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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tolnaftate
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Accession:CHEBI:9620 term browser browse the term
Definition:A monothiocarbamic ester that is the methyl(3-tolyl)carbamothioate ester of 2-naphthol. A synthetic anti-fungal agent used to treat jock itch, athlete's foot and ringworm.
Synonyms:exact_synonym: O-2-naphthyl methyl(3-methylphenyl)carbamothioate
 related_synonym: 2-Naphthyl N-methyl-N-(3-tolyl)thionocarbamate;   Formula=C19H17NOS;   InChI=1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3;   InChIKey=FUSNMLFNXJSCDI-UHFFFAOYSA-N;   Methyl (3-methylphenyl)carbamothioic acid O-2-naphthalenyl ester;   N-methyl-N-(3-methylphenyl)-1-(naphthalen-2-yloxy)methanethioamide;   O-2-Naphthyl m,N-dimethylthiocarbanilate;   SMILES=CN(C(=S)Oc1ccc2ccccc2c1)c1cccc(C)c1;   Separin;   Tinactin;   Tolnaphthate;   m,N-Dimethylthiocarbanilic acid O-2-naphthyl ester;   tolnaftato;   tolnaftatum
 xref: CAS:2398-96-1;   DrugBank:DB00525;   Drug_Central:3617;   HMDB:HMDB0005005;   KEGG:D00381;   LINCS:LSM-5554
 xref_mesh: MESH:D014047
 xref: PMID:20347664;   PMID:2061794;   PMID:20635527;   PMID:21565546;   PMID:22125963;   PMID:24706116;   PMID:3509341;   PMID:4568708;   PMID:5319027;   PMID:5705341;   PMID:5745067;   PMID:5847820;   PMID:5856396;   PMID:5952516;   PMID:697362;   Patent:US2010035939;   Patent:WO2010037089;   Reaxys:2752620;   Wikipedia:Tolnaftate


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tolnaftate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLI1 GLI family zinc finger 1 multiple interactions EXP
ISO		 Tolnaftate inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 NCBI chr12:57,459,785...57,472,268
Ensembl chr12:57,459,785...57,472,268 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions EXP Tolnaftate inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656 		JBrowse link
G IL4 interleukin 4 multiple interactions
decreases expression
decreases secretion		 EXP 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased expression of IL4 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased secretion of IL4 protein]; Bucladesine inhibits the reaction [Tolnaftate results in decreased expression of IL4 mRNA]; Bucladesine inhibits the reaction [Tolnaftate results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Tolnaftate results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Tolnaftate results in decreased secretion of IL4 protein] CTD PMID:11886533 PMID:15284827 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G IL5 interleukin 5 multiple interactions
decreases secretion
decreases expression		 EXP 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein]; Bucladesine inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA]; Bucladesine inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein] CTD PMID:11886533 PMID:15284827 NCBI chr 5:132,541,445...132,556,815
Ensembl chr 5:132,541,445...132,556,838 		JBrowse link
G SHH sonic hedgehog signaling molecule multiple interactions EXP
ISO		 Tolnaftate inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 NCBI chr 7:155,799,980...155,812,463
Ensembl chr 7:155,799,980...155,812,463 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    role 25957
      chemical role 24249
        antioxidant 17501
          radical scavenger 7216
            2-naphthol 34
              tolnaftate 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    main group molecular entity 25841
                      s-block molecular entity 25162
                        hydrogen molecular entity 24761
                          hydrides 22973
                            organic hydride 21936
                              organic fundamental parent 21936
                                hydrocarbon 21359
                                  cyclic hydrocarbon 20003
                                    arene 19983
                                      polycyclic arene 19679
                                        ortho-fused polycyclic arene 10295
                                          ortho-fused bicyclic arene 2407
                                            naphthalene 2350
                                              naphthol 197
                                                2-naphthol 34
                                                  tolnaftate 5
paths to the root