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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:triamterene
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Accession:CHEBI:9671 term browser browse the term
Definition:Pteridine substituted at positions 2, 4 and 7 with amino groups and at position 6 with a phenyl group. A sodium channel blocker, it is used as a diuretic in the treatment of hypertension and oedema.
Synonyms:exact_synonym: 6-phenylpteridine-2,4,7-triamine
 related_synonym: Formula=C12H11N7;   InChI=1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19);   InChIKey=FNYLWPVRPXGIIP-UHFFFAOYSA-N;   SMILES=C1=CC=C(C=C1)C2=NC3=C(N=C2N)N=C(N=C3N)N;   triamterena;   triamterenum
 alt_id: CHEBI:93604
 xref: CAS:396-01-0;   Drug_Central:2728;   KEGG:D00386;   LINCS:LSM-4060
 xref_mesh: MESH:D014223
 xref: PMID:26194642;   PMID:26385116;   PMID:27913567;   PMID:28166217;   PMID:28435224;   PMID:28588673;   Wikipedia:Triamterene



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triamterene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects transport ISO ABCB1A protein affects the transport of Triamterene CTD PMID:18322075 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects transport ISO ABCG2 protein affects the transport of Triamterene CTD PMID:18322075 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Bcat1 branched chain amino acid transaminase 1 increases expression EXP Triamterene results in increased expression of BCAT1 mRNA CTD PMID:23558518 NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases hydroxylation ISO CYP1A2 protein results in increased hydroxylation of Triamterene CTD PMID:16035375 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Egfr epidermal growth factor receptor affects response to substance ISO EGFR gene SNP affects the susceptibility to Triamterene CTD PMID:25622337 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases activity ISO Triamterene results in increased activity of HIF1A protein CTD PMID:19502547 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression EXP Triamterene results in increased expression of LMCD1 mRNA CTD PMID:23558518 NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046
JBrowse link
G Rnd1 Rho family GTPase 1 increases expression EXP Triamterene results in increased expression of RND1 mRNA CTD PMID:23558518 NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399
JBrowse link
G Serpine1 serpin family E member 1 increases expression EXP Triamterene results in increased expression of SERPINE1 mRNA CTD PMID:23558518 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Tp53 tumor protein p53 affects activity ISO Triamterene affects the activity of TP53 protein; Triamterene metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      application 19650
        pharmaceutical 19491
          drug 19491
            diuretic 4109
              triamterene 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            organic molecule 19677
                              organic cyclic compound 19490
                                organic heterocyclic compound 18852
                                  organic heteropolycyclic compound 18295
                                    organic heterobicyclic compound 17240
                                      pteridines 10262
                                        triamterene 10
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