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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tetrabenazine
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Accession:CHEBI:9467 term browser browse the term
Definition:A racemate consisting of equal amounts of (3R,11bR)- and (3S,11bS)-9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one. An adrenergic uptake inhibitor, it was formerly used as an antipsychotic, but it is now used mainly for the treatment of various movement disorders including chorea, ballism, dystonias, and tardive dyskinesia.
Synonyms:exact_synonym: rac-(3S,11bS)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one
 related_synonym: 1,2,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-2H-benzo[a]quinolizin-2-one;   1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-2H-benzo(a)quinolizin-2-one;   2-oxo-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-benzoquinolizine;   Nitoman;   Ro 1-9569;   TBZ;   Xenazine;   tetrabenazina;   tetrabenazinum
 xref: CAS:58-46-8;   DrugBank:DB04844;   KEGG:C11168;   KEGG:D08575
 xref_mesh: MESH:D013747
 xref: PMID:10686169;   PMID:19929707;   PMID:20442355;   PMID:20869622;   PMID:21487088;   PMID:9040721;   Patent:US2830993;   Reaxys:9356999;   Wikipedia:Tetrabenazine


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tetrabenazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc18a1 solute carrier family 18 (vesicular monoamine), member 1 multiple interactions ISO Tetrabenazine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin] CTD PMID:8245983 NCBI chr 8:69,490,360...69,547,951
Ensembl chr 8:69,490,363...69,541,887 		JBrowse link
G Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 affects binding
decreases activity
multiple interactions		 ISO
EXP		 Tetrabenazine binds to SLC18A2 protein
Tetrabenazine results in decreased activity of SLC18A2 protein
Tetrabenazine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]
Tetrabenazine binds to Slc8a2 protein		 CTD
RGD		 PMID:1438304 PMID:7912402 PMID:15475732 PMID:19616025 PMID:33378168 More... RGD:5130957 NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    chemical entity 22208
      chemical substance 14846
        mixture 14069
          racemate 12370
            tetrabenazine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    main group molecular entity 22104
                      s-block molecular entity 21729
                        hydrogen molecular entity 21646
                          hydrides 20758
                            inorganic hydride 18672
                              pnictogen hydride 18652
                                nitrogen hydride 18519
                                  azane 18426
                                    ammonia 18425
                                      organic amino compound 18425
                                        tertiary amino compound 10293
                                          9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one 2
                                            (3S,11bS)-9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one 2
                                              tetrabenazine 2
paths to the root