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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:triamterene
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Accession:CHEBI:9671 term browser browse the term
Definition:Pteridine substituted at positions 2, 4 and 7 with amino groups and at position 6 with a phenyl group. A sodium channel blocker, it is used as a diuretic in the treatment of hypertension and oedema.
Synonyms:exact_synonym: 6-phenylpteridine-2,4,7-triamine
 related_synonym: Formula=C12H11N7;   InChI=1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19);   InChIKey=FNYLWPVRPXGIIP-UHFFFAOYSA-N;   SMILES=C1=CC=C(C=C1)C2=NC3=C(N=C2N)N=C(N=C3N)N;   triamterena;   triamterenum
 alt_id: CHEBI:93604
 xref: CAS:396-01-0;   Drug_Central:2728;   KEGG:D00386;   LINCS:LSM-4060
 xref_mesh: MESH:D014223
 xref: PMID:26194642;   PMID:26385116;   PMID:27913567;   PMID:28166217;   PMID:28435224;   PMID:28588673;   Wikipedia:Triamterene



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triamterene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects transport ISO ABCB1A protein affects the transport of Triamterene CTD PMID:18322075 NCBI chr 4:26,312,403...26,488,456 JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects transport ISO ABCG2 protein affects the transport of Triamterene CTD PMID:18322075 NCBI chr 4:89,006,056...89,132,915 JBrowse link
G Bcat1 branched chain amino acid transaminase 1 increases expression EXP Triamterene results in increased expression of BCAT1 mRNA CTD PMID:23558518 NCBI chr 4:179,695,662...179,777,973 JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases hydroxylation ISO CYP1A2 protein results in increased hydroxylation of Triamterene CTD PMID:16035375 NCBI chr 8:66,971,261...66,978,149 JBrowse link
G Egfr epidermal growth factor receptor affects response to substance ISO EGFR gene SNP affects the susceptibility to Triamterene CTD PMID:25622337 NCBI chr14:95,378,626...95,551,358 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases activity ISO Triamterene results in increased activity of HIF1A protein CTD PMID:19502547 NCBI chr 6:98,357,788...98,405,068 JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression EXP Triamterene results in increased expression of LMCD1 mRNA CTD PMID:23558518 NCBI chr 4:145,393,153...145,452,049 JBrowse link
G Rnd1 Rho family GTPase 1 increases expression EXP Triamterene results in increased expression of RND1 mRNA CTD PMID:23558518 NCBI chr 7:129,821,311...129,828,385 JBrowse link
G Serpine1 serpin family E member 1 increases expression EXP Triamterene results in increased expression of SERPINE1 mRNA CTD PMID:23558518 NCBI chr12:25,237,977...25,248,356 JBrowse link
G Tp53 tumor protein p53 affects activity ISO Triamterene affects the activity of TP53 protein; Triamterene metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,798,871...54,810,300 JBrowse link

Term paths to the root
Path 1
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  CHEBI ontology 19898
    role 19869
      application 19715
        pharmaceutical 19551
          drug 19551
            diuretic 4108
              triamterene 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            organic molecule 19724
                              organic cyclic compound 19516
                                organic heterocyclic compound 18896
                                  organic heteropolycyclic compound 18323
                                    organic heterobicyclic compound 17262
                                      pteridines 10268
                                        triamterene 10
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