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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tranylcypromine
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Accession:CHEBI:9652 term browser browse the term
Definition:A racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1-amine. An irreversible monoamine oxidase inhibitor that is used as an antidepressant (INN tranylcypromine).
Synonyms:exact_synonym: rac-(1R,2S)-2-phenylcyclopropan-1-amine
 related_synonym: (1R*,2S*)-2-phenylcyclopropan-1-amine;   DL-tranylcypromine;   Racemic Tranylcypromine;   SKF 385;   SKF Trans-385;   Transamine;   Tranylcypromin;   tranilcipromina;   trans-2-phenylcyclopropylamine;   trans-DL-2-Phenylcyclopropylamine;   tranylcyprominum
 alt_id: CHEBI:39677;   CHEBI:46075
 xref: CAS:155-09-9;   DrugBank:DB00752;   HMDB:HMDB0014890;   KEGG:C07155;   KEGG:D08625
 xref_mesh: MESH:D014191
 xref: MetaCyc:CPD-17677;   PDBeChem:TPA;   PMID:11181487;   PMID:12495786;   PMID:13948833;   PMID:15049511;   PMID:18974922;   PMID:20148560;   PMID:26257022;   PMID:26302763;   PMID:26348077;   PMID:26479223;   PMID:26748182;   PMID:26917855;   PMID:7236991;   PMID:7511710;   PMID:7531152;   PMID:7675827;   PMID:7776254;   PMID:8831798;   PMID:9049597;   PMID:9829163;   Reaxys:3195803;   Wikipedia:Tranylcypromine


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tranylcypromine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARC activity regulated cytoskeleton associated protein increases expression ISO Tranylcypromine results in increased expression of ARC mRNA CTD PMID:14580947 NCBI chr 8:142,611,049...142,614,479
Ensembl chr 8:142,611,049...142,614,479 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO Tranylcypromine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein] CTD PMID:19135049 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO Tranylcypromine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein] CTD PMID:19135049 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BDNF brain derived neurotrophic factor increases expression ISO Tranylcypromine results in increased expression of BDNF mRNA CTD PMID:8601816 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058 		JBrowse link
G CASP3 caspase 3 multiple interactions ISO Tranylcypromine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein] CTD PMID:19135049 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 increases expression ISO Tranylcypromine results in increased expression of CREB1 mRNA CTD PMID:8601816 NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions
decreases activity		 EXP Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]
Tranylcypromine results in decreased activity of CYP1A2 protein		 CTD PMID:15916432 PMID:24120545 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP2A13 cytochrome P450 family 2 subfamily A member 13 multiple interactions EXP Tranylcypromine inhibits the reaction [CYP2A13 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] CTD PMID:18669584 NCBI chr19:41,088,451...41,096,195
Ensembl chr19:41,088,451...41,096,195 		JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 multiple interactions
decreases activity		 EXP [[Tranylcypromine results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin] which results in decreased chemical synthesis of 3-cyano-7-hydroxycoumarin; [Tranylcypromine results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin; [Tranylcypromine results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; Tranylcypromine inhibits the reaction [[CYP2A6 protein results in increased metabolism of Methimazole] which results in increased abundance of N-methylthiourea]; Tranylcypromine inhibits the reaction [CYP2A6 protein results in increased abundance of N-methylthiourea]; Tranylcypromine inhibits the reaction [CYP2A6 protein results in increased chemical synthesis of 7-hydroxycoumarin]; Tranylcypromine inhibits the reaction [CYP2A6 protein results in increased glutathionylation of Lamotrigine]; Tranylcypromine inhibits the reaction [CYP2A6 protein results in increased metabolism of coumarin]; Tranylcypromine inhibits the reaction [CYP2A6 protein results in increased metabolism of Nicotine] CTD PMID:10911933 PMID:11353760 PMID:15155557 PMID:15980104 PMID:19328226 More... NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 multiple interactions
decreases activity		 EXP Tranylcypromine inhibits the reaction [[CYP2B6 protein results in increased metabolism of 7-ethoxy-4-trifluoromethylcoumarin] which results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]; Tranylcypromine inhibits the reaction [CYP2B6 protein results in increased metabolism of Bupropion]
Tranylcypromine results in decreased activity of CYP2B6 protein		 CTD PMID:23850985 PMID:28119166 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 multiple interactions
decreases activity		 EXP Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Tranylcypromine inhibits the reaction [[CYP2C19 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein]; Tranylcypromine inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]
Tranylcypromine results in decreased activity of CYP2C19 protein		 CTD PMID:12569440 PMID:15306208 PMID:23850985 PMID:24120545 PMID:28119166 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547 		JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 multiple interactions EXP Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 multiple interactions EXP Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 multiple interactions EXP Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases activity EXP Tranylcypromine results in decreased activity of CYP2E1 protein CTD PMID:15155557 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G CYP2J2 cytochrome P450 family 2 subfamily J member 2 decreases activity EXP Tranylcypromine results in decreased activity of CYP2J2 protein CTD PMID:12851038 NCBI chr 1:59,893,308...59,969,212
Ensembl chr 1:59,893,308...59,926,773 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions EXP Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G EGR1 early growth response 1 decreases expression ISO Tranylcypromine results in decreased expression of EGR1 mRNA CTD PMID:7612155 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Tranylcypromine results in decreased expression of FOS mRNA CTD PMID:7612155 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO Tranylcypromine inhibits the reaction [[Methimazole co-treated with Buthionine Sulfoximine] results in increased activity of GPT protein] CTD PMID:34788025 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions ISO Tranylcypromine inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA] CTD PMID:12763371 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 increases expression ISO Tranylcypromine results in increased expression of NTRK2 mRNA CTD PMID:8601816 NCBI chr 9:84,668,522...85,027,054
Ensembl chr 9:84,668,375...85,095,751 		JBrowse link
G POR cytochrome p450 oxidoreductase multiple interactions EXP Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855 		JBrowse link
G TAAR1 trace amine associated receptor 1 increases activity
multiple interactions		 ISO Tranylcypromine results in increased activity of TAAR1 protein
[Tranylcypromine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP		 CTD PMID:19725810 NCBI chr 6:132,643,312...132,659,182
Ensembl chr 6:132,643,312...132,659,182 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    chemical entity 26020
      chemical substance 15508
        mixture 14678
          racemate 12884
            tranylcypromine 24
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    main group molecular entity 25841
                      s-block molecular entity 25162
                        hydrogen molecular entity 24761
                          hydrides 22973
                            inorganic hydride 20500
                              pnictogen hydride 20441
                                nitrogen hydride 20219
                                  azane 19961
                                    ammonia 19960
                                      organic amino compound 19960
                                        amine 8481
                                          primary amine 6521
                                            2-phenylcyclopropan-1-amine 24
                                              (1R,2S)-tranylcypromine 24
                                                tranylcypromine 24
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