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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Triptolide
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Accession:CHEBI:9747 term browser browse the term
Definition:An oxacycle that has formula C20H24O6.
Synonyms:related_synonym: Formula=C20H24O6;   InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1;   InChIKey=DFBIRQPKNDILPW-CIVMWXNOSA-N;   SMILES=CC(C)[C@]12O[C@H]1[C@@H]1O[C@]11[C@]3(O[C@H]3C[C@H]3C4=C(CC[C@]13C)C(=O)OC4)[C@@H]2O
 xref: CAS:38748-32-2;   KEGG:C09204;   KNApSAcK:C00003494;   LINCS:LSM-5518
 xref_mesh: MESH:C001899
 xref: Wikipedia:Triptolide


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Triptolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 increases expression EXP triptolide results in increased expression of ABCB11 protein CTD PMID:32519852 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
decreases response to substance
ISO
EXP
[ABCB1A mutant form co-treated with triptolide] results in increased abundance of Malondialdehyde; ABCB1A mutant form promotes the reaction [triptolide results in decreased expression of BCL2 protein]; ABCB1A mutant form promotes the reaction [triptolide results in increased activity of GPT protein]; ABCB1A mutant form promotes the reaction [triptolide results in increased expression of BAX protein]
triptolide results in increased expression of ABCB1A protein
ABCB1A protein results in decreased susceptibility to triptolide
CTD PMID:26134275, PMID:32519852 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression EXP triptolide results in increased expression of ABCG2 protein CTD PMID:32519852 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Acaa1b acetyl-Coenzyme A acyltransferase 1B decreases expression EXP triptolide results in decreased expression of ACAA1B protein CTD PMID:32519852 NCBI chr 8:127,836,235...127,845,296 JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation ISO triptolide results in increased phosphorylation of ACACA protein CTD PMID:29723566 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acot1 acyl-CoA thioesterase 1 decreases expression
increases expression
ISO
EXP
triptolide results in decreased expression of ACOT1 mRNA
triptolide results in increased expression of ACOT1 protein
CTD PMID:31241159, PMID:32519852 NCBI chr 6:107,485,088...107,493,082
Ensembl chr 6:107,485,249...107,493,798
JBrowse link
G Acox2 acyl-CoA oxidase 2 decreases expression
increases expression
ISO
EXP
triptolide results in decreased expression of ACOX2 mRNA
triptolide results in increased expression of ACOX2 protein
CTD PMID:31241159, PMID:32519852 NCBI chr15:18,449,304...18,481,472
Ensembl chr15:18,451,144...18,481,470
JBrowse link
G Acsm1 acyl-CoA synthetase medium-chain family member 1 decreases expression EXP triptolide results in decreased expression of ACSM1 protein CTD PMID:32519852 NCBI chr 1:189,359,374...189,395,277
Ensembl chr 1:189,289,957...189,395,276
JBrowse link
G Acsm2 acyl-CoA synthetase medium-chain family member 2 decreases expression EXP triptolide results in decreased expression of ACSM2 protein CTD PMID:32519852 NCBI chr 1:189,289,957...189,329,007
Ensembl chr 1:189,289,957...189,395,276
JBrowse link
G Actb actin, beta decreases expression EXP triptolide results in decreased expression of ACTB mRNA; triptolide results in decreased expression of ACTB protein CTD PMID:27554044 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Ada adenosine deaminase increases expression EXP triptolide results in increased expression of ADA protein CTD PMID:32519852 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) decreases expression EXP triptolide results in decreased expression of ADH1 mRNA CTD PMID:23639586 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857
JBrowse link
G Adpgk ADP-dependent glucokinase increases expression EXP triptolide results in increased expression of ADPGK mRNA CTD PMID:23639586 NCBI chr 8:64,088,871...64,116,832
Ensembl chr 8:64,088,913...64,116,832
JBrowse link
G Afm afamin increases expression EXP triptolide results in increased expression of AFM protein CTD PMID:32519852 NCBI chr14:19,078,678...19,132,212
Ensembl chr14:19,078,680...19,132,208
JBrowse link
G Agps alkylglycerone phosphate synthase increases expression EXP triptolide results in increased expression of AGPS protein CTD PMID:32519852 NCBI chr 3:62,648,352...62,749,250
Ensembl chr 3:62,648,447...62,749,153
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 decreases expression ISO triptolide results in decreased expression of AIFM1 protein CTD PMID:26990902 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases expression EXP triptolide results in increased expression of AKR1B1 protein CTD PMID:32519852 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 decreases expression EXP triptolide results in decreased expression of AKR1B10 protein CTD PMID:32519852 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 increases expression EXP triptolide results in increased expression of AKR1B8 protein CTD PMID:32519852 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 increases expression EXP triptolide results in increased expression of AKR7A2 protein CTD PMID:32519852 NCBI chr 5:157,759,448...157,768,473
Ensembl chr 5:157,759,416...157,768,471
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
EXP
ISO
triptolide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [triptolide results in decreased phosphorylation of AKT1 protein]
CTD PMID:21717513, PMID:32061799 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt2 AKT serine/threonine kinase 2 decreases expression EXP triptolide results in decreased expression of AKT2 mRNA CTD PMID:23639586 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Alb albumin increases expression EXP triptolide results in increased expression of ALB protein CTD PMID:32519852 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldob aldolase, fructose-bisphosphate B decreases expression EXP triptolide results in decreased expression of ALDOB mRNA CTD PMID:23639586 NCBI chr 5:64,805,772...64,818,813
Ensembl chr 5:64,805,773...64,818,824
JBrowse link
G Amacr alpha-methylacyl-CoA racemase affects expression EXP triptolide affects the expression of AMACR protein CTD PMID:32519852 NCBI chr 2:60,949,276...60,961,342
Ensembl chr 2:60,949,256...60,961,326
JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor increases expression EXP triptolide results in increased expression of AMBP protein CTD PMID:32519852 NCBI chr 5:78,975,690...78,986,021
Ensembl chr 5:78,975,678...78,985,990
JBrowse link
G Ano6 anoctamin 6 increases expression EXP triptolide results in increased expression of ANO6 protein CTD PMID:32519852 NCBI chr 7:137,142,063...137,335,208
Ensembl chr 7:137,142,170...137,335,208
JBrowse link
G Anp32e acidic nuclear phosphoprotein 32 family member E increases expression EXP triptolide results in increased expression of ANP32E protein CTD PMID:32519852 NCBI chr 2:198,040,573...198,057,005
Ensembl chr 2:198,040,536...198,057,003
JBrowse link
G Anpep alanyl aminopeptidase, membrane affects expression EXP triptolide affects the expression of ANPEP protein CTD PMID:32519852 NCBI chr 1:141,561,364...141,604,249
Ensembl chr 1:141,561,334...141,604,273
JBrowse link
G Anxa13 annexin A13 increases expression EXP triptolide results in increased expression of ANXA13 protein CTD PMID:32519852 NCBI chr 7:98,217,642...98,270,442
Ensembl chr 7:98,217,642...98,270,110
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression
multiple interactions
ISO
EXP
triptolide results in increased expression of APAF1 protein
NFE2L2 protein inhibits the reaction [triptolide results in increased expression of APAF1 protein]
CTD PMID:25169008, PMID:26990902 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Apoa1 apolipoprotein A1 increases expression EXP triptolide results in increased expression of APOA1 protein CTD PMID:32519852 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Aqp1 aquaporin 1 increases expression EXP triptolide results in increased expression of AQP1 protein CTD PMID:32519852 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Aqp2 aquaporin 2 increases expression EXP triptolide results in increased expression of AQP2 protein CTD PMID:32519852 NCBI chr 7:141,237,802...141,242,837
Ensembl chr 7:141,237,768...141,245,165
JBrowse link
G Arglu1 arginine and glutamate rich 1 increases expression EXP triptolide results in increased expression of ARGLU1 protein CTD PMID:32519852 NCBI chr16:86,600,877...86,625,084
Ensembl chr16:86,600,877...86,625,083
JBrowse link
G Arl8b ADP-ribosylation factor like GTPase 8B decreases expression EXP triptolide results in decreased expression of ARL8B protein CTD PMID:32519852 NCBI chr 4:140,837,745...140,881,866
Ensembl chr 4:140,837,745...140,881,865
JBrowse link
G Armc9 armadillo repeat containing 9 increases expression EXP triptolide results in increased expression of ARMC9 protein CTD PMID:32519852 NCBI chr 9:93,172,718...93,299,119
Ensembl chr 9:93,172,673...93,296,750
JBrowse link
G Arrb1 arrestin, beta 1 increases expression EXP triptolide results in increased expression of ARRB1 protein CTD PMID:32519852 NCBI chr 1:164,502,099...164,573,947
Ensembl chr 1:164,502,389...164,593,139
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression EXP triptolide results in increased expression of ASNS protein CTD PMID:32519852 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Ass1 argininosuccinate synthase 1 decreases expression EXP triptolide results in decreased expression of ASS1 protein CTD PMID:32519852 NCBI chr 3:10,327,411...10,375,847
Ensembl chr 3:10,327,414...10,375,826
JBrowse link
G Atf4 activating transcription factor 4 decreases expression EXP triptolide results in decreased expression of ATF4 mRNA CTD PMID:23639586 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atf6 activating transcription factor 6 decreases expression ISO triptolide results in decreased expression of ATF6 protein CTD PMID:26990902 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Atf6b activating transcription factor 6 beta decreases expression ISO triptolide results in decreased expression of ATF6B protein CTD PMID:26990902 NCBI chr20:4,414,283...4,422,283
Ensembl chr20:4,414,276...4,422,283
JBrowse link
G Atg12 autophagy related 12 increases expression ISO triptolide results in increased expression of ATG12 protein CTD PMID:26990902 NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126
JBrowse link
G Atg5 autophagy related 5 increases expression ISO triptolide results in increased expression of ATG5 protein CTD PMID:26990902 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Atg7 autophagy related 7 increases expression ISO triptolide results in increased expression of ATG7 protein CTD PMID:26990902 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Atp11a ATPase phospholipid transporting 11A increases expression EXP triptolide results in increased expression of ATP11A protein CTD PMID:32519852 NCBI chr16:81,990,340...82,100,222
Ensembl chr16:81,990,340...82,100,222
JBrowse link
G Atp5f1e ATP synthase F1 subunit epsilon decreases expression EXP triptolide results in decreased expression of ATP5E protein CTD PMID:32519852 NCBI chr 3:172,563,105...172,566,007
Ensembl chr 3:172,563,105...172,566,010
JBrowse link
G Atp5mc3 ATP synthase membrane subunit c locus 3 increases expression EXP triptolide results in increased expression of ATP5G3 protein CTD PMID:32519852 NCBI chr 3:60,811,218...60,813,903
Ensembl chr 3:60,811,210...60,813,869
JBrowse link
G Atp5me ATP synthase membrane subunit e increases expression EXP triptolide results in increased expression of ATP5I protein CTD PMID:32519852 NCBI chr14:2,325,308...2,326,436
Ensembl chr14:2,325,308...2,326,436
JBrowse link
G Atp5mpl ATP synthase membrane subunit 6.8PL decreases expression EXP triptolide results in decreased expression of ATP5MPL protein CTD PMID:32519852
G Atp6v0a1 ATPase H+ transporting V0 subunit a1 increases expression EXP triptolide results in increased expression of ATP6V0A1 protein CTD PMID:32519852 NCBI chr10:88,914,264...88,967,736
Ensembl chr10:88,914,276...88,967,748
JBrowse link
G Atp6v0a4 ATPase H+ transporting V0 subunit a4 increases expression EXP triptolide results in increased expression of ATP6V0A4 protein CTD PMID:32519852 NCBI chr 4:65,736,585...65,821,916
Ensembl chr 4:65,736,585...65,818,521
JBrowse link
G Atp6v0c ATPase H+ transporting V0 subunit C increases expression EXP triptolide results in increased expression of ATP6V0C protein CTD PMID:32519852 NCBI chr10:13,537,031...13,543,407
Ensembl chr10:13,537,033...13,542,077
JBrowse link
G Atp6v0d1 ATPase H+ transporting V0 subunit D1 increases expression EXP triptolide results in increased expression of ATP6V0D1 protein CTD PMID:32519852 NCBI chr19:37,481,782...37,525,762
Ensembl chr19:37,481,782...37,525,762
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions
increases expression
EXP
ISO
pifithrin inhibits the reaction [triptolide results in increased expression of BAK1 protein]
TRP53 gene mutant form inhibits the reaction [triptolide results in increased expression of BAK1 protein]
CTD PMID:30009776 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
affects expression
EXP
ISO
NFE2L2 protein inhibits the reaction [triptolide results in increased expression of BAX protein]; pifithrin inhibits the reaction [triptolide results in increased expression of BAX protein]; Quercetin inhibits the reaction [triptolide affects the expression of BAX protein]; Val-Pro-Met-Leu-Lys inhibits the reaction [triptolide results in increased expression of BAX protein]
10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide inhibits the reaction [triptolide results in increased expression of BAX protein]; ABCB1A mutant form promotes the reaction [triptolide results in increased expression of BAX protein]; tariquidar promotes the reaction [triptolide results in increased expression of BAX protein]; TRP53 gene mutant form inhibits the reaction [triptolide results in increased expression of BAX protein]
CTD PMID:25169008, PMID:26134275, PMID:26277538, PMID:26990902, PMID:30009776, PMID:30836114 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression EXP triptolide results in increased expression of BBC3 protein CTD PMID:30009776 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
increases expression
multiple interactions
affects expression
EXP
ISO
triptolide results in decreased expression of BCL2 protein
triptolide results in increased expression of BCL2 protein
ABCB1A mutant form promotes the reaction [triptolide results in decreased expression of BCL2 protein]; NOTCH1 protein modified form inhibits the reaction [triptolide results in decreased expression of BCL2 protein]; tariquidar promotes the reaction [triptolide results in decreased expression of BCL2 protein]; TRP53 gene mutant form inhibits the reaction [triptolide results in decreased expression of BCL2 protein]
triptolide affects the expression of BCL2 protein
Lithium Chloride inhibits the reaction [triptolide results in decreased expression of BCL2 protein]; NFE2L2 protein inhibits the reaction [triptolide results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [triptolide results in decreased expression of BCL2 protein]; Quercetin inhibits the reaction [triptolide affects the expression of BCL2 protein]; Val-Pro-Met-Leu-Lys inhibits the reaction [triptolide results in decreased expression of BCL2 protein]
CTD PMID:25169008, PMID:26134275, PMID:26277538, PMID:26990902, PMID:30009776, PMID:30394310, PMID:30836114, PMID:30926361 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression
decreases expression
multiple interactions
ISO
EXP
triptolide results in increased expression of BCL2L1 protein
triptolide results in decreased expression of BCL2L1 protein
TRP53 gene mutant form inhibits the reaction [triptolide results in decreased expression of BCL2L1 protein]
pifithrin inhibits the reaction [triptolide results in decreased expression of BCL2L1 protein]
CTD PMID:26990902, PMID:30009776 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Becn1 beclin 1 increases expression ISO triptolide results in increased expression of BECN1 protein CTD PMID:26990902 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO triptolide results in increased expression of BID protein CTD PMID:26990902 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO triptolide results in decreased expression of BIRC3 mRNA CTD PMID:15972136 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Blvra biliverdin reductase A affects expression EXP triptolide affects the expression of BLVRA protein CTD PMID:32519852 NCBI chr 3:119,552,550...119,577,796
Ensembl chr 3:119,561,290...119,577,806
JBrowse link
G Bsnd barttin CLCNK type accessory subunit beta decreases expression EXP triptolide results in decreased expression of BSND protein CTD PMID:32519852 NCBI chr 5:126,071,849...126,080,647
Ensembl chr 5:126,071,846...126,080,698
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 increases expression EXP triptolide results in increased expression of BST2 protein CTD PMID:32519852 NCBI chr16:19,938,781...19,942,353
Ensembl chr16:19,938,784...19,942,353
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase decreases expression
increases expression
EXP triptolide results in decreased expression of BUB1 mRNA
triptolide results in increased expression of BUB1 mRNA
CTD PMID:23639586 NCBI chr 3:120,373,604...120,404,910
Ensembl chr 3:120,373,604...120,404,910
JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B increases expression EXP triptolide results in increased expression of BUB1B mRNA CTD PMID:23639586 NCBI chr 3:110,367,949...110,420,471
Ensembl chr 3:110,367,939...110,420,458
JBrowse link
G Bub3 BUB3 mitotic checkpoint protein decreases expression EXP triptolide results in decreased expression of BUB3 mRNA CTD PMID:23639586 NCBI chr 1:203,526,853...203,537,459
Ensembl chr 1:203,524,426...203,557,337
JBrowse link
G C1qa complement C1q A chain increases expression EXP triptolide results in increased expression of C1QA protein CTD PMID:32519852 NCBI chr 5:155,261,254...155,264,101
Ensembl chr 5:155,261,250...155,264,143
JBrowse link
G C3 complement C3 increases expression EXP triptolide results in increased expression of C3 protein CTD PMID:32519852 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G C4a complement C4A increases expression EXP triptolide results in increased expression of C4A protein CTD PMID:32519852 NCBI chr20:2,651,599...2,678,183
Ensembl chr20:2,651,599...2,678,141
JBrowse link
G Ca3 carbonic anhydrase 3 increases expression EXP triptolide results in increased expression of CA3 protein CTD PMID:32519852 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
JBrowse link
G Ca9 carbonic anhydrase 9 multiple interactions ISO triptolide inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein] CTD PMID:24842335 NCBI chr 5:59,008,277...59,015,535
Ensembl chr 5:59,008,933...59,015,528
JBrowse link
G Cald1 caldesmon 1 decreases expression EXP triptolide results in decreased expression of CALD1 protein CTD PMID:32519852 NCBI chr 4:62,103,948...62,291,375
Ensembl chr 4:62,220,736...62,291,489
JBrowse link
G Capg capping actin protein, gelsolin like increases expression EXP triptolide results in increased expression of CAPG protein CTD PMID:32519852 NCBI chr 4:100,395,693...100,419,447
Ensembl chr 4:100,407,658...100,419,446
JBrowse link
G Capn1 calpain 1 increases expression ISO triptolide results in increased expression of CAPN1 protein CTD PMID:26990902 NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322
JBrowse link
G Capn2 calpain 2 increases expression ISO triptolide results in increased expression of CAPN2 protein CTD PMID:26990902 NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811
JBrowse link
G Car1 carbonic anhydrase 1 increases expression EXP triptolide results in increased expression of CA1 protein CTD PMID:32519852 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479
JBrowse link
G Carhsp1 calcium regulated heat stable protein 1 decreases expression EXP triptolide results in decreased expression of CARHSP1 protein CTD PMID:32519852 NCBI chr10:7,041,510...7,055,107
Ensembl chr10:7,041,510...7,055,101
JBrowse link
G Casp12 caspase 12 increases expression ISO triptolide results in increased expression of CASP12 protein CTD PMID:26990902 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases expression
increases activity
ISO
EXP
triptolide results in increased activity of and results in increased cleavage of CASP3 protein
triptolide results in increased cleavage of CASP3 protein
triptolide results in increased expression of CASP3 protein modified form
10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; [triptolide co-treated with Lipopolysaccharides] results in increased expression of CASP3 protein modified form; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased expression of CASP3 protein modified form]; NOTCH1 protein modified form inhibits the reaction [triptolide results in increased expression of CASP3 protein modified form]; triptolide results in increased expression of and results in increased activity of CASP3 protein; TRP53 gene mutant form inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]
triptolide results in increased activity of CASP3 protein
benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; Lithium Chloride inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; NFE2L2 protein inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; Quercetin inhibits the reaction [triptolide results in increased activity of CASP3 protein]; Val-Pro-Met-Leu-Lys inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]
CTD PMID:12533674, PMID:15972136, PMID:19233258, PMID:21640813, PMID:23639586, PMID:25169008, PMID:26277538, PMID:26990902, PMID:30009776, PMID:30394310, PMID:30633930, PMID:30836114, PMID:30926361 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity
increases expression
ISO
EXP
triptolide results in increased activity of CASP7 protein
triptolide results in increased expression of CASP7 protein
CTD PMID:21640813, PMID:32519852 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [triptolide co-treated with Lipopolysaccharides] results in increased expression of CASP8 protein modified form; triptolide results in increased expression of and results in increased activity of CASP8 protein CTD PMID:26990902, PMID:30633930 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
increases activity
EXP
ISO
pifithrin inhibits the reaction [triptolide results in increased expression of CASP9 protein modified form]; Quercetin inhibits the reaction [triptolide results in increased activity of CASP9 protein]; Val-Pro-Met-Leu-Lys inhibits the reaction [triptolide results in increased expression of CASP9 protein modified form]
triptolide results in increased expression of and results in increased activity of CASP9 protein; TRP53 gene mutant form inhibits the reaction [triptolide results in increased expression of CASP9 protein modified form]
CTD PMID:26277538, PMID:26990902, PMID:30009776 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Castor1 cytosolic arginine sensor for mTORC1 subunit 1 increases expression EXP triptolide results in increased expression of CASTOR1 protein CTD PMID:32519852 NCBI chr14:84,447,552...84,457,396
Ensembl chr14:84,447,885...84,452,367
JBrowse link
G Cav1 caveolin 1 increases expression EXP triptolide results in increased expression of CAV1 protein CTD PMID:32519852 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Cblc Cbl proto-oncogene C decreases expression EXP triptolide results in decreased expression of CBLC mRNA CTD PMID:23639586 NCBI chr 1:80,699,321...80,716,146
Ensembl chr 1:80,699,323...80,716,146
JBrowse link
G Ccdc196 coiled-coil domain containing 196 increases expression EXP triptolide results in increased expression of CCDC196 protein CTD PMID:32519852 NCBI chr 6:101,288,951...101,304,220
Ensembl chr 6:101,287,035...101,304,220
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 increases expression
multiple interactions
ISO triptolide results in increased expression of CCL11 mRNA
IL17A protein promotes the reaction [triptolide results in increased expression of CCL11 mRNA]
CTD PMID:24949944 NCBI chr10:69,434,965...69,439,566
Ensembl chr10:69,434,941...69,439,575
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO triptolide promotes the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] CTD PMID:30633930 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccna1 cyclin A1 decreases expression ISO triptolide results in decreased expression of CCNA1 protein CTD PMID:12533674 NCBI chr 2:144,456,689...144,503,570
Ensembl chr 2:144,458,153...144,467,912
JBrowse link
G Ccna2 cyclin A2 increases expression EXP triptolide results in increased expression of CCNA2 mRNA CTD PMID:23639586 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 increases expression
decreases expression
EXP
ISO
triptolide results in increased expression of CCNB1 mRNA
triptolide results in decreased expression of CCNB1 protein
CTD PMID:12533674, PMID:23639586 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnb2 cyclin B2 increases expression EXP triptolide results in increased expression of CCNB2 mRNA CTD PMID:23639586 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP
ISO
triptolide results in decreased expression of CCND1 mRNA
triptolide results in decreased expression of CCND1 protein
CTD PMID:12533674, PMID:23639586, PMID:26990902 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 increases expression EXP triptolide results in increased expression of CCND2 mRNA CTD PMID:23639586 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccne1 cyclin E1 increases expression ISO triptolide results in increased expression of CCNE1 protein CTD PMID:26990902 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccne2 cyclin E2 increases expression EXP triptolide results in increased expression of CCNE2 mRNA CTD PMID:23639586 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Cd24 CD24 molecule multiple interactions ISO triptolide inhibits the reaction [cobaltous chloride results in increased expression of CD24 protein] CTD PMID:24842335 NCBI chr20:48,335,540...48,340,847
Ensembl chr20:48,335,540...48,340,846
JBrowse link
G Cd36 CD36 molecule increases expression EXP triptolide results in increased expression of CD36 protein CTD PMID:32519852 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cd44 CD44 molecule (Indian blood group) multiple interactions ISO triptolide inhibits the reaction [cobaltous chloride results in increased expression of CD44 protein] CTD PMID:24842335 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cd47 Cd47 molecule increases expression EXP triptolide results in increased expression of CD47 protein CTD PMID:32519852 NCBI chr11:53,511,485...53,575,754
Ensembl chr11:53,514,595...53,575,175
JBrowse link
G Cd59 CD59 molecule increases expression EXP triptolide results in increased expression of CD59 protein CTD PMID:32519852 NCBI chr 3:94,010,481...94,028,660
Ensembl chr 3:94,010,475...94,028,621
JBrowse link
G Cd80 Cd80 molecule multiple interactions ISO triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CD80 protein] CTD PMID:15663903 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
JBrowse link
G Cd86 CD86 molecule multiple interactions ISO triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CD86 protein] CTD PMID:15663903 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cdc16 cell division cycle 16 decreases expression EXP triptolide results in decreased expression of CDC16 mRNA CTD PMID:23639586 NCBI chr16:81,493,355...81,516,493
Ensembl chr16:81,493,355...81,516,493
JBrowse link
G Cdc25b cell division cycle 25B increases expression EXP triptolide results in increased expression of CDC25B mRNA CTD PMID:23639586 NCBI chr 3:123,731,539...123,741,696
Ensembl chr 3:123,731,539...123,741,339
JBrowse link
G Cdc42 cell division cycle 42 decreases expression EXP triptolide results in decreased expression of CDC42 mRNA; triptolide results in decreased expression of CDC42 protein CTD PMID:27554044 NCBI chr 5:155,690,267...155,728,385
Ensembl chr 5:155,691,390...155,728,300
JBrowse link
G Cdc45 cell division cycle 45 increases expression EXP triptolide results in increased expression of CDC45 mRNA CTD PMID:23639586 NCBI chr11:86,328,785...86,354,099
Ensembl chr11:86,329,012...86,358,453
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression
decreases expression
EXP
ISO
triptolide results in increased expression of CDK1 mRNA
triptolide results in decreased expression of CDK1 protein
CTD PMID:12533674, PMID:23639586 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression
increases expression
EXP
ISO
triptolide results in decreased expression of CDK2 mRNA
triptolide results in decreased expression of CDK2 protein
triptolide results in increased expression of CDK2 protein
CTD PMID:12533674, PMID:23639586, PMID:26990902 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression ISO triptolide results in increased expression of CDK4 protein CTD PMID:26990902 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk6 cyclin-dependent kinase 6 increases expression ISO triptolide results in increased expression of CDK6 protein CTD PMID:26990902 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdk7 cyclin-dependent kinase 7 increases expression EXP triptolide results in increased expression of CDK7 mRNA CTD PMID:23639586 NCBI chr 2:30,710,642...30,735,522
Ensembl chr 2:30,710,643...30,735,514
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP
ISO
triptolide results in increased expression of CDKN1A mRNA
triptolide results in increased expression of CDKN1A protein
CTD PMID:23639586, PMID:26990902 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression EXP triptolide results in increased expression of CDKN1B protein CTD PMID:32519852 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C increases expression EXP triptolide results in increased expression of CDKN2C mRNA CTD PMID:23639586 NCBI chr 5:129,347,731...129,352,886
Ensembl chr 5:129,347,732...129,352,886
JBrowse link
G Ces1d carboxylesterase 1D increases expression EXP triptolide results in increased expression of CES1D protein CTD PMID:32519852 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Cfh complement factor H increases expression EXP triptolide results in increased expression of CFH protein CTD PMID:32519852 NCBI chr13:56,979,155...57,080,540
Ensembl chr13:56,978,607...57,080,622
JBrowse link
G Cfl2 cofilin 2 increases expression EXP triptolide results in increased expression of CFL2 protein CTD PMID:32519852 NCBI chr 6:75,759,140...75,763,185
Ensembl chr 6:75,759,140...75,763,185
JBrowse link
G Chchd3 coiled-coil-helix-coiled-coil-helix domain containing 3 increases expression EXP triptolide results in increased expression of CHCHD3 protein CTD PMID:32519852 NCBI chr 4:60,080,536...60,358,592
Ensembl chr 4:60,080,538...60,358,562
JBrowse link
G Chchd6 coiled-coil-helix-coiled-coil-helix domain containing 6 increases expression EXP triptolide results in increased expression of CHCHD6 protein CTD PMID:32519852 NCBI chr 4:121,340,952...121,565,222
Ensembl chr 4:121,340,952...121,565,212
JBrowse link
G Clcnkb chloride voltage-gated channel Kb increases expression EXP triptolide results in increased expression of CLCNKB protein CTD PMID:32519852 NCBI chr 5:159,950,384...159,973,576
Ensembl chr 5:159,950,392...159,962,676
JBrowse link
G Cldn11 claudin 11 decreases expression
multiple interactions
ISO triptolide results in decreased expression of CLDN11 mRNA; triptolide results in decreased expression of CLDN11 protein
10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide inhibits the reaction [triptolide results in decreased expression of CLDN11 mRNA]; 10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide inhibits the reaction [triptolide results in decreased expression of CLDN11 protein]
CTD PMID:30836114 NCBI chr 2:115,823,541...115,836,846
Ensembl chr 2:115,823,538...115,836,846
JBrowse link
G Clu clusterin increases expression EXP triptolide results in increased expression of CLU protein CTD PMID:32519852 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cmpk2 cytidine/uridine monophosphate kinase 2 increases expression EXP triptolide results in increased expression of CMPK2 protein CTD PMID:32519852 NCBI chr 6:45,683,242...45,694,824
Ensembl chr 6:45,683,234...45,694,822
JBrowse link
G Cnbp CCHC-type zinc finger, nucleic acid binding protein decreases expression EXP triptolide results in decreased expression of CNBP protein CTD PMID:32519852 NCBI chr 4:119,747,890...119,756,787
Ensembl chr 4:119,747,911...119,756,765
JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase increases expression EXP triptolide results in increased expression of CNP protein CTD PMID:32519852 NCBI chr10:88,490,798...88,497,357
Ensembl chr10:88,490,798...88,497,356
JBrowse link
G Cog5 component of oligomeric golgi complex 5 decreases expression EXP triptolide results in decreased expression of COG5 protein CTD PMID:32519852 NCBI chr 6:50,953,868...51,230,860
Ensembl chr 6:50,954,631...51,230,701
JBrowse link
G Comt catechol-O-methyltransferase decreases expression EXP triptolide results in decreased expression of COMT protein CTD PMID:32519852 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Cp ceruloplasmin increases expression EXP triptolide results in increased expression of CP protein CTD PMID:32519852 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Cpsf2 cleavage and polyadenylation specific factor 2 decreases expression EXP triptolide results in decreased expression of CPSF2 protein CTD PMID:32519852 NCBI chr 6:125,870,372...125,898,039
Ensembl chr 6:125,870,372...125,898,874
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression ISO triptolide results in increased expression of CPT1A mRNA CTD PMID:29723566 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B decreases expression ISO triptolide results in decreased expression of CPT1B mRNA CTD PMID:31241159 NCBI chr 7:130,395,211...130,404,731
Ensembl chr 7:130,395,194...130,405,347
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression ISO triptolide results in decreased expression of CPT2 mRNA CTD PMID:31241159 NCBI chr 5:127,505,646...127,523,016
Ensembl chr 5:127,505,614...127,523,089
JBrowse link
G Crbn cereblon increases expression EXP triptolide results in increased expression of CRBN protein CTD PMID:32519852 NCBI chr 4:138,864,910...138,885,786
Ensembl chr 4:138,866,761...138,885,556
JBrowse link
G Crem cAMP responsive element modulator decreases expression EXP triptolide results in decreased expression of CREM mRNA CTD PMID:23639586 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888
JBrowse link
G Crk CRK proto-oncogene, adaptor protein decreases expression
increases expression
EXP triptolide results in decreased expression of CRK mRNA
triptolide results in increased expression of CRK mRNA
CTD PMID:23639586 NCBI chr10:63,829,731...63,855,999
Ensembl chr10:63,829,807...63,852,780
JBrowse link
G Crp C-reactive protein increases expression EXP triptolide results in increased expression of CRP protein CTD PMID:32519852 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression
multiple interactions
ISO triptolide results in increased expression of CXCL2 mRNA
IL17A protein promotes the reaction [triptolide results in increased expression of CXCL2 mRNA]
CTD PMID:24949944 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions
increases expression
ISO IL17A protein promotes the reaction [triptolide results in increased expression of CXCL1 mRNA]; triptolide inhibits the reaction [Chlorine results in increased expression of CXCL1 protein] CTD PMID:20348278, PMID:24949944 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO triptolide results in decreased expression of CXCR4 protein CTD PMID:26420756 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions
decreases expression
EXP
ISO
triptolide results in decreased expression of and results in decreased activity of CYP11A1 protein
[Colforsin co-treated with triptolide] results in decreased expression of CYP11A1 mRNA
triptolide results in decreased expression of CYP11A1 mRNA
CTD PMID:22592319, PMID:31557376 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 multiple interactions ISO [Colforsin co-treated with triptolide] results in decreased expression of CYP11B1 mRNA CTD PMID:31557376 NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 multiple interactions ISO [Colforsin co-treated with triptolide] results in decreased expression of CYP11B2 mRNA CTD PMID:31557376 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO [Colforsin co-treated with triptolide] results in decreased expression of CYP17A1 mRNA CTD PMID:31557376 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP triptolide results in decreased expression of CYP2C11 protein CTD PMID:32519852 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing EXP CYP3A2 affects the metabolism of triptolide CTD PMID:20223271 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO triptolide results in increased expression of DDIT3 protein CTD PMID:26990902 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddrgk1 DDRGK domain containing 1 decreases expression EXP triptolide results in decreased expression of DDRGK1 protein CTD PMID:32519852 NCBI chr 3:123,195,580...123,206,828
Ensembl chr 3:123,195,580...123,206,828
JBrowse link
G Dennd1a DENN domain containing 1A increases expression EXP triptolide results in increased expression of DENND1A protein CTD PMID:32519852 NCBI chr 3:22,061,120...22,501,502
Ensembl chr 3:22,058,400...22,500,765
JBrowse link
G Des desmin multiple interactions EXP triptolide inhibits the reaction [Puromycin Aminonucleoside results in increased expression of DES protein] CTD PMID:18509322 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294
JBrowse link
G Dglucy D-glutamate cyclase decreases expression EXP triptolide results in decreased expression of DGLUCY protein CTD PMID:32519852 NCBI chr 6:124,786,164...124,870,244
Ensembl chr 6:124,786,097...124,872,277
JBrowse link
G Dhrs7b dehydrogenase/reductase 7B increases expression EXP triptolide results in increased expression of DHRS7B protein CTD PMID:32519852 NCBI chr10:47,065,755...47,111,089
Ensembl chr10:47,065,850...47,111,101
JBrowse link
G Dhrs7l1 dehydrogenase/reductase (SDR family) member 7-like 1 decreases expression EXP triptolide results in decreased expression of DHRS7L1 protein CTD PMID:32519852 NCBI chr 6:95,387,709...95,502,845
Ensembl chr 6:95,387,718...95,502,845
JBrowse link
G Dhx58 DEXH-box helicase 58 increases expression EXP triptolide results in increased expression of DHX58 protein CTD PMID:32519852 NCBI chr10:88,599,722...88,611,562
Ensembl chr10:88,599,680...88,611,105
JBrowse link
G Dnajb12 DnaJ heat shock protein family (Hsp40) member B12 increases expression EXP triptolide results in increased expression of DNAJB12 protein CTD PMID:32519852 NCBI chr20:29,445,510...29,463,739
Ensembl chr20:29,445,510...29,463,738
JBrowse link
G Dnajc6 DnaJ heat shock protein family (Hsp40) member C6 decreases expression EXP triptolide results in decreased expression of DNAJC6 protein CTD PMID:32519852 NCBI chr 5:120,330,372...120,492,515
Ensembl chr 5:120,340,646...120,492,487
JBrowse link
G Dnm1l dynamin 1-like multiple interactions
decreases expression
ISO 10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide inhibits the reaction [triptolide results in decreased expression of DNM1L protein] CTD PMID:30836114 NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198
JBrowse link
G Dpep1 dipeptidase 1 increases expression EXP triptolide results in increased expression of DPEP1 protein CTD PMID:32519852 NCBI chr19:55,973,447...55,998,830
Ensembl chr19:55,982,740...55,998,208
JBrowse link
G Dpp4 dipeptidylpeptidase 4 affects expression EXP triptolide affects the expression of DPP4 protein CTD PMID:32519852 NCBI chr 3:48,291,055...48,372,672
Ensembl chr 3:48,291,055...48,372,672
JBrowse link
G Dtnbp1 dystrobrevin binding protein 1 decreases expression EXP triptolide results in decreased expression of DTNBP1 protein CTD PMID:32519852 NCBI chr17:20,090,136...20,182,332
Ensembl chr17:20,090,246...20,182,206
JBrowse link
G Dusp1 dual specificity phosphatase 1 decreases expression ISO triptolide results in decreased expression of DUSP1 protein CTD PMID:17507666 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Dync2h1 dynein cytoplasmic 2 heavy chain 1 increases expression EXP triptolide results in increased expression of DYNC2H1 protein CTD PMID:32519852 NCBI chr 8:5,217,054...5,436,969
Ensembl chr 8:5,217,217...5,429,581
JBrowse link
G E2f1 E2F transcription factor 1 increases expression EXP triptolide results in increased expression of E2F1 mRNA CTD PMID:23639586 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G E2f3 E2F transcription factor 3 increases expression EXP triptolide results in increased expression of E2F3 mRNA CTD PMID:23639586 NCBI chr17:36,334,136...36,408,831
Ensembl chr17:36,334,147...36,408,831
JBrowse link
G Echdc2 enoyl CoA hydratase domain containing 2 decreases expression EXP triptolide results in decreased expression of ECHDC2 protein CTD PMID:32519852 NCBI chr 5:127,770,570...127,789,568
Ensembl chr 5:127,770,570...127,789,567
JBrowse link
G Ehd2 EH-domain containing 2 increases expression EXP triptolide results in increased expression of EHD2 protein CTD PMID:32519852 NCBI chr 1:77,847,599...77,865,870
Ensembl chr 1:77,847,600...77,865,870
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression ISO triptolide results in increased expression of EHHADH mRNA CTD PMID:29723566 NCBI chr11:82,945,104...82,978,364
Ensembl chr11:82,945,104...82,978,364
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 increases expression EXP triptolide results in increased expression of EIF2AK2 protein CTD PMID:32519852 NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201
JBrowse link
G Eif2b4 eukaryotic translation initiation factor 2B subunit delta increases expression EXP triptolide results in increased expression of EIF2B4 protein CTD PMID:32519852 NCBI chr 6:26,546,917...26,552,474
Ensembl chr 6:26,546,924...26,552,430
JBrowse link
G Eipr1 EARP complex and GARP complex interacting protein 1 increases expression EXP triptolide results in increased expression of EIPR1 protein CTD PMID:32519852 NCBI chr 6:48,021,771...48,135,241
Ensembl chr 6:48,021,771...48,135,241
JBrowse link
G Emc3 ER membrane protein complex subunit 3 increases expression EXP triptolide results in increased expression of EMC3 protein CTD PMID:32519852 NCBI chr 4:145,471,466...145,487,375
Ensembl chr 4:145,471,454...145,487,426
JBrowse link
G Emc8 ER membrane protein complex subunit 8 increases expression EXP triptolide results in increased expression of EMC8 protein CTD PMID:32519852 NCBI chr19:54,235,949...54,245,810
Ensembl chr19:54,235,936...54,245,855
JBrowse link
G Endog endonuclease G increases expression ISO triptolide results in increased expression of ENDOG protein CTD PMID:26990902 NCBI chr 3:8,741,833...8,744,414
Ensembl chr 3:8,741,766...8,744,592
JBrowse link
G Enpep glutamyl aminopeptidase affects expression EXP triptolide affects the expression of ENPEP protein CTD PMID:32519852 NCBI chr 2:233,667,253...233,743,866
Ensembl chr 2:233,667,254...233,743,866
JBrowse link
G Erlin1 ER lipid raft associated 1 increases expression EXP triptolide results in increased expression of ERLIN1 protein CTD PMID:32519852 NCBI chr 1:263,810,439...263,845,762
Ensembl chr 1:263,810,439...263,845,762
JBrowse link
G Ermp1 endoplasmic reticulum metallopeptidase 1 increases expression EXP triptolide results in increased expression of ERMP1 protein CTD PMID:32519852 NCBI chr 1:247,784,830...247,821,771
Ensembl chr 1:247,787,582...247,821,728
JBrowse link
G Espl1 extra spindle pole bodies like 1, separase increases expression EXP triptolide results in increased expression of ESPL1 mRNA CTD PMID:23639586 NCBI chr 7:143,896,890...143,923,868
Ensembl chr 7:143,897,014...143,923,868
JBrowse link
G Esrrb estrogen-related receptor beta increases expression EXP triptolide results in increased expression of ESRRB protein CTD PMID:32519852 NCBI chr 6:110,360,940...110,458,406
Ensembl chr 6:110,410,141...110,455,906
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit decreases expression ISO triptolide results in decreased expression of EZH2 protein CTD PMID:19879315 NCBI chr 4:77,284,404...77,347,011
Ensembl chr 4:77,284,404...77,347,011
JBrowse link
G F5 coagulation factor V increases expression EXP triptolide results in increased expression of F5 protein CTD PMID:32519852 NCBI chr13:82,479,997...82,535,540
Ensembl chr13:82,479,998...82,535,534
JBrowse link
G F9 coagulation factor IX increases expression EXP triptolide results in increased expression of F9 protein CTD PMID:32519852 NCBI chr  X:143,097,507...143,141,791
Ensembl chr  X:143,097,525...143,141,794
JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression EXP triptolide results in increased expression of FABP4 protein CTD PMID:32519852 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fam210b family with sequence similarity 210, member B increases expression EXP triptolide results in increased expression of FAM210B protein CTD PMID:32519852 NCBI chr 3:170,354,109...170,364,265
Ensembl chr 3:170,354,141...170,362,513
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO triptolide results in increased expression of FAS protein CTD PMID:26990902 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions
increases expression
ISO IL17A protein promotes the reaction [triptolide results in increased expression of FASL mRNA]
triptolide results in increased expression of FASL mRNA; triptolide results in increased expression of FASL protein
CTD PMID:24949944, PMID:26990902 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fbn2 fibrillin 2 decreases expression EXP triptolide results in decreased expression of FBN2 protein CTD PMID:32519852 NCBI chr18:53,068,495...53,272,254
Ensembl chr18:53,068,495...53,181,503
JBrowse link
G Fbp2 fructose-bisphosphatase 2 decreases expression EXP triptolide results in decreased expression of FBP2 mRNA CTD PMID:23639586 NCBI chr17:372,554...389,918
Ensembl chr17:372,551...389,967
JBrowse link
G Fbxl4 F-box and leucine-rich repeat protein 4 increases expression EXP triptolide results in increased expression of FBXL4 protein CTD PMID:32519852 NCBI chr 5:36,555,061...36,628,920
Ensembl chr 5:36,555,109...36,629,689
JBrowse link
G Fbxo7 F-box protein 7 increases expression EXP triptolide results in increased expression of FBXO7 protein CTD PMID:32519852 NCBI chr 7:23,815,246...23,843,505
Ensembl chr 7:23,815,245...23,843,634
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression EXP triptolide results in increased expression of FDFT1 protein CTD PMID:32519852 NCBI chr15:46,339,248...46,367,302
Ensembl chr15:46,339,249...46,367,302
JBrowse link
G Fetub fetuin B increases expression EXP triptolide results in increased expression of FETUB protein CTD PMID:32519852 NCBI chr11:81,648,890...81,660,472
Ensembl chr11:81,648,885...81,660,395
JBrowse link
G Fga fibrinogen alpha chain increases expression EXP triptolide results in increased expression of FGA protein CTD PMID:32519852 NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763
JBrowse link
G Fgb fibrinogen beta chain increases expression EXP triptolide results in increased expression of FGB protein CTD PMID:32519852 NCBI chr 2:182,028,044...182,035,026
Ensembl chr 2:182,027,115...182,038,178
JBrowse link
G Fgf1 fibroblast growth factor 1 decreases expression EXP triptolide results in decreased expression of FGF1 protein CTD PMID:32519852 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fgg fibrinogen gamma chain increases expression EXP triptolide results in increased expression of FGG protein CTD PMID:32519852 NCBI chr 2:181,987,080...181,994,523
Ensembl chr 2:181,987,217...181,994,514
JBrowse link
G Fjx1 four-jointed box kinase 1 increases expression EXP triptolide results in increased expression of FJX1 protein CTD PMID:32519852 NCBI chr 3:92,288,818...92,290,919
Ensembl chr 3:92,288,818...92,290,919
JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 affects expression EXP triptolide affects the expression of FMO5 protein CTD PMID:32519852 NCBI chr 2:199,796,870...199,823,927
Ensembl chr 2:199,796,881...199,823,927
JBrowse link
G Foxo3 forkhead box O3 decreases phosphorylation ISO triptolide results in decreased phosphorylation of FOXO3 protein CTD PMID:32061799 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Foxp3 forkhead box P3 decreases expression ISO triptolide results in decreased expression of FOXP3 mRNA CTD PMID:24949944 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression EXP triptolide results in increased expression of FTH1 protein CTD PMID:32519852 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Ftl1 ferritin light chain 1 increases expression EXP triptolide results in increased expression of FTL1 protein CTD PMID:32519852 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G Fundc2 FUN14 domain containing 2 decreases expression EXP triptolide results in decreased expression of FUNDC2 protein CTD PMID:32519852 NCBI chr18:401,878...407,954
Ensembl chr18:402,295...407,954
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase multiple interactions
increases expression
EXP Lithium Chloride inhibits the reaction [triptolide results in increased expression of FYN protein] CTD PMID:30926361 NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317
JBrowse link
G G6pc glucose-6-phosphatase, catalytic subunit decreases expression
multiple interactions
EXP
ISO
triptolide results in decreased expression of G6PC mRNA
Lipopolysaccharides promotes the reaction [triptolide results in decreased expression of G6PC mRNA]; triptolide promotes the reaction [Lipopolysaccharides results in decreased expression of G6PC mRNA]
CTD PMID:23639586, PMID:30633930 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Gaa glucosidase, alpha, acid increases expression EXP triptolide results in increased expression of GAA protein CTD PMID:32519852 NCBI chr10:108,395,873...108,412,999
Ensembl chr10:108,395,860...108,413,059
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma decreases expression EXP triptolide results in decreased expression of GADD45G mRNA CTD PMID:23639586 NCBI chr17:13,391,474...13,393,219
Ensembl chr17:13,391,467...13,393,243
JBrowse link
G Galm galactose mutarotase decreases expression EXP triptolide results in decreased expression of GALM mRNA CTD PMID:23639586 NCBI chr 6:2,808,988...2,860,742
Ensembl chr 6:2,808,841...2,860,744
JBrowse link
G Galnt11 polypeptide N-acetylgalactosaminyltransferase 11 increases expression EXP triptolide results in increased expression of GALNT11 protein CTD PMID:32519852 NCBI chr 4:6,297,255...6,330,765
Ensembl chr 4:6,297,258...6,330,765
JBrowse link
G Galnt3 polypeptide N-acetylgalactosaminyltransferase 3 increases expression EXP triptolide results in increased expression of GALNT3 protein CTD PMID:32519852 NCBI chr 3:52,174,469...52,212,395
Ensembl chr 3:52,175,547...52,212,412
JBrowse link
G Galnt7 polypeptide N-acetylgalactosaminyltransferase 7 increases expression EXP triptolide results in increased expression of GALNT7 protein CTD PMID:32519852 NCBI chr16:35,935,059...36,062,734
Ensembl chr16:35,934,970...36,062,719
JBrowse link
G Gbp2 guanylate binding protein 2 increases expression EXP triptolide results in increased expression of GBP2 protein CTD PMID:32519852 NCBI chr 2:248,276,795...248,293,784
Ensembl chr 2:248,276,709...248,293,784
JBrowse link
G Gck glucokinase decreases expression EXP triptolide results in decreased expression of GCK mRNA CTD PMID:23639586 NCBI chr14:86,149,146...86,191,589
Ensembl chr14:86,148,928...86,190,659
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression
multiple interactions
ISO
EXP
triptolide results in decreased expression of GCLC protein
NFE2L2 protein inhibits the reaction [triptolide results in decreased expression of GCLC protein]
CTD PMID:25169008 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gimap4 GTPase, IMAP family member 4 increases expression EXP triptolide results in increased expression of GIMAP4 protein CTD PMID:32519852 NCBI chr 4:78,320,230...78,327,144
Ensembl chr 4:78,320,190...78,327,144
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression
multiple interactions
ISO triptolide results in decreased expression of GJA1 mRNA; triptolide results in decreased expression of GJA1 protein
10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide inhibits the reaction [triptolide results in decreased expression of GJA1 mRNA]; 10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide inhibits the reaction [triptolide results in decreased expression of GJA1 protein]
CTD PMID:30836114 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Glmp glycosylated lysosomal membrane protein decreases expression EXP triptolide results in decreased expression of GLMP protein CTD PMID:32519852 NCBI chr 2:187,697,528...187,701,118
Ensembl chr 2:187,697,523...187,701,118
JBrowse link
G Gmds GDP-mannose 4, 6-dehydratase increases expression EXP triptolide results in increased expression of GMDS protein CTD PMID:32519852 NCBI chr17:33,408,722...33,938,086
Ensembl chr17:33,408,722...33,938,085
JBrowse link
G Gpaa1 glycosylphosphatidylinositol anchor attachment 1 increases expression EXP triptolide results in increased expression of GPAA1 protein CTD PMID:32519852 NCBI chr 7:117,394,367...117,397,950
Ensembl chr 7:117,394,372...117,397,956
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity
increases expression
multiple interactions
ISO triptolide results in increased activity of GPT protein
triptolide results in increased expression of GPT protein
catalpol inhibits the reaction [triptolide results in increased expression of GPT protein]; catalpol promotes the reaction [Saponins inhibits the reaction [triptolide results in increased expression of GPT protein]]; NFE2L2 protein affects the reaction [catalpol promotes the reaction [Saponins inhibits the reaction [triptolide results in increased expression of GPT protein]]]; NFE2L2 protein affects the reaction [Saponins promotes the reaction [catalpol inhibits the reaction [triptolide results in increased expression of GPT protein]]]; NFE2L2 protein affects the reaction [triptolide results in increased expression of GPT protein]; Saponins inhibits the reaction [triptolide results in increased expression of GPT protein]; Saponins promotes the reaction [catalpol inhibits the reaction [triptolide results in increased expression of GPT protein]]
ABCB1A mutant form promotes the reaction [triptolide results in increased activity of GPT protein]
CTD PMID:23836259, PMID:26134275, PMID:30682494 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases expression
ISO
EXP
Fenofibrate inhibits the reaction [triptolide results in increased expression of GPX1 mRNA]
triptolide results in increased expression of GPX1 protein
CTD PMID:31241159, PMID:32519852 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions
increases expression
ISO Fenofibrate inhibits the reaction [triptolide results in increased expression of GPX2 mRNA] CTD PMID:31241159 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions
increases expression
ISO Fenofibrate inhibits the reaction [triptolide results in increased expression of GPX3 mRNA] CTD PMID:31241159 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
JBrowse link
G Gpx4 glutathione peroxidase 4 increases expression
multiple interactions
ISO triptolide results in increased expression of GPX4 mRNA
Fenofibrate inhibits the reaction [triptolide results in increased expression of GPX4 mRNA]
CTD PMID:31241159 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
JBrowse link
G Grb2 growth factor receptor bound protein 2 decreases expression ISO triptolide results in decreased expression of GRB2 protein CTD PMID:26420756 NCBI chr10:104,193,953...104,263,071
Ensembl chr10:104,193,955...104,263,071
JBrowse link
G Gsdmd gasdermin D increases expression EXP triptolide results in increased expression of GSDMD protein CTD PMID:32519852 NCBI chr 7:116,889,147...116,894,134
Ensembl chr 7:116,889,572...116,894,134
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation
EXP Lithium Chloride inhibits the reaction [triptolide results in increased phosphorylation of GSK3B protein] CTD PMID:30926361 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gusb glucuronidase, beta multiple interactions
decreases activity
ISO resveratrol inhibits the reaction [triptolide results in decreased activity of GUSB protein] CTD PMID:29723566 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 increases expression EXP triptolide results in increased expression of HBA-A2 protein; triptolide results in increased expression of HBA1 protein CTD PMID:32519852 NCBI chr10:15,589,364...15,590,207
Ensembl chr10:15,589,364...15,590,220
JBrowse link
G Hbb hemoglobin subunit beta increases expression EXP triptolide results in increased expression of HBB protein CTD PMID:32519852 NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725
JBrowse link
G Hdac1 histone deacetylase 1 increases expression EXP triptolide results in increased expression of HDAC1 mRNA CTD PMID:23639586 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
JBrowse link
G Hdac1l histone deacetylase 1-like increases expression EXP triptolide results in increased expression of HDAC1L protein CTD PMID:32519852 NCBI chr 9:84,893,145...84,894,599
Ensembl chr 9:84,893,145...84,894,599
JBrowse link
G Hdac2 histone deacetylase 2 increases expression EXP triptolide results in increased expression of HDAC2 protein CTD PMID:32519852 NCBI chr20:43,084,870...43,108,198
Ensembl chr20:43,084,870...43,108,198
JBrowse link
G Hdac6 histone deacetylase 6 increases expression ISO triptolide results in increased expression of HDAC6 mRNA; triptolide results in increased expression of HDAC6 protein CTD PMID:32061799 NCBI chr  X:15,295,372...15,316,673
Ensembl chr  X:15,295,473...15,316,671
JBrowse link
G Herc6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 increases expression EXP triptolide results in increased expression of HERC6 protein CTD PMID:32519852 NCBI chr 4:88,606,851...88,649,424
Ensembl chr 4:88,607,518...88,649,216
JBrowse link
G Hes1 hes family bHLH transcription factor 1 decreases expression
increases expression
multiple interactions
ISO triptolide results in decreased expression of HES1 protein
triptolide results in increased expression of HES1 mRNA
triptolide results in decreased expression of HES1 mRNA; triptolide results in decreased expression of HES1 protein
Fenofibrate inhibits the reaction [triptolide results in increased expression of HES1 mRNA]; NOTCH1 protein modified form inhibits the reaction [triptolide results in decreased expression of HES1 protein]
CTD PMID:30394310, PMID:31241159 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link
G Higd2al1 HIG1 hypoxia inducible domain family, member 2A-like 1 increases expression EXP triptolide results in increased expression of HIGD2AL1 protein CTD PMID:32519852 NCBI chr12:4,546,240...4,546,871 JBrowse link
G Hikeshi heat shock protein nuclear import factor increases expression EXP triptolide results in increased expression of HIKESHI protein CTD PMID:32519852 NCBI chr 1:154,147,098...154,170,429
Ensembl chr 1:154,142,836...154,170,409
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO [Colforsin co-treated with triptolide] results in decreased expression of HMGCR mRNA CTD PMID:31557376 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
affects expression
decreases expression
EXP
ISO
triptolide results in increased expression of HMOX1 mRNA
10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide inhibits the reaction [triptolide results in decreased expression of HMOX1 mRNA]; 10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide inhibits the reaction [triptolide results in decreased expression of HMOX1 protein]
[triptolide co-treated with catalpol co-treated with Saponins] results in increased expression of HMOX1 protein; [triptolide co-treated with catalpol] results in increased expression of HMOX1 protein; [triptolide co-treated with Saponins] results in increased expression of HMOX1 protein
NFE2L2 protein inhibits the reaction [triptolide results in decreased expression of HMOX1 protein]
triptolide affects the expression of HMOX1 mRNA
triptolide results in decreased expression of HMOX1 mRNA; triptolide results in decreased expression of HMOX1 protein
CTD PMID:23639586, PMID:25169008, PMID:30682494, PMID:30836114 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hp haptoglobin increases expression EXP triptolide results in increased expression of HP protein CTD PMID:32519852 NCBI chr19:42,096,255...42,100,805
Ensembl chr19:42,097,995...42,100,804
JBrowse link
G Hpx hemopexin increases expression EXP triptolide results in increased expression of HPX protein CTD PMID:32519852 NCBI chr 1:170,423,558...170,431,066
Ensembl chr 1:170,423,483...170,431,073
JBrowse link
G Hras HRas proto-oncogene, GTPase decreases expression EXP triptolide results in decreased expression of HRAS mRNA CTD PMID:23639586 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Hrg histidine-rich glycoprotein increases expression EXP triptolide results in increased expression of HRG protein CTD PMID:32519852 NCBI chr11:81,621,274...81,639,938
Ensembl chr11:81,621,283...81,639,952
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 multiple interactions ISO [Colforsin co-treated with triptolide] results in decreased expression of HSD3B2 mRNA CTD PMID:31557376 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A decreases response to substance ISO HSPA1A results in decreased susceptibility to triptolide CTD PMID:19546256 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression EXP triptolide results in increased expression of HSPA1B protein CTD PMID:32519852 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 increases expression EXP triptolide results in increased expression of HSPA2 protein CTD PMID:32519852 NCBI chr 6:99,433,575...99,436,288
Ensembl chr 6:99,433,550...99,436,289
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression ISO triptolide results in decreased expression of HSPA5 protein CTD PMID:26990902 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 decreases expression EXP triptolide results in decreased expression of HSPD1 protein CTD PMID:32519852 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO triptolide results in decreased expression of ICAM1 mRNA; triptolide results in decreased expression of ICAM1 protein CTD PMID:17931847 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifit1bl interferon-induced protein with tetratricopeptide repeats 1B-like increases expression EXP triptolide results in increased expression of IFIT1 protein CTD PMID:32519852 NCBI chr 1:252,914,684...252,959,348
Ensembl chr 1:252,914,684...252,922,486
JBrowse link
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 increases expression EXP triptolide results in increased expression of IFIT2 protein CTD PMID:32519852 NCBI chr 1:252,894,663...252,900,727
Ensembl chr 1:252,894,663...252,900,726
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 increases expression EXP triptolide results in increased expression of IFIT3 protein CTD PMID:32519852 NCBI chr 1:252,906,234...252,911,377
Ensembl chr 1:252,906,234...252,911,382
JBrowse link
G Ifng interferon gamma multiple interactions ISO triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]]; triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CD80 protein]; triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CD86 protein]; triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:15663903 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 increases expression EXP triptolide results in increased expression of IGDCC3 protein CTD PMID:32519852 NCBI chr 8:70,630,546...70,685,882
Ensembl chr 8:70,630,767...70,684,115
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 decreases expression EXP triptolide results in decreased expression of IGFBP1 mRNA CTD PMID:23639586 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785
JBrowse link
G IgG-2a gamma-2a immunoglobulin heavy chain increases expression EXP triptolide results in increased expression of IGG-2A protein CTD PMID:32519852
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions
decreases phosphorylation
ISO
EXP
TRP53 protein affects the reaction [triptolide results in decreased phosphorylation of IKBKB protein]
pifithrin inhibits the reaction [triptolide results in decreased phosphorylation of IKBKB protein]
CTD PMID:31618665 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il12a interleukin 12A multiple interactions ISO triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]] CTD PMID:15663903 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il12b interleukin 12B multiple interactions ISO triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]]; triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:15663903 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il17a interleukin 17A multiple interactions
increases expression
ISO IL17A protein promotes the reaction [triptolide results in increased expression of CCL11 mRNA]; IL17A protein promotes the reaction [triptolide results in increased expression of CXCL1 mRNA]; IL17A protein promotes the reaction [triptolide results in increased expression of CXCL2 mRNA]; IL17A protein promotes the reaction [triptolide results in increased expression of FASL mRNA]; IL17A protein promotes the reaction [triptolide results in increased expression of IL1B mRNA]
triptolide results in increased expression of IL17A mRNA; triptolide results in increased expression of IL17A protein
CTD PMID:24949944 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO Fenofibrate inhibits the reaction [triptolide results in increased expression of IL1B mRNA]; IL17A protein promotes the reaction [triptolide results in increased expression of IL1B mRNA]; triptolide promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:24949944, PMID:30633930, PMID:31241159 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO Fenofibrate inhibits the reaction [triptolide results in increased expression of IL6 mRNA]; triptolide promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:30633930, PMID:31241159 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Insr insulin receptor increases expression EXP triptolide results in increased expression of INSR protein CTD PMID:32519852 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Irgm immunity-related GTPase M increases expression EXP triptolide results in increased expression of IRGM protein CTD PMID:32519852 NCBI chr10:34,213,885...34,221,968
Ensembl chr10:34,213,936...34,221,928
JBrowse link
G Irs1 insulin receptor substrate 1 increases degradation
multiple interactions
ISO triptolide results in increased degradation of IRS1 protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [triptolide results in decreased expression of IRS1 protein]; triptolide results in decreased expression of and results in decreased phosphorylation of IRS1 protein
CTD PMID:32061799 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Isca1 iron-sulfur cluster assembly 1 decreases expression EXP triptolide results in decreased expression of ISCA1 protein CTD PMID:32519852 NCBI chr17:5,281,727...5,294,386
Ensembl chr17:5,281,727...5,294,384
JBrowse link
G Iscu iron-sulfur cluster assembly enzyme decreases expression EXP triptolide results in decreased expression of ISCU protein CTD PMID:32519852 NCBI chr12:48,621,454...48,627,297
Ensembl chr12:48,621,454...48,627,297
JBrowse link
G Isyna1 inositol-3-phosphate synthase 1 increases expression EXP triptolide results in increased expression of ISYNA1 protein CTD PMID:32519852 NCBI chr16:20,589,497...20,592,333
Ensembl chr16:20,589,481...20,592,449
JBrowse link
G Itga5 integrin subunit alpha 5 increases expression EXP triptolide results in increased expression of ITGA5 protein CTD PMID:32519852 NCBI chr 7:144,970,444...144,993,652
Ensembl chr 7:144,970,444...144,993,652
JBrowse link
G Itih3 inter-alpha trypsin inhibitor, heavy chain 3 increases expression EXP triptolide results in increased expression of ITIH3 protein CTD PMID:32519852 NCBI chr16:6,983,779...7,007,288
Ensembl chr16:6,992,062...7,007,287
JBrowse link
G Itih4 inter-alpha-trypsin inhibitor heavy chain 4 increases expression EXP triptolide results in increased expression of ITIH4 protein CTD PMID:32519852 NCBI chr16:6,970,367...6,985,538
Ensembl chr16:6,970,342...6,985,579
JBrowse link
G Itpr3 inositol 1,4,5-trisphosphate receptor, type 3 increases expression EXP triptolide results in increased expression of ITPR3 protein CTD PMID:32519852 NCBI chr20:5,645,894...5,711,702
Ensembl chr20:5,646,097...5,711,702
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression ISO triptolide results in decreased expression of KEAP1 protein CTD PMID:30682494 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Khsrp KH-type splicing regulatory protein decreases expression EXP triptolide results in decreased expression of KHSRP protein CTD PMID:32519852 NCBI chr 9:10,013,795...10,023,670
Ensembl chr 9:10,013,854...10,022,924
JBrowse link
G Kif21a kinesin family member 21A increases expression EXP triptolide results in increased expression of KIF21A protein CTD PMID:32519852 NCBI chr 7:132,069,962...132,200,947
Ensembl chr 7:132,071,116...132,143,470
JBrowse link
G Kng2 kininogen 2 increases expression EXP triptolide results in increased expression of KNG1 protein; triptolide results in increased expression of MAP1 protein CTD PMID:32519852 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Kras KRAS proto-oncogene, GTPase increases expression EXP triptolide results in increased expression of KRAS mRNA CTD PMID:23639586 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G L1cam L1 cell adhesion molecule increases expression EXP triptolide results in increased expression of L1CAM protein CTD PMID:32519852 NCBI chr  X:156,901,244...156,928,064
Ensembl chr  X:156,909,913...156,928,057
JBrowse link
G Lamtor1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 decreases expression EXP triptolide results in decreased expression of LAMTOR1 protein CTD PMID:32519852 NCBI chr 1:166,991,474...166,997,045
Ensembl chr 1:166,991,474...166,997,045
JBrowse link
G Letmd1 LETM1 domain containing 1 increases expression EXP triptolide results in increased expression of LETMD1 protein CTD PMID:32519852 NCBI chr 7:142,106,364...142,119,900
Ensembl chr 7:142,106,465...142,119,899
JBrowse link
G Ly6e lymphocyte antigen 6 family member E increases expression EXP triptolide results in increased expression of LY6E protein CTD PMID:32519852 NCBI chr 7:116,355,426...116,359,862
Ensembl chr 7:116,355,698...116,359,862
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 increases expression EXP triptolide results in increased expression of MAD2L1 mRNA CTD PMID:23639586 NCBI chr 4:97,530,993...97,543,179
Ensembl chr 4:97,531,083...97,537,086
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP triptolide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:21717513 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO triptolide inhibits the reaction [Asbestos, Crocidolite results in decreased phosphorylation of MAPK14 protein] CTD PMID:17507666 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP triptolide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:21717513 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mast3 microtubule associated serine/threonine kinase 3 increases expression EXP triptolide results in increased expression of MAST3 protein CTD PMID:32519852 NCBI chr16:20,387,330...20,414,767
Ensembl chr16:20,395,845...20,414,767
JBrowse link
G Mbnl1 muscleblind-like splicing regulator 1 increases expression EXP triptolide results in increased expression of MBNL1 protein CTD PMID:32519852 NCBI chr 2:150,698,248...150,867,791
Ensembl chr 2:150,756,185...150,869,690
JBrowse link
G Mcee methylmalonyl CoA epimerase increases expression EXP triptolide results in increased expression of MCEE protein CTD PMID:32519852 NCBI chr 1:125,229,487...125,252,692
Ensembl chr 1:125,229,469...125,252,666
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases expression ISO triptolide results in increased expression of MCL1 protein CTD PMID:26990902 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mcm6 minichromosome maintenance complex component 6 increases expression EXP triptolide results in increased expression of MCM6 mRNA CTD PMID:23639586 NCBI chr13:45,042,882...45,068,073
Ensembl chr13:45,042,882...45,068,077
JBrowse link
G Med23 mediator complex subunit 23 increases expression EXP triptolide results in increased expression of MED23 protein CTD PMID:32519852 NCBI chr 1:21,539,765...21,587,675
Ensembl chr 1:21,539,765...21,586,910
JBrowse link
G Mep1a meprin A subunit alpha increases expression EXP triptolide results in increased expression of MEP1A protein CTD PMID:32519852 NCBI chr 9:20,048,163...20,077,678
Ensembl chr 9:20,048,121...20,077,702
JBrowse link
G Mep1b meprin A subunit beta increases expression EXP triptolide results in increased expression of MEP1B protein CTD PMID:32519852 NCBI chr18:15,063,159...15,090,877
Ensembl chr18:15,063,079...15,089,988
JBrowse link
G Mfn2 mitofusin 2 decreases expression
multiple interactions
ISO triptolide results in decreased expression of MFN2 protein
10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide inhibits the reaction [triptolide results in decreased expression of MFN2 protein]
CTD PMID:30836114 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Mir141 microRNA 141 multiple interactions ISO [triptolide co-treated with tariquidar] results in increased activity of MIR141 protein CTD PMID:26134275 NCBI chr 4:157,236,346...157,236,439
Ensembl chr 4:157,236,346...157,236,439
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO triptolide results in decreased expression of MKI67 protein CTD PMID:24842335 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase multiple interactions ISO [triptolide co-treated with Lipopolysaccharides] results in increased expression of MLKL protein; [triptolide co-treated with Lipopolysaccharides] results in increased expression of MLKL protein modified form; necrostatin-1 inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased expression of MLKL protein modified form]; necrostatin-1 inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased expression of MLKL protein] CTD PMID:30633930 NCBI chr19:43,508,416...43,535,050
Ensembl chr19:43,506,976...43,528,851
JBrowse link
G Mme membrane metallo-endopeptidase increases expression EXP triptolide results in increased expression of MME protein CTD PMID:32519852 NCBI chr 2:153,799,203...153,880,910
Ensembl chr 2:153,803,349...153,880,738
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO triptolide results in decreased expression of MMP2 mRNA; triptolide results in decreased expression of MMP2 protein CTD PMID:26420756 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
ISO triptolide results in decreased expression of MMP9 protein
triptolide inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of MMP9 mRNA]; triptolide inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased secretion of MMP9 protein]
CTD PMID:25200491, PMID:26420756 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpc1 mitochondrial pyruvate carrier 1 decreases expression EXP triptolide results in decreased expression of MPC1 protein CTD PMID:32519852 NCBI chr 1:53,026,608...53,038,229
Ensembl chr 1:53,026,608...53,038,229
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO triptolide promotes the reaction [Lipopolysaccharides results in increased expression of MPO mRNA] CTD PMID:30633930 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mrps5 mitochondrial ribosomal protein S5 increases expression EXP triptolide results in increased expression of MRPS5 protein CTD PMID:32519852 NCBI chr 3:120,165,953...120,182,536
Ensembl chr 3:120,165,913...120,182,536
JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 increases expression EXP triptolide results in increased expression of ND1 protein CTD PMID:32519852 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694
JBrowse link
G Mt1 metallothionein 1 decreases expression
increases expression
EXP triptolide results in decreased expression of MT1 protein
triptolide results in increased expression of MT1M protein
CTD PMID:32519852 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO triptolide results in increased expression of and results in increased phosphorylation of MTOR protein CTD PMID:26990902 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Mug1 murinoglobulin 1 increases expression EXP triptolide results in increased expression of MUG1 protein CTD PMID:32519852 NCBI chr 4:154,676,382...154,729,288
Ensembl chr 4:154,391,647...154,729,310
JBrowse link
G Mvd mevalonate diphosphate decarboxylase increases expression EXP triptolide results in increased expression of MVD protein CTD PMID:32519852 NCBI chr19:55,258,910...55,268,933
Ensembl chr19:55,258,905...55,268,951
JBrowse link
G Mx2 MX dynamin like GTPase 2 increases expression EXP triptolide results in increased expression of MX1 protein CTD PMID:32519852 NCBI chr11:38,035,306...38,066,185
Ensembl chr11:38,035,450...38,059,950
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression EXP
ISO
triptolide results in decreased expression of MYC mRNA
triptolide results in decreased expression of MYC protein
CTD PMID:12533674, PMID:23639586 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myh1 myosin heavy chain 1 decreases expression ISO triptolide results in decreased expression of MYH1 mRNA CTD PMID:32061799 NCBI chr10:53,740,841...53,764,610
Ensembl chr10:53,713,938...53,848,347
JBrowse link
G Myh2 myosin heavy chain 2 decreases expression ISO triptolide results in decreased expression of MYH2 mRNA CTD PMID:32061799 NCBI chr10:53,711,895...53,738,164
Ensembl chr10:53,713,938...53,848,347
JBrowse link
G Myh4 myosin heavy chain 4 decreases expression ISO triptolide results in decreased expression of MYH4 mRNA CTD PMID:32061799 NCBI chr10:53,778,456...53,801,605
Ensembl chr10:53,713,938...53,848,347
JBrowse link
G Myh7 myosin heavy chain 7 decreases expression ISO triptolide results in decreased expression of MYH7 mRNA CTD PMID:32061799 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Myl9 myosin light chain 9 decreases expression EXP triptolide results in decreased expression of MYL9 protein CTD PMID:32519852 NCBI chr 3:152,857,573...152,863,961
Ensembl chr 3:152,857,592...152,863,960
JBrowse link
G Myo5c myosin VC increases expression EXP triptolide results in increased expression of MYO5C protein CTD PMID:32519852 NCBI chr 8:82,171,296...82,248,109
Ensembl chr 8:82,171,497...82,247,544
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase decreases expression ISO triptolide results in decreased expression of NAMPT mRNA CTD PMID:29723566 NCBI chr 6:52,122,085...52,156,473
Ensembl chr 6:52,122,085...52,156,472
JBrowse link
G Ncoa6 nuclear receptor coactivator 6 increases expression EXP triptolide results in increased expression of NCOA6 protein CTD PMID:32519852 NCBI chr 3:150,919,317...150,990,391
Ensembl chr 3:150,919,317...150,960,030
JBrowse link
G Ndufa7 NADH:ubiquinone oxidoreductase subunit A7 increases expression EXP triptolide results in increased expression of NDUFA7 protein CTD PMID:32519852 NCBI chr 7:18,683,553...18,696,332
Ensembl chr 7:18,683,553...18,696,330
JBrowse link
G Ndufb9 NADH:ubiquinone oxidoreductase subunit B9 increases expression EXP triptolide results in increased expression of NDUFB9 protein CTD PMID:32519852 NCBI chr 7:98,813,062...98,819,408
Ensembl chr 7:98,813,040...98,819,452
JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 increases expression EXP triptolide results in increased expression of NDUFS4 protein CTD PMID:32519852 NCBI chr 2:46,372,488...46,476,162
Ensembl chr 2:46,372,518...46,476,203
JBrowse link
G Ndufs8 NADH:ubiquinone oxidoreductase core subunit S8 decreases expression ISO triptolide results in decreased expression of NDUFS8 mRNA CTD PMID:29723566 NCBI chr 1:219,141,289...219,144,610
Ensembl chr 1:219,141,292...219,144,610
JBrowse link
G Ndufv3 NADH:ubiquinone oxidoreductase subunit V3 increases expression EXP triptolide results in increased expression of NDUFV3 protein CTD PMID:32519852 NCBI chr20:10,265,826...10,275,298
Ensembl chr20:10,265,806...10,275,304
JBrowse link
G Necap1 NECAP endocytosis associated 1 decreases expression EXP triptolide results in decreased expression of NECAP1 protein CTD PMID:32519852 NCBI chr 4:155,709,712...155,724,801
Ensembl chr 4:155,709,613...155,724,790
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
decreases expression
decreases phosphorylation
affects localization
affects expression
decreases response to substance
EXP
ISO
Acetylcysteine inhibits the reaction [triptolide affects the expression of NFE2L2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the reaction [triptolide affects the expression of NFE2L2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [triptolide results in increased ubiquitination of NFE2L2 protein]; Lithium Chloride affects the reaction [triptolide affects the expression of NFE2L2 protein]; NFE2L2 protein inhibits the reaction [triptolide results in decreased abundance of Glutathione]; NFE2L2 protein inhibits the reaction [triptolide results in decreased expression of BCL2 protein]; NFE2L2 protein inhibits the reaction [triptolide results in decreased expression of GCLC protein]; NFE2L2 protein inhibits the reaction [triptolide results in decreased expression of HMOX1 protein]; NFE2L2 protein inhibits the reaction [triptolide results in decreased expression of NQO1 protein]; NFE2L2 protein inhibits the reaction [triptolide results in increased abundance of Reactive Oxygen Species]; NFE2L2 protein inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; NFE2L2 protein inhibits the reaction [triptolide results in increased expression of APAF1 protein]; NFE2L2 protein inhibits the reaction [triptolide results in increased expression of BAX protein]; triptolide affects the expression of and results in increased ubiquitination of NFE2L2 protein
triptolide results in increased expression of NFE2L2 mRNA; triptolide results in increased expression of NFE2L2 protein
10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide inhibits the reaction [triptolide results in decreased expression of and affects the localization of NFE2L2 protein]; Fenofibrate inhibits the reaction [triptolide results in increased expression of NFE2L2 mRNA]; Fenofibrate inhibits the reaction [triptolide results in increased expression of NFE2L2 protein]; triptolide results in decreased expression of and affects the localization of NFE2L2 protein
triptolide results in decreased expression of NFE2L2 mRNA
[catalpol co-treated with Saponins co-treated with triptolide] affects the localization of NFE2L2 protein; [catalpol co-treated with triptolide] affects the localization of NFE2L2 protein; [Saponins co-treated with triptolide] affects the localization of NFE2L2 protein; [triptolide co-treated with catalpol] results in increased expression of NFE2L2 protein; [triptolide co-treated with Saponins] results in increased expression of NFE2L2 protein; catalpol inhibits the reaction [Saponins inhibits the reaction [triptolide results in decreased phosphorylation of NFE2L2 protein]]; catalpol inhibits the reaction [triptolide results in decreased expression of NFE2L2 mRNA]; NFE2L2 protein affects the reaction [catalpol promotes the reaction [Saponins inhibits the reaction [triptolide results in increased expression of GPT protein]]]; NFE2L2 protein affects the reaction [Saponins promotes the reaction [catalpol inhibits the reaction [triptolide results in increased expression of GPT protein]]]; NFE2L2 protein affects the reaction [triptolide results in increased expression of GPT protein]; Saponins inhibits the reaction [triptolide results in decreased phosphorylation of NFE2L2 protein]; Saponins promotes the reaction [[triptolide co-treated with catalpol] results in increased expression of NFE2L2 protein]; Saponins promotes the reaction [catalpol inhibits the reaction [triptolide results in decreased expression of NFE2L2 mRNA]]
triptolide affects the localization of NFE2L2 protein
triptolide affects the expression of NFE2L2 mRNA; triptolide affects the expression of NFE2L2 protein
triptolide results in decreased expression of NFE2L2 protein
NFE2L2 protein results in decreased susceptibility to triptolide
CTD PMID:22820427, PMID:25169008, PMID:30682494, PMID:30836114, PMID:30926361, PMID:31241159 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases phosphorylation
ISO
EXP
TRP53 protein affects the reaction [triptolide results in decreased phosphorylation of NFKBIA protein] CTD PMID:31618665 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ngf nerve growth factor increases expression
increases secretion
EXP triptolide results in increased expression of NGF mRNA; triptolide results in increased expression of NGF protein
triptolide results in increased secretion of NGF protein
CTD PMID:17401680 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Ngfr nerve growth factor receptor increases expression ISO triptolide results in increased expression of TNFRSF10B protein CTD PMID:26990902 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
JBrowse link
G Niban1 niban apoptosis regulator 1 increases expression EXP triptolide results in increased expression of FAM129A protein CTD PMID:32519852 NCBI chr13:68,949,665...69,101,600
Ensembl chr13:68,949,665...69,101,588
JBrowse link
G Nnt nicotinamide nucleotide transhydrogenase increases expression EXP triptolide results in increased expression of NNT protein CTD PMID:32519852 NCBI chr 2:52,189,523...52,283,095
Ensembl chr 2:52,189,529...52,282,548
JBrowse link
G Notch1 notch receptor 1 multiple interactions
increases expression
decreases expression
ISO NOTCH1 protein modified form inhibits the reaction [triptolide results in decreased expression of TXN protein]
triptolide results in increased expression of NOTCH1 mRNA
triptolide results in decreased expression of NOTCH1 mRNA; triptolide results in decreased expression of NOTCH1 protein; triptolide results in decreased expression of NOTCH1 protein modified form
Fenofibrate inhibits the reaction [triptolide results in increased expression of NOTCH1 mRNA]; NOTCH1 protein modified form inhibits the reaction [triptolide results in decreased expression of BCL2 protein]; NOTCH1 protein modified form inhibits the reaction [triptolide results in decreased expression of HES1 protein]; NOTCH1 protein modified form inhibits the reaction [triptolide results in decreased expression of TXN protein]; NOTCH1 protein modified form inhibits the reaction [triptolide results in increased expression of CASP3 protein modified form]; NOTCH1 protein modified form inhibits the reaction [triptolide results in increased expression of PTEN protein]; NOTCH1 protein modified form inhibits the reaction [triptolide results in increased expression of TXNIP protein]
CTD PMID:30394310, PMID:31241159 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Notch3 notch receptor 3 increases expression
multiple interactions
ISO triptolide results in increased expression of NOTCH3 mRNA; triptolide results in increased expression of NOTCH3 protein
Fenofibrate inhibits the reaction [triptolide results in increased expression of NOTCH3 mRNA]; Fenofibrate inhibits the reaction [triptolide results in increased expression of NOTCH3 protein]
CTD PMID:31241159 NCBI chr 7:14,138,495...14,189,688
Ensembl chr 7:14,138,495...14,189,688
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP
ISO
triptolide inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 protein] CTD PMID:18509322 NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559
JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions ISO
EXP
triptolide inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS2 protein] CTD PMID:18509322 NCBI chr13:73,929,136...73,941,522
Ensembl chr13:73,929,136...73,941,522
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression
increases expression
multiple interactions
ISO
EXP
triptolide results in decreased expression of NQO1 mRNA; triptolide results in decreased expression of NQO1 protein
triptolide results in increased expression of NQO1 protein
10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide inhibits the reaction [triptolide results in decreased expression of NQO1 mRNA]; 10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide inhibits the reaction [triptolide results in decreased expression of NQO1 protein]
[triptolide co-treated with catalpol] results in increased expression of NQO1 protein; [triptolide co-treated with Saponins] results in increased expression of NQO1 protein; catalpol promotes the reaction [[triptolide co-treated with Saponins] results in increased expression of NQO1 protein]; Saponins promotes the reaction [[triptolide co-treated with catalpol] results in increased expression of NQO1 protein]
NFE2L2 protein inhibits the reaction [triptolide results in decreased expression of NQO1 protein]
CTD PMID:25169008, PMID:30682494, PMID:30836114, PMID:32519852 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression
multiple interactions
ISO triptolide results in decreased expression of NR0B2 mRNA
Lipopolysaccharides promotes the reaction [triptolide results in decreased expression of NR0B2 mRNA]
CTD PMID:30633930 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression
multiple interactions
ISO triptolide results in decreased expression of NR1H4 mRNA
[triptolide co-treated with Lipopolysaccharides] results in decreased expression of NR1H4 protein; Lipopolysaccharides promotes the reaction [triptolide results in decreased expression of NR1H4 mRNA]
CTD PMID:30633930 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
decreases expression
increases expression
ISO
EXP
triptolide results in increased expression of and results in increased phosphorylation of NR3C1 protein
triptolide results in decreased expression of NR3C1 mRNA
triptolide results in increased expression of NR3C1 mRNA
CTD PMID:19330649, PMID:23639586 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nrf1 nuclear respiratory factor 1 decreases expression ISO triptolide results in decreased expression of NRF1 mRNA CTD PMID:29723566 NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341
JBrowse link
G Nt5c 5', 3'-nucleotidase, cytosolic increases expression EXP triptolide results in increased expression of NT5C protein CTD PMID:32519852 NCBI chr10:104,052,807...104,054,805
Ensembl chr10:104,052,831...104,054,805
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 decreases expression EXP triptolide results in decreased expression of NTRK1 mRNA CTD PMID:23639586 NCBI chr 2:187,143,568...187,160,373
Ensembl chr 2:187,143,568...187,160,373
JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like increases expression EXP triptolide results in increased expression of OASL protein CTD PMID:32519852 NCBI chr12:47,444,138...47,456,680
Ensembl chr12:47,444,104...47,456,894
JBrowse link
G Ocln occludin multiple interactions
decreases expression
ISO 10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide inhibits the reaction [triptolide results in decreased expression of OCLN mRNA]; 10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide inhibits the reaction [triptolide results in decreased expression of OCLN protein]
triptolide results in decreased expression of OCLN mRNA; triptolide results in decreased expression of OCLN protein
CTD PMID:30836114 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Orc1 origin recognition complex, subunit 1 increases expression EXP triptolide results in increased expression of ORC1 mRNA CTD PMID:23639586 NCBI chr 5:128,186,651...128,212,901
Ensembl chr 5:128,190,708...128,210,445
JBrowse link
G Orc3 origin recognition complex, subunit 3 increases expression EXP triptolide results in increased expression of ORC3 mRNA CTD PMID:23639586 NCBI chr 5:50,019,159...50,075,533
Ensembl chr 5:50,020,815...50,075,454
JBrowse link
G P2rx7 purinergic receptor P2X 7 increases expression EXP triptolide results in increased expression of P2RX7 protein CTD PMID:32519852 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
increases expression
ISO triptolide results in increased cleavage of PARP1 protein
10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide inhibits the reaction [triptolide results in increased cleavage of PARP1 protein]; [triptolide co-treated with Lipopolysaccharides] results in increased expression of PARP1 protein modified form; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased expression of PARP1 protein modified form]
triptolide results in increased expression of PARP1 protein
CTD PMID:12533674, PMID:15972136, PMID:26990902, PMID:30633930, PMID:30836114 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Parp14 poly (ADP-ribose) polymerase family, member 14 increases expression EXP triptolide results in increased expression of PARP14 protein CTD PMID:32519852 NCBI chr11:68,105,442...68,137,509
Ensembl chr11:68,105,369...68,137,535
JBrowse link
G Parp9 poly (ADP-ribose) polymerase family, member 9 increases expression EXP triptolide results in increased expression of PARP9 protein CTD PMID:32519852 NCBI chr11:67,724,071...67,758,027
Ensembl chr11:67,724,076...67,756,799
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 decreases expression
multiple interactions
EXP
ISO
triptolide results in decreased expression of PCK1 mRNA; triptolide results in decreased expression of PCK1 protein
Lipopolysaccharides promotes the reaction [triptolide results in decreased expression of PCK1 mRNA]; triptolide promotes the reaction [Lipopolysaccharides results in decreased expression of PCK1 mRNA]
CTD PMID:23639586, PMID:30633930, PMID:32519852 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 decreases expression EXP triptolide results in decreased expression of PDK2 mRNA CTD PMID:31618665 NCBI chr10:82,838,270...82,852,758
Ensembl chr10:82,839,153...82,852,660
JBrowse link
G Pdlim1 PDZ and LIM domain 1 decreases expression EXP triptolide results in decreased expression of PDLIM1 protein CTD PMID:32519852 NCBI chr 1:259,308,326...259,357,006
Ensembl chr 1:259,308,296...259,357,056
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 increases expression EXP triptolide results in increased expression of PDPK1 mRNA CTD PMID:23639586 NCBI chr10:13,446,373...13,525,248
Ensembl chr10:13,451,624...13,515,448
JBrowse link
G Pds5a PDS5 cohesin associated factor A decreases expression EXP triptolide results in decreased expression of PDS5A protein CTD PMID:32519852 NCBI chr14:44,185,445...44,282,308
Ensembl chr14:44,185,446...44,280,079
JBrowse link
G Pfkm phosphofructokinase, muscle increases expression EXP triptolide results in increased expression of PFKM protein CTD PMID:32519852 NCBI chr 7:139,702,066...139,722,132
Ensembl chr 7:139,685,573...139,722,132
JBrowse link
G Pfkp phosphofructokinase, platelet increases expression EXP triptolide results in increased expression of PFKP protein CTD PMID:32519852 NCBI chr17:68,510,765...68,574,387
Ensembl chr17:68,511,064...68,559,471
JBrowse link
G Pgam2 phosphoglycerate mutase 2 decreases expression EXP triptolide results in decreased expression of PGAM2 mRNA CTD PMID:31618665 NCBI chr14:86,045,005...86,047,116
Ensembl chr14:86,044,969...86,047,162
JBrowse link
G Phb2 prohibitin 2 increases expression EXP triptolide results in increased expression of PHB2 protein CTD PMID:32519852 NCBI chr 4:157,230,769...157,235,375
Ensembl chr 4:157,230,769...157,235,367
JBrowse link
G Phf5a PHD finger protein 5A increases expression EXP triptolide results in increased expression of PHF5A protein CTD PMID:32519852 NCBI chr 7:123,095,286...123,101,851
Ensembl chr 7:123,095,288...123,101,869
JBrowse link
G Pklr pyruvate kinase L/R decreases expression EXP triptolide results in decreased expression of PKLR mRNA CTD PMID:23639586 NCBI chr 2:188,449,158...188,458,034
Ensembl chr 2:188,449,210...188,459,592
JBrowse link
G Plcb3 phospholipase C beta 3 increases expression EXP triptolide results in increased expression of PLCB3 protein CTD PMID:32519852 NCBI chr 1:222,207,887...222,224,993
Ensembl chr 1:222,209,575...222,224,910
JBrowse link
G Plekha1 pleckstrin homology domain containing A1 decreases expression EXP triptolide results in decreased expression of PLEKHA1 protein CTD PMID:32519852 NCBI chr 1:201,429,716...201,481,411
Ensembl chr 1:201,429,771...201,480,877
JBrowse link
G Plg plasminogen increases expression EXP triptolide results in increased expression of PLG protein CTD PMID:32519852 NCBI chr 1:48,521,828...48,563,895
Ensembl chr 1:48,521,772...48,563,776
JBrowse link
G Plk1 polo-like kinase 1 increases expression EXP triptolide results in increased expression of PLK1 mRNA CTD PMID:23639586 NCBI chr 1:192,115,990...192,125,969
Ensembl chr 1:192,115,966...192,125,989
JBrowse link
G Plpp1 phospholipid phosphatase 1 increases expression EXP triptolide results in increased expression of PLPP1 protein CTD PMID:32519852 NCBI chr 2:44,664,076...44,726,820
Ensembl chr 2:44,664,124...44,726,689
JBrowse link
G Plpp3 phospholipid phosphatase 3 increases expression EXP triptolide results in increased expression of PLPP3 protein CTD PMID:32519852 NCBI chr 5:124,690,214...124,765,499
Ensembl chr 5:124,690,214...124,765,498
JBrowse link
G Pml PML nuclear body scaffold increases expression EXP triptolide results in increased expression of PML protein CTD PMID:32519852 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Pnkd PNKD metallo-beta-lactamase domain containing decreases expression EXP triptolide results in decreased expression of PNKD protein CTD PMID:32519852 NCBI chr 9:81,566,074...81,634,531
Ensembl chr 9:81,566,074...81,634,534
JBrowse link
G Pnpla7 patatin-like phospholipase domain containing 7 increases expression EXP triptolide results in increased expression of PNPLA7 protein CTD PMID:32519852 NCBI chr 3:2,182,191...2,261,890
Ensembl chr 3:2,182,957...2,261,878
JBrowse link
G Pnpla8 patatin-like phospholipase domain containing 8 decreases expression EXP triptolide results in decreased expression of PNPLA8 protein CTD PMID:32519852 NCBI chr 6:64,224,870...64,288,465
Ensembl chr 6:64,224,861...64,286,785
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
affects response to substance
ISO POR protein results in increased hydroxylation of and results in decreased abundance of triptolide
POR protein affects the susceptibility to triptolide
CTD PMID:21596114 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression
increases expression
ISO triptolide results in decreased expression of PPARA mRNA; triptolide results in decreased expression of PPARA protein
triptolide results in increased expression of PPARA mRNA
CTD PMID:26219505, PMID:29723566, PMID:31241159 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta decreases expression ISO triptolide results in decreased expression of PPARD protein CTD PMID:26219505 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO resveratrol inhibits the reaction [triptolide affects the localization of and results in increased acetylation of PPARGC1A protein]; triptolide affects the localization of and results in increased acetylation of PPARGC1A protein; triptolide results in decreased expression of and results in decreased activity of PPARGC1A protein CTD PMID:29723566 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ppid peptidylprolyl isomerase D increases expression EXP triptolide results in increased expression of PPID protein CTD PMID:32519852 NCBI chr 2:178,354,830...178,366,843
Ensembl chr 2:178,354,890...178,366,685
JBrowse link
G Ppl periplakin increases expression EXP triptolide results in increased expression of PPL protein CTD PMID:32519852 NCBI chr10:10,644,572...10,690,223
Ensembl chr10:10,644,572...10,690,223
JBrowse link
G Ppp1cb protein phosphatase 1 catalytic subunit beta decreases expression EXP triptolide results in decreased expression of PPP1CB mRNA CTD PMID:23639586 NCBI chr 6:23,548,507...23,581,136
Ensembl chr 6:23,549,317...23,581,052
JBrowse link
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C increases expression EXP triptolide results in increased expression of PPP1R3C mRNA CTD PMID:23639586 NCBI chr 1:255,371,830...255,376,833
Ensembl chr 1:255,371,810...255,376,833
JBrowse link
G Ppp1r3d protein phosphatase 1, regulatory subunit 3D increases expression EXP triptolide results in increased expression of PPP1R3D mRNA CTD PMID:23639586 NCBI chr 3:173,950,613...173,953,684
Ensembl chr 3:173,950,613...173,953,684
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases expression EXP triptolide results in increased expression of PRKAA1 mRNA CTD PMID:23639586 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 increases expression EXP triptolide results in increased expression of PRKAA2 mRNA CTD PMID:23639586 NCBI chr 5:124,568,845...124,642,569
Ensembl chr 5:124,574,079...124,642,569
JBrowse link
G Prkab2 protein kinase AMP-activated non-catalytic subunit beta 2 increases expression EXP triptolide results in increased expression of PRKAB2 mRNA CTD PMID:23639586 NCBI chr 2:199,831,990...199,847,623
Ensembl chr 2:199,831,990...199,847,629
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha increases expression EXP triptolide results in increased expression of PRKACA mRNA CTD PMID:23639586 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860
JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 decreases expression EXP triptolide results in decreased expression of PRKAG2 mRNA CTD PMID:23639586 NCBI chr 4:6,559,153...6,799,888
Ensembl chr 4:6,559,545...6,799,632
JBrowse link
G Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta increases expression EXP triptolide results in increased expression of PRKAR2B mRNA CTD PMID:23639586 NCBI chr 6:51,265,509...51,356,383
Ensembl chr 6:51,265,515...51,356,383
JBrowse link
G Prkca protein kinase C, alpha increases expression EXP triptolide results in increased expression of PRKCA protein CTD PMID:32519852 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prkcsh protein kinase C substrate 80K-H decreases expression EXP triptolide results in decreased expression of PRKCSH protein CTD PMID:32519852 NCBI chr 8:23,014,802...23,026,507
Ensembl chr 8:23,014,956...23,026,503
JBrowse link
G Prom1 prominin 1 multiple interactions ISO triptolide inhibits the reaction [cobaltous chloride results in increased expression of PROM1 protein] CTD PMID:24842335 NCBI chr14:71,532,321...71,637,400
Ensembl chr14:71,533,063...71,637,417
JBrowse link
G Prpf4b pre-mRNA processing factor 4B increases expression EXP triptolide results in increased expression of PRPF4B protein CTD PMID:32519852 NCBI chr17:30,680,454...30,714,542
Ensembl chr17:30,683,640...30,714,495
JBrowse link
G Psmb10 proteasome 20S subunit beta 10 increases expression EXP triptolide results in increased expression of PSMB10 protein CTD PMID:32519852 NCBI chr19:37,909,543...37,912,027
Ensembl chr19:37,909,546...37,912,027
JBrowse link
G Psmb9 proteasome 20S subunit beta 9 increases expression EXP triptolide results in increased expression of PSMB9 protein CTD PMID:32519852 NCBI chr20:3,973,424...3,978,845
Ensembl chr20:3,973,420...3,978,845
JBrowse link
G Pten phosphatase and tensin homolog increases expression
multiple interactions
ISO triptolide results in increased expression of PTEN protein
NOTCH1 protein modified form inhibits the reaction [triptolide results in increased expression of PTEN protein]
CTD PMID:30394310 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO
EXP
triptolide inhibits the reaction [Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]
triptolide results in increased expression of PTGS2 protein
triptolide inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; triptolide inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
CTD PMID:16765938, PMID:21717513, PMID:26420756 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases expression
increases expression
ISO
EXP
triptolide results in decreased expression of PTK2 mRNA; triptolide results in decreased expression of PTK2 protein
triptolide results in increased expression of PTK2 protein
CTD PMID:26420756, PMID:26990902, PMID:32519852 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C increases expression EXP triptolide results in increased expression of PTPRC protein CTD PMID:32519852 NCBI chr13:55,061,561...55,174,150
Ensembl chr13:55,061,562...55,173,692
JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F decreases expression EXP triptolide results in decreased expression of PTPRF mRNA CTD PMID:23639586 NCBI chr 5:137,036,936...137,112,930
Ensembl chr 5:137,036,935...137,112,927
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin increases expression EXP triptolide results in increased expression of PTTG1 mRNA CTD PMID:23639586 NCBI chr10:29,014,332...29,026,088
Ensembl chr10:29,020,049...29,026,002
JBrowse link
G Pygl glycogen phosphorylase L decreases expression EXP triptolide results in decreased expression of PYGL mRNA CTD PMID:23639586 NCBI chr 6:92,597,759...92,643,734
Ensembl chr 6:92,597,706...92,643,847
JBrowse link
G Rab5a RAB5A, member RAS oncogene family increases expression EXP triptolide results in increased expression of RAB5A protein CTD PMID:32519852 NCBI chr 9:5,910...6,065 JBrowse link
G Rac1 Rac family small GTPase 1 decreases expression EXP triptolide results in decreased expression of RAC1 mRNA CTD PMID:27554044 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rbks ribokinase decreases expression EXP triptolide results in decreased expression of RBKS protein CTD PMID:32519852 NCBI chr 6:26,051,568...26,128,762
Ensembl chr 6:26,051,396...26,128,906
JBrowse link
G Rbp4 retinol binding protein 4 decreases expression EXP triptolide results in decreased expression of RBP4 protein CTD PMID:32519852 NCBI chr 1:256,806,476...256,813,678
Ensembl chr 1:256,806,472...256,813,711
JBrowse link
G Rdh16 retinol dehydrogenase 16 increases expression EXP triptolide results in increased expression of RDH2 protein CTD PMID:32519852 NCBI chr 7:71,058,150...71,072,685
Ensembl chr 7:70,980,422...71,072,689
JBrowse link
G Reg3b regenerating family member 3 beta increases expression EXP triptolide results in increased expression of REG3B protein CTD PMID:32519852 NCBI chr 4:109,467,272...109,470,510
Ensembl chr 4:109,467,272...109,470,510
JBrowse link
G Reg3g regenerating family member 3 gamma increases expression EXP triptolide results in increased expression of REG3G protein CTD PMID:32519852 NCBI chr 4:109,529,679...109,532,234
Ensembl chr 4:109,529,679...109,532,234
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
EXP
ISO
pifithrin inhibits the reaction [triptolide results in decreased expression of RELA protein]; triptolide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of RELA protein]
TRP53 protein affects the reaction [triptolide results in decreased expression of RELA protein]
CTD PMID:21717513, PMID:31618665 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Retsat retinol saturase increases expression EXP triptolide results in increased expression of RETSAT protein CTD PMID:32519852 NCBI chr 4:100,465,365...100,474,128
Ensembl chr 4:100,465,170...100,474,301
JBrowse link
G RGD1309362 similar to interferon-inducible GTPase increases expression EXP triptolide results in increased expression of RGD1309362 protein CTD PMID:32519852 NCBI chr18:55,483,059...55,508,714
Ensembl chr18:55,505,993...55,508,704
JBrowse link
G RGD1310507 similar to RIKEN cDNA 1300017J02 increases expression EXP triptolide results in increased expression of RGD1310507 protein CTD PMID:32519852 NCBI chr 8:111,742,987...111,762,747
Ensembl chr 8:111,727,984...111,777,677
JBrowse link
G Rgs10 regulator of G-protein signaling 10 increases expression EXP triptolide results in increased expression of RGS10 protein CTD PMID:32519852 NCBI chr 1:199,782,076...199,823,440
Ensembl chr 1:199,782,078...199,823,386
JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression EXP triptolide results in increased expression of RGS2 protein CTD PMID:32519852 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094
JBrowse link
G Rhbg Rh family B glycoprotein increases expression EXP triptolide results in increased expression of RHBG protein CTD PMID:32519852 NCBI chr 2:187,610,081...187,622,408
Ensembl chr 2:187,610,087...187,622,373
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO
EXP
triptolide results in decreased expression of RHOA protein
triptolide results in decreased expression of RHOA mRNA; triptolide results in decreased expression of RHOA protein
CTD PMID:26420756, PMID:27554044 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rhob ras homolog family member B decreases expression EXP triptolide results in decreased expression of RHOB mRNA; triptolide results in decreased expression of RHOB protein CTD PMID:27554044 NCBI chr 6:33,689,127...33,691,301
Ensembl chr 6:33,689,127...33,691,301
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions ISO [triptolide co-treated with Lipopolysaccharides] results in increased expression of RIPK1 protein; necrostatin-1 inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased expression of RIPK1 protein] CTD PMID:30633930 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 increases expression EXP triptolide results in increased expression of RIPK2 protein CTD PMID:32519852 NCBI chr 5:29,838,713...29,870,390
Ensembl chr 5:29,838,747...29,870,735
JBrowse link
G Rnf20 ring finger protein 20 increases expression EXP triptolide results in increased expression of RNF20 protein CTD PMID:32519852 NCBI chr 5:64,892,996...64,920,397
Ensembl chr 5:64,892,802...64,920,390
JBrowse link
G Rnf213 ring finger protein 213 increases expression EXP triptolide results in increased expression of RNF213 protein CTD PMID:32519852 NCBI chr10:108,527,351...108,626,372
Ensembl chr10:108,527,740...108,624,688
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 decreases expression ISO
EXP
triptolide results in decreased expression of ROCK1 mRNA CTD PMID:26420756, PMID:27554044 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 decreases expression EXP triptolide results in decreased expression of ROCK2 mRNA CTD PMID:27554044 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
G Rorc RAR-related orphan receptor C increases expression ISO triptolide results in increased expression of RORC mRNA CTD PMID:24949944 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
JBrowse link
G Rpf2 ribosome production factor 2 homolog increases expression EXP triptolide results in increased expression of RPF2 protein CTD PMID:32519852 NCBI chr20:45,321,381...45,342,865
Ensembl chr20:45,321,405...45,342,948
JBrowse link
G Rpl24 ribosomal protein L24 increases expression EXP triptolide results in increased expression of RPL24 protein CTD PMID:32519852 NCBI chr11:47,116,885...47,122,093
Ensembl chr11:47,116,886...47,122,095
JBrowse link
G Rpl28 ribosomal protein L28 increases expression EXP triptolide results in increased expression of RPL28 protein CTD PMID:32519852 NCBI chr 1:72,619,282...72,621,941
Ensembl chr 1:72,619,282...72,621,519
JBrowse link
G RT1-A2 RT1 class Ia, locus A2 increases expression EXP triptolide results in increased expression of RT1-A2 protein CTD PMID:32519852 NCBI chr20:5,374,990...5,378,536
Ensembl chr20:5,374,985...5,378,539
JBrowse link
G RT1-CE7 RT1 class I, locus CE7 increases expression EXP triptolide results in increased expression of RT1-CE7 protein CTD PMID:32519852 NCBI chr20:4,695,765...4,698,712
Ensembl chr20:4,694,472...4,896,970
JBrowse link
G S100a10 S100 calcium binding protein A10 increases expression EXP triptolide results in increased expression of S100A10 protein CTD PMID:32519852 NCBI chr 2:193,892,589...193,901,236
Ensembl chr 2:193,892,589...193,901,236
JBrowse link
G S100a11 S100 calcium binding protein A11 increases expression EXP triptolide results in increased expression of S100A11 protein CTD PMID:32519852 NCBI chr 2:193,863,185...193,868,646
Ensembl chr 2:193,866,951...193,868,502
JBrowse link
G S100a4 S100 calcium-binding protein A4 increases expression EXP triptolide results in increased expression of S100A4 protein CTD PMID:32519852 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
JBrowse link
G Samhd1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 increases expression EXP triptolide results in increased expression of SAMHD1 protein CTD PMID:32519852 NCBI chr 3:153,210,829...153,250,705
Ensembl chr 3:153,210,829...153,250,641
JBrowse link
G Samm50 SAMM50 sorting and assembly machinery component increases expression EXP triptolide results in increased expression of SAMM50 protein CTD PMID:32519852 NCBI chr 7:125,058,966...125,082,506
Ensembl chr 7:125,058,897...125,082,505
JBrowse link
G Scamp2 secretory carrier membrane protein 2 decreases expression EXP triptolide results in decreased expression of SCAMP2 protein CTD PMID:32519852 NCBI chr 8:62,341,584...62,368,215
Ensembl chr 8:62,341,613...62,368,214
JBrowse link
G Sdc4 syndecan 4 decreases expression EXP triptolide results in decreased expression of SDC4 protein CTD PMID:32519852 NCBI chr 3:160,872,503...160,891,190
Ensembl chr 3:160,872,503...160,891,190
JBrowse link
G Serpina1 serpin family A member 1 increases expression EXP triptolide results in increased expression of SERPINA1 protein CTD PMID:32519852 NCBI chr 6:127,610,241...127,632,265
Ensembl chr 6:127,610,243...127,632,265
JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N increases expression EXP triptolide results in increased expression of SERPINA3N protein CTD PMID:32519852 NCBI chr 6:128,073,344...128,080,878
Ensembl chr 6:127,941,526...128,080,889
JBrowse link
G Serpinc1 serpin family C member 1 increases expression EXP triptolide results in increased expression of SERPINC1 protein CTD PMID:32519852 NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192
JBrowse link
G Sf3a2 splicing factor 3a, subunit 2 increases expression EXP triptolide results in increased expression of SF3A2 protein CTD PMID:32519852 NCBI chr 7:11,777,826...11,784,373
Ensembl chr 7:11,777,826...11,783,849
JBrowse link
G Sfn stratifin increases expression ISO triptolide results in increased expression of SFN protein CTD PMID:26990902 NCBI chr 5:151,823,422...151,824,937
Ensembl chr 5:151,823,887...151,824,633
JBrowse link
G Shc1 SHC adaptor protein 1 increases expression EXP triptolide results in increased expression of SHC1 protein CTD PMID:32519852 NCBI chr 2:188,745,503...188,757,066
Ensembl chr 2:188,745,503...188,757,066
JBrowse link
G Sirt1 sirtuin 1 decreases expression
multiple interactions
EXP
ISO
triptolide results in decreased expression of SIRT1 protein
[triptolide co-treated with resveratrol] results in increased expression of SIRT1 protein
CTD PMID:29723566 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions
decreases expression
ISO Lipopolysaccharides promotes the reaction [triptolide results in decreased expression of SLC10A1 mRNA]; triptolide promotes the reaction [Lipopolysaccharides results in decreased expression of SLC10A1 mRNA] CTD PMID:30633930 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Slc12a7 solute carrier family 12 member 7 increases expression EXP triptolide results in increased expression of SLC12A7 protein CTD PMID:32519852 NCBI chr 1:32,086,755...32,167,950
Ensembl chr 1:32,086,755...32,141,036
JBrowse link
G Slc13a3 solute carrier family 13 member 3 affects expression EXP triptolide affects the expression of SLC13A3 protein CTD PMID:32519852 NCBI chr 3:162,084,336...162,147,398
Ensembl chr 3:162,084,315...162,147,393
JBrowse link
G Slc14a1 solute carrier family 14 member 1 (Kidd blood group) increases expression EXP triptolide results in increased expression of SLC14A1 protein CTD PMID:32519852 NCBI chr18:74,461,064...74,504,475
Ensembl chr18:74,461,055...74,485,139
JBrowse link
G Slc17a1 solute carrier family 17 member 1 increases expression EXP triptolide results in increased expression of SLC17A1 protein CTD PMID:32519852 NCBI chr17:43,473,048...43,504,645 JBrowse link
G Slc1a1 solute carrier family 1 member 1 increases expression EXP triptolide results in increased expression of SLC1A1 protein CTD PMID:32519852 NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056
JBrowse link
G Slc22a13 solute carrier family 22 member 13 decreases expression EXP triptolide results in decreased expression of SLC22A13 protein CTD PMID:32519852 NCBI chr 8:127,885,268...127,900,829
Ensembl chr 8:127,885,268...127,900,463
JBrowse link
G Slc22a18 solute carrier family 22, member 18 increases expression EXP triptolide results in increased expression of SLC22A18 protein CTD PMID:32519852 NCBI chr 1:216,676,330...216,700,632
Ensembl chr 1:216,677,373...216,700,641
JBrowse link
G Slc22a7 solute carrier family 22 member 7 increases expression EXP triptolide results in increased expression of SLC22A7 protein CTD PMID:32519852 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G Slc23a1 solute carrier family 23 member 1 increases expression EXP triptolide results in increased expression of SLC23A1 protein CTD PMID:32519852 NCBI chr18:28,413,910...28,428,133
Ensembl chr18:28,414,009...28,428,117
JBrowse link
G Slc25a24 solute carrier family 25 member 24 increases expression EXP triptolide results in increased expression of SLC25A24 protein CTD PMID:32519852 NCBI chr 2:211,930,371...211,967,511
Ensembl chr 2:211,930,326...211,967,505
JBrowse link
G Slc29a1 solute carrier family 29 member 1 decreases expression EXP triptolide results in decreased expression of SLC29A1 protein CTD PMID:32519852 NCBI chr 9:17,784,468...17,799,008
Ensembl chr 9:17,784,468...17,799,005
JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases expression
multiple interactions
EXP
ISO
triptolide results in decreased expression of SLC2A1 protein
TRP53 protein affects the reaction [triptolide results in decreased expression of SLC2A1 protein]
pifithrin inhibits the reaction [triptolide results in decreased expression of SLC2A1 protein]
CTD PMID:31618665 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc2a2 solute carrier family 2 member 2 decreases expression
multiple interactions
ISO triptolide results in decreased expression of SLC2A2 mRNA
Lipopolysaccharides promotes the reaction [triptolide results in decreased expression of SLC2A2 mRNA]
CTD PMID:30633930 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions
decreases expression
ISO
EXP
TRP53 protein affects the reaction [triptolide results in decreased expression of SLC2A4 protein]
pifithrin inhibits the reaction [triptolide results in decreased expression of SLC2A4 protein]
CTD PMID:31618665 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slc34a3 solute carrier family 34 member 3 decreases expression EXP triptolide results in decreased expression of SLC34A3 protein CTD PMID:32519852 NCBI chr 3:2,448,391...2,454,019
Ensembl chr 3:2,448,381...2,453,933
JBrowse link
G Slc49a3 solute carrier family 49 member 3 decreases expression EXP triptolide results in decreased expression of MFSD7 protein CTD PMID:32519852 NCBI chr14:2,309,759...2,322,269
Ensembl chr14:2,311,122...2,319,574
JBrowse link
G Slc4a1 solute carrier family 4 member 1 (Diego blood group) increases expression EXP triptolide results in increased expression of SLC4A1 protein CTD PMID:32519852 NCBI chr10:90,296,144...90,312,401
Ensembl chr10:90,296,141...90,312,386
JBrowse link
G Slc7a12 solute carrier family 7 (cationic amino acid transporter, y+ system), member 12 increases expression EXP triptolide results in increased expression of SLC7A12 protein CTD PMID:32519852 NCBI chr 2:88,559,677...88,660,449
Ensembl chr 2:88,559,702...88,660,449
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression
multiple interactions
ISO triptolide results in decreased expression of SLCO1B2 mRNA
Lipopolysaccharides promotes the reaction [triptolide results in decreased expression of SLCO1B2 mRNA]; triptolide promotes the reaction [Lipopolysaccharides results in decreased expression of SLCO1B2 mRNA]
CTD PMID:30633930 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 increases expression EXP triptolide results in increased expression of SLCO2A1 protein CTD PMID:32519852 NCBI chr 8:111,495,443...111,577,320
Ensembl chr 8:111,495,331...111,577,833
JBrowse link
G Slfn5 schlafen family member 5 increases expression EXP triptolide results in increased expression of SLFN5 protein CTD PMID:32519852 NCBI chr10:70,298,094...70,312,062
Ensembl chr10:70,298,519...70,312,070
JBrowse link
G Slk STE20-like kinase increases expression EXP triptolide results in increased expression of SLK protein CTD PMID:32519852 NCBI chr 1:267,359,761...267,415,735
Ensembl chr 1:267,359,830...267,412,810
JBrowse link
G Socs1 suppressor of cytokine signaling 1 increases expression EXP triptolide results in increased expression of SOCS1 mRNA CTD PMID:23639586 NCBI chr10:4,956,795...4,958,472
Ensembl chr10:4,957,326...4,958,461
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 decreases expression ISO triptolide results in decreased expression of SOS1 protein CTD PMID:26420756 NCBI chr 6:3,105,443...3,182,977
Ensembl chr 6:3,104,861...3,182,996
JBrowse link
G Sox2 SRY-box transcription factor 2 multiple interactions ISO triptolide inhibits the reaction [cobaltous chloride results in increased expression of SOX2 protein] CTD PMID:24842335 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
JBrowse link
G Spcs1 signal peptidase complex subunit 1 increases expression EXP triptolide results in increased expression of SPCS1 protein CTD PMID:32519852 NCBI chr16:7,080,389...7,081,957
Ensembl chr16:7,080,454...7,082,193
JBrowse link
G Spcs2 signal peptidase complex subunit 2 increases expression EXP triptolide results in increased expression of SPCS2 protein CTD PMID:32519852 NCBI chr 1:164,829,896...164,849,749
Ensembl chr 1:164,829,896...164,849,749
JBrowse link
G Sptb spectrin, beta, erythrocytic increases expression EXP triptolide results in increased expression of SPTB protein CTD PMID:32519852 NCBI chr 6:99,657,144...99,783,189
Ensembl chr 6:99,659,651...99,783,047
JBrowse link
G Sqor sulfide quinone oxidoreductase increases expression EXP triptolide results in increased expression of SQOR protein CTD PMID:32519852 NCBI chr 3:114,894,944...114,939,375
Ensembl chr 3:114,900,343...114,939,370
JBrowse link
G Srp19 signal recognition particle 19 increases expression EXP triptolide results in increased expression of SRP19 protein CTD PMID:32519852 NCBI chr18:27,114,822...27,121,062
Ensembl chr18:27,114,822...27,121,059
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression EXP triptolide results in decreased expression of STAR mRNA; triptolide results in decreased expression of STAR protein CTD PMID:22592319 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Stat1 signal transducer and activator of transcription 1 increases expression EXP triptolide results in increased expression of STAT1 protein CTD PMID:32519852 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression ISO triptolide results in increased expression of STAT3 mRNA CTD PMID:24949944 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stmn1 stathmin 1 decreases expression EXP triptolide results in decreased expression of STMN1 protein CTD PMID:32519852 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Sts steroid sulfatase increases expression EXP triptolide results in increased expression of STS protein CTD PMID:32519852 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750
JBrowse link
G Sumo1 small ubiquitin-like modifier 1 increases expression EXP triptolide results in increased expression of SUMO1 protein CTD PMID:32519852 NCBI chr 9:66,453,428...66,483,614
Ensembl chr 9:66,453,438...66,483,614
JBrowse link
G Susd2 sushi domain containing 2 decreases expression EXP triptolide results in decreased expression of SUSD2 protein CTD PMID:32519852 NCBI chr20:13,965,098...13,972,547
Ensembl chr20:13,965,121...13,972,547
JBrowse link
G Suv39h1 suppressor of variegation 3-9 homolog 1 decreases expression ISO triptolide results in decreased expression of SUV39H1 protein CTD PMID:19879315 NCBI chr  X:146,532,002...146,533,538 JBrowse link
G Syap1 synapse associated protein 1 decreases expression EXP triptolide results in decreased expression of SYAP1 protein CTD PMID:32519852 NCBI chr  X:33,528,071...33,562,584
Ensembl chr  X:33,528,081...33,562,589
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions ISO triptolide inhibits the reaction [TAC1 protein results in increased expression of CXCL8 protein] CTD PMID:20348278 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member increases expression EXP triptolide results in increased expression of TAP1 protein CTD PMID:32519852 NCBI chr20:3,979,302...3,989,669
Ensembl chr20:3,979,035...3,989,669
JBrowse link
G Tapbp TAP binding protein increases expression EXP triptolide results in increased expression of TAPBP protein CTD PMID:32519852 NCBI chr20:5,468,056...5,476,007
Ensembl chr20:5,468,078...5,476,193
JBrowse link
G Tat tyrosine aminotransferase decreases expression
increases expression
EXP triptolide results in decreased expression of TAT mRNA
triptolide results in increased expression of TAT mRNA
CTD PMID:23639586 NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229
JBrowse link
G Testin testin gene increases expression EXP triptolide results in increased expression of TESTIN mRNA CTD PMID:27554044 NCBI chr17:4,194,796...4,225,376
Ensembl chr17:4,212,890...4,225,376
JBrowse link
G Tf transferrin increases expression EXP triptolide results in increased expression of TF protein CTD PMID:32519852 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tfam transcription factor A, mitochondrial decreases expression ISO triptolide results in decreased expression of TFAM mRNA CTD PMID:29723566 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Tfb1m transcription factor B1, mitochondrial decreases expression ISO triptolide results in decreased expression of TFB1M mRNA CTD PMID:29723566 NCBI chr 1:44,433,116...44,474,674
Ensembl chr 1:44,433,116...44,474,674
JBrowse link
G Tfb2m transcription factor B2, mitochondrial increases expression ISO triptolide results in increased expression of TFB2M mRNA CTD PMID:29723566 NCBI chr13:97,820,493...97,838,275
Ensembl chr13:97,820,493...97,838,228
JBrowse link
G Tfdp2 transcription factor Dp-2 increases expression EXP triptolide results in increased expression of TFDP2 mRNA CTD PMID:23639586 NCBI chr 8:104,040,795...104,181,228
Ensembl chr 8:104,040,934...104,176,446
JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase increases expression EXP triptolide results in increased expression of TIGAR mRNA CTD PMID:31618665 NCBI chr 4:159,635,145...159,654,108
Ensembl chr 4:159,635,153...159,654,063
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions
decreases expression
ISO 10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide inhibits the reaction [triptolide results in decreased expression of TJP1 mRNA]; 10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide inhibits the reaction [triptolide results in decreased expression of TJP1 protein]
triptolide results in decreased expression of TJP1 mRNA; triptolide results in decreased expression of TJP1 protein
CTD PMID:30836114 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tmed1 transmembrane p24 trafficking protein 1 increases expression EXP triptolide results in increased expression of TMED1 protein CTD PMID:32519852 NCBI chr 8:22,540,422...22,544,369
Ensembl chr 8:22,540,424...22,542,997
JBrowse link
G Tmem30a transmembrane protein 30A increases expression EXP triptolide results in increased expression of TMEM30A protein CTD PMID:32519852 NCBI chr 8:87,222,107...87,245,953
Ensembl chr 8:87,223,948...87,245,951
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO triptolide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Fenofibrate inhibits the reaction [triptolide results in increased expression of TNF mRNA]; triptolide promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD PMID:17678712, PMID:24949944, PMID:30633930, PMID:31241159 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO triptolide results in increased expression of TNFRSF10A protein CTD PMID:26990902 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression ISO triptolide results in increased expression of TNFSF10 protein CTD PMID:26990902 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions
increases secretion
ISO TRP53 gene mutant form inhibits the reaction [triptolide results in increased secretion of TNNI3 protein] CTD PMID:30009776 NCBI chr 1:72,882,806...72,886,490
Ensembl chr 1:72,882,806...72,886,488
JBrowse link
G Tp53 tumor protein p53 increases expression
affects localization
multiple interactions
decreases response to substance
ISO
EXP
triptolide results in increased expression of TRP53 protein
triptolide affects the localization of TP53 protein
triptolide results in increased expression of and results in increased phosphorylation of TRP53 protein; TRP53 gene mutant form inhibits the reaction [triptolide results in decreased expression of BCL2 protein]; TRP53 gene mutant form inhibits the reaction [triptolide results in decreased expression of BCL2L1 protein]; TRP53 gene mutant form inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; TRP53 gene mutant form inhibits the reaction [triptolide results in increased expression of BAK1 protein]; TRP53 gene mutant form inhibits the reaction [triptolide results in increased expression of BAX protein]; TRP53 gene mutant form inhibits the reaction [triptolide results in increased expression of CASP9 protein modified form]; TRP53 gene mutant form inhibits the reaction [triptolide results in increased secretion of TNNI3 protein]; TRP53 protein affects the reaction [triptolide results in decreased expression of RELA protein]; TRP53 protein affects the reaction [triptolide results in decreased expression of SLC2A1 protein]; TRP53 protein affects the reaction [triptolide results in decreased expression of SLC2A4 protein]; TRP53 protein affects the reaction [triptolide results in decreased phosphorylation of IKBKB protein]; TRP53 protein affects the reaction [triptolide results in decreased phosphorylation of NFKBIA protein]; TRP53 protein affects the reaction [triptolide results in increased expression of and results in increased phosphorylation of TRP53 protein]
pifithrin inhibits the reaction [triptolide results in increased expression of and results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [triptolide results in increased expression of TP53 protein modified form]; pifithrin inhibits the reaction [triptolide results in increased expression of TP53 protein]; triptolide results in increased expression of and results in increased phosphorylation of TP53 protein
triptolide results in increased expression of TP53 mRNA; triptolide results in increased expression of TP53 protein; triptolide results in increased expression of TP53 protein modified form
TRP53 gene mutant form results in decreased susceptibility to triptolide
CTD PMID:26990902, PMID:30009776, PMID:31618665 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tram1 translocation associated membrane protein 1 increases expression EXP triptolide results in increased expression of TRAM1 protein CTD PMID:32519852 NCBI chr 5:5,215,196...5,297,337
Ensembl chr 5:5,215,196...5,316,685
JBrowse link
G Trappc13 trafficking protein particle complex 13 increases expression EXP triptolide results in increased expression of TRAPPC13 protein CTD PMID:32519852 NCBI chr 2:34,223,396...34,254,995
Ensembl chr 2:34,223,352...34,254,968
JBrowse link
G Trappc2 trafficking protein particle complex 2 increases expression EXP triptolide results in increased expression of TRAPPC2 protein CTD PMID:32519852 NCBI chr  X:29,550,871...29,562,135
Ensembl chr  X:29,550,873...29,556,610
JBrowse link
G Trip10 thyroid hormone receptor interactor 10 increases expression EXP triptolide results in increased expression of TRIP10 mRNA CTD PMID:23639586 NCBI chr 9:9,689,214...9,702,353
Ensembl chr 9:9,689,475...9,702,306
JBrowse link
G Tsr2 TSR2, ribosome maturation factor increases expression EXP triptolide results in increased expression of TSR2 protein CTD PMID:32519852 NCBI chr  X:20,141,406...20,146,082
Ensembl chr  X:20,144,432...20,232,639
JBrowse link
G Ttc12 tetratricopeptide repeat domain 12 increases expression EXP triptolide results in increased expression of TTC12 protein CTD PMID:32519852 NCBI chr 8:53,770,685...53,818,873
Ensembl chr 8:53,770,681...53,816,447
JBrowse link
G Ttk Ttk protein kinase increases expression EXP triptolide results in increased expression of TTK mRNA CTD PMID:23639586 NCBI chr 8:91,368,065...91,405,995
Ensembl chr 8:91,368,111...91,405,993
JBrowse link
G Tubal3 tubulin, alpha-like 3 increases expression EXP triptolide results in increased expression of TUBAL3 protein CTD PMID:32519852 NCBI chr17:69,974,272...69,982,957
Ensembl chr17:69,974,272...69,982,957
JBrowse link
G Txn1 thioredoxin 1 multiple interactions
decreases expression
ISO NOTCH1 protein modified form inhibits the reaction [triptolide results in decreased expression of TXN protein] CTD PMID:30394310 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Txnip thioredoxin interacting protein increases expression
multiple interactions
ISO triptolide results in increased expression of TXNIP protein
NOTCH1 protein modified form inhibits the reaction [triptolide results in increased expression of TXNIP protein]
CTD PMID:30394310 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression EXP triptolide results in increased expression of TXNRD1 protein CTD PMID:32519852 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Tyk2 tyrosine kinase 2 increases expression EXP triptolide results in increased expression of TYK2 protein CTD PMID:32519852 NCBI chr 8:22,118,224...22,149,807
Ensembl chr 8:22,124,560...22,150,005
JBrowse link
G Uba7 ubiquitin-like modifier activating enzyme 7 increases expression EXP triptolide results in increased expression of UBA7 protein CTD PMID:32519852 NCBI chr 8:116,754,178...116,766,765
Ensembl chr 8:116,754,178...116,764,126
JBrowse link
G Ubxn1 UBX domain protein 1 decreases expression EXP triptolide results in decreased expression of UBXN1 protein CTD PMID:32519852 NCBI chr 1:225,067,953...225,071,944
Ensembl chr 1:225,068,009...225,071,945
JBrowse link
G Ubxn4 UBX domain protein 4 decreases expression EXP triptolide results in decreased expression of UBXN4 protein CTD PMID:32519852 NCBI chr13:44,956,963...44,989,653
Ensembl chr13:44,957,014...44,990,535
JBrowse link
G Ubxn8 UBX domain protein 8 increases expression EXP triptolide results in increased expression of UBXN8 protein CTD PMID:32519852 NCBI chr16:62,251,243...62,272,838
Ensembl chr16:62,251,243...62,272,838
JBrowse link
G Upp1 uridine phosphorylase 1 increases expression EXP triptolide results in increased expression of UPP1 protein CTD PMID:32519852 NCBI chr14:89,314,234...89,334,060
Ensembl chr14:89,314,176...89,334,276
JBrowse link
G Uqcr10 ubiquinol-cytochrome c reductase, complex III subunit X increases expression EXP triptolide results in increased expression of UQCR10 protein CTD PMID:32519852 NCBI chr14:84,935,480...84,937,741
Ensembl chr14:84,935,486...84,937,725
JBrowse link
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 decreases expression ISO triptolide results in decreased expression of UQCRC1 mRNA CTD PMID:29723566 NCBI chr 8:117,679,328...117,691,073
Ensembl chr 8:117,679,278...117,691,071
JBrowse link
G Usp39 ubiquitin specific peptidase 39 increases expression EXP triptolide results in increased expression of USP39 protein CTD PMID:32519852 NCBI chr 4:100,181,408...100,211,425
Ensembl chr 4:100,181,455...100,213,858
JBrowse link
G Usp40 ubiquitin specific peptidase 40 increases expression EXP triptolide results in increased expression of USP40 protein CTD PMID:32519852 NCBI chr 9:95,072,096...95,143,092
Ensembl chr 9:95,072,112...95,143,142
JBrowse link
G UST4r integral membrane transport protein UST4r increases expression EXP triptolide results in increased expression of UST4R protein CTD PMID:32519852 NCBI chr 1:224,319,927...224,389,499
Ensembl chr 1:224,319,077...224,389,499
JBrowse link
G Vcan versican increases expression EXP triptolide results in increased expression of VCAN protein CTD PMID:32519852 NCBI chr 2:18,490,102...18,587,340
Ensembl chr 2:18,490,102...18,565,842
JBrowse link
G Vdac3 voltage-dependent anion channel 3 increases expression EXP triptolide results in increased expression of VDAC3 protein CTD PMID:32519852 NCBI chr16:74,292,466...74,308,910
Ensembl chr16:74,292,438...74,308,903
JBrowse link
G Vps53 VPS53 subunit of GARP complex increases expression EXP triptolide results in increased expression of VPS53 protein CTD PMID:32519852 NCBI chr10:64,218,596...64,341,064
Ensembl chr10:64,222,276...64,341,109
JBrowse link
G Vtn vitronectin increases expression EXP triptolide results in increased expression of VTN protein CTD PMID:32519852 NCBI chr10:65,767,960...65,771,040
Ensembl chr10:65,767,053...65,771,038
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO [Idarubicin co-treated with triptolide] affects the expression of XIAP protein CTD PMID:18922616 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
G Xpnpep2 X-prolyl aminopeptidase 2 increases expression EXP triptolide results in increased expression of XPNPEP2 protein CTD PMID:32519852 NCBI chr  X:134,940,656...134,969,874
Ensembl chr  X:134,940,615...134,969,996
JBrowse link
G Yipf5 Yip1 domain family, member 5 decreases expression EXP triptolide results in decreased expression of YIPF5 protein CTD PMID:32519852 NCBI chr18:33,401,103...33,436,885
Ensembl chr18:33,401,106...33,434,775
JBrowse link
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma increases expression EXP triptolide results in increased expression of YWHAG mRNA CTD PMID:23639586 NCBI chr12:23,789,547...23,817,884
Ensembl chr12:23,789,638...23,817,883
JBrowse link
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta increases expression EXP triptolide results in increased expression of YWHAH mRNA CTD PMID:23639586 NCBI chr14:83,053,041...83,062,424
Ensembl chr14:83,053,041...83,062,424
JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta increases expression EXP triptolide results in increased expression of YWHAQ mRNA CTD PMID:23639586 NCBI chr 6:43,463,294...43,493,816
Ensembl chr 6:43,463,294...43,493,816
JBrowse link
G Zc3hav1 zinc finger CCCH-type containing, antiviral 1 increases expression EXP triptolide results in increased expression of ZC3HAV1 protein CTD PMID:32519852 NCBI chr 4:66,012,111...66,062,160
Ensembl chr 4:66,011,915...66,062,089
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        antispermatogenic agent 564
          Triptolide 533
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            carbamoyl group 17134
                                              carboxamide 17134
                                                lactam 8027
                                                  gamma-lactam 6266
                                                    Triptolide 533
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.