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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:toremifene
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Accession:CHEBI:9635 term browser browse the term
Definition:A tertiary amine that has formula C26H28ClNO.
Synonyms:exact_synonym: 2-{4-[(1Z)-4-chloro-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine
 related_synonym: Formula=C26H28ClNO;   InChI=1S/C26H28ClNO/c1-28(2)19-20-29-24-15-13-23(14-16-24)26(22-11-7-4-8-12-22)25(17-18-27)21-9-5-3-6-10-21/h3-16H,17-20H2,1-2H3/b26-25-;   InChIKey=XFCLJVABOIYOMF-QPLCGJKRSA-N;   SMILES=CN(C)CCOc1ccc(cc1)C(\\c1ccccc1)=C(\\CCCl)c1ccccc1;   toremifeno;   toremifenum
 xref: CAS:89778-26-7;   DrugBank:DB00539;   Drug_Central:2709;   KEGG:C08166;   KEGG:D08620
 xref_mesh: MESH:D017312
 xref: Patent:EP95875;   Patent:US4696949;   Wikipedia:Toremifene


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toremifene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor decreases activity ISO Toremifene results in decreased activity of AR protein CTD PMID:15316697 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Toremifene results in increased expression of CYP3A23-3A1 protein CTD PMID:10959800 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Toremifene inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Toremifene inhibits the reaction [Estradiol results in increased expression of ESR1 protein]
Toremifene binds to and results in decreased activity of ESR1 protein
CTD PMID:12079510 PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 increases expression
multiple interactions
ISO Toremifene results in increased expression of ESR2 mRNA
Toremifene binds to and results in decreased activity of ESR2 protein
CTD PMID:12079510 PMID:25752796 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Toremifene inhibits the reaction [Estradiol results in increased expression of FOS mRNA]; Toremifene inhibits the reaction [Estradiol results in increased expression of FOS protein] CTD PMID:12079510 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases expression EXP Toremifene results in decreased expression of GSTA1 mRNA CTD PMID:9744569 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Toremifene inhibits the reaction [Estradiol results in increased expression of IL1A mRNA]; Toremifene inhibits the reaction [Estradiol results in increased expression of IL1A protein] CTD PMID:12079510 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Toremifene results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Serpinc1 serpin family C member 1 decreases expression ISO Toremifene results in decreased expression of SERPINC1 protein CTD PMID:14692654 NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192
JBrowse link
G Shbg sex hormone binding globulin increases expression
affects binding
ISO Toremifene results in increased expression of SHBG protein
Toremifene binds to SHBG protein
CTD PMID:14692654 PMID:25349334 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19786
    role 19732
      application 19423
        pharmaceutical 19321
          drug 19321
            antineoplastic agent 17310
              toremifene 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19786
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19675
                    main group molecular entity 19675
                      s-block molecular entity 19443
                        hydrogen molecular entity 19439
                          hydrides 18763
                            inorganic hydride 17484
                              pnictogen hydride 17461
                                nitrogen hydride 17315
                                  azane 17021
                                    ammonia 17020
                                      organic amino compound 17019
                                        tertiary amino compound 8677
                                          tertiary amine 618
                                            toremifene 10
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