|
G
|
Abcc1
|
ATP binding cassette subfamily C member 1
|
affects response to substance
|
ISO
|
ABCC1 gene SNP affects the susceptibility to nitazoxanide
|
CTD |
PMID:25622337 |
|
NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404
|
|
G
|
Ar
|
androgen receptor
|
multiple interactions
|
ISO
|
nitazoxanide binds to and results in decreased activity of AR protein
|
CTD |
PMID:25752796 |
|
NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467
|
|
G
|
Arg1
|
arginase 1
|
increases expression multiple interactions
|
ISO
|
nitazoxanide results in increased expression of ARG1 mRNA; nitazoxanide results in increased expression of ARG1 protein nitazoxanide inhibits the reaction [Lipopolysaccharides results in decreased expression of ARG1 mRNA]
|
CTD |
PMID:38663798 |
|
NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:22,295,322...22,307,713
|
|
G
|
Atf4
|
activating transcription factor 4
|
multiple interactions increases expression
|
ISO
|
nitazoxanide promotes the reaction [EIF2A protein results in increased expression of ATF4 protein] nitazoxanide results in increased expression of ATF4 protein
|
CTD |
PMID:19664635 |
|
NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739
|
|
G
|
Ccl2
|
C-C motif chemokine ligand 2
|
multiple interactions
|
ISO
|
nitazoxanide inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]
|
CTD |
PMID:38663798 |
|
NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
|
|
G
|
Cdh1
|
cadherin 1
|
increases expression
|
ISO
|
nitazoxanide results in increased expression of CDH1 protein
|
CTD |
PMID:39084502 |
|
NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565
|
|
G
|
Cdh2
|
cadherin 2
|
decreases expression
|
ISO
|
nitazoxanide results in decreased expression of CDH2 protein
|
CTD |
PMID:39084502 |
|
NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288
|
|
G
|
Cdx2
|
caudal type homeo box 2
|
multiple interactions increases expression
|
ISO
|
nitazoxanide inhibits the reaction [Dextran Sulfate results in decreased expression of CDX2 protein] nitazoxanide results in increased expression of CDX2 protein
|
CTD |
PMID:38663798 |
|
NCBI chr12:12,762,769...12,769,246
Ensembl chr12:12,762,904...12,769,246
|
|
G
|
Dock8
|
dedicator of cytokinesis 8
|
affects response to substance
|
ISO
|
DOCK8 gene SNP affects the susceptibility to nitazoxanide
|
CTD |
PMID:25622337 |
|
NCBI chr 1:232,075,468...232,268,830
Ensembl chr 1:232,075,588...232,268,833
|
|
G
|
Eif2a
|
eukaryotic translation initiation factor 2A
|
multiple interactions increases phosphorylation
|
ISO
|
IFNA2 protein promotes the reaction [nitazoxanide results in increased phosphorylation of EIF2A protein]; nitazoxanide promotes the reaction [EIF2A protein results in increased expression of ATF4 protein]; nitazoxanide promotes the reaction [EIF2AK2 protein results in increased phosphorylation of EIF2A protein]
|
CTD |
PMID:19664635 |
|
NCBI chr 2:144,911,247...144,944,705
Ensembl chr 2:144,911,153...144,945,201
|
|
G
|
Eif2ak2
|
eukaryotic translation initiation factor 2-alpha kinase 2
|
multiple interactions
|
ISO
|
IFNA2 protein promotes the reaction [nitazoxanide promotes the reaction [EIF2AK2 protein results in increased phosphorylation of and results in increased activity of EIF2AK2 protein]]; nitazoxanide promotes the reaction [EIF2AK2 protein results in increased phosphorylation of and results in increased activity of EIF2AK2 protein]; nitazoxanide promotes the reaction [EIF2AK2 protein results in increased phosphorylation of EIF2A protein]
|
CTD |
PMID:19664635 |
|
NCBI chr 6:21,941,147...21,977,115
Ensembl chr 6:21,952,631...21,977,116
|
|
G
|
Il17a
|
interleukin 17A
|
multiple interactions
|
ISO
|
nitazoxanide inhibits the reaction [Dextran Sulfate results in increased expression of IL17A mRNA]
|
CTD |
PMID:38663798 |
|
NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331
|
|
G
|
Il6
|
interleukin 6
|
multiple interactions
|
ISO
|
nitazoxanide inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased secretion of IL6 protein]; nitazoxanide inhibits the reaction [Dextran Sulfate results in increased expression of IL6 mRNA]; nitazoxanide inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] nitazoxanide inhibits the reaction [IL6 protein results in decreased expression of TJP1 protein]
|
CTD |
PMID:38663798 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
|
|
G
|
Jak2
|
Janus kinase 2
|
decreases phosphorylation multiple interactions
|
ISO
|
nitazoxanide results in decreased phosphorylation of JAK2 protein nitazoxanide inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased phosphorylation of JAK2 protein]; nitazoxanide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK2 protein]
|
CTD |
PMID:38663798 |
|
NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762
|
|
G
|
Lats1
|
large tumor suppressor kinase 1
|
increases expression
|
ISO
|
nitazoxanide results in increased expression of LATS1 mRNA
|
CTD |
PMID:39084502 |
|
NCBI chr 1:3,980,801...4,014,029
Ensembl chr 1:3,980,544...4,014,029
|
|
G
|
Mpo
|
myeloperoxidase
|
multiple interactions
|
ISO
|
nitazoxanide inhibits the reaction [Dextran Sulfate results in increased secretion of MPO protein]
|
CTD |
PMID:38663798 |
|
NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056
|
|
G
|
Nos2
|
nitric oxide synthase 2
|
multiple interactions
|
ISO
|
nitazoxanide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
|
CTD |
PMID:38663798 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
|
|
G
|
Nr1i3
|
nuclear receptor subfamily 1, group I, member 3
|
increases activity
|
ISO
|
nitazoxanide results in increased activity of NR1I3 protein
|
CTD |
PMID:30247703 |
|
NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370
|
|
G
|
Ocln
|
occludin
|
multiple interactions
|
ISO
|
nitazoxanide inhibits the reaction [Dextran Sulfate results in decreased expression of OCLN protein]
|
CTD |
PMID:38663798 |
|
NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411
|
|
G
|
Slit3
|
slit guidance ligand 3
|
affects response to substance
|
ISO
|
SLIT3 gene SNP affects the susceptibility to nitazoxanide
|
CTD |
PMID:25622337 |
|
NCBI chr10:19,571,798...20,156,634
Ensembl chr10:20,076,021...20,660,704
|
|
G
|
Snai1
|
snail family transcriptional repressor 1
|
decreases expression
|
ISO
|
nitazoxanide results in decreased expression of SNAI1 protein
|
CTD |
PMID:39084502 |
|
NCBI chr 3:176,667,476...176,671,965
|
|
G
|
Stat3
|
signal transducer and activator of transcription 3
|
multiple interactions decreases phosphorylation
|
ISO
|
nitazoxanide inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased phosphorylation of STAT3 protein]; nitazoxanide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein] nitazoxanide results in decreased phosphorylation of STAT3 protein
|
CTD |
PMID:38663798 |
|
NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359
|
|
G
|
Susd6
|
sushi domain containing 6
|
affects response to substance
|
ISO
|
SUSD6 gene SNP affects the susceptibility to nitazoxanide
|
CTD |
PMID:25622337 |
|
NCBI chr 6:100,437,834...100,531,621
Ensembl chr 6:106,169,118...106,262,900
|
|
G
|
Tjp1
|
tight junction protein 1
|
multiple interactions
|
ISO
|
nitazoxanide inhibits the reaction [Dextran Sulfate results in decreased expression of TJP1 protein] nitazoxanide inhibits the reaction [IL6 protein results in decreased expression of TJP1 protein]; nitazoxanide inhibits the reaction [Lipopolysaccharides results in decreased expression of TJP1 protein]
|
CTD |
PMID:38663798 |
|
NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158
|
|
G
|
Vim
|
vimentin
|
decreases expression
|
ISO
|
nitazoxanide results in decreased expression of VIM protein
|
CTD |
PMID:39084502 |
|
NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746
|
|
G
|
Yap1
|
Yes1 associated transcriptional regulator
|
decreases expression
|
ISO
|
nitazoxanide results in decreased expression of YAP1 protein
|
CTD |
PMID:39084502 |
|
NCBI chr 8:13,380,551...13,451,640
Ensembl chr 8:13,380,551...13,451,437
|
|