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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide
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Accession:CHEBI:94988 term browser browse the term
Definition:An organohalogen compound that has formula C15H11Cl2NO3.
Synonyms:related_synonym: Formula=C15H11Cl2NO3;   InChI=1S/C15H11Cl2NO3/c16-10-2-1-3-11(17)14(10)15(19)18-7-9-4-5-12-13(6-9)21-8-20-12/h1-6H,7-8H2,(H,18,19);   InChIKey=NMKJFZCBCIUYHI-UHFFFAOYSA-N;   SMILES=C1OC2=C(O1)C=C(C=C2)CNC(=O)C3=C(C=CC=C3Cl)Cl
 xref: LINCS:LSM-6212
 xref_mesh: MESH:C531525


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N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member increases activity
multiple interactions
increases expression
EXP
ISO
N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide results in increased activity of ALDH2 protein
Alda-1 (N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide) increases activity of ALDH2 protein in liver in rat
ALDH2 protein affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide results in increased expression of ALDH2 protein]; ALDH2 protein affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide results in increased expression of BMP2 protein]; N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Acetaldehyde results in decreased expression of ALDH2 protein]; N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of ALDH2 protein]
CTD PMID:24496638 PMID:25263579 PMID:28017615 PMID:29128638, PMID:29589772 RGD:14975297 NCBI chr12:34,949,549...34,982,527 JBrowse link
G Atg5 autophagy related 5 multiple interactions EXP 3-methyladenine inhibits the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of ATG5 protein]]; N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of ATG5 protein]; Sirolimus promotes the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of ATG5 protein]]; ULK1 protein affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of ATG5 protein]] CTD PMID:29128638 NCBI chr20:47,798,222...47,889,216 JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP
N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Rotenone results in increased expression of BAX protein] CTD PMID:25263579 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression
multiple interactions
EXP N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide results in increased expression of BMP2 mRNA; N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide results in increased expression of BMP2 protein
ALDH2 protein affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide results in increased expression of BMP2 protein]; N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Acetaldehyde results in decreased expression of BMP2 protein]; N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide results in increased expression of and results in increased secretion of BMP2 protein
CTD PMID:28017615 NCBI chr 3:120,812,660...120,822,579 JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Rotenone results in increased activity of CASP3 protein] CTD PMID:25263579 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp9 caspase 9 multiple interactions ISO
EXP
N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Rotenone results in increased activity of CASP9 protein] CTD PMID:25263579 NCBI chr 5:154,108,872...154,126,628 JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP 3-methyladenine inhibits the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of MAP1LC3B protein]]; N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of MAP1LC3B protein]; Sirolimus promotes the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of MAP1LC3B protein]]; ULK1 protein affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of MAP1LC3B protein]] CTD PMID:29128638 NCBI chr19:49,665,795...49,673,655 JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP 3-methyladenine inhibits the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in increased expression of SQSTM1 protein]]; N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in increased expression of SQSTM1 protein]; Sirolimus promotes the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in increased expression of SQSTM1 protein]]; ULK1 protein affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in increased expression of SQSTM1 protein]] CTD PMID:29128638 NCBI chr10:34,525,517...34,536,685 JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 multiple interactions EXP 3-methyladenine affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide affects the reaction [Glucose affects the phosphorylation of ULK1 protein]]; bafilomycin A1 affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide affects the reaction [Glucose affects the phosphorylation of ULK1 protein]]; N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide affects the reaction [Glucose affects the phosphorylation of ULK1 protein]; Sirolimus affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide affects the reaction [Glucose affects the phosphorylation of ULK1 protein]]; ULK1 protein affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide affects the reaction [Glucose affects the phosphorylation of ULK1 protein]]; ULK1 protein affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of ATG5 protein]]; ULK1 protein affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of MAP1LC3B protein]]; ULK1 protein affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in increased expression of SQSTM1 protein]] CTD PMID:29128638 NCBI chr12:45,851,710...45,877,966 JBrowse link

Term paths to the root
Path 1
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  CHEBI ontology 19762
    chemical entity 19762
      molecular entity 19760
        polyatomic entity 19680
          heteroatomic molecular entity 19610
            halide 18083
              organohalogen compound 17857
                N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19762
    subatomic particle 19760
      composite particle 19760
        hadron 19760
          baryon 19760
            nucleon 19760
              atomic nucleus 19760
                atom 19760
                  main group element atom 19651
                    p-block element atom 19651
                      carbon group element atom 19570
                        carbon atom 19560
                          organic molecular entity 19560
                            organic group 18611
                              organic divalent group 18602
                                organodiyl group 18602
                                  carbonyl group 18519
                                    carbonyl compound 18519
                                      N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide 9
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