CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: terpinolene
Accession: CHEBI:9457
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Definition: A p-menthadiene with double bonds at positions 1 and 4(8).
Synonyms: exact_synonym: 1-methyl-4-(propan-2-ylidene)cyclohexene; p-mentha-1,4(8)-diene
related_synonym: 1,4(8)-p-menthadiene; 1-methyl-4-(1-methylethylidene)-1-cyclohexene; 1-methyl-4-(1-methylethylidene)cyclohexene; 4-isopropylidene-1-methylcyclohexene; Formula=C10H16; InChI=1S/C10H16/c1-8(2)10-6-4-9(3)5-7-10/h4H,5-7H2,1-3H3; InChIKey=MOYAFQVGZZPNRA-UHFFFAOYSA-N; SMILES=CC1=CCC(CC1)=C(C)C; Terpinolen; alpha-terpinolene; isoterpinene
xref: BPDB:2016; Beilstein:1851203; CAS:586-62-9; HMDB:HMDB0036994; KEGG:C06075; KNApSAcK:C00000861; LIPID_MAPS_instance:LMPR0102090062
xref_mesh: MESH:C027009
xref: MetaCyc:CPD-4890; PMID:22160253; PMID:22428252; PMID:22740904; PMID:23339024; Reaxys:1851203
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Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions
ISO
terpinolene inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]
CTD
PMID:16904803
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Akt1
AKT serine/threonine kinase 1
decreases expression
ISO
terpinolene results in decreased expression of AKT1 protein
CTD
PMID:22740904
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Ar
androgen receptor
multiple interactions
ISO
Tea Tree Oil inhibits the reaction [Testosterone results in increased activity of AR protein]
CTD
PMID:31393563
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
G
Ctsd
cathepsin D
multiple interactions increases expression
ISO
Fulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of CTSD mRNA]
CTD
PMID:31393563
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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Cyp4f6
cytochrome P450, family 4, subfamily f, polypeptide 6
multiple interactions
ISO
Tea Tree Oil inhibits the reaction [Testosterone results in increased expression of CYP4F8 mRNA]
CTD
PMID:31393563
NCBI chr 7:12,030,276...12,058,020
Ensembl chr 7:12,030,301...12,057,782
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Esr1
estrogen receptor 1
increases activity
ISO
Tea Tree Oil results in increased activity of ESR1 protein
CTD
PMID:31393563
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Greb1
growth regulating estrogen receptor binding 1
multiple interactions increases expression
ISO
Fulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of GREB1 mRNA]
CTD
PMID:31393563
NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
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Pgr
progesterone receptor
increases expression multiple interactions
ISO
Tea Tree Oil results in increased expression of PGR mRNA Fulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of PGR mRNA]
CTD
PMID:31393563
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Sec14l2
SEC14-like lipid binding 2
multiple interactions
ISO
Tea Tree Oil inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA]
CTD
PMID:31393563
NCBI chr14:78,973,805...78,998,480
Ensembl chr14:78,973,808...78,993,788
G
Ugt2b34l1
UDP glucuronosyltransferase 2 family, polypeptide B34 like 1
multiple interactions
ISO
Tea Tree Oil inhibits the reaction [Testosterone results in increased expression of UGT2B28 mRNA]
CTD
PMID:31393563
NCBI chr14:21,146,140...21,167,706
Ensembl chr14:21,145,827...21,167,704
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