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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Tiron
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Accession:CHEBI:9607 term browser browse the term
Definition:An organic molecular entity that has formula C6H4O8S2.2Na.
Synonyms:related_synonym: Formula=C6H4O8S2.2Na;   InChI=1S/C6H6O8S2.2Na/c7-4-1-3(15(9,10)11)2-5(6(4)8)16(12,13)14;;/h1-2,7-8H,(H,9,10,11)(H,12,13,14);;/q;2*+1/p-2;   InChIKey=ISWQCIVKKSOKNN-UHFFFAOYSA-L;   SMILES=[Na+].[Na+].Oc1cc(cc(c1O)S([O-])(=O)=O)S([O-])(=O)=O
 xref: CAS:149-45-1;   KEGG:C11159
 xref_mesh: MESH:D014013



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Tiron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Oxygen results in increased expression of ACTA2 protein] CTD PMID:23517783 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Agt angiotensinogen multiple interactions ISO
EXP
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA]
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Glucose results in increased expression of AGT mRNA]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Glucose results in increased expression of AGT protein]
CTD PMID:12130563 PMID:15677497 PMID:17391658 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Arsenic Trioxide results in increased expression of ATF4 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Bortezomib results in increased expression of ATF4 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [perfluorooctanoic acid results in increased expression of ATF4 mRNA]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt promotes the reaction [Hydrogen Peroxide results in increased expression of ATF4 mRNA] CTD PMID:15509775 PMID:23892647 PMID:32578922 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [arsenic trioxide results in increased expression of and results in increased cleavage of ATF6 protein] CTD PMID:23892647 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of BAD protein] CTD PMID:22915474 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of BAX protein] CTD PMID:22915474 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [arsenic trioxide results in increased expression of BBC3 mRNA] CTD PMID:23892647 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline results in decreased expression of BCL2 protein] CTD PMID:17395010 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Becn1 beclin 1 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [9-bromo-5-(4,5-dimethoxy-1,3-dihydroisobenzofuran-1-yl)-4-methoxy-6-methyl-5,6,7,8-tetrahydro-(1,3)-dioxolo(4,5-g)isoquinoline results in increased expression of BECN1 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Rotenone results in increased expression of BECN1 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Thenoyltrifluoroacetone results in increased expression of BECN1 protein] CTD PMID:18032788 PMID:20404319 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Casp3 caspase 3 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt affects the reaction [Bortezomib results in increased cleavage of CASP3 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [4-nerolidylcatechol results in increased cleavage of CASP3 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [5-methylselenylmethyl-2'-deoxyuridine results in increased cleavage of and results in increased activity of CASP3 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [5-phenylselenylmethyl-2'-deoxyuridine results in increased cleavage of and results in increased activity of CASP3 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased cleavage of CASP3 protein]
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt results in increased cleavage of and results in increased activity of CASP3 protein
CTD PMID:15509775 PMID:22002103 PMID:22372875 PMID:22915474 PMID:23892647 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [N,N-dimethylphytosphingosine results in increased activity of CASP8 protein] CTD PMID:19481559 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt affects the reaction [Bortezomib results in increased cleavage of CASP9 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [4-nerolidylcatechol results in increased cleavage of CASP9 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [5-methylselenylmethyl-2'-deoxyuridine results in increased cleavage of CASP9 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [5-phenylselenylmethyl-2'-deoxyuridine results in increased cleavage of CASP9 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased cleavage of CASP9 protein] CTD PMID:15509775 PMID:22002103 PMID:22372875 PMID:22915474 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CAT protein] CTD PMID:33368846 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of CCL2 mRNA] CTD PMID:22915474 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein] CTD PMID:22648416 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdk2 cyclin dependent kinase 2 increases activity ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt results in increased activity of CDK2 protein CTD PMID:22785532 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [arsenic trioxide results in increased expression of CDKN1A mRNA] CTD PMID:22532027 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Ctsb cathepsin B multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Bortezomib results in increased localization of CTSB protein] CTD PMID:16446371 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt results in increased expression of CXCL1 protein CTD PMID:17395010 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Paraquat results in increased expression of CXCL2 protein] CTD PMID:16919916 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt results in increased expression of CXCL1 protein CTD PMID:17395010 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Bortezomib results in increased expression of DDIT3 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Hydrogen Peroxide results in increased expression of DDIT3 mRNA] CTD PMID:15509775 PMID:23892647 PMID:32578922 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA] CTD PMID:17391658 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A multiple interactions
decreases phosphorylation
ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [arsenic trioxide results in increased phosphorylation of EIF2A protein]
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt results in decreased phosphorylation of EIF2A protein
CTD PMID:23892647 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of FN1 mRNA]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of FN1 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [nickel chloride results in increased expression of FN1 protein] CTD PMID:22648416 PMID:22915474 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [nickel chloride results in increased expression of HIF1A protein] CTD PMID:22648416 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Cadmium Chloride results in increased activity of HMOX1 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Zinc results in increased expression of HMOX1 mRNA]
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HMOX1 protein]
CTD PMID:20934533 PMID:22564156 PMID:26945724 PMID:33368846 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [arsenic trioxide results in increased expression of HSPA5 protein] CTD PMID:23892647 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions ISO HSPB1 protein inhibits the reaction [1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Hydrogen Peroxide results in increased activity of MAPK1 protein]]; HSPB1 protein inhibits the reaction [1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Hydrogen Peroxide results in increased activity of MAPK3 protein]]; HSPB1 protein inhibits the reaction [1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt results in decreased susceptibility to Hydrogen Peroxide] CTD PMID:14975446 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Ifng interferon gamma multiple interactions EXP 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Free Radicals]]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]] CTD PMID:16488514 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein] CTD PMID:17458902 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [IL1B protein results in increased expression of MMP1 protein] CTD PMID:16987005 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il24 interleukin 24 decreases activity ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt results in decreased activity of IL24 protein CTD PMID:14678967 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of IL6 mRNA] CTD PMID:22915474 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein] CTD PMID:17458902 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]] CTD PMID:15677497 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein] CTD PMID:17458902 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of KEAP1 protein] CTD PMID:33368846 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[Apigenin results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Patulin results in increased phosphorylation of MAPK1 protein]
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Hydrogen Peroxide results in increased activity of MAPK1 protein]; HSPB1 protein inhibits the reaction [1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Hydrogen Peroxide results in increased activity of MAPK1 protein]]
CTD PMID:14975446 PMID:17090621 PMID:17458902 PMID:19647729 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Hydrogen Peroxide results in increased activity of MAPK3 protein]; HSPB1 protein inhibits the reaction [1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Hydrogen Peroxide results in increased activity of MAPK3 protein]]
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[Apigenin results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Patulin results in increased phosphorylation of MAPK3 protein]
CTD PMID:14975446 PMID:17090621 PMID:17458902 PMID:19647729 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [IL1B protein results in increased expression of MMP1 protein] CTD PMID:16987005 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Acrolein results in increased expression of MMP9 protein] CTD PMID:19371603 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mrtfa myocardin related transcription factor A multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Oxygen affects the localization of MRTFA protein] CTD PMID:23517783 NCBI chr 7:112,544,312...112,714,431
Ensembl chr 7:112,544,312...112,714,418
JBrowse link
G Ndrg1 N-myc downstream regulated 1 increases expression ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt results in increased expression of NDRG1 mRNA; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt results in increased expression of NDRG1 protein CTD PMID:11006124 NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization
multiple interactions
ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt affects the localization of NFE2L2 protein
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NFE2L2 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 mRNA]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 protein]
CTD PMID:22488045 PMID:22564156 PMID:33368846 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases activity ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt results in increased activity of NFKB1 protein CTD PMID:17395010 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]] CTD PMID:16488514 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Nickel results in decreased expression of [NOS3 protein binds to NOS3 protein]] CTD PMID:23788629 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [5-methylselenylmethyl-2'-deoxyuridine results in increased cleavage of PARP1 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [5-phenylselenylmethyl-2'-deoxyuridine results in increased cleavage of PARP1 protein] CTD PMID:22002103 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Plk4 polo-like kinase 4 increases expression ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt results in increased expression of PLK4 protein CTD PMID:22785532 NCBI chr 2:123,802,512...123,820,942
Ensembl chr 2:123,802,512...123,820,942
JBrowse link
G Pln phospholamban multiple interactions EXP 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Ditiocarb results in increased phosphorylation of PLN protein] CTD PMID:16288776 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [4-nerolidylcatechol results in increased expression of PMAIP1 protein] CTD PMID:22372875 NCBI chr18:59,986,187...59,990,174
Ensembl chr18:59,986,017...59,992,429
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions EXP
ISO
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Ketoconazole results in increased expression of PRKN mRNA]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Ketoconazole results in increased expression of PRKN protein]
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]
CTD PMID:22872702 PMID:25787151 NCBI chr 1:48,688,651...49,882,520 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity
decreases phosphorylation
ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [arsenic trioxide results in increased phosphorylation of RELA protein]
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt results in increased activity of RELA protein
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt results in decreased phosphorylation of RELA protein
CTD PMID:17395010 PMID:22488045 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Oxygen results in increased activity of RHOA protein] CTD PMID:21439370 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions EXP 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form] CTD PMID:19168439 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [perfluorooctanoic acid results in increased expression of SOD1 mRNA]; [1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt co-treated with Thapsigargin] results in decreased expression of SOD1 mRNA CTD PMID:32578922 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [manganese chloride results in increased expression of SOD2 mRNA]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [manganese chloride results in increased expression of SOD2 protein] CTD PMID:10328827 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO SP1 protein affects the reaction [1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt results in decreased expression of TGFB1 mRNA] CTD PMID:11163763 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of TGFB1 mRNA]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of TGFB1 protein]
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt results in decreased expression of TGFB1 mRNA
SP1 protein affects the reaction [1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt results in decreased expression of TGFB1 mRNA]
CTD PMID:11163763 PMID:22915474 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]] CTD PMID:16488514 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of VCAM1 mRNA] CTD PMID:22915474 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link

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  CHEBI ontology 19823
    chemical entity 19823
      atom 19821
        nonmetal atom 19709
          carbon atom 19633
            organic molecular entity 19633
              Tiron 62
Path 2
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  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            Tiron 62
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