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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:terazosin
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Accession:CHEBI:9445 term browser browse the term
Definition:A primary amino compound that has formula C19H25N5O4.
Synonyms:exact_synonym: 6,7-dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine
 related_synonym: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine;   Formula=C19H25N5O4;   InChI=1S/C19H25N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);   InChIKey=VCKUSRYTPJJLNI-UHFFFAOYSA-N;   SMILES=COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1;   Terazosine;   terazosina;   terazosinum
 xref: Beilstein:719452;   CAS:63590-64-7;   DrugBank:DB01162;   Drug_Central:3584;   KEGG:C07127;   KEGG:D08569;   LINCS:LSM-4997
 xref_mesh: MESH:C041226
 xref: Patent:DE2646186;   Patent:DE2831112;   Patent:US4026894;   Patent:US4251532;   Wikipedia:Terazosin



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terazosin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A affects binding EXP
ISO
Terazosin binds to ADRA1A protein CTD PMID:7536677 PMID:8183249 PMID:21544540 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Adra1b adrenoceptor alpha 1B affects binding ISO Terazosin binds to ADRA1B protein CTD PMID:8183249 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919
JBrowse link
G Adra1d adrenoceptor alpha 1D affects binding ISO
EXP
Terazosin binds to ADRA1D protein CTD PMID:8183249 PMID:9294627 NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Terazosin results in increased expression of BAX protein CTD PMID:12883741 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Terazosin results in decreased expression of BCL2 protein CTD PMID:12883741 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Terazosin results in increased expression of CDKN1B protein CTD PMID:12883741 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Il24 interleukin 24 increases expression ISO Terazosin results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link

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  CHEBI ontology 19823
    role 19773
      application 19486
        pharmaceutical 19335
          drug 19335
            antineoplastic agent 17378
              terazosin 7
                terazosin hydrochloride dihydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    main group molecular entity 19720
                      s-block molecular entity 19502
                        hydrogen molecular entity 19495
                          hydrides 18855
                            inorganic hydride 17694
                              pnictogen hydride 17675
                                nitrogen hydride 17547
                                  azane 17280
                                    ammonia 17279
                                      organic amino compound 17279
                                        primary amino compound 7980
                                          terazosin 7
                                            terazosin hydrochloride dihydrate 0
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