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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one
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Accession:CHEBI:94995 term browser browse the term
Definition:A quinuclidine that has formula C9H15NO3.
Synonyms:related_synonym: Formula=C9H15NO3;   InChI=1S/C9H15NO3/c11-5-9(6-12)8(13)7-1-3-10(9)4-2-7/h7,11-12H,1-6H2;   InChIKey=RFBVBRVVOPAAFS-UHFFFAOYSA-N;   SMILES=C1CN2CCC1C(=O)C2(CO)CO
 xref: LINCS:LSM-6220
 xref_mesh: MESH:C451219



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2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of BAX; 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of BAX mRNA; 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of BAX protein
Cisplatin promotes the reaction [2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of BAX mRNA]; TP53 protein affects the reaction [2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of BAX mRNA]
CTD PMID:21109480 PMID:21647879 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one promotes the reaction [Cisplatin results in increased expression of BBC3 mRNA] CTD PMID:21109480 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in decreased expression of BCL2L1 protein CTD PMID:21109480 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 multiple interactions ISO 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:21109480 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of CDKN1A; 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of CDKN1A mRNA; 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of CDKN1A protein
Cisplatin promotes the reaction [2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of CDKN1A mRNA]; Cisplatin promotes the reaction [2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of CDKN1A protein]; TP53 protein affects the reaction [2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of CDKN1A mRNA]
CTD PMID:21109480 PMID:21647879 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of MDM2 CTD PMID:21647879 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions ISO [2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one co-treated with Cisplatin] results in increased expression of PMAIP1 mRNA CTD PMID:21109480 NCBI chr18:59,986,187...59,990,174
Ensembl chr18:59,986,017...59,992,429
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases activity
ISO 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one inhibits the reaction [TP53 protein mutant form binds to TP73 protein]; 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one promotes the reaction [Cisplatin results in increased localization of TP53 protein mutant form]; 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one promotes the reaction [TP53 protein results in increased susceptibility to resveratrol]; 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of and results in increased localization of and results in increased activity of TP53 protein mutant form; TP53 protein affects the reaction [2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of BAX mRNA]; TP53 protein affects the reaction [2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of CDKN1A mRNA]
2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased activity of TP53 protein; TP53 protein mutant form results in increased activity of 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one
CTD PMID:15860260 PMID:21109480 PMID:21647879 PMID:23152798 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tp73 tumor protein p73 multiple interactions ISO 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one inhibits the reaction [TP53 protein mutant form binds to TP73 protein] CTD PMID:21647879 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one inhibits the reaction [Progestins results in increased expression of VEGFA mRNA] CTD PMID:15860260 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

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  CHEBI ontology 19795
    chemical entity 19795
      group 19717
        inorganic group 19241
          oxo group 18646
            organic oxo compound 18646
              carbonyl compound 18646
                ketone 16955
                  cyclic ketone 15523
                    2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            organic group 18713
                              organic divalent group 18697
                                organodiyl group 18697
                                  carbonyl group 18646
                                    carbonyl compound 18646
                                      ketone 16955
                                        cyclic ketone 15523
                                          2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one 10
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