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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1-[(2,3,4-trimethoxyphenyl)methyl]piperazine
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Accession:CHEBI:94789 term browser browse the term
Definition:An aromatic amine that has formula C14H22N2O3.
Synonyms:related_synonym: Formula=C14H22N2O3;   InChI=1S/C14H22N2O3/c1-17-12-5-4-11(13(18-2)14(12)19-3)10-16-8-6-15-7-9-16/h4-5,15H,6-10H2,1-3H3;   InChIKey=UHWVSEOVJBQKBE-UHFFFAOYSA-N;   SMILES=COC1=C(C(=C(C=C1)CN2CCNCC2)OC)OC;   trimetazidine HCl;   trimetazidine dihydrochloride;   trimetazidine hydrochloride;   vastarel
 xref: CAS:5011-34-7;   Drug_Central:2750;   LINCS:LSM-5938
 xref_mesh: MESH:D014292


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1-[(2,3,4-trimethoxyphenyl)methyl]piperazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions EXP Trimetazidine promotes the reaction [Oxygen deficiency results in decreased expression of ACADM mRNA] CTD PMID:25937560 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
JBrowse link
G Ache acetylcholinesterase multiple interactions EXP Trimetazidine promotes the reaction [Oxygen deficiency results in decreased expression of ACHE mRNA] CTD PMID:25937560 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions EXP Trimetazidine inhibits the reaction [Oxygen deficiency results in decreased expression of ATP2A2 mRNA] CTD PMID:25937560 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Trimetazidine inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; Trimetazidine inhibits the reaction [Oxygen deficiency results in increased expression of BAX mRNA] CTD PMID:25937560 PMID:33704910 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Trimetazidine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2 mRNA] CTD PMID:25937560 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions EXP Trimetazidine inhibits the reaction [Oxygen deficiency results in increased expression of CASP3 mRNA] CTD PMID:25937560 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions EXP Trimetazidine inhibits the reaction [Doxorubicin results in decreased expression of CAT protein] CTD PMID:33704910 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Trimetazidine inhibits the reaction [Doxorubicin results in increased expression of IL1B protein] CTD PMID:33704910 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP Trimetazidine inhibits the reaction [Oxygen deficiency results in increased expression of MYH7 mRNA] CTD PMID:25937560 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions EXP Trimetazidine inhibits the reaction [Oxygen deficiency results in decreased expression of RYR2 mRNA] CTD PMID:25937560 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142
JBrowse link
G Slc18a3 solute carrier family 18 member A3 multiple interactions EXP Trimetazidine promotes the reaction [Oxygen deficiency results in increased expression of SLC18A3 mRNA] CTD PMID:25937560 NCBI chr16:7,713,630...7,716,491 JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions EXP Trimetazidine promotes the reaction [Oxygen deficiency results in increased expression of SLC2A1 mRNA] CTD PMID:25937560 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc8a1 solute carrier family 8 member A1 multiple interactions EXP Trimetazidine inhibits the reaction [Oxygen deficiency results in decreased expression of SLC8A1 mRNA] CTD PMID:25937560 NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Trimetazidine inhibits the reaction [Doxorubicin results in increased expression of TNF protein] CTD PMID:33704910 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Trimetazidine inhibits the reaction [Doxorubicin results in increased expression of VEGFA protein] CTD PMID:33704910 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      chemical role 19345
        base 17286
          Bronsted base 17286
            organic amino compound 17278
              aromatic amine 13704
                1-[(2,3,4-trimethoxyphenyl)methyl]piperazine 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        aromatic amine 13704
                                          1-[(2,3,4-trimethoxyphenyl)methyl]piperazine 15
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