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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tomatidine
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Accession:CHEBI:9629 term browser browse the term
Definition:A 3beta-hydroxy steroid resulting from the substitution of the 3beta-hydrogen of tomatidane by a hydroxy group.
Synonyms:exact_synonym: (22S,25S)-5alpha-spirosolan-3beta-ol
 related_synonym: (3beta,5alpha,22beta,25S)-spirosolan-3-ol;   5alpha-tomatidan-3beta-ol;   Formula=C27H45NO2;   InChI=1S/C27H45NO2/c1-16-7-12-27(28-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(29)8-10-25(18,3)21(20)9-11-26(22,24)4/h16-24,28-29H,5-15H2,1-4H3/t16-,17-,18-,19-,20+,21-,22-,23-,24-,25-,26-,27-/m0/s1;   InChIKey=XYNPYHXGMWJBLV-VXPJTDKGSA-N;   SMILES=[H][C@@]12CC[C@]3([H])[C@]([H])(CC[C@@]4(C)[C@@]3([H])C[C@]3([H])O[C@@]5(CC[C@H](C)CN5)[C@@H](C)[C@]43[H])[C@@]1(C)CC[C@H](O)C2;   Tomatidin
 xref: Beilstein:91747;   CAS:77-59-8;   KEGG:C10826;   KNApSAcK:C00002267
 xref_mesh: MESH:C003677
 xref: PMID:18544347;   PMID:21357296;   PMID:5704163;   PMID:6056488;   Patent:US2770618;   Reaxys:91747
 cyclic_relationship: is_conjugate_base_of CHEBI:166999


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tomatidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity ISO tomatidine results in decreased activity of BCHE protein CTD PMID:31152736 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO tomatidine results in decreased phosphorylation of MAPK1 protein CTD PMID:23566884 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO tomatidine results in decreased phosphorylation of MAPK3 protein CTD PMID:23566884 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
multiple interactions		 ISO tomatidine results in decreased expression of MMP2 mRNA; tomatidine results in decreased expression of MMP2 protein
tomatidine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein modified form]		 CTD PMID:23566884 PMID:31545954 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions		 ISO tomatidine results in decreased expression of MMP9 mRNA; tomatidine results in decreased expression of MMP9 protein
tomatidine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]		 CTD PMID:23566884 PMID:31545954 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs increases expression ISO tomatidine results in increased expression of RECK mRNA CTD PMID:23566884 NCBI chr 5:58,102,961...58,169,516
Ensembl chr 5:58,102,981...58,169,502 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO tomatidine results in decreased expression of RELA protein CTD PMID:23566884 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO tomatidine results in increased expression of TIMP1 mRNA CTD PMID:23566884 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      biological role 19805
        biochemical role 19515
          metabolite 19502
            alkaloid 7816
              spirosolane 8
                tomatidane 8
                  tomatidine 8
                    tomatidine 3-O-beta-D-glucopyranoside(1+) 0
                    tomatine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            organic molecule 19677
                              organic cyclic compound 19490
                                organic heterocyclic compound 18852
                                  organonitrogen heterocyclic compound 18148
                                    azaspiro compound 878
                                      spirosolane 8
                                        tomatidane 8
                                          tomatidine 8
                                            tomatidine 3-O-beta-D-glucopyranoside(1+) 0
                                            tomatine + 0
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