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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:triamcinolone
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Accession:CHEBI:9667 term browser browse the term
Definition:A C21-steroid hormone that is 1,4-pregnadiene-3,20-dione carrying four hydroxy substituents at positions 11beta, 16alpha, 17alpha and 21 as well as a fluoro substituent at position 9. Used in the form of its 16,17-acetonide to treat various skin infections.
Synonyms:exact_synonym: (11beta,16alpha)-9-fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
 related_synonym: 11beta,16alpha,17alpha,21-tetrahydroxy-9alpha-fluoro-1,4-pregnadiene-3,20-dione;   9-fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione;   9alpha-fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione;   9alpha-fluoro-11beta,16alpha,17alpha,21-tetrahydroxypregna-1,4-diene-3,20-dione;   9alpha-fluoro-16alpha-hydroxyprednisolone;   Fluoxyprednisolone;   Formula=C21H27FO6;   InChI=1S/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1;   InChIKey=GFNANZIMVAIWHM-OBYCQNJPSA-N;   SMILES=[H][C@@]12C[C@@H](O)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C;   triamcinolona;   triamcinolonum
 xref: CAS:124-94-7;   DrugBank:DB00620;   Drug_Central:2725;   HMDB:HMDB0014758;   KEGG:D00385
 xref_mesh: MESH:D014221
 xref: PMID:11583068;   PMID:15305946;   PMID:19668443;   PMID:22846803;   PMID:23151875;   PMID:23337526;   PMID:23370580;   PMID:23440982;   PMID:23449717;   PMID:23473287;   PMID:23562859;   PMID:7509503;   Patent:WO2005028495;   Reaxys:2341955;   Wikipedia:Triamcinolone

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triamcinolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Triamcinolone inhibits the reaction [ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] CTD PMID:15365089 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO [Triamcinolone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein CTD PMID:29782964 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation EXP Triamcinolone results in decreased phosphorylation of AKT1 protein CTD PMID:15187100 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Ar androgen receptor multiple interactions ISO Triamcinolone binds to and results in increased activity of AR protein mutant form CTD PMID:11956172 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Casp9 caspase 9 increases activity ISO Triamcinolone results in increased activity of CASP9 protein CTD PMID:11734450 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Triamcinolone results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO [Triamcinolone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein CTD PMID:29782964 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase multiple interactions ISO Triamcinolone results in increased expression of and results in increased activity of HPGD protein CTD PMID:15680906 NCBI chr16:37,457,134...37,495,758
Ensembl chr16:37,457,135...37,495,758 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO [Triamcinolone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein; [Triamcinolone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein CTD PMID:29782964 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034 		JBrowse link
G Mb myoglobin increases secretion EXP Triamcinolone results in increased secretion of MB protein CTD PMID:19628585 NCBI chr 7:118,101,633...118,108,864
Ensembl chr 7:118,101,634...118,108,864 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
increases activity		 ISO NR3C1 protein alternative form inhibits the reaction [Triamcinolone results in increased activity of NR3C1 protein alternative form]; Triamcinolone binds to and results in increased activity of NR3C1 protein CTD PMID:11956172 PMID:15362971 PMID:15755863 PMID:21543282 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 decreases activity
increases activity		 ISO Triamcinolone results in decreased activity of NR3C2 protein
Triamcinolone results in increased activity of NR3C2 protein		 CTD PMID:15362971 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Triamcinolone binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796 		JBrowse link
G Pomc proopiomelanocortin decreases response to substance ISO Triamcinolone results in decreased susceptibility to POMC protein modified form CTD PMID:7788158 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Triamcinolone results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
triamcinolone acetonide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects transport ISO ABCB1A protein affects the transport of Triamcinolone Acetonide CTD PMID:16105236 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of ALOX5 protein] CTD PMID:23751068 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression EXP Triamcinolone Acetonide results in increased expression of BAD protein CTD PMID:15987869 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Triamcinolone Acetonide results in increased expression of BAX protein CTD PMID:15987869 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bid BH3 interacting domain death agonist increases expression EXP Triamcinolone Acetonide results in increased expression of BID protein CTD PMID:15987869 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203 		JBrowse link
G Casp8 caspase 8 increases activity EXP Triamcinolone Acetonide results in increased activity of CASP8 protein CTD PMID:15987869 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [TNF protein results in increased secretion of CCL5 protein] CTD PMID:10903220 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO Triamcinolone Acetonide promotes the reaction [Paraquat results in increased expression of CCN2 mRNA] CTD PMID:15728566 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
decreases secretion		 ISO Triamcinolone Acetonide inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]
Triamcinolone Acetonide results in decreased secretion of CSF2 protein		 CTD PMID:10460758 PMID:10868704 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070 		JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 decreases expression ISO Triamcinolone Acetonide results in decreased expression of CYP2S1 mRNA CTD PMID:22155357 NCBI chr 1:82,595,211...82,610,350
Ensembl chr 1:82,595,211...82,610,350 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression
multiple interactions		 ISO Triamcinolone Acetonide results in increased expression of CYP3A5 mRNA
Ketoconazole inhibits the reaction [Triamcinolone Acetonide results in increased expression of CYP3A5 mRNA]		 CTD PMID:24555085 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399 		JBrowse link
G Fadd Fas associated via death domain increases expression EXP Triamcinolone Acetonide results in increased expression of FADD protein CTD PMID:15987869 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [IL1B protein results in increased abundance of Thromboxane B2]; Triamcinolone Acetonide inhibits the reaction [IL1B protein results in increased expression of TNF protein]; Triamcinolone Acetonide inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]; Triamcinolone Acetonide inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:10460758 PMID:15337628 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of IL4 mRNA] CTD PMID:23751068 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of IL5 mRNA] CTD PMID:23751068 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Triamcinolone Acetonide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of IL6 mRNA] CTD PMID:27916735 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Ltc4s leukotriene C4 synthase multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of LTC4S mRNA] CTD PMID:23751068 NCBI chr10:35,736,486...35,743,088
Ensembl chr10:35,737,664...35,739,625 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Triamcinolone Acetonide results in decreased expression of MKI67 protein CTD PMID:16029572 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions EXP Triamcinolone Acetonide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC mRNA] CTD PMID:27916735 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
affects binding
decreases expression		 ISO
EXP		 [Triamcinolone Acetonide binds to NR3C1 protein] which results in decreased secretion of VEGFA protein; Triamcinolone Acetonide binds to and affects the localization of NR3C1 protein
Dithiothreitol inhibits the reaction [Mercuric Chloride inhibits the reaction [Triamcinolone Acetonide binds to NR3C1 protein]]; Mercuric Chloride inhibits the reaction [Triamcinolone Acetonide binds to NR3C1 protein]; Triamcinolone Acetonide binds to and affects the activity of NR3C1 protein
Triamcinolone Acetonide results in decreased expression of NR3C1 protein
Triamcinolone Acetonide analog binds to NR3C1 protein; Triamcinolone Acetonide binds to NR3C1 protein		 CTD PMID:926113 PMID:15250541 PMID:15705660 PMID:15976447 PMID:16029572 PMID:16507850 PMID:23765520 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647 		JBrowse link
G Pla2g4a phospholipase A2 group IVA decreases activity ISO Triamcinolone Acetonide results in decreased activity of PLA2G4A protein CTD PMID:15337628 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [[OVAL protein co-treated with enterotoxin B, staphylococcal co-treated with Dimethyl Sulfoxide] results in increased expression of PTGS2 protein] CTD PMID:23751068 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Serpinb1a serpin family B member 1A multiple interactions EXP
ISO		 Triamcinolone Acetonide results in increased cleavage of and results in increased activity of and affects the localization of SERPINB1A protein modified form
Triamcinolone Acetonide results in increased cleavage of and results in increased activity of and affects the localization of SERPINB1 protein modified form		 CTD PMID:25447644 NCBI chr17:32,903,089...32,911,498
Ensembl chr17:32,904,119...32,911,495 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases expression EXP Triamcinolone Acetonide results in increased expression of SULT1A1 mRNA; Triamcinolone Acetonide results in increased expression of SULT1A1 protein CTD PMID:10799342 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA] CTD PMID:15728566 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 Triamcinolone Acetonide inhibits the reaction [IL1B protein results in increased expression of TNF protein]; Triamcinolone Acetonide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Triamcinolone Acetonide inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Triamcinolone Acetonide inhibits the reaction [TNF protein results in increased secretion of CCL5 protein]
Triamcinolone Acetonide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TNF mRNA]		 CTD PMID:10100995 PMID:10903220 PMID:15337628 PMID:27916735 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Triamcinolone Acetonide inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:10100995 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression		 ISO [Triamcinolone Acetonide binds to NR3C1 protein] which results in decreased secretion of VEGFA protein; Triamcinolone Acetonide inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]; Triamcinolone Acetonide inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein]; Triamcinolone Acetonide inhibits the reaction [Paraquat results in increased expression of VEGFA mRNA]
Triamcinolone Acetonide results in decreased expression of VEGFA protein		 CTD PMID:15728566 PMID:16029572 PMID:16249516 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
Term paths to the root
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  CHEBI ontology 19771
    role 19716
      application 19406
        anti-inflammatory agent 15771
          anti-inflammatory drug 13626
            triamcinolone 42
              triamcinolone acetonide 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      ketone 16829
                                        oxyketone 8661
                                          alpha-oxyketone 8661
                                            alpha-hydroxy ketone 8661
                                              primary alpha-hydroxy ketone 7539
                                                triamcinolone 42
                                                  triamcinolone acetonide 29
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