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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thiram
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Accession:CHEBI:9495 term browser browse the term
Definition:An organic disulfide that results from the formal oxidative dimerisation of N,N-dimethyldithiocarbamic acid. It is widely used as a fungicidal seed treatment.
Synonyms:exact_synonym: [disulfanediylbis(carbonothioylnitrilo)]tetramethane
 related_synonym: Arasan;   Bis(dimethyl-thiocarbamoyl)-disulfid;   Formula=C6H12N2S4;   InChI=1S/C6H12N2S4/c1-7(2)5(9)11-12-6(10)8(3)4/h1-4H3;   InChIKey=KUAZQDVKQLNFPE-UHFFFAOYSA-N;   N(1),N(1),N(3),N(3)-tetramethyl-2-dithioperoxy-1,3-dithiodicarbonic diamide;   N,N'-(dithiodicarbonothioyl)bis(N-methylmethanamine);   N,N-tetramethylthiuram disulfide;   Nomersan;   Pomarsol;   Rezifilm;   SMILES=CN(C)C(=S)SSC(=S)N(C)C;   TMTD;   Tetramethyl-thiram disulfid;   Tetramethylthioperoxydicarbonic diamide;   [Me2NC(S)S]2;   alpha,alpha'-dithiobis(dimethylthio)formamide;   bis((dimethylamino)carbonothioyl) disulfide;   bis(dimethyl thiocarbamoyl)disulfide;   bis(dimethylthiocarbamoyl) disulfide;   disulfure de tetramethylthiourame;   tetramethylenethiuram disulfide;   tetramethylthiuram disulfide;   tetramethylthiurane disulfide;   tetrathiuram disulfide;   thirame;   thiramum;   thiuram;   tiramo
 xref: CAS:137-26-8;   Drug_Central:3601;   KEGG:C11160;   KEGG:D06114
 xref_mesh: MESH:D013893
 xref: PMID:14587840;   PMID:1842585;   PMID:20940038;   PMID:3055654;   PMID:3176026;   PPDB:642;   Pesticides:thiram;   Reaxys:1725821;   Wikipedia:Thiram


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thiram term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c2 aldo-keto reductase family 1, member C2 increases activity ISO Thiram results in increased activity of AKR1C2 promoter CTD PMID:21195160 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 increases expression ISO Thiram results in increased expression of AMPD3 mRNA CTD PMID:24211530 NCBI chr 1:175,585,301...175,630,479
Ensembl chr 1:175,586,097...175,630,467
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Thiram results in increased expression of ATF3 mRNA CTD PMID:23999411, PMID:27965148 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Casp1 caspase 1 affects expression ISO Thiram affects the expression of CASP1 protein CTD PMID:25929180 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 decreases expression ISO Thiram results in decreased expression of CCR2 mRNA CTD PMID:19371601
G Cd86 CD86 molecule increases expression ISO Thiram results in increased expression of CD86 protein CTD PMID:19665512 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression ISO Thiram results in increased expression of CREB1 mRNA CTD PMID:20385217 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crem cAMP responsive element modulator increases expression ISO Thiram results in increased expression of CREM mRNA CTD PMID:19371601 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing
multiple interactions
EXP CYP2E1 protein results in increased metabolism of Thiram
Thiram inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]
CTD PMID:12458634 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Thiram results in increased expression of DNAJB4 mRNA CTD PMID:23999411, PMID:27965148 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO Thiram results in increased expression of FTH1 mRNA CTD PMID:24211530 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO Thiram results in increased expression of FTL mRNA CTD PMID:24211530 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Thiram results in increased expression of GCLM mRNA CTD PMID:23999411, PMID:24211530, PMID:27965148 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Thiram results in increased expression of HMOX1 mRNA CTD PMID:23445166, PMID:24211530 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions
decreases activity
ISO Dithiothreitol inhibits the reaction [Thiram results in decreased activity of HSD11B2 protein]; Ethylmaleimide promotes the reaction [Thiram results in decreased activity of HSD11B2 protein]; Thiram inhibits the reaction [HSD11B2 protein results in increased oxidation of Dexamethasone] CTD PMID:12901862, PMID:16857225, PMID:22796344 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression
ISO Thiram promotes the reaction [TNF protein results in increased expression of ICAM1 protein]
Thiram results in increased expression of ICAM1 protein
CTD PMID:25752435 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma increases expression ISO Thiram results in increased expression of IFNG protein CTD PMID:12062936 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il18 interleukin 18 increases expression ISO Thiram results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il4 interleukin 4 increases expression ISO Thiram results in increased expression of IL4 protein CTD PMID:12062936 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Lep leptin multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lepr leptin receptor multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in decreased expression of LEPR mRNA CTD PMID:29321614 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO Thiram results in increased expression of MYC mRNA CTD PMID:24211530 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase increases expression ISO Thiram results in increased expression of NAMPT mRNA CTD PMID:19371601 NCBI chr 6:52,122,085...52,156,473
Ensembl chr 6:52,122,085...52,156,472
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO Thiram results in decreased expression of NFKB1 mRNA CTD PMID:20385217 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 affects expression ISO Thiram affects the expression of NLRP3 protein CTD PMID:25929180 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nmb neuromedin B multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in decreased expression of NMB mRNA CTD PMID:29321614 NCBI chr 1:142,721,263...142,724,646
Ensembl chr 1:142,721,002...142,724,511
JBrowse link
G Nmbr neuromedin B receptor multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of NMBR mRNA CTD PMID:29321614 NCBI chr 1:8,933,744...8,945,850
Ensembl chr 1:8,933,831...8,944,987
JBrowse link
G Npy1r neuropeptide Y receptor Y1 multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of NPY1R mRNA CTD PMID:29321614 NCBI chr16:24,779,480...24,789,131
Ensembl chr16:24,779,477...24,788,740
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Thiram results in increased expression of NQO1 mRNA CTD PMID:24211530 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Dithiothreitol inhibits the reaction [Thiram inhibits the reaction [Dexamethasone binds to NR3C1 protein]]; Thiram inhibits the reaction [Dexamethasone binds to NR3C1 protein]; Thiram inhibits the reaction [Hydrocortisone binds to NR3C1 protein] CTD PMID:16857225 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO Thiram inhibits the reaction [TNF protein results in decreased expression of PECAM1 protein] CTD PMID:25752435 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Prkca protein kinase C, alpha decreases activity ISO Thiram results in decreased activity of PRKCA protein CTD PMID:15998240 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prkcb protein kinase C, beta decreases activity ISO Thiram results in decreased activity of PRKCB protein CTD PMID:15998240 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Prkcd protein kinase C, delta increases activity ISO Thiram results in increased activity of PRKCD protein CTD PMID:15998240 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkce protein kinase C, epsilon decreases activity ISO Thiram results in decreased activity of PRKCE protein CTD PMID:15998240 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
JBrowse link
G Prkcg protein kinase C, gamma decreases activity ISO Thiram results in decreased activity of PRKCG protein CTD PMID:15998240 NCBI chr 1:64,407,098...64,433,698
Ensembl chr 1:64,407,114...64,433,636
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Thiram results in increased expression of PTGS2 mRNA CTD PMID:19371601 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Sel1l3 SEL1L family member 3 increases expression ISO Thiram results in increased expression of SEL1L3 mRNA CTD PMID:24211530 NCBI chr14:60,122,968...60,229,565
Ensembl chr14:60,123,169...60,229,734
JBrowse link
G Sftpa1 surfactant protein A1 multiple interactions ISO Thiram inhibits the reaction [Dexamethasone results in decreased expression of SFTPA1 mRNA] CTD PMID:16857225 NCBI chr16:18,716,019...18,719,404
Ensembl chr16:18,716,019...18,719,403
JBrowse link
G Sftpb surfactant protein B multiple interactions ISO Thiram inhibits the reaction [Dexamethasone results in increased expression of SFTPB mRNA] CTD PMID:16857225 NCBI chr 4:100,166,855...100,175,941
Ensembl chr 4:100,166,863...100,175,938
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Thiram results in increased expression of SLC7A11 mRNA CTD PMID:24211530 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Thiram results in increased expression of SQSTM1 mRNA CTD PMID:24211530 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Syne2 spectrin repeat containing nuclear envelope protein 2 decreases expression ISO Thiram results in decreased expression of SYNE2 mRNA CTD PMID:24211530 NCBI chr 6:98,884,269...99,153,551 JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases activity ISO Thiram results in decreased activity of TGFB1 protein CTD PMID:31652400 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO Thiram results in increased expression of TNF mRNA
Thiram inhibits the reaction [TNF protein results in decreased expression of PECAM1 protein]; Thiram inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Thiram promotes the reaction [TNF protein results in increased expression of ICAM1 protein]
CTD PMID:20385217, PMID:25752435 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnnt2 troponin T2, cardiac type decreases expression ISO Thiram results in decreased expression of TNNT2 mRNA CTD PMID:24211530 NCBI chr13:52,662,974...52,680,992
Ensembl chr13:52,662,996...52,680,990
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Thiram results in increased expression of TXNRD1 mRNA CTD PMID:23445166, PMID:24211530 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 multiple interactions ISO Thiram results in decreased activity of and results in decreased ubiquitination of UBA1 protein CTD PMID:25714994 NCBI chr  X:1,723,135...1,745,147
Ensembl chr  X:1,723,174...1,741,701
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Thiram inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:25752435 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pesticide 16263
          antifungal agrochemical 7529
            thiram 49
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            heteroorganic entity 19147
                              organochalcogen compound 18855
                                organosulfur compound 15188
                                  dithiocarbamic acids 368
                                    dimethyldithiocarbamic acid 118
                                      thiram 49
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.