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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:MST-312
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Accession:CHEBI:95003 term browser browse the term
Definition:A member of the class of benzamides that results from the formal condensation of the two amino groups of benzene-1,3-diamine with the carboxylic acid groups of two molar equivalents of 2,3-dihydroxybenzoic acid. It is telomerase inhibitor (IC50 = 0.67 muM in a TRAP assay) and exhibits antineoplastic activity.
Synonyms:exact_synonym: N,N'-benzene-1,3-diylbis(2,3-dihydroxybenzamide)
 related_synonym: Formula=C20H16N2O6;   InChI=1S/C20H16N2O6/c23-15-8-2-6-13(17(15)25)19(27)21-11-4-1-5-12(10-11)22-20(28)14-7-3-9-16(24)18(14)26/h1-10,23-26H,(H,21,27)(H,22,28);   InChIKey=MIQUEZGHEJGPJB-UHFFFAOYSA-N;   MST312;   N,N'-(1,3-phenylene)bis(2,3-dihydroxybenzamide);   N,N'-bis(2,3-dihydroxybenzoyl)-1,3-phenylenediamine;   N-[3-[[(2,3-dihydroxyphenyl)-oxomethyl]amino]phenyl]-2,3-dihydroxybenzamide;   SMILES=OC1=CC=CC(C(=O)NC2=CC(NC(=O)C3=C(O)C(O)=CC=C3)=CC=C2)=C1O;   telomerase inhibitor IX
 xref: CAS:368449-04-1;   LINCS:LSM-6230
 xref_mesh: MESH:C470197
 xref: PMID:12479362;   PMID:25596016;   PMID:26022158;   PMID:26022559;   PMID:26178994;   PMID:27279256;   PMID:28520570;   PMID:29604359;   PMID:30170357;   PMID:31012504;   PMID:31029779;   PMID:31921617;   PMID:33922244;   PMID:34957975;   PMID:35809296;   PMID:35811464;   PMID:36274541;   PMID:36378860;   PMID:38216120;   PMID:38252348;   PMID:38765717


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MST-312 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G H2ax H2A.X variant histone increases expression ISO MST 312 results in increased expression of H2AX protein modified form CTD PMID:26022559 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 19917
    role 19887
      biological role 19885
        biochemical role 19569
          apoptosis inducer 13664
            MST-312 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    p-block element atom 19855
                      carbon group element atom 19774
                        carbon atom 19790
                          organic molecular entity 19790
                            heteroorganic entity 19549
                              organochalcogen compound 19309
                                organooxygen compound 19204
                                  carbon oxoacid 18689
                                    carboxylic acid 18686
                                      carboacyl group 17723
                                        univalent carboacyl group 17704
                                          carbamoyl group 17574
                                            carboxamide 17574
                                              monocarboxylic acid amide 15749
                                                arenecarboxamide 8258
                                                  benzamides 8258
                                                    MST-312 1
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