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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:terpinolene
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Accession:CHEBI:9457 term browser browse the term
Definition:A p-menthadiene with double bonds at positions 1 and 4(8).
Synonyms:related_synonym: 1,4(8)-p-menthadiene;   1-methyl-4-(1-methylethylidene)-1-cyclohexene;   1-methyl-4-(1-methylethylidene)cyclohexene;   1-methyl-4-(propan-2-ylidene)cyclohexene;   4-isopropylidene-1-methylcyclohexene;   Terpinolen;   alpha-terpinolene;   isoterpinene;   p-mentha-1,4(8)-diene
 xref: BPDB:2016;   CAS:586-62-9;   HMDB:HMDB0036994;   KNApSAcK:C00000861
 xref_mesh: MESH:C027009
 xref: Reaxys:1851203;   kegg.compound:C06075;   lipidmaps:LMPR0102090062;   metacyc.compound:CPD-4890;   pubmed:22160253;   pubmed:22428252;   pubmed:22740904;   pubmed:23339024
 chemrof_formula: C10H16
 chemrof_smiles: CC1=CCC(=C(C)C)CC1
 chemrof_inchi: InChI=1S/C10H16/c1-8(2)10-6-4-9(3)5-7-10/h4H,5-7H2,1-3H3
 chemrof_inchikey: MOYAFQVGZZPNRA-UHFFFAOYSA-N


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terpinolene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO terpinolene inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin] CTD PMID:16904803 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases expression ISO terpinolene results in decreased expression of AKT1 protein CTD PMID:22740904 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
tea tree oil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Tea Tree Oil inhibits the reaction [Testosterone results in increased activity of AR protein] CTD PMID:31393563 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Ctsd cathepsin D multiple interactions
increases expression 		ISO Fulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of CTSD mRNA] CTD PMID:31393563 NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821 		JBrowse link
G Cyp4f6 cytochrome P450, family 4, subfamily f, polypeptide 6 multiple interactions ISO Tea Tree Oil inhibits the reaction [Testosterone results in increased expression of CYP4F8 mRNA] CTD PMID:31393563 NCBI chr 7:12,680,799...12,708,378
Ensembl chr 7:12,680,806...12,708,402 		JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO Tea Tree Oil results in increased activity of ESR1 protein CTD PMID:31393563 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression 		ISO Fulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of GREB1 mRNA] CTD PMID:31393563 NCBI chr 6:45,169,289...45,321,973
Ensembl chr 6:45,169,289...45,291,126 		JBrowse link
G Pgr progesterone receptor increases expression
multiple interactions 		ISO Tea Tree Oil results in increased expression of PGR mRNA
Fulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of PGR mRNA] 		CTD PMID:31393563 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271 		JBrowse link
G Sec14l2 SEC14-like lipid binding 2 multiple interactions ISO Tea Tree Oil inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA] CTD PMID:31393563 NCBI chr14:83,197,384...83,222,059
Ensembl chr14:83,197,387...83,217,317 		JBrowse link
G Ugt2b34l1 UDP glucuronosyltransferase 2 family, polypeptide B34 like 1 multiple interactions ISO Tea Tree Oil inhibits the reaction [Testosterone results in increased expression of UGT2B28 mRNA] CTD PMID:31393563 NCBI chr14:21,500,948...21,524,095
Ensembl chr14:21,501,091...21,522,265 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        biochemical role 19888
          volatile oil component 1878
            terpinolene 10
              tea tree oil 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    main group molecular entity 20809
                      s-block molecular entity 20147
                        hydrogen molecular entity 20117
                          hydrides 17673
                            organic hydride 16947
                              organic fundamental parent 16947
                                hydrocarbon 16602
                                  terpene 2491
                                    monoterpene 2143
                                      p-menthadiene 381
                                        terpinolene 10
                                          tea tree oil 8
paths to the root