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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:benzydamine
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Accession:CHEBI:94563 term browser browse the term
Definition:A member of the class of indazoles carrying benzyl and 3-(dimethylamino)propyl groups at positions 1 and 3 respectively. A locally-acting nonsteroidal anti-inflammatory drug that also exhibits local anaesthetic and analgesic properties.
Synonyms:exact_synonym: 3-[(1-benzyl-1H-indazol-3-yl)oxy]-N,N-dimethylpropan-1-aminie
 related_synonym: 1-Benzyl-3-(3-(dimethylamino)propoxy)-1H-indazole;   Formula=C19H23N3O;   InChI=1S/C19H23N3O/c1-21(2)13-8-14-23-19-17-11-6-7-12-18(17)22(20-19)15-16-9-4-3-5-10-16/h3-7,9-12H,8,13-15H2,1-2H3;   InChIKey=CNBGNNVCVSKAQZ-UHFFFAOYSA-N;   N,N-dimethyl-3-[[1-(phenylmethyl)-3-indazolyl]oxy]-1-propanamine;   SMILES=CN(C)CCCOC1=NN(C2=CC=CC=C21)CC3=CC=CC=C3;   bencidamina;   benzidamine;   benzindamine;   benzydamide;   benzydaminum
 xref: Beilstein:896536;   CAS:642-72-8;   Drug_Central:3881;   KEGG:D07516;   LINCS:LSM-5423
 xref_mesh: MESH:D001591
 xref: PMID:22267708;   PMID:23209922;   PMID:23439942;   PMID:23752801;   PMID:24263969;   PMID:24350416;   PMID:25343054;   PMID:25371873;   PMID:25431805;   PMID:25471468;   PMID:25715374;   PMID:25729498;   PMID:25760531;   PMID:26006195;   PMID:26149601;   PMID:26993406;   PMID:27108819;   PMID:27523475;   PMID:27644912;   PMID:27776399;   PMID:27987094;   PMID:28054999;   PMID:28127472;   PMID:28137602;   PMID:28145791;   PMID:28195065;   PMID:28247977;   PMID:28258069;   PMID:28352949;   PMID:28429885;   PMID:28442642;   Reaxys:896536;   Wikipedia:Benzydamine
 cyclic_relationship: is_conjugate_base_of CHEBI:134500


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benzydamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fmo1 flavin containing dimethylaniline monoxygenase 1 increases oxidation
multiple interactions
ISO FMO1 protein results in increased oxidation of Benzydamine
Benzydamine inhibits the reaction [FMO1 protein results in increased chemical synthesis of clozapine N-oxide]
CTD PMID:18809730 PMID:21435388 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 increases oxidation
multiple interactions
ISO FMO2 protein results in increased oxidation of Benzydamine
[FMO2 protein results in increased oxidation of Benzydamine] which results in increased chemical synthesis of benzydamine N-oxide
CTD PMID:26062974 NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 multiple interactions
affects metabolic processing
increases metabolic processing
increases oxidation
ISO Benzydamine inhibits the reaction [FMO3 protein results in increased chemical synthesis of clozapine N-oxide]
FMO3 gene polymorphism affects the metabolism of Benzydamine
FMO3 protein results in increased metabolism of Benzydamine
FMO3 protein results in increased oxidation of Benzydamine
CTD PMID:17142560 PMID:18809730 PMID:21435388 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Benzydamine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        pharmacological role 18842
          analgesic 13302
            benzydamine 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    main group molecular entity 19708
                      s-block molecular entity 19493
                        hydrogen molecular entity 19488
                          hydrides 18845
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        tertiary amino compound 8677
                                          benzydamine 4
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