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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:toremifene
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Accession:CHEBI:9635 term browser browse the term
Definition:A tertiary amine that has formula C26H28ClNO.
Synonyms:exact_synonym: 2-{4-[(1Z)-4-chloro-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine
 related_synonym: Formula=C26H28ClNO;   InChI=1S/C26H28ClNO/c1-28(2)19-20-29-24-15-13-23(14-16-24)26(22-11-7-4-8-12-22)25(17-18-27)21-9-5-3-6-10-21/h3-16H,17-20H2,1-2H3/b26-25-;   InChIKey=XFCLJVABOIYOMF-QPLCGJKRSA-N;   SMILES=CN(C)CCOc1ccc(cc1)C(\\c1ccccc1)=C(\\CCCl)c1ccccc1;   toremifeno;   toremifenum
 xref: CAS:89778-26-7;   DrugBank:DB00539;   Drug_Central:2709;   KEGG:C08166;   KEGG:D08620
 xref_mesh: MESH:D017312
 xref: Patent:EP95875;   Patent:US4696949;   Wikipedia:Toremifene



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toremifene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor decreases activity ISO Toremifene results in decreased activity of AR protein CTD PMID:15316697 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Toremifene results in increased expression of CYP3A23-3A1 protein CTD PMID:10959800 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Toremifene inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Toremifene inhibits the reaction [Estradiol results in increased expression of ESR1 protein]
Toremifene binds to and results in decreased activity of ESR1 protein
CTD PMID:12079510 PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 increases expression
multiple interactions
ISO Toremifene results in increased expression of ESR2 mRNA
Toremifene binds to and results in decreased activity of ESR2 protein
CTD PMID:12079510 PMID:25752796 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Toremifene inhibits the reaction [Estradiol results in increased expression of FOS mRNA]; Toremifene inhibits the reaction [Estradiol results in increased expression of FOS protein] CTD PMID:12079510 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases expression EXP Toremifene results in decreased expression of GSTA1 mRNA CTD PMID:9744569 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Toremifene inhibits the reaction [Estradiol results in increased expression of IL1A mRNA]; Toremifene inhibits the reaction [Estradiol results in increased expression of IL1A protein] CTD PMID:12079510 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Toremifene results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Serpinc1 serpin family C member 1 decreases expression ISO Toremifene results in decreased expression of SERPINC1 protein CTD PMID:14692654 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
JBrowse link
G Shbg sex hormone binding globulin increases expression
affects binding
ISO Toremifene results in increased expression of SHBG protein
Toremifene binds to SHBG protein
CTD PMID:14692654 PMID:25349334 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
JBrowse link

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  CHEBI ontology 19659
    role 19634
      application 19465
        pharmaceutical 19355
          drug 19355
            antineoplastic agent 17598
              toremifene 10
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  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    main group molecular entity 19649
                      s-block molecular entity 19457
                        hydrogen molecular entity 19450
                          hydrides 18928
                            inorganic hydride 17765
                              pnictogen hydride 17748
                                nitrogen hydride 17633
                                  azane 17403
                                    ammonia 17402
                                      organic amino compound 17402
                                        tertiary amino compound 9087
                                          tertiary amine 628
                                            toremifene 10
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