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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:terbutaline
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Accession:CHEBI:9449 term browser browse the term
Definition:A member of the class of phenylethanolamines that is catechol substuted at position 5 by a 2-(tert-butylamino)-1-hydroxyethyl group.
Synonyms:exact_synonym: 5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol
 related_synonym: Formula=C12H19NO3;   InChI=1S/C12H19NO3/c1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8/h4-6,11,13-16H,7H2,1-3H3;   InChIKey=XWTYSIMOBUGWOL-UHFFFAOYSA-N;   SMILES=CC(C)(C)NCC(O)c1cc(O)cc(O)c1;   terbutalina;   terbutalinum
 xref: CAS:23031-25-6;   DrugBank:DB00871;   Drug_Central:2598;   HMDB:HMDB0015009;   KEGG:C07129;   KEGG:D08570
 xref_mesh: MESH:D013726
 xref: PMID:12423672;   PMID:12569076;   PMID:21618259;   PMID:21996060;   PMID:22310877;   PMID:22363704;   PMID:22765375;   PMID:22767151;   PMID:22782385;   PMID:22813780;   PMID:22872661;   PMID:22988932;   PMID:23075357;   PMID:23126237;   PMID:23204625;   PMID:23283786;   PMID:23299764;   PMID:23325598;   PMID:23341043;   PMID:8298802;   PMID:9596106;   Patent:WO2011112499;   Reaxys:2370513;   Wikipedia:Terbutaline


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terbutaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1b adrenoceptor alpha 1B increases expression ISO Terbutaline results in increased expression of ADRA1B mRNA; Terbutaline results in increased expression of ADRA1B protein CTD PMID:10229127 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919 		JBrowse link
G Adra1d adrenoceptor alpha 1D increases expression ISO Terbutaline results in increased expression of ADRA1D mRNA; Terbutaline results in increased expression of ADRA1D protein CTD PMID:10229127 NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354 		JBrowse link
G Adrb1 adrenoceptor beta 1 multiple interactions ISO
EXP		 Terbutaline binds to and results in decreased activity of ADRB1 protein; Terbutaline binds to and results in increased activity of ADRB1 protein mutant form; Terbutaline inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Terbutaline inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein] CTD PMID:8096834 PMID:14730417 PMID:16648137 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Adrb2 adrenoceptor beta 2 affects response to substance
increases activity
multiple interactions
affects binding
increases phosphorylation
decreases expression
increases response to substance		 ISO
EXP		 ADRB2 gene polymorphism affects the susceptibility to Terbutaline; ADRB2 protein affects the susceptibility to Terbutaline; ADRB2 protein polymorphism affects the susceptibility to Terbutaline
Terbutaline results in increased activity of ADRB2 protein
[Terbutaline binds to and results in increased activity of ADRB2 protein] which affects the abundance of Calcium; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Levodopa; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Dopamine; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased expression of TNF protein; [Terbutaline results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; [Terbutaline results in increased activity of ADRB2 protein] which results in increased secretion of Histamine; [Terbutaline results in increased activity of ADRB2 protein] which results in increased transport of Chlorides; [Terbutaline results in increased activity of ADRB2 protein] which results in increased transport of Sodium; ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK1 protein]]; ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK3 protein]]; ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; ADRB2 protein promotes the reaction [Terbutaline promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; CGP 20712A inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; ICI 118551 inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Levodopa]; ICI 118551 inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Dopamine]; ICI 118551 inhibits the reaction [Terbutaline results in increased activity of ADRB2 protein]; Pertussis Toxin promotes the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; Terbutaline binds to and results in increased activity of ADRB2 protein
Terbutaline binds to ADRB2 protein
ADRB2 protein promotes the reaction [Terbutaline results in increased secretion of SFTPB protein]; ADRB2 protein promotes the reaction [Terbutaline results in increased secretion of SFTPC protein]; Terbutaline binds to and results in increased activity of ADRB2 protein
Terbutaline results in increased phosphorylation of ADRB2 protein
Terbutaline results in decreased expression of ADRB2 protein
ADRB2 protein results in increased susceptibility to Terbutaline; ADRB2 protein SNP results in increased susceptibility to Terbutaline
[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Isoproterenol; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Potassium; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of CASP3 protein]; [Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of CASP7 protein]; [Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of MAPK1 protein]; [Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of MAPK3 protein]; ADRB2 gene polymorphism affects the reaction [Terbutaline results in increased metabolism of Lipids]; ADRB2 protein promotes the reaction [Terbutaline promotes the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein]]; ADRB2 protein promotes the reaction [Terbutaline results in decreased activity of NFKB1 protein]; ADRB2 protein promotes the reaction [Terbutaline results in increased metabolism of Lipids]; ADRB2 protein promotes the reaction [Terbutaline results in increased secretion of GAST protein]; Atenolol inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [Terbutaline binds to and results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; ICI 118551 inhibits the reaction [Terbutaline binds to and results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [Terbutaline results in increased activity of ADRB2 protein]; Ketotifen inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Isoproterenol]; Propranolol inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [Terbutaline binds to and results in increased activity of ADRB2 protein]; Terbutaline binds to and results in increased activity of ADRB2 protein; Terbutaline inhibits the reaction [cyanopindolol binds to ADRB2 protein]		 CTD PMID:1280742 PMID:9258252 PMID:9277405 PMID:10094932 PMID:10192281 More... NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions ISO
EXP		 [Terbutaline binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Terbutaline binds to and results in increased activity of ADRB3 protein; Terbutaline inhibits the reaction [cyanopindolol binds to ADRB3 protein] CTD PMID:7815362 PMID:14730417 PMID:16648137 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552 		JBrowse link
G Ahsg alpha-2-HS-glycoprotein affects response to substance
increases response to substance		 ISO AHSG protein affects the susceptibility to Terbutaline
AHSG gene polymorphism results in increased susceptibility to Terbutaline		 CTD PMID:16024912 NCBI chr11:78,117,903...78,145,956
Ensembl chr11:78,117,918...78,145,999 		JBrowse link
G Aoc1 amine oxidase, copper containing 1 multiple interactions
increases activity		 EXP Cycloheximide inhibits the reaction [Terbutaline results in increased activity of AOC1 protein]; Dactinomycin inhibits the reaction [Terbutaline results in increased activity of AOC1 protein] CTD PMID:2860926 NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840 		JBrowse link
G Aqp4 aquaporin 4 increases expression EXP Terbutaline results in increased expression of AQP4 mRNA CTD PMID:9409467 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856 		JBrowse link
G Aqp5 aquaporin 5 affects expression ISO Terbutaline affects the expression of AQP5 protein CTD PMID:15536076 NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 multiple interactions
increases expression		 EXP [Terbutaline results in increased expression of ATP1A1 protein] which results in increased transport of Sodium; Propranolol inhibits the reaction [Terbutaline results in increased expression of ATP1A1 mRNA]
Terbutaline results in increased expression of ATP1A1 mRNA; Terbutaline results in increased expression of ATP1A1 protein		 CTD PMID:9700104 PMID:19880505 NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of CASP3 protein]; Terbutaline inhibits the reaction [Shiga Toxin 2 results in increased activity of CASP3 protein] CTD PMID:12826277 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO [Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of CASP7 protein]; Terbutaline inhibits the reaction [Shiga Toxin 2 results in increased activity of CASP7 protein] CTD PMID:12826277 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Chat choline O-acetyltransferase decreases expression EXP Terbutaline results in decreased expression of CHAT protein CTD PMID:29524569 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093 		JBrowse link
G Crh corticotropin releasing hormone decreases expression ISO Terbutaline results in decreased expression of CRH mRNA CTD PMID:17127497 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Csk C-terminal Src kinase multiple interactions ISO CSK protein promotes the reaction [Terbutaline results in increased abundance of Cyclic AMP] CTD PMID:1699227 NCBI chr 8:58,029,748...58,048,742
Ensembl chr 8:58,029,749...58,048,292 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Terbutaline results in increased expression of FOS mRNA CTD PMID:7544033 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity EXP Terbutaline results in increased activity of G6PD protein CTD PMID:1978808 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gast gastrin multiple interactions
increases secretion		 ISO ADRB2 protein promotes the reaction [Terbutaline results in increased secretion of GAST protein]; Calcium promotes the reaction [Terbutaline results in increased secretion of GAST protein]; Nitrendipine inhibits the reaction [Terbutaline results in increased secretion of GAST protein] CTD PMID:9277405 NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496 		JBrowse link
G Gcg glucagon increases secretion
multiple interactions		 ISO Terbutaline results in increased secretion of GCG protein
NPY protein inhibits the reaction [Terbutaline results in increased secretion of GCG protein]		 CTD PMID:3329090 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929 		JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP Terbutaline results in increased expression of GFAP protein CTD PMID:14610225 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gnas GNAS complex locus increases localization
affects localization		 EXP Terbutaline results in increased localization of GNAS protein alternative form
Terbutaline affects the localization of GNAS protein		 CTD PMID:12376418 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [IFNG protein co-treated with Lipopolysaccharides] inhibits the reaction [Terbutaline results in increased secretion of REN protein] CTD PMID:9256163 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression		 ISO Terbutaline promotes the reaction [IL1B protein results in increased expression of IL10 protein]; Terbutaline promotes the reaction [Lipopolysaccharides results in increased expression of IL10 protein]
Terbutaline results in increased expression of IL10 protein		 CTD PMID:9258252 PMID:10690878 PMID:12417450 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Terbutaline promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]; Terbutaline promotes the reaction [IL1B protein results in increased expression of IL10 protein]
[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Terbutaline; Budesonide inhibits the reaction [[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Terbutaline]		 CTD PMID:9258252 PMID:20061444 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
affects expression		 EXP ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; ADRB2 protein promotes the reaction [Terbutaline promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; ICI 118551 inhibits the reaction [Terbutaline promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; Terbutaline affects the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Terbutaline affects the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Terbutaline inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Terbutaline promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
Terbutaline results in increased expression of IL6 mRNA
Terbutaline affects the expression of IL6 mRNA; Terbutaline affects the expression of IL6 protein		 CTD PMID:10469353 PMID:10525314 PMID:10857765 PMID:11096136 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins2 insulin 2 multiple interactions
increases expression		 ISO Atenolol inhibits the reaction [Terbutaline results in increased expression of INS protein]; Bisoprolol inhibits the reaction [Terbutaline results in increased expression of INS protein]; SST inhibits the reaction [Terbutaline results in increased expression of INS protein] CTD PMID:2563217 PMID:6373350 PMID:7042176 PMID:9186877 PMID:12795776 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Lep leptin decreases expression ISO Terbutaline results in decreased expression of LEP mRNA; Terbutaline results in decreased expression of LEP protein CTD PMID:9002984 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP		 [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of MAPK1 protein]; ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of MAPK1 protein]]; KT 5720 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of MAPK1 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of MAPK1 protein]]; Terbutaline inhibits the reaction [Shiga Toxin 2 results in increased activity of MAPK1 protein]; Terbutaline inhibits the reaction [Shiga Toxin results in increased activity of MAPK1 protein]
ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK1 protein]]; ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK1 protein]]; Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK1 protein]		 CTD PMID:10469353 PMID:10857765 PMID:11675405 PMID:12608646 PMID:12826277 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP		 [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Terbutaline results in increased activity of ADRB2 protein] inhibits the reaction [Shiga Toxin 2 results in increased activity of MAPK3 protein]; ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of MAPK3 protein]]; KT 5720 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of MAPK3 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of MAPK3 protein]]; Terbutaline inhibits the reaction [Shiga Toxin 2 results in increased activity of MAPK3 protein]; Terbutaline inhibits the reaction [Shiga Toxin results in increased activity of MAPK3 protein]
ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK3 protein]]; ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK3 protein]]; Terbutaline inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK3 protein]		 CTD PMID:10469353 PMID:10857765 PMID:11675405 PMID:12608646 PMID:12826277 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Terbutaline CTD PMID:19462961 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO Terbutaline affects the reaction [Budesonide results in increased expression of MT2A mRNA] CTD PMID:9973176 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Nefl neurofilament light chain increases expression EXP Terbutaline results in increased expression of NEFL protein CTD PMID:14610225 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
decreases activity		 ISO ADRB2 protein promotes the reaction [Terbutaline results in decreased activity of NFKB1 protein]; Terbutaline inhibits the reaction [Shiga Toxin results in increased activity of NFKB1 protein] CTD PMID:11675405 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Ngf nerve growth factor decreases expression EXP Terbutaline results in decreased expression of NGF mRNA; Terbutaline results in decreased expression of NGF protein CTD PMID:11325809 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Npy neuropeptide Y multiple interactions ISO NPY protein inhibits the reaction [Terbutaline results in increased secretion of GCG protein] CTD PMID:3329090 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression
multiple interactions		 ISO Terbutaline results in increased expression of NR3C1 mRNA
Budesonide affects the reaction [Terbutaline results in increased expression of NR3C1 mRNA]		 CTD PMID:9973176 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Odc1 ornithine decarboxylase 1 increases activity EXP Terbutaline results in increased activity of ODC1 protein CTD PMID:2472593 PMID:8421708 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 multiple interactions EXP PAFAH1B1 protein promotes the reaction [Terbutaline results in increased secretion of Phosphatidylcholines] CTD PMID:12013527 NCBI chr10:59,533,042...59,591,808
Ensembl chr10:59,534,117...59,591,808 		JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression EXP Terbutaline results in increased expression of PHGDH mRNA CTD PMID:12423672 NCBI chr 2:185,906,964...185,936,160
Ensembl chr 2:185,906,966...185,935,944 		JBrowse link
G Ren renin multiple interactions
increases expression
increases secretion		 ISO 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone promotes the reaction [Terbutaline results in increased secretion of REN protein]; [IFNG protein co-treated with Lipopolysaccharides] inhibits the reaction [Terbutaline results in increased secretion of REN protein]; Cycloheximide inhibits the reaction [Terbutaline results in increased secretion of REN protein]; Dactinomycin inhibits the reaction [Terbutaline results in increased secretion of REN protein]; TNF protein inhibits the reaction [Terbutaline results in increased secretion of REN protein]
Terbutaline results in increased expression of REN mRNA		 CTD PMID:9203624 PMID:9256163 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha multiple interactions
increases response to substance
increases expression		 EXP Propranolol inhibits the reaction [Terbutaline results in increased expression of SCNN1A mRNA]
SCNN1A protein results in increased susceptibility to Terbutaline		 CTD PMID:9700104 PMID:16258001 NCBI chr 4:158,122,962...158,146,184
Ensembl chr 4:158,122,962...158,146,181 		JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta multiple interactions EXP Brefeldin A inhibits the reaction [Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1B protein]]; Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1B protein] CTD PMID:12372821 PMID:12608646 NCBI chr 1:176,430,063...176,484,451
Ensembl chr 1:176,430,103...176,484,451 		JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma multiple interactions EXP Brefeldin A inhibits the reaction [Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1G protein]]; Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1G protein] CTD PMID:12372821 PMID:12608646 NCBI chr 1:176,304,942...176,338,816
Ensembl chr 1:176,304,942...176,338,816 		JBrowse link
G Sftpb surfactant protein B increases expression
multiple interactions
increases secretion		 ISO
EXP		 Terbutaline results in increased expression of SFTPB mRNA
ADRB2 protein promotes the reaction [Terbutaline results in increased secretion of SFTPB protein]		 CTD PMID:2539393 PMID:11704537 PMID:14565945 NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436 		JBrowse link
G Sftpc surfactant protein C increases secretion
multiple interactions		 EXP
ISO		 Terbutaline results in increased secretion of SFTPC protein
ADRB2 protein promotes the reaction [Terbutaline results in increased secretion of SFTPC protein]		 CTD PMID:11704537 PMID:14565945 NCBI chr15:45,596,565...45,599,615
Ensembl chr15:45,596,574...45,610,777 		JBrowse link
G Sftpd surfactant protein D multiple interactions EXP [Terbutaline co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SFTPD protein CTD PMID:9476903 NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Terbutaline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Sst somatostatin multiple interactions ISO SST inhibits the reaction [Terbutaline results in increased expression of INS protein] CTD PMID:2563217 NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion
decreases expression
affects expression		 ISO
EXP		 ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of TNF protein]]; KT 5720 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of TNF mRNA]]; KT 5720 inhibits the reaction [Terbutaline results in decreased expression of TNF mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of TNF protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Terbutaline results in decreased expression of TNF mRNA]; Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of TNF mRNA]; Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of TNF protein]; TNF protein inhibits the reaction [Terbutaline results in increased secretion of REN protein]
Terbutaline results in decreased secretion of TNF protein
[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased expression of TNF protein; ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ADRB2 protein promotes the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ICI 118551 inhibits the reaction [Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Terbutaline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Terbutaline inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Terbutaline affects the expression of TNF mRNA; Terbutaline affects the expression of TNF protein
[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Terbutaline; Budesonide inhibits the reaction [[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Terbutaline]
Terbutaline results in decreased expression of TNF mRNA; Terbutaline results in decreased expression of TNF protein		 CTD PMID:9256163 PMID:10094932 PMID:10469353 PMID:10525314 PMID:10690878 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Usf1 upstream transcription factor 1 multiple interactions ISO USF1 gene polymorphism promotes the reaction [Terbutaline results in increased metabolism of Lipids]; USF1 protein affects the reaction [Terbutaline results in increased metabolism of Lipids] CTD PMID:15985485 NCBI chr13:83,845,230...83,854,875
Ensembl chr13:83,822,035...83,854,885 		JBrowse link
bambuterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO bambuterol results in decreased activity of ACHE protein CTD PMID:18582854 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Adrb2 adrenoceptor beta 2 increases activity ISO bambuterol results in increased activity of ADRB2 protein CTD PMID:34601065 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Bche butyrylcholinesterase decreases activity ISO bambuterol results in decreased activity of BCHE protein CTD PMID:15652380 PMID:18582854 PMID:18977317 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      application 19745
        anti-asthmatic agent 9286
          anti-asthmatic drug 8662
            terbutaline 52
              bambuterol + 3
              terbutaline sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    main group molecular entity 19956
                      s-block molecular entity 19752
                        hydrogen molecular entity 19745
                          hydrides 19114
                            inorganic hydride 17882
                              pnictogen hydride 17865
                                nitrogen hydride 17754
                                  azane 17503
                                    ammonia 17502
                                      organic amino compound 17502
                                        amino alcohol 1033
                                          ethanolamines 798
                                            phenylethanolamines 592
                                              terbutaline 52
                                                bambuterol + 3
                                                terbutaline sulfate 0
paths to the root