Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:terbutaline
go back to main search page
Accession:CHEBI:9449 term browser browse the term
Definition:A member of the class of phenylethanolamines that is catechol substuted at position 5 by a 2-(tert-butylamino)-1-hydroxyethyl group.
Synonyms:exact_synonym: 5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol
 related_synonym: Formula=C12H19NO3;   InChI=1S/C12H19NO3/c1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8/h4-6,11,13-16H,7H2,1-3H3;   InChIKey=XWTYSIMOBUGWOL-UHFFFAOYSA-N;   SMILES=CC(C)(C)NCC(O)c1cc(O)cc(O)c1;   terbutalina;   terbutalinum
 xref: CAS:23031-25-6;   DrugBank:DB00871;   Drug_Central:2598;   HMDB:HMDB0015009;   KEGG:C07129;   KEGG:D08570
 xref_mesh: MESH:D013726
 xref: PMID:12423672;   PMID:12569076;   PMID:21618259;   PMID:21996060;   PMID:22310877;   PMID:22363704;   PMID:22765375;   PMID:22767151;   PMID:22782385;   PMID:22813780;   PMID:22872661;   PMID:22988932;   PMID:23075357;   PMID:23126237;   PMID:23204625;   PMID:23283786;   PMID:23299764;   PMID:23325598;   PMID:23341043;   PMID:8298802;   PMID:9596106;   Patent:WO2011112499;   Reaxys:2370513;   Wikipedia:Terbutaline


show annotations for term's descendants           Sort by:
 
terbutaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1b adrenoceptor alpha 1B increases expression ISO Terbutaline results in increased expression of ADRA1B mRNA; Terbutaline results in increased expression of ADRA1B protein CTD PMID:10229127 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
JBrowse link
G Adra1d adrenoceptor alpha 1D increases expression ISO Terbutaline results in increased expression of ADRA1D mRNA; Terbutaline results in increased expression of ADRA1D protein CTD PMID:10229127 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566
JBrowse link
G Adrb1 adrenoceptor beta 1 multiple interactions ISO
EXP
Terbutaline binds to and results in decreased activity of ADRB1 protein; Terbutaline binds to and results in increased activity of ADRB1 protein mutant form; Terbutaline inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Terbutaline inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein] CTD PMID:8096834, PMID:14730417, PMID:16648137 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 affects response to substance
increases activity
multiple interactions
affects binding
increases phosphorylation
decreases expression
increases response to substance
ISO
EXP
ADRB2 gene polymorphism affects the susceptibility to Terbutaline; ADRB2 protein affects the susceptibility to Terbutaline; ADRB2 protein polymorphism affects the susceptibility to Terbutaline
Terbutaline results in increased activity of ADRB2 protein
[Terbutaline binds to and results in increased activity of ADRB2 protein] which affects the abundance of Calcium; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Levodopa; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Dopamine; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased expression of TNF protein; [Terbutaline results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; [Terbutaline results in increased activity of ADRB2 protein] which results in increased secretion of Histamine; [Terbutaline results in increased activity of ADRB2 protein] which results in increased transport of Chlorides; [Terbutaline results in increased activity of ADRB2 protein] which results in increased transport of Sodium; ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK1 protein]]; ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK3 protein]]; ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; ADRB2 protein promotes the reaction [Terbutaline promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; CGP 20712A inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; ICI 118551 inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Levodopa]; ICI 118551 inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Dopamine]; ICI 118551 inhibits the reaction [Terbutaline results in increased activity of ADRB2 protein]; Pertussis Toxin promotes the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; Terbutaline binds to and results in increased activity of ADRB2 protein
Terbutaline binds to ADRB2 protein
ADRB2 protein promotes the reaction [Terbutaline results in increased secretion of SFTPB protein]; ADRB2 protein promotes the reaction [Terbutaline results in increased secretion of SFTPC protein]; Terbutaline binds to and results in increased activity of ADRB2 protein
Terbutaline results in increased phosphorylation of ADRB2 protein
Terbutaline results in decreased expression of ADRB2 protein
ADRB2 protein results in increased susceptibility to Terbutaline; ADRB2 protein SNP results in increased susceptibility to Terbutaline
[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Isoproterenol; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Potassium; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of CASP3 protein]; [Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of CASP7 protein]; [Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of MAPK1 protein]; [Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of MAPK3 protein]; ADRB2 gene polymorphism affects the reaction [Terbutaline results in increased metabolism of Lipids]; ADRB2 protein promotes the reaction [Terbutaline promotes the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein]]; ADRB2 protein promotes the reaction [Terbutaline results in decreased activity of NFKB1 protein]; ADRB2 protein promotes the reaction [Terbutaline results in increased metabolism of Lipids]; ADRB2 protein promotes the reaction [Terbutaline results in increased secretion of GAST protein]; Atenolol inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [Terbutaline binds to and results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; ICI 118551 inhibits the reaction [Terbutaline binds to and results in increased activity of ADRB2 protein]; Ketotifen inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Isoproterenol]; Propranolol inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [Terbutaline binds to and results in increased activity of ADRB2 protein]; Terbutaline binds to and results in increased activity of ADRB2 protein; Terbutaline inhibits the reaction [cyanopindolol binds to ADRB2 protein]
CTD PMID:1280742, PMID:9258252, PMID:9277405, PMID:10094932, PMID:10192281, PMID:10226872, PMID:10229127, PMID:10372813, PMID:10469353, PMID:10516654, PMID:10857765, PMID:10894789, PMID:10952688, PMID:11096136, PMID:11164953, PMID:11429395, PMID:11675405, PMID:11713096, PMID:11753577, PMID:12563174, PMID:12826277, PMID:12920204, PMID:14565945, PMID:14722251, PMID:14730417, PMID:15467267, PMID:16024912, PMID:16153394, PMID:16395068, PMID:16474418, PMID:16648137, PMID:16980553, PMID:17292646, PMID:17430990, PMID:19098126, PMID:20054151, PMID:20061444, PMID:20519311 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions ISO
EXP
[Terbutaline binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Terbutaline binds to and results in increased activity of ADRB3 protein; Terbutaline inhibits the reaction [cyanopindolol binds to ADRB3 protein] CTD PMID:7815362, PMID:14730417, PMID:16648137 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Ahsg alpha-2-HS-glycoprotein affects response to substance
increases response to substance
ISO AHSG protein affects the susceptibility to Terbutaline
AHSG gene polymorphism results in increased susceptibility to Terbutaline
CTD PMID:16024912 NCBI chr11:81,711,269...81,717,594 JBrowse link
G Aoc1 amine oxidase, copper containing 1 multiple interactions
increases activity
EXP Cycloheximide inhibits the reaction [Terbutaline results in increased activity of AOC1 protein]; Dactinomycin inhibits the reaction [Terbutaline results in increased activity of AOC1 protein] CTD PMID:2860926 NCBI chr 4:78,496,043...78,515,582
Ensembl chr 4:78,496,043...78,515,584
JBrowse link
G Aqp4 aquaporin 4 increases expression EXP Terbutaline results in increased expression of AQP4 mRNA CTD PMID:9409467 NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996
JBrowse link
G Aqp5 aquaporin 5 affects expression ISO Terbutaline affects the expression of AQP5 protein CTD PMID:15536076 NCBI chr 7:141,249,044...141,252,576
Ensembl chr 7:141,249,044...141,252,578
JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 multiple interactions
increases expression
EXP [Terbutaline results in increased expression of ATP1A1 protein] which results in increased transport of Sodium; Propranolol inhibits the reaction [Terbutaline results in increased expression of ATP1A1 mRNA]
Terbutaline results in increased expression of ATP1A1 mRNA; Terbutaline results in increased expression of ATP1A1 protein
CTD PMID:9700104, PMID:19880505 NCBI chr 2:204,003,742...204,032,023
Ensembl chr 2:204,003,742...204,032,023
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of CASP3 protein]; Terbutaline inhibits the reaction [Shiga Toxin 2 results in increased activity of CASP3 protein] CTD PMID:12826277 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO [Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of CASP7 protein]; Terbutaline inhibits the reaction [Shiga Toxin 2 results in increased activity of CASP7 protein] CTD PMID:12826277 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Chat choline O-acetyltransferase decreases expression EXP Terbutaline results in decreased expression of CHAT protein CTD PMID:29524569 NCBI chr16:8,576,858...8,686,131
Ensembl chr16:8,577,840...8,686,131
JBrowse link
G Crh corticotropin releasing hormone decreases expression ISO Terbutaline results in decreased expression of CRH mRNA CTD PMID:17127497 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Csk C-terminal Src kinase multiple interactions ISO CSK protein promotes the reaction [Terbutaline results in increased abundance of Cyclic AMP] CTD PMID:1699227 NCBI chr 8:62,405,714...62,424,707
Ensembl chr 8:62,405,715...62,424,303
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Terbutaline results in increased expression of FOS mRNA CTD PMID:7544033 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity EXP Terbutaline results in increased activity of G6PD protein CTD PMID:1978808 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gast gastrin multiple interactions
increases secretion
ISO ADRB2 protein promotes the reaction [Terbutaline results in increased secretion of GAST protein]; Calcium promotes the reaction [Terbutaline results in increased secretion of GAST protein]; Nitrendipine inhibits the reaction [Terbutaline results in increased secretion of GAST protein] CTD PMID:9277405 NCBI chr10:88,245,532...88,248,485
Ensembl chr10:88,245,532...88,248,484
JBrowse link
G Gcg glucagon increases secretion
multiple interactions
ISO Terbutaline results in increased secretion of GCG protein
NPY protein inhibits the reaction [Terbutaline results in increased secretion of GCG protein]
CTD PMID:3329090 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP Terbutaline results in increased expression of GFAP protein CTD PMID:14610225 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gnas GNAS complex locus increases localization
affects localization
EXP Terbutaline results in increased localization of GNAS protein alternative form
Terbutaline affects the localization of GNAS protein
CTD PMID:12376418 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link
G Ifng interferon gamma multiple interactions ISO [IFNG protein co-treated with Lipopolysaccharides] inhibits the reaction [Terbutaline results in increased secretion of REN protein] CTD PMID:9256163 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
ISO Terbutaline promotes the reaction [IL1B protein results in increased expression of IL10 protein]; Terbutaline promotes the reaction [Lipopolysaccharides results in increased expression of IL10 protein]
Terbutaline results in increased expression of IL10 protein
CTD PMID:9258252, PMID:10690878, PMID:12417450 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Terbutaline promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]; Terbutaline promotes the reaction [IL1B protein results in increased expression of IL10 protein]
[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Terbutaline; Budesonide inhibits the reaction [[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Terbutaline]
CTD PMID:9258252, PMID:20061444 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
affects expression
EXP ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; ADRB2 protein promotes the reaction [Terbutaline promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; ICI 118551 inhibits the reaction [Terbutaline promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; Terbutaline affects the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Terbutaline affects the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Terbutaline inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Terbutaline promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
Terbutaline results in increased expression of IL6 mRNA
Terbutaline affects the expression of IL6 mRNA; Terbutaline affects the expression of IL6 protein
CTD PMID:10469353, PMID:10525314, PMID:10857765, PMID:11096136 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions
increases expression
ISO Atenolol inhibits the reaction [Terbutaline results in increased expression of INS protein]; Bisoprolol inhibits the reaction [Terbutaline results in increased expression of INS protein]; SST inhibits the reaction [Terbutaline results in increased expression of INS protein] CTD PMID:2563217, PMID:6373350, PMID:7042176, PMID:9186877, PMID:12795776 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Lep leptin decreases expression ISO Terbutaline results in decreased expression of LEP mRNA; Terbutaline results in decreased expression of LEP protein CTD PMID:9002984 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of MAPK1 protein]; ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of MAPK1 protein]]; KT 5720 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of MAPK1 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of MAPK1 protein]]; Terbutaline inhibits the reaction [Shiga Toxin 2 results in increased activity of MAPK1 protein]; Terbutaline inhibits the reaction [Shiga Toxin results in increased activity of MAPK1 protein]
ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK1 protein]]; ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK1 protein]]; Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK1 protein]
CTD PMID:10469353, PMID:10857765, PMID:11675405, PMID:12608646, PMID:12826277, PMID:16980553 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of MAPK3 protein]; ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of MAPK3 protein]]; KT 5720 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of MAPK3 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of MAPK3 protein]]; Terbutaline inhibits the reaction [Shiga Toxin 2 results in increased activity of MAPK3 protein]; Terbutaline inhibits the reaction [Shiga Toxin results in increased activity of MAPK3 protein]
ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK3 protein]]; ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK3 protein]]; Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK3 protein]
CTD PMID:10469353, PMID:10857765, PMID:11675405, PMID:12608646, PMID:12826277, PMID:16980553 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Terbutaline CTD PMID:19462961 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO Terbutaline affects the reaction [Budesonide results in increased expression of MT2A mRNA] CTD PMID:9973176 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Nefl neurofilament light increases expression EXP Terbutaline results in increased expression of NEFL protein CTD PMID:14610225 NCBI chr15:44,799,378...44,803,251
Ensembl chr15:44,799,334...44,804,574
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
decreases activity
ISO ADRB2 protein promotes the reaction [Terbutaline results in decreased activity of NFKB1 protein]; Terbutaline inhibits the reaction [Shiga Toxin results in increased activity of NFKB1 protein] CTD PMID:11675405 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Ngf nerve growth factor decreases expression EXP Terbutaline results in decreased expression of NGF mRNA; Terbutaline results in decreased expression of NGF protein CTD PMID:11325809 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Npy neuropeptide Y multiple interactions ISO NPY protein inhibits the reaction [Terbutaline results in increased secretion of GCG protein] CTD PMID:3329090 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression
multiple interactions
ISO Terbutaline results in increased expression of NR3C1 mRNA
Budesonide affects the reaction [Terbutaline results in increased expression of NR3C1 mRNA]
CTD PMID:9973176 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Odc1 ornithine decarboxylase 1 increases activity EXP Terbutaline results in increased activity of ODC1 protein CTD PMID:2472593, PMID:8421708 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 multiple interactions EXP PAFAH1B1 protein promotes the reaction [Terbutaline results in increased secretion of Phosphatidylcholines] CTD PMID:12013527 NCBI chr10:61,456,144...61,577,412
Ensembl chr10:61,456,145...61,577,412
JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression EXP Terbutaline results in increased expression of PHGDH mRNA CTD PMID:12423672 NCBI chr 2:200,484,245...200,513,564
Ensembl chr 2:200,484,246...200,513,564
JBrowse link
G Ren renin multiple interactions
increases expression
increases secretion
ISO 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone promotes the reaction [Terbutaline results in increased secretion of REN protein]; [IFNG protein co-treated with Lipopolysaccharides] inhibits the reaction [Terbutaline results in increased secretion of REN protein]; Cycloheximide inhibits the reaction [Terbutaline results in increased secretion of REN protein]; Dactinomycin inhibits the reaction [Terbutaline results in increased secretion of REN protein]; TNF protein inhibits the reaction [Terbutaline results in increased secretion of REN protein]
Terbutaline results in increased expression of REN mRNA
CTD PMID:9203624, PMID:9256163 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha multiple interactions
increases response to substance
increases expression
EXP Propranolol inhibits the reaction [Terbutaline results in increased expression of SCNN1A mRNA]
SCNN1A protein results in increased susceptibility to Terbutaline
CTD PMID:9700104, PMID:16258001 NCBI chr 4:157,834,339...157,860,472
Ensembl chr 4:157,836,912...157,860,049
JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta multiple interactions EXP Brefeldin A inhibits the reaction [Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1B protein]]; Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1B protein] CTD PMID:12372821, PMID:12608646 NCBI chr 1:191,829,547...191,883,991
Ensembl chr 1:191,829,555...191,884,298
JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma multiple interactions EXP Brefeldin A inhibits the reaction [Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1G protein]]; Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1G protein] CTD PMID:12372821, PMID:12608646 NCBI chr 1:191,704,397...191,738,271
Ensembl chr 1:191,704,311...191,738,268
JBrowse link
G Sftpb surfactant protein B increases expression
multiple interactions
increases secretion
ISO
EXP
Terbutaline results in increased expression of SFTPB mRNA
ADRB2 protein promotes the reaction [Terbutaline results in increased secretion of SFTPB protein]
CTD PMID:2539393, PMID:11704537, PMID:14565945 NCBI chr 4:100,166,855...100,175,941
Ensembl chr 4:100,166,863...100,175,938
JBrowse link
G Sftpc surfactant protein C increases secretion
multiple interactions
EXP
ISO
Terbutaline results in increased secretion of SFTPC protein
ADRB2 protein promotes the reaction [Terbutaline results in increased secretion of SFTPC protein]
CTD PMID:11704537, PMID:14565945 NCBI chr15:52,211,538...52,214,480
Ensembl chr15:52,211,544...52,214,616
JBrowse link
G Sftpd surfactant protein D multiple interactions EXP [Terbutaline co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SFTPD protein CTD PMID:9476903 NCBI chr16:18,753,535...18,766,100
Ensembl chr16:18,745,458...18,766,174
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Terbutaline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Sst somatostatin multiple interactions ISO SST inhibits the reaction [Terbutaline results in increased expression of INS protein] CTD PMID:2563217 NCBI chr11:80,358,172...80,359,449
Ensembl chr11:80,358,211...80,359,444
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion
decreases expression
affects expression
ISO
EXP
ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of TNF protein]]; KT 5720 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of TNF mRNA]]; KT 5720 inhibits the reaction [Terbutaline results in decreased expression of TNF mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of TNF protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Terbutaline results in decreased expression of TNF mRNA]; Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of TNF mRNA]; Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of TNF protein]; TNF protein inhibits the reaction [Terbutaline results in increased secretion of REN protein]
Terbutaline results in decreased secretion of TNF protein
[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased expression of TNF protein; ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Terbutaline inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Terbutaline affects the expression of TNF mRNA; Terbutaline affects the expression of TNF protein
[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Terbutaline; Budesonide inhibits the reaction [[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Terbutaline]
Terbutaline results in decreased expression of TNF mRNA; Terbutaline results in decreased expression of TNF protein
CTD PMID:9256163, PMID:10094932, PMID:10469353, PMID:10525314, PMID:10690878, PMID:10857765, PMID:11096136, PMID:11675405, PMID:12423672, PMID:20061444 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Usf1 upstream transcription factor 1 multiple interactions ISO USF1 gene polymorphism promotes the reaction [Terbutaline results in increased metabolism of Lipids]; USF1 protein affects the reaction [Terbutaline results in increased metabolism of Lipids] CTD PMID:15985485 NCBI chr13:89,797,750...89,805,561
Ensembl chr13:89,797,800...89,805,558
JBrowse link
bambuterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO bambuterol results in decreased activity of ACHE protein CTD PMID:18582854 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Bche butyrylcholinesterase decreases activity ISO bambuterol results in decreased activity of BCHE protein CTD PMID:15652380, PMID:18582854, PMID:18977317 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        anti-asthmatic agent 9173
          anti-asthmatic drug 8547
            terbutaline 52
              bambuterol + 2
              terbutaline sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            inorganic hydride 17409
                              pnictogen hydride 17381
                                nitrogen hydride 17223
                                  azane 16940
                                    ammonia 16939
                                      organic amino compound 16938
                                        amino alcohol 882
                                          ethanolamines 769
                                            phenylethanolamines 586
                                              terbutaline 52
                                                bambuterol + 2
                                                terbutaline sulfate 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.