloxacin] results in increased expression of TNF mRNA; [Pentoxifylline results in decreased expression of TNF mRNA] results in decreased susceptibility to [lipopolysaccharide, E coli O55-B5 co-treated with trovafloxacin]; [TNF protein co-treated with trovafloxacin] results in increased cleavage of CASP3 protein; [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TNF protein; [trovafloxacin co-treated with TNF protein] results in decreased expression of NFKBIA protein; IFNG protein promotes the reaction [[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TNF protein]; pyrazolanthrone inhibits the reaction [trovafloxacin promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; pyrazolanthrone inhibits the reaction [trovafloxacin results in increased expression of TNF mRNA]; TNF protein affects the susceptibility to [lipopolysaccharide, E coli O55-B5 co-treated with trovafloxacin]; TNF protein results in increased susceptibility to [Lipopolysaccharides co-treated with trovafloxacin]; trovafloxacin inhibits the reaction [TNF protein results in increased expression of BIRC2 mRNA]; trovafloxacin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; trovafloxacin promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]; trovafloxacin promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; trovafloxacin promotes the reaction [TNF protein results in increased expression of CCL2 protein]; trovafloxacin promotes the reaction [TNF protein results in increased expression of CXCL1 protein]; trovafloxacin promotes the reaction [TNF protein results in increased expression of CXCL2 protein]; trovafloxacin promotes the reaction [TNF protein results in increased expression of IFNG protein]; trovafloxacin promotes the reaction [TNF protein results in increased expression of IL18 protein]; trovafloxacin promotes the reaction [TNF protein results in increased expression of IL1B protein]; trovafloxacin promotes the reaction [TNF protein results in increased expression of IL6 protein]; trovafloxacin promotes the reaction [TNF protein results in increased expression of NFKBIA mRNA]; trovafloxacin promotes the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]; trovafloxacin results in increased expression of and results in increased stability of TNF mRNA; U 0126 inhibits the reaction [trovafloxacin promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; U 0126 inhibits the reaction [trovafloxacin results in increased expression of TNF mRNA]
TNF protein results in increased susceptibility to trovafloxacin
CTD PMID:17709330 PMID:18930950 PMID:19362101 PMID:19638433 PMID:24097668 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 multiple interactions
increases expression
ISO [Lipopolysaccharides co-treated with trovafloxacin] results in increased expression of TNFAIP3 mRNA; [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TNFAIP3 mRNA; trovafloxacin promotes the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]
[trovafloxacin co-treated with TNF protein] results in increased expression of TNFAIP3 mRNA; [trovafloxacin co-treated with TNF protein] results in increased expression of TNFAIP3 protein
trovafloxacin results in increased expression of TNFAIP3 mRNA
trovafloxacin results in increased expression of TNFAIP3 mRNA; trovafloxacin results in increased expression of TNFAIP3 protein
CTD PMID:18930950 PMID:32035082 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
JBrowse link
G Tob2 transducer of ERBB2, 2 increases expression EXP trovafloxacin results in increased expression of TOB2 mRNA CTD PMID:24136188 NCBI chr 7:113,362,703...113,371,423
Ensembl chr 7:113,361,148...113,372,688
JBrowse link
G Tomm70 translocase of outer mitochondrial membrane 70 decreases expression EXP trovafloxacin results in decreased expression of TOMM70A mRNA CTD PMID:24136188 NCBI chr11:43,378,719...43,417,166
Ensembl chr11:43,377,216...43,417,202
JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO trovafloxacin results in decreased activity of TOP2A protein CTD PMID:24817034 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Tpi1 triosephosphate isomerase 1 decreases expression EXP trovafloxacin results in decreased expression of TPI1 mRNA CTD PMID:24136188 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541
JBrowse link
G Tpm3 tropomyosin 3 decreases expression EXP trovafloxacin results in decreased expression of TPM3 mRNA CTD PMID:24136188 NCBI chr 2:175,517,198...175,545,014
Ensembl chr 2:175,517,226...175,545,013
JBrowse link
G Tpst1 tyrosylprotein sulfotransferase 1 increases expression EXP trovafloxacin results in increased expression of TPST1 mRNA CTD PMID:24136188 NCBI chr12:26,544,536...26,605,706
Ensembl chr12:26,544,536...26,605,704
JBrowse link
G Trak1 trafficking kinesin protein 1 increases expression EXP trovafloxacin results in increased expression of TRAK1 mRNA CTD PMID:24136188 NCBI chr 8:120,984,445...121,139,357
Ensembl chr 8:120,984,431...121,139,367
JBrowse link
G Ttc7a tetratricopeptide repeat domain 7A decreases expression EXP trovafloxacin results in decreased expression of TTC7A mRNA CTD PMID:24136188 NCBI chr 6:7,159,285...7,261,826
Ensembl chr 6:7,159,061...7,261,892
JBrowse link
G Tuba1c tubulin, alpha 1C decreases expression EXP trovafloxacin results in decreased expression of TUBA1C mRNA CTD PMID:24136188 NCBI chr 7:130,192,050...130,199,655
Ensembl chr 7:130,192,016...130,199,647
Ensembl chr  X:130,192,016...130,199,647
JBrowse link
G Tuba4a tubulin, alpha 4A decreases expression EXP trovafloxacin results in decreased expression of TUBA4A mRNA CTD PMID:24136188 NCBI chr 9:76,709,617...76,714,327
Ensembl chr 9:76,709,614...76,713,918
JBrowse link
G Tubb2a tubulin, beta 2A class IIa decreases expression EXP trovafloxacin results in decreased expression of TUBB2A mRNA CTD PMID:24136188 NCBI chr17:30,796,842...30,800,713
Ensembl chr17:30,747,503...30,800,714
JBrowse link
G Tubb4b tubulin, beta 4B class IVb multiple interactions
decreases expression
ISO
EXP
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of TUBB4B mRNA
trovafloxacin results in decreased expression of TUBB4B mRNA
CTD PMID:18930950 PMID:24136188 NCBI chr 3:8,037,844...8,040,294
Ensembl chr 3:8,037,799...8,040,296
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression EXP trovafloxacin results in decreased expression of TUBB5 mRNA CTD PMID:24136188 NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940
JBrowse link
G Txlng taxilin gamma multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of TXLNG mRNA CTD PMID:18930950 NCBI chr  X:31,864,066...31,912,931
Ensembl chr  X:31,864,111...31,912,926
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C decreases expression EXP trovafloxacin results in decreased expression of UBE2C mRNA CTD PMID:24136188 NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of UBE2I mRNA CTD PMID:18930950 NCBI chr10:14,277,749...14,294,681
Ensembl chr10:69,701,618...69,702,443
Ensembl chr10:69,701,618...69,702,443
JBrowse link
G Ubqln1 ubiquilin 1 decreases expression EXP trovafloxacin results in decreased expression of UBQLN1 mRNA CTD PMID:24136188 NCBI chr17:6,439,002...6,477,096
Ensembl chr17:6,439,002...6,477,090
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 decreases expression EXP trovafloxacin results in decreased expression of UGT2B17 mRNA CTD PMID:24136188 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 increases expression EXP trovafloxacin results in increased expression of ULK1 mRNA CTD PMID:24136188 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
JBrowse link
G Ulk2 unc-51 like autophagy activating kinase 2 increases expression
multiple interactions
ISO trovafloxacin results in increased expression of ULK2 mRNA
[trovafloxacin co-treated with TNF protein] results in increased expression of ULK2 mRNA
CTD PMID:33609687 NCBI chr10:46,451,578...46,530,462
Ensembl chr10:46,454,030...46,530,407
JBrowse link
G Umps uridine monophosphate synthetase decreases expression EXP trovafloxacin results in decreased expression of UMPS mRNA CTD PMID:24136188 NCBI chr11:66,806,107...66,816,520
Ensembl chr11:66,806,045...66,821,903
JBrowse link
G Upp1 uridine phosphorylase 1 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of UPP1 mRNA CTD PMID:18930950 NCBI chr14:83,809,495...83,829,299
Ensembl chr14:83,809,960...83,829,462
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of VEGFA mRNA CTD PMID:18930950 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Wbp1l WW domain binding protein 1-like increases expression EXP trovafloxacin results in increased expression of WBP1L mRNA CTD PMID:24136188 NCBI chr 1:245,472,292...245,528,627
Ensembl chr 1:245,472,296...245,528,627
JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 decreases expression ISO trovafloxacin results in decreased expression of WIPI1 mRNA CTD PMID:33609687 NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846
JBrowse link
G Xbp1 X-box binding protein 1 increases expression EXP trovafloxacin results in increased expression of XBP1 mRNA CTD PMID:24136188 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of XDH mRNA CTD PMID:18930950 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions
decreases expression
ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of XIAP mRNA
[trovafloxacin co-treated with TNF protein] results in decreased expression of XIAP mRNA
trovafloxacin results in decreased expression of XIAP mRNA
CTD PMID:18930950 PMID:32035082 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
G Xpnpep2 X-prolyl aminopeptidase 2 decreases expression EXP trovafloxacin results in decreased expression of XPNPEP2 mRNA CTD PMID:24136188 NCBI chr  X:127,287,765...127,317,036
Ensembl chr  X:127,287,979...127,317,223
JBrowse link
G Xpo1 exportin 1 decreases expression EXP trovafloxacin results in decreased expression of XPO1 mRNA CTD PMID:24136188 NCBI chr14:97,233,263...97,275,536
Ensembl chr14:97,233,270...97,275,498
JBrowse link
G Yars1 tyrosyl-tRNA synthetase 1 decreases expression EXP trovafloxacin results in decreased expression of YARS1 mRNA CTD PMID:24136188 NCBI chr 5:141,535,815...141,564,029
Ensembl chr 5:141,535,759...141,563,833
JBrowse link
G Ypel3 yippee-like 3 increases expression EXP trovafloxacin results in increased expression of YPEL3 mRNA CTD PMID:24136188 NCBI chr 1:181,384,385...181,387,706
Ensembl chr 1:181,384,357...181,387,705
JBrowse link
G Ypel5 yippee-like 5 increases expression EXP trovafloxacin results in increased expression of YPEL5 mRNA CTD PMID:24136188 NCBI chr 6:22,656,284...22,671,741
Ensembl chr 6:22,656,285...22,671,691
JBrowse link
G Zfand5 zinc finger AN1-type containing 5 multiple interactions ISO [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ZFAND5 mRNA CTD PMID:18930950 NCBI chr 1:218,765,735...218,776,118
Ensembl chr 1:218,766,614...218,775,843
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      biological role 19746
        antimicrobial agent 17469
          trovafloxacin 405
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            organic molecule 19545
                              organic cyclic compound 19339
                                organic heterocyclic compound 18579
                                  organic heteropolycyclic compound 18039
                                    organic heterobicyclic compound 16857
                                      mancude organic heterobicyclic parent 5415
                                        naphthyridine 801
                                          1,8-naphthyridine 409
                                            1,8-naphthyridine derivative 409
                                              trovafloxacin 405
paths to the root