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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:triamterene
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Accession:CHEBI:9671 term browser browse the term
Definition:Pteridine substituted at positions 2, 4 and 7 with amino groups and at position 6 with a phenyl group. A sodium channel blocker, it is used as a diuretic in the treatment of hypertension and oedema.
Synonyms:exact_synonym: 6-phenylpteridine-2,4,7-triamine
 related_synonym: Formula=C12H11N7;   InChI=1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19);   InChIKey=FNYLWPVRPXGIIP-UHFFFAOYSA-N;   SMILES=C1=CC=C(C=C1)C2=NC3=C(N=C2N)N=C(N=C3N)N;   triamterena;   triamterenum
 alt_id: CHEBI:93604
 xref: CAS:396-01-0;   Drug_Central:2728;   KEGG:D00386;   LINCS:LSM-4060
 xref_mesh: MESH:D014223
 xref: PMID:26194642;   PMID:26385116;   PMID:27913567;   PMID:28166217;   PMID:28435224;   PMID:28588673;   Wikipedia:Triamterene



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triamterene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects transport ISO ABCB1A protein affects the transport of Triamterene CTD PMID:18322075 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects transport ISO ABCG2 protein affects the transport of Triamterene CTD PMID:18322075 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Bcat1 branched chain amino acid transaminase 1 increases expression EXP Triamterene results in increased expression of BCAT1 mRNA CTD PMID:23558518 NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases hydroxylation ISO CYP1A2 protein results in increased hydroxylation of Triamterene CTD PMID:16035375 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Egfr epidermal growth factor receptor affects response to substance ISO EGFR gene SNP affects the susceptibility to Triamterene CTD PMID:25622337 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases activity ISO Triamterene results in increased activity of HIF1A protein CTD PMID:19502547 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression EXP Triamterene results in increased expression of LMCD1 mRNA CTD PMID:23558518 NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046
JBrowse link
G Rnd1 Rho family GTPase 1 increases expression EXP Triamterene results in increased expression of RND1 mRNA CTD PMID:23558518 NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399
JBrowse link
G Serpine1 serpin family E member 1 increases expression EXP Triamterene results in increased expression of SERPINE1 mRNA CTD PMID:23558518 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19757
    role 19730
      application 19563
        pharmaceutical 19440
          drug 19440
            diuretic 4077
              triamterene 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19757
    subatomic particle 19755
      composite particle 19755
        hadron 19755
          baryon 19755
            nucleon 19755
              atomic nucleus 19755
                atom 19755
                  main group element atom 19703
                    p-block element atom 19703
                      carbon group element atom 19649
                        carbon atom 19645
                          organic molecular entity 19645
                            organic molecule 19604
                              organic cyclic compound 19407
                                organic heterocyclic compound 18772
                                  organic heteropolycyclic compound 18256
                                    organic heterobicyclic compound 17218
                                      pteridines 10228
                                        triamterene 9
paths to the root