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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thiamylal
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Accession:CHEBI:9536 term browser browse the term
Definition:A member of the class of barbiturates that is 2-thioxodihydropyrimidine-4,6(1H,5H)-dione substituted by a pentan-2-yl and prop-2-en-1-yl group at position 5.
Synonyms:exact_synonym: 5-(pentan-2-yl)-5-(prop-2-en-1-yl)-2-sulfanylidenedihydropyrimidine-4,6(1H,5H)-dione
 related_synonym: 5-Allyl-5-(1-methylbutyl)-2-thiobarbituric acid;   5-allyl-5-(1-methylbutyl)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione;   5-allyl-5-(1-methylbutyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione;   Formula=C12H18N2O2S;   InChI=1S/C12H18N2O2S/c1-4-6-8(3)12(7-5-2)9(15)13-11(17)14-10(12)16/h5,8H,2,4,6-7H2,1,3H3,(H2,13,14,15,16,17);   InChIKey=XLOMZPUITCYLMJ-UHFFFAOYSA-N;   SMILES=CCCC(C)C1(CC=C)C(=O)NC(=S)NC1=O;   dihydro-5-(1-methylbutyl)-5-(2-propenyl)-2-thioxo-4,6(1H,5H)-pyrimidinedione;   thioseconal
 xref: Beilstein:225331;   CAS:77-27-0;   DrugBank:DB01154;   Drug_Central:2626;   HMDB:HMDB0015285;   KEGG:C07846;   KEGG:D06106;   LINCS:LSM-4367
 xref_mesh: MESH:D013840
 xref: PMID:1943061;   PMID:20434100;   PMID:23852608;   PMID:24351886;   Reaxys:225331;   Wikipedia:Thiamylal


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thiamylal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Thiamylal inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of JUN mRNA] CTD PMID:15263067 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO Thiamylal inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of KRAS protein] CTD PMID:15263067 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Thiamylal results in decreased phosphorylation of MAPK1 protein CTD PMID:15263067 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO Thiamylal results in decreased phosphorylation of MAPK3 protein CTD PMID:15263067 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO Thiamylal inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of RAC1 protein] CTD PMID:15263067 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link

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  CHEBI ontology 19821
    role 19769
      biological role 19769
        biophysical role 13085
          membrane transport modulator 12899
            GABA modulator 4663
              barbiturates 4392
                thiamylal 5
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  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic heterocyclic compound 18591
                                  organic heteromonocyclic compound 17084
                                    diazines 12328
                                      pyrimidines 12157
                                        pyrimidone 8856
                                          barbiturates 4392
                                            thiamylal 5
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