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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:trandolapril
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Accession:CHEBI:9649 term browser browse the term
Synonyms:exact_synonym: (2S,3aR,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid
 related_synonym: Formula=C24H34N2O5;   InChI=1S/C24H34N2O5/c1-3-31-24(30)19(14-13-17-9-5-4-6-10-17)25-16(2)22(27)26-20-12-8-7-11-18(20)15-21(26)23(28)29/h4-6,9-10,16,18-21,25H,3,7-8,11-15H2,1-2H3,(H,28,29)/t16-,18+,19-,20-,21-/m0/s1;   InChIKey=VXFJYXUZANRPDJ-WTNASJBWSA-N;   SMILES=C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(OCC)=O)C)(=O)N2[C@@]3([C@@](C[C@H]2C(O)=O)(CCCC3)[H])[H];   gopten;   mavik;   odrik
 xref: CAS:87679-37-6;   DrugBank:DB00519;   Drug_Central:2712;   HMDB:HMDB0014660;   KEGG:D00383
 xref_mesh: MESH:C052035
 xref: PMID:19337528;   PMID:23784370;   PMID:25864194;   PMID:29319234;   Reaxys:8655766;   Wikipedia:Trandolapril


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trandolapril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity EXP trandolapril results in decreased activity of ACE protein CTD PMID:27428043 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Ace2 angiotensin I converting enzyme 2 multiple interactions ISO trandolapril promotes the reaction [REN2 protein results in increased expression of ACE2 protein] CTD PMID:27428043 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Ache acetylcholinesterase multiple interactions EXP trandolapril inhibits the reaction [3-nitropropionic acid results in increased activity of ACHE protein] CTD PMID:25445565 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Adrb1 adrenoceptor beta 1 increases expression EXP trandolapril results in increased expression of ADRB1 protein CTD PMID:7586371 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Agt angiotensinogen multiple interactions
decreases expression
EXP
ISO
trandolapril inhibits the reaction [Isoproterenol results in increased expression of AGT protein]
trandolapril results in decreased expression of AGT protein modified form
trandolapril inhibits the reaction [REN2 protein results in increased expression of AGT protein modified form]
CTD PMID:1534315, PMID:27428043 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Cat catalase multiple interactions EXP trandolapril inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein] CTD PMID:25445565 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
decreases expression
EXP [trandolapril co-treated with eplerenone] results in decreased expression of CYBA mRNA
trandolapril results in decreased expression of CYBA mRNA
CTD PMID:17324946 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP [trandolapril co-treated with eplerenone] results in decreased expression of FN1 protein CTD PMID:17324946 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions
decreases expression
EXP [trandolapril co-treated with eplerenone] results in decreased expression of NCF1 mRNA; [trandolapril co-treated with eplerenone] results in decreased expression of NCF1 protein
trandolapril results in decreased expression of NCF1 mRNA; trandolapril results in decreased expression of NCF1 protein
CTD PMID:17324946 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Ren renin multiple interactions
increases expression
ISO
EXP
[Bumetanide co-treated with trandolapril] results in increased expression of REN protein
trandolapril results in increased expression of REN protein
CTD PMID:16635047, PMID:27428043 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO trandolapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:106,800,081...106,844,668
Ensembl chr15:106,800,081...106,844,426
JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions EXP trandolapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:66,932,664...66,961,708
Ensembl chr11:66,932,614...66,961,713
JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP trandolapril results in increased expression of SOD2 protein CTD PMID:17324946 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pro-agent 8829
          prodrug 8609
            trandolapril 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        carboacyl group 17346
                                          univalent carboacyl group 17346
                                            carbamoyl group 17132
                                              carboxamide 17132
                                                peptide 9391
                                                  oligopeptide 1196
                                                    dipeptide 372
                                                      trandolapril 13
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