Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester
go back to main search page
Accession:CHEBI:94807 term browser browse the term
Definition:A carboxylic ester that has formula C12H9N3O5S.
Synonyms:related_synonym: Formula=C12H9N3O5S;   InChI=1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17);   InChIKey=YQNQNVDNTFHQSW-UHFFFAOYSA-N;   SMILES=CC(=O)OC1=CC=CC=C1C(=O)NC2=NC=C(S2)[N+](=O)[O-];   nitazode;   nitazoxanida;   nizonide
 xref: CAS:55981-09-4;   Drug_Central:1943;   HMDB:HMDB0014649;   LINCS:LSM-6002
 xref_mesh: MESH:C041747


show annotations for term's descendants           Sort by:
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 affects response to substance ISO ABCC1 gene SNP affects the susceptibility to nitazoxanide CTD PMID:25622337 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404 		JBrowse link
G Ar androgen receptor multiple interactions ISO nitazoxanide binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Arg1 arginase 1 increases expression
multiple interactions 		ISO nitazoxanide results in increased expression of ARG1 mRNA; nitazoxanide results in increased expression of ARG1 protein
nitazoxanide inhibits the reaction [Lipopolysaccharides results in decreased expression of ARG1 mRNA] 		CTD PMID:38663798 NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:22,295,322...22,307,713 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression 		ISO nitazoxanide promotes the reaction [EIF2A protein results in increased expression of ATF4 protein]
nitazoxanide results in increased expression of ATF4 protein 		CTD PMID:19664635 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO nitazoxanide inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] CTD PMID:38663798 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO nitazoxanide results in increased expression of CDH1 protein CTD PMID:39084502 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Cdh2 cadherin 2 decreases expression ISO nitazoxanide results in decreased expression of CDH2 protein CTD PMID:39084502 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288 		JBrowse link
G Cdx2 caudal type homeo box 2 multiple interactions
increases expression 		ISO nitazoxanide inhibits the reaction [Dextran Sulfate results in decreased expression of CDX2 protein]
nitazoxanide results in increased expression of CDX2 protein 		CTD PMID:38663798 NCBI chr12:12,762,769...12,769,246
Ensembl chr12:12,762,904...12,769,246 		JBrowse link
G Dock8 dedicator of cytokinesis 8 affects response to substance ISO DOCK8 gene SNP affects the susceptibility to nitazoxanide CTD PMID:25622337 NCBI chr 1:232,075,468...232,268,830
Ensembl chr 1:232,075,588...232,268,833 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A multiple interactions
increases phosphorylation 		ISO IFNA2 protein promotes the reaction [nitazoxanide results in increased phosphorylation of EIF2A protein]; nitazoxanide promotes the reaction [EIF2A protein results in increased expression of ATF4 protein]; nitazoxanide promotes the reaction [EIF2AK2 protein results in increased phosphorylation of EIF2A protein] CTD PMID:19664635 NCBI chr 2:144,911,247...144,944,705
Ensembl chr 2:144,911,153...144,945,201 		JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 multiple interactions ISO IFNA2 protein promotes the reaction [nitazoxanide promotes the reaction [EIF2AK2 protein results in increased phosphorylation of and results in increased activity of EIF2AK2 protein]]; nitazoxanide promotes the reaction [EIF2AK2 protein results in increased phosphorylation of and results in increased activity of EIF2AK2 protein]; nitazoxanide promotes the reaction [EIF2AK2 protein results in increased phosphorylation of EIF2A protein] CTD PMID:19664635 NCBI chr 6:21,941,147...21,977,115
Ensembl chr 6:21,952,631...21,977,116 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO nitazoxanide inhibits the reaction [Dextran Sulfate results in increased expression of IL17A mRNA] CTD PMID:38663798 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO nitazoxanide inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased secretion of IL6 protein]; nitazoxanide inhibits the reaction [Dextran Sulfate results in increased expression of IL6 mRNA]; nitazoxanide inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
nitazoxanide inhibits the reaction [IL6 protein results in decreased expression of TJP1 protein] 		CTD PMID:38663798 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation
multiple interactions 		ISO nitazoxanide results in decreased phosphorylation of JAK2 protein
nitazoxanide inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased phosphorylation of JAK2 protein]; nitazoxanide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK2 protein] 		CTD PMID:38663798 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762 		JBrowse link
G Lats1 large tumor suppressor kinase 1 increases expression ISO nitazoxanide results in increased expression of LATS1 mRNA CTD PMID:39084502 NCBI chr 1:3,980,801...4,014,029
Ensembl chr 1:3,980,544...4,014,029 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO nitazoxanide inhibits the reaction [Dextran Sulfate results in increased secretion of MPO protein] CTD PMID:38663798 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO nitazoxanide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:38663798 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO nitazoxanide results in increased activity of NR1I3 protein CTD PMID:30247703 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370 		JBrowse link
G Ocln occludin multiple interactions ISO nitazoxanide inhibits the reaction [Dextran Sulfate results in decreased expression of OCLN protein] CTD PMID:38663798 NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411 		JBrowse link
G Slit3 slit guidance ligand 3 affects response to substance ISO SLIT3 gene SNP affects the susceptibility to nitazoxanide CTD PMID:25622337 NCBI chr10:19,571,798...20,156,634
Ensembl chr10:20,076,021...20,660,704 		JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO nitazoxanide results in decreased expression of SNAI1 protein CTD PMID:39084502 NCBI chr 3:176,667,476...176,671,965 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases phosphorylation 		ISO nitazoxanide inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased phosphorylation of STAT3 protein]; nitazoxanide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]
nitazoxanide results in decreased phosphorylation of STAT3 protein 		CTD PMID:38663798 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Susd6 sushi domain containing 6 affects response to substance ISO SUSD6 gene SNP affects the susceptibility to nitazoxanide CTD PMID:25622337 NCBI chr 6:100,437,834...100,531,621
Ensembl chr 6:106,169,118...106,262,900 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO nitazoxanide inhibits the reaction [Dextran Sulfate results in decreased expression of TJP1 protein]
nitazoxanide inhibits the reaction [IL6 protein results in decreased expression of TJP1 protein]; nitazoxanide inhibits the reaction [Lipopolysaccharides results in decreased expression of TJP1 protein] 		CTD PMID:38663798 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158 		JBrowse link
G Vim vimentin decreases expression ISO nitazoxanide results in decreased expression of VIM protein CTD PMID:39084502 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746 		JBrowse link
G Yap1 Yes1 associated transcriptional regulator decreases expression ISO nitazoxanide results in decreased expression of YAP1 protein CTD PMID:39084502 NCBI chr 8:13,380,551...13,451,640
Ensembl chr 8:13,380,551...13,451,437 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        pharmacological role 19911
          analgesic 14901
            non-narcotic analgesic 14050
              salicylamide 904
                acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester 26
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbon oxoacid 19155
                                    carboxylic acid 19152
                                      carboacyl group 18085
                                        univalent carboacyl group 18085
                                          carbamoyl group 17921
                                            carboxamide 17921
                                              monocarboxylic acid amide 15953
                                                arenecarboxamide 8285
                                                  benzamides 8285
                                                    salicylamides 929
                                                      salicylamide 904
                                                        acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester 26
paths to the root