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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tramadol
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Accession:CHEBI:9648 term browser browse the term
Definition:A racemate consisting of equal amounts of (R,R)- and (S,S)-tramadol. A centrally acting synthetic opioid analgesic, used (as the hydrochloride salt) to treat moderately severe pain. The (R,R)-enantiomer exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer. Originally developed by Gruenenthal GmbH and launched in 1977, it was subsequently isolated from the root bark of the South African tree Nauclea latifolia.
Synonyms:exact_synonym: rac-(1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol
 related_synonym: (+-)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol;   CG-315E;   E-265;   Formula=C16H25NO2;   U-26225A;   tramadolum
 xref: CAS:27203-92-5;   DrugBank:DB00193;   HMDB:HMDB0014339;   KEGG:C07153;   KEGG:D08623
 xref_mesh: MESH:D014147
 xref: PMID:22674657;   PMID:22943675;   PMID:22964800;   PMID:23031839;   PMID:23061925;   PMID:23095734;   PMID:23098678;   PMID:23099620;   PMID:23102445;   PMID:23145962;   PMID:23292128;   PMID:23328338;   PMID:23433451;   PMID:23543914;   PMID:23668411;   PMID:23755929;   PMID:23756535;   PMID:23773348;   PMID:23822079;   PMID:23825758;   PMID:23840975;   PMID:23843224;   PMID:23872384;   PMID:23907474;   PMID:23962470;   PMID:24014188;   PMID:25219922;   Patent:GB997399;   Patent:US3652589;   Reaxys:2943832;   Wikipedia:Tramadol
 cyclic_relationship: is_conjugate_base_of CHEBI:75736



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Term Annotations click to browse term
  CHEBI ontology 5059
    role 5022
      biological role 5022
        xenobiotic 156
          tramadol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 5059
    subatomic particle 5050
      composite particle 5050
        hadron 5050
          baryon 5050
            nucleon 5050
              atomic nucleus 5050
                atom 5050
                  main group element atom 5017
                    main group molecular entity 5016
                      s-block molecular entity 4947
                        hydrogen molecular entity 4941
                          hydrides 4564
                            inorganic hydride 405
                              pnictogen hydride 401
                                nitrogen hydride 401
                                  azane 392
                                    ammonia 392
                                      organic amino compound 285
                                        tertiary amino compound 69
                                          2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol 0
                                            (S,S)-tramadol 0
                                              tramadol 0
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