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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tomatidine
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Accession:CHEBI:9629 term browser browse the term
Definition:A 3beta-hydroxy steroid resulting from the substitution of the 3beta-hydrogen of tomatidane by a hydroxy group.
Synonyms:exact_synonym: (22S,25S)-5alpha-spirosolan-3beta-ol
 related_synonym: (3beta,5alpha,22beta,25S)-spirosolan-3-ol;   5alpha-tomatidan-3beta-ol;   Formula=C27H45NO2;   InChI=1S/C27H45NO2/c1-16-7-12-27(28-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(29)8-10-25(18,3)21(20)9-11-26(22,24)4/h16-24,28-29H,5-15H2,1-4H3/t16-,17-,18-,19-,20+,21-,22-,23-,24-,25-,26-,27-/m0/s1;   InChIKey=XYNPYHXGMWJBLV-VXPJTDKGSA-N;   SMILES=[H][C@@]12CC[C@]3([H])[C@]([H])(CC[C@@]4(C)[C@@]3([H])C[C@]3([H])O[C@@]5(CC[C@H](C)CN5)[C@@H](C)[C@]43[H])[C@@]1(C)CC[C@H](O)C2;   Tomatidin
 xref: Beilstein:91747;   CAS:77-59-8;   KEGG:C10826;   KNApSAcK:C00002267
 xref_mesh: MESH:C003677
 xref: PMID:18544347;   PMID:21357296;   PMID:5704163;   PMID:6056488;   Patent:US2770618;   Reaxys:91747
 cyclic_relationship: is_conjugate_base_of CHEBI:166999


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tomatidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity ISO tomatidine results in decreased activity of BCHE protein CTD PMID:31152736 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO tomatidine results in decreased phosphorylation of MAPK1 protein CTD PMID:23566884 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO tomatidine results in decreased phosphorylation of MAPK3 protein CTD PMID:23566884 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
multiple interactions
ISO tomatidine results in decreased expression of MMP2 mRNA; tomatidine results in decreased expression of MMP2 protein
tomatidine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein modified form]
CTD PMID:23566884 PMID:31545954 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
ISO tomatidine results in decreased expression of MMP9 mRNA; tomatidine results in decreased expression of MMP9 protein
tomatidine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]
CTD PMID:23566884 PMID:31545954 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs increases expression ISO tomatidine results in increased expression of RECK mRNA CTD PMID:23566884 NCBI chr 5:59,348,568...59,415,169
Ensembl chr 5:59,348,639...59,415,135
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO tomatidine results in decreased expression of RELA protein CTD PMID:23566884 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO tomatidine results in increased expression of TIMP1 mRNA CTD PMID:23566884 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19781
    role 19726
      biological role 19726
        biochemical role 19319
          metabolite 19301
            alkaloid 5651
              spirosolane 8
                tomatidane 8
                  tomatidine 8
                    tomatidine 3-O-beta-D-glucopyranoside(1+) 0
                    tomatine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19781
    subatomic particle 19779
      composite particle 19779
        hadron 19779
          baryon 19779
            nucleon 19779
              atomic nucleus 19779
                atom 19779
                  main group element atom 19669
                    p-block element atom 19669
                      carbon group element atom 19588
                        carbon atom 19578
                          organic molecular entity 19578
                            organic molecule 19510
                              organic cyclic compound 19337
                                organic heterocyclic compound 18550
                                  organonitrogen heterocyclic compound 17522
                                    azaspiro compound 819
                                      spirosolane 8
                                        tomatidane 8
                                          tomatidine 8
                                            tomatidine 3-O-beta-D-glucopyranoside(1+) 0
                                            tomatine + 0
paths to the root