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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tolterodine
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Accession:CHEBI:9622 term browser browse the term
Definition:A tertiary amine that has formula C22H31NO.
Synonyms:exact_synonym: 2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-methylphenol
 related_synonym: (+)-(R)-2-(alpha-(2-(Diisopropylamino)ethyl)benzyl)-p-cresol;   Formula=C22H31NO;   InChI=1S/C22H31NO/c1-16(2)23(17(3)4)14-13-20(19-9-7-6-8-10-19)21-15-18(5)11-12-22(21)24/h6-12,15-17,20,24H,13-14H2,1-5H3/t20-/m1/s1;   InChIKey=OOGJQPCLVADCPB-HXUWFJFHSA-N;   SMILES=CC(C)N(CC[C@H](c1ccccc1)c1cc(C)ccc1O)C(C)C;   tolterodina;   tolterodinum
 xref: Beilstein:8070733;   CAS:124937-51-5;   DrugBank:DB01036;   Drug_Central:2705;   KEGG:C07750;   KEGG:D00646;   LINCS:LSM-5645
 xref_mesh: MESH:C099041
 xref: Patent:EP325571;   Patent:US5382600;   Wikipedia:Tolterodine

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tolterodine tartrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Tolterodine Tartrate results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Ahr aryl hydrocarbon receptor decreases expression ISO Tolterodine Tartrate results in decreased expression of AHR mRNA CTD PMID:24316275 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO Tolterodine Tartrate binds to and results in decreased activity of CHRM2 protein CTD PMID:15140916 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions ISO Tolterodine Tartrate binds to and results in decreased activity of CHRM3 protein CTD PMID:15140916 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
multiple interactions
affects metabolic processing		 ISO CYP2D6 protein results in increased metabolism of Tolterodine Tartrate
Fluoxetine inhibits the reaction [CYP2D6 protein results in increased metabolism of Tolterodine Tartrate]
CYP2D6 polymorphism affects the metabolism of Tolterodine Tartrate		 CTD PMID:10583026 PMID:28087463 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
decreases expression		 ISO Tolterodine Tartrate inhibits the reaction [Dexamethasone results in increased expression of NR3C1 mRNA]
Tolterodine Tartrate results in decreased expression of NR3C1 mRNA		 CTD PMID:24316275 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Tolterodine Tartrate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    role 19833
      biological role 19833
        poison 18150
          toxin 14263
            uremic toxin 61
              p-cresol 55
                tolterodine 7
                  tolterodine tartrate 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon atom 19668
                          organic molecular entity 19668
                            organic molecule 19596
                              organic cyclic compound 19407
                                carbocyclic compound 18312
                                  benzenoid aromatic compound 17350
                                    benzenes 17091
                                      toluenes 6235
                                        hydroxytoluene 116
                                          cresol 112
                                            p-cresol 55
                                              tolterodine 7
                                                tolterodine tartrate 7
paths to the root