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ONTOLOGY REPORT - ANNOTATIONS


Term:tranylcypromine
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Accession:CHEBI:9652 term browser browse the term
Definition:A racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1-amine. An irreversible monoamine oxidase inhibitor that is used as an antidepressant (INN tranylcypromine).
Synonyms:exact_synonym: rac-(1R,2S)-2-phenylcyclopropan-1-amine
 related_synonym: (1R*,2S*)-2-phenylcyclopropan-1-amine;   DL-tranylcypromine;   Racemic Tranylcypromine;   SKF 385;   SKF Trans-385;   Transamine;   Tranylcypromin;   tranilcipromina;   trans-2-phenylcyclopropylamine;   trans-DL-2-Phenylcyclopropylamine;   tranylcyprominum
 alt_id: CHEBI:39677;   CHEBI:46075
 xref: CAS:155-09-9 "ChemIDplus";   CAS:155-09-9 "KEGG COMPOUND";   CAS:155-09-9 "NIST Chemistry WebBook";   DrugBank:DB00752;   HMDB:HMDB0014890;   KEGG:C07155;   KEGG:D08625
 xref_mesh: MESH:D014191
 xref: MetaCyc:CPD-17677;   PDBeChem:TPA;   PMID:11181487 "Europe PMC";   PMID:12495786 "Europe PMC";   PMID:13948833 "Europe PMC";   PMID:15049511 "Europe PMC";   PMID:18974922 "Europe PMC";   PMID:20148560 "Europe PMC";   PMID:26257022 "Europe PMC";   PMID:26302763 "Europe PMC";   PMID:26348077 "Europe PMC";   PMID:26479223 "Europe PMC";   PMID:26748182 "Europe PMC";   PMID:26917855 "Europe PMC";   PMID:7236991 "Europe PMC";   PMID:7511710 "Europe PMC";   PMID:7531152 "Europe PMC";   PMID:7675827 "Europe PMC";   PMID:7776254 "Europe PMC";   PMID:8831798 "Europe PMC";   PMID:9049597 "Europe PMC";   PMID:9829163 "Europe PMC";   Reaxys:3195803 "Reaxys";   Wikipedia:Tranylcypromine


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tranylcypromine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arc activity-regulated cytoskeleton-associated protein JBrowse link 7 115,907,097 115,911,059 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 JBrowse link 1 83,163,103 83,236,615 RGD:6480464
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 JBrowse link 1 147,713,879 147,814,410 RGD:6480464
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 JBrowse link 1 147,236,480 147,307,988 RGD:6480464
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:6480464
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 JBrowse link 5 119,546,458 119,564,843 RGD:6480464
G Egr1 early growth response 1 JBrowse link 18 27,657,903 27,660,101 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Ntrk2 neurotrophic receptor tyrosine kinase 2 JBrowse link 17 5,934,651 6,245,778 RGD:6480464
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:6480464
G Taar1 trace-amine-associated receptor 1 JBrowse link 1 22,595,477 22,596,475 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        inhibitor 18059
          lysine-specific histone demethylase 1A inhibitor 19
            tranylcypromine 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    main group molecular entity 19545
                      s-block molecular entity 19329
                        hydrogen molecular entity 19319
                          hydrides 18242
                            inorganic hydride 17104
                              pnictogen hydride 17062
                                nitrogen hydride 16885
                                  azane 16564
                                    ammonia 16561
                                      organic amino compound 16560
                                        amine 6415
                                          primary amine 4136
                                            2-phenylcyclopropan-1-amine 19
                                              (1R,2S)-tranylcypromine 19
                                                tranylcypromine 19
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.