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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester
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Accession:CHEBI:94807 term browser browse the term
Definition:A carboxylic ester that has formula C12H9N3O5S.
Synonyms:related_synonym: Formula=C12H9N3O5S;   InChI=1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17);   InChIKey=YQNQNVDNTFHQSW-UHFFFAOYSA-N;   SMILES=CC(=O)OC1=CC=CC=C1C(=O)NC2=NC=C(S2)[N+](=O)[O-];   nitazode;   nitazoxanida;   nizonide
 xref: CAS:55981-09-4;   Drug_Central:1943;   HMDB:HMDB0014649;   LINCS:LSM-6002
 xref_mesh: MESH:C041747


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acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 affects response to substance ISO ABCC1 gene SNP affects the susceptibility to nitazoxanide CTD PMID:25622337 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Ar androgen receptor multiple interactions ISO nitazoxanide binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression		 ISO nitazoxanide promotes the reaction [EIF2A protein results in increased expression of ATF4 protein]
nitazoxanide results in increased expression of ATF4 protein		 CTD PMID:19664635 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Dock8 dedicator of cytokinesis 8 affects response to substance ISO DOCK8 gene SNP affects the susceptibility to nitazoxanide CTD PMID:25622337 NCBI chr 1:222,649,309...222,842,474
Ensembl chr 1:222,649,309...222,842,474 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A multiple interactions
increases phosphorylation		 ISO IFNA2 protein promotes the reaction [nitazoxanide results in increased phosphorylation of EIF2A protein]; nitazoxanide promotes the reaction [EIF2A protein results in increased expression of ATF4 protein]; nitazoxanide promotes the reaction [EIF2AK2 protein results in increased phosphorylation of EIF2A protein] CTD PMID:19664635 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068 		JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 multiple interactions ISO IFNA2 protein promotes the reaction [nitazoxanide promotes the reaction [EIF2AK2 protein results in increased phosphorylation of and results in increased activity of EIF2AK2 protein]]; nitazoxanide promotes the reaction [EIF2AK2 protein results in increased phosphorylation of and results in increased activity of EIF2AK2 protein]; nitazoxanide promotes the reaction [EIF2AK2 protein results in increased phosphorylation of EIF2A protein] CTD PMID:19664635 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO nitazoxanide results in increased activity of NR1I3 protein CTD PMID:30247703 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Slit3 slit guidance ligand 3 affects response to substance ISO SLIT3 gene SNP affects the susceptibility to nitazoxanide CTD PMID:25622337 NCBI chr10:19,571,798...20,156,634
Ensembl chr10:19,571,684...20,156,634 		JBrowse link
G Susd6 sushi domain containing 6 affects response to substance ISO SUSD6 gene SNP affects the susceptibility to nitazoxanide CTD PMID:25622337 NCBI chr 6:100,437,826...100,531,621
Ensembl chr 6:100,437,642...100,531,606 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    role 19713
      biological role 19711
        pharmacological role 18974
          analgesic 14642
            non-narcotic analgesic 13802
              salicylamide 282
                acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic group 18846
                              organic divalent group 18832
                                organodiyl group 18832
                                  carbonyl group 18798
                                    carbonyl compound 18798
                                      carboxylic acid 18518
                                        carboacyl group 17656
                                          univalent carboacyl group 17656
                                            carbamoyl group 17497
                                              carboxamide 17497
                                                monocarboxylic acid amide 15562
                                                  arenecarboxamide 7310
                                                    benzamides 7310
                                                      salicylamides 309
                                                        salicylamide 282
                                                          acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester 9
paths to the root