Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one
go back to main search page
Accession:CHEBI:94995 term browser browse the term
Definition:A quinuclidine that has formula C9H15NO3.
Synonyms:related_synonym: Formula=C9H15NO3;   InChI=1S/C9H15NO3/c11-5-9(6-12)8(13)7-1-3-10(9)4-2-7/h7,11-12H,1-6H2;   InChIKey=RFBVBRVVOPAAFS-UHFFFAOYSA-N;   SMILES=C1CN2CCC1C(=O)C2(CO)CO
 xref: LINCS:LSM-6220
 xref_mesh: MESH:C451219


show annotations for term's descendants           Sort by:
 
2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of BAX; 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of BAX mRNA; 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of BAX protein
Cisplatin promotes the reaction [2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of BAX mRNA]; TP53 protein affects the reaction [2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of BAX mRNA]
CTD PMID:21109480 PMID:21647879 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one promotes the reaction [Cisplatin results in increased expression of BBC3 mRNA] CTD PMID:21109480 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in decreased expression of BCL2L1 protein CTD PMID:21109480 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 multiple interactions ISO 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:21109480 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of CDKN1A; 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of CDKN1A mRNA; 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of CDKN1A protein
Cisplatin promotes the reaction [2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of CDKN1A mRNA]; Cisplatin promotes the reaction [2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of CDKN1A protein]; TP53 protein affects the reaction [2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of CDKN1A mRNA]
CTD PMID:21109480 PMID:21647879 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of MDM2 CTD PMID:21647879 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions ISO [2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one co-treated with Cisplatin] results in increased expression of PMAIP1 mRNA CTD PMID:21109480 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases activity
ISO 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one inhibits the reaction [TP53 protein mutant form binds to TP73 protein]; 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one promotes the reaction [Cisplatin results in increased localization of TP53 protein mutant form]; 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one promotes the reaction [TP53 protein results in increased susceptibility to resveratrol]; 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of and results in increased localization of and results in increased activity of TP53 protein mutant form; TP53 protein affects the reaction [2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of BAX mRNA]; TP53 protein affects the reaction [2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of CDKN1A mRNA]
2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased activity of TP53 protein; TP53 protein mutant form results in increased activity of 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one
CTD PMID:15860260 PMID:21109480 PMID:21647879 PMID:23152798 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp73 tumor protein p73 multiple interactions ISO 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one inhibits the reaction [TP53 protein mutant form binds to TP73 protein] CTD PMID:21647879 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one inhibits the reaction [Progestins results in increased expression of VEGFA mRNA] CTD PMID:15860260 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      group 19722
        inorganic group 19180
          oxo group 18427
            organic oxo compound 18427
              carbonyl compound 18427
                ketone 16171
                  cyclic ketone 13874
                    2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      ketone 16171
                                        cyclic ketone 13874
                                          2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one 10
paths to the root