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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tetracaine
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Accession:CHEBI:9468 term browser browse the term
Definition:A benzoate ester in which 4-N-butylbenzoic acid and 2-(dimethylamino)ethanol have combined to form the ester bond; a local ester anaesthetic (ester caine) used for surface and spinal anaesthesia.
Synonyms:exact_synonym: 2-(dimethylamino)ethyl 4-(butylamino)benzoate
 related_synonym: 2-(Dimethylamino)ethyl p-(butylamino)benzoate;   Amethocaine;   Diaethylaminoaethanol ester der p-butylaminobenzoesaeure;   Formula=C15H24N2O2;   InChI=1S/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H3;   InChIKey=GKCBAIGFKIBETG-UHFFFAOYSA-N;   SMILES=CCCCNc1ccc(cc1)C(=O)OCCN(C)C;   p-(butylamino)benzoic acid beta-(dimethylamino)ethyl ester;   p-Butylaminobenzoyl-2-dimethylaminoethanol;   tetracaina;   tetracainum
 alt_id: CHEBI:132027
 xref: Beilstein:2216051;   CAS:94-24-6;   Drug_Central:2610;   KEGG:C07526;   KEGG:D00551;   LINCS:LSM-4633
 xref_mesh: MESH:D013748
 xref: PMID:25119673;   PMID:7567006;   PMID:7574001;   PMID:9989796;   Patent:US1889645;   Reaxys:2216051;   Wikipedia:Tetracaine


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tetracaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO Tetracaine results in increased activity of CASP3 protein CTD PMID:11981161 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression		 ISO
EXP		 HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased expression of CCND1 protein] CTD PMID:34822839 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Ccne1 cyclin E1 decreases expression
multiple interactions		 ISO Tetracaine results in decreased expression of CCNE1 protein
HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased expression of CCNE1 protein]		 CTD PMID:34822839 NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases phosphorylation
multiple interactions		 ISO
EXP		 Tetracaine results in decreased phosphorylation of CDK2 protein
HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased phosphorylation of CDK2 protein]		 CTD PMID:34822839 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900 		JBrowse link
G Cdk4 cyclin dependent kinase 4 decreases phosphorylation ISO
EXP		 Tetracaine results in decreased phosphorylation of CDK4 protein CTD PMID:34822839 NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789 		JBrowse link
G Cdk6 cyclin dependent kinase 6 multiple interactions
decreases phosphorylation		 ISO HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased phosphorylation of CDK6 protein] CTD PMID:34822839 NCBI chr 5:3,391,004...3,581,008
Ensembl chr 5:3,391,485...3,581,008 		JBrowse link
G Hnrnpa0 heterogeneous nuclear ribonucleoprotein A0 increases expression ISO
EXP		 Tetracaine results in increased expression of HNRNPA0 mRNA CTD PMID:34822839 NCBI chr13:58,273,693...58,276,370
Ensembl chr13:58,273,693...58,276,370 		JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 decreases response to substance
decreases expression
multiple interactions		 EXP
ISO		 HNRNPA1 protein results in decreased susceptibility to Tetracaine
Tetracaine results in decreased expression of HNRNPA1 protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetracaine results in decreased expression of HNRNPA1 mRNA]; HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased expression of CCND1 protein]; HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased phosphorylation of CDK2 protein]; Tetracaine results in decreased expression of and results in increased degradation of HNRNPA1 protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetracaine results in decreased expression of HNRNPA1 mRNA]; HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased expression of CCND1 protein]; HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased expression of CCNE1 protein]; HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased phosphorylation of CDK2 protein]; HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased phosphorylation of CDK6 protein]; Tetracaine results in decreased expression of and results in increased degradation of HNRNPA1 protein		 CTD PMID:34822839 NCBI chr15:103,148,840...103,155,119
Ensembl chr15:103,148,859...103,155,119 		JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 decreases expression EXP Tetracaine results in decreased expression of HNRNPA2B1 mRNA CTD PMID:34822839 NCBI chr 6:51,437,414...51,448,054
Ensembl chr 6:51,437,912...51,446,874 		JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C increases expression
decreases expression		 ISO
EXP		 Tetracaine results in increased expression of HNRNPC mRNA
Tetracaine results in decreased expression of HNRNPC mRNA		 CTD PMID:34822839 NCBI chr14:52,310,834...52,341,462
Ensembl chr14:52,310,834...52,341,485 		JBrowse link
G Hrh1 histamine receptor H1 multiple interactions
affects binding		 ISO [HRH1 protein binds to Tetracaine] which results in increased import of Calcium CTD PMID:32061592 NCBI chr 6:114,374,897...114,459,432
Ensembl chr 6:114,374,897...114,460,257 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK1 protein]; Egtazic Acid promotes the reaction [Tetracaine results in increased phosphorylation of MAPK1 protein] CTD PMID:11981161 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK3 protein]; Egtazic Acid promotes the reaction [Tetracaine results in increased phosphorylation of MAPK3 protein] CTD PMID:11981161 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation		 ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK8 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Tetracaine results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK8 protein]; Egtazic Acid inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK8 protein] CTD PMID:11981161 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation		 ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK9 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Tetracaine results in increased phosphorylation of MAPK9 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK9 protein]; Egtazic Acid inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK9 protein] CTD PMID:11981161 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases activity
decreases expression		 ISO Tetracaine results in decreased activity of MMP2 protein
Tetracaine results in decreased expression of MMP2 mRNA		 CTD PMID:37806380 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity
decreases expression		 ISO Tetracaine results in decreased activity of MMP9 protein
Tetracaine results in decreased expression of MMP9 mRNA		 CTD PMID:37806380 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Ryr1 ryanodine receptor 1, skeletal muscle multiple interactions EXP Tetracaine inhibits the reaction [tetrabromobisphenol A results in increased activity of RYR1 protein] CTD PMID:18329244 NCBI chr 7:28,702,765...28,824,599
Ensembl chr 7:28,702,769...28,824,604 		JBrowse link
G Scn10a sodium channel, voltage-gated, type X, alpha multiple interactions ISO Tetracaine inhibits the reaction [decamethrin results in increased activity of SCN10A protein] CTD PMID:16325806 NCBI chr 9:119,437,522...119,548,388
Ensembl chr 9:119,437,522...119,548,388 		JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Tetracaine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375 		JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 increases expression ISO Tetracaine results in increased expression of TIMP2 mRNA CTD PMID:37806380 NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,887...118,246,566 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases activity
multiple interactions		 ISO Tetracaine results in increased activity of TRPV1 protein
Tetracaine promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]		 CTD PMID:15854744 PMID:18172555 NCBI chr11:73,124,975...73,152,148
Ensembl chr11:73,125,118...73,152,068 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      application 21760
        pharmaceutical 21174
          drug 21174
            anaesthetic 11951
              local anaesthetic 7906
                tetracaine 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    p-block element atom 22120
                      carbon group element atom 21920
                        carbon atom 21846
                          organic molecular entity 21846
                            heteroorganic entity 21500
                              organochalcogen compound 20983
                                organooxygen compound 20824
                                  carbon oxoacid 19606
                                    carboxylic acid 19602
                                      aromatic carboxylic acid 12760
                                        benzoic acids 12738
                                          benzoate ester 5535
                                            tetracaine 22
paths to the root