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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:toremifene
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Accession:CHEBI:9635 term browser browse the term
Definition:A tertiary amine that has formula C26H28ClNO.
Synonyms:exact_synonym: 2-{4-[(1Z)-4-chloro-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine
 related_synonym: Formula=C26H28ClNO;   InChI=1S/C26H28ClNO/c1-28(2)19-20-29-24-15-13-23(14-16-24)26(22-11-7-4-8-12-22)25(17-18-27)21-9-5-3-6-10-21/h3-16H,17-20H2,1-2H3/b26-25-;   InChIKey=XFCLJVABOIYOMF-QPLCGJKRSA-N;   SMILES=CN(C)CCOc1ccc(cc1)C(\\c1ccccc1)=C(\\CCCl)c1ccccc1;   toremifeno;   toremifenum
 xref: CAS:89778-26-7;   DrugBank:DB00539;   Drug_Central:2709;   KEGG:C08166;   KEGG:D08620
 xref_mesh: MESH:D017312
 xref: Patent:EP95875;   Patent:US4696949;   Wikipedia:Toremifene


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toremifene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor decreases activity ISO Toremifene results in decreased activity of AR protein CTD PMID:15316697 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions EXP
ISO		 Toremifene inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Toremifene inhibits the reaction [Estradiol results in increased expression of ESR1 protein]
Toremifene binds to and results in decreased activity of ESR1 protein		 CTD PMID:12079510 PMID:25752796 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Esr2 estrogen receptor 2 (beta) increases expression
multiple interactions		 EXP
ISO		 Toremifene results in increased expression of ESR2 mRNA
Toremifene binds to and results in decreased activity of ESR2 protein		 CTD PMID:12079510 PMID:25752796 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions EXP Toremifene inhibits the reaction [Estradiol results in increased expression of FOS mRNA]; Toremifene inhibits the reaction [Estradiol results in increased expression of FOS protein] CTD PMID:12079510 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP Toremifene inhibits the reaction [Estradiol results in increased expression of IL1A mRNA]; Toremifene inhibits the reaction [Estradiol results in increased expression of IL1A protein] CTD PMID:12079510 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO Toremifene results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602 		JBrowse link
G Serpinc1 serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 decreases expression ISO Toremifene results in decreased expression of SERPINC1 protein CTD PMID:14692654 NCBI chr 1:160,806,153...160,830,113
Ensembl chr 1:160,806,155...160,833,433 		JBrowse link
G Shbg sex hormone binding globulin increases expression
affects binding		 ISO Toremifene results in increased expression of SHBG protein
Toremifene binds to SHBG protein		 CTD PMID:14692654 PMID:25349334 NCBI chr11:69,501,108...69,508,852
Ensembl chr11:69,505,630...69,508,731 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      application 21744
        pharmaceutical 21187
          drug 21159
            antineoplastic agent 18896
              toremifene 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    main group molecular entity 22104
                      s-block molecular entity 21729
                        hydrogen molecular entity 21646
                          hydrides 20758
                            inorganic hydride 18672
                              pnictogen hydride 18652
                                nitrogen hydride 18519
                                  azane 18426
                                    ammonia 18425
                                      organic amino compound 18425
                                        tertiary amino compound 10293
                                          tertiary amine 637
                                            toremifene 8
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