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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide
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Accession:CHEBI:95129 term browser browse the term
Definition:A benzamide that has formula C23H29ClFN3O4.
Synonyms:related_synonym: Formula=C23H29ClFN3O4;   InChI=1S/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29);   InChIKey=DCSUBABJRXZOMT-UHFFFAOYSA-N;   R 51619;   R51619;   SMILES=COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F;   acenalin;   alimix;   cipril;   cisapride monohydrate;   coordinax;   prepulsid;   propulsid;   risamal
 xref: CAS:81098-60-4;   Drug_Central:660;   LINCS:LSM-6397
 xref_mesh: MESH:D020117



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4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Cisapride results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA] CTD PMID:31150804 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
JBrowse link
G Ctsk cathepsin K multiple interactions ISO Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA] CTD PMID:31150804 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
affects metabolic processing
multiple interactions
affects chemical synthesis
ISO Cisapride results in decreased activity of CYP3A4 protein
CYP3A4 protein affects the metabolism of Cisapride
Cisapride inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]
CYP3A4 protein affects the chemical synthesis of Cisapride metabolite
CTD PMID:11717173 PMID:15306208 PMID:19299527 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein multiple interactions ISO Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA] CTD PMID:31150804 NCBI chr 7:70,807,455...70,822,067
Ensembl chr 7:70,807,581...70,822,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA] CTD PMID:31150804 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
affects localization
affects binding
decreases activity
ISO beta-Cyclodextrins analog inhibits the reaction [Cisapride results in decreased activity of KCNH2 protein]; Cisapride binds to and results in decreased activity of KCNH2 protein; Cisapride inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Cisapride affects the localization of KCNH2 protein mutant form
Cisapride binds to KCNH2 protein
CTD PMID:9395068 PMID:10531299 PMID:11005845 PMID:11741928 PMID:12388285 More... NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA] CTD PMID:31150804 NCBI chr18:74,046,421...74,156,041
Ensembl chr18:74,046,904...74,156,028
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 increases localization ISO Cisapride results in increased localization of SCN5A protein mutant form CTD PMID:16301357 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Cisapride inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]; Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA] CTD PMID:31150804 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19812
      atom 19811
        nonmetal atom 19698
          nitrogen atom 18774
            nitrogen molecular entity 18774
              amide 17590
                aromatic amide 7463
                  arenecarboxamide 7271
                    benzamides 7271
                      4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19710
                    p-block element atom 19710
                      carbon group element atom 19631
                        carbon atom 19621
                          organic molecular entity 19621
                            organic group 18730
                              organic divalent group 18721
                                organodiyl group 18721
                                  carbonyl group 18670
                                    carbonyl compound 18670
                                      carboxylic acid 18367
                                        carboacyl group 17487
                                          univalent carboacyl group 17487
                                            carbamoyl group 17303
                                              carboxamide 17303
                                                monocarboxylic acid amide 15020
                                                  arenecarboxamide 7271
                                                    benzamides 7271
                                                      4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide 11
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