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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:terazosin
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Accession:CHEBI:9445 term browser browse the term
Definition:A primary amino compound that has formula C19H25N5O4.
Synonyms:exact_synonym: 6,7-dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine
 related_synonym: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine;   Formula=C19H25N5O4;   InChI=1S/C19H25N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);   InChIKey=VCKUSRYTPJJLNI-UHFFFAOYSA-N;   SMILES=COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1;   Terazosine;   terazosina;   terazosinum
 xref: Beilstein:719452;   CAS:63590-64-7;   DrugBank:DB01162;   Drug_Central:3584;   KEGG:C07127;   KEGG:D08569;   LINCS:LSM-4997
 xref_mesh: MESH:C041226
 xref: Patent:DE2646186;   Patent:DE2831112;   Patent:US4026894;   Patent:US4251532;   Wikipedia:Terazosin



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terazosin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A affects binding EXP
ISO
Terazosin binds to ADRA1A protein CTD PMID:7536677 PMID:8183249 PMID:21544540 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Adra1b adrenoceptor alpha 1B affects binding ISO Terazosin binds to ADRA1B protein CTD PMID:8183249 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919
JBrowse link
G Adra1d adrenoceptor alpha 1D affects binding ISO
EXP
Terazosin binds to ADRA1D protein CTD PMID:8183249 PMID:9294627 NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Terazosin results in increased expression of BAX protein CTD PMID:12883741 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Terazosin results in decreased expression of BCL2 protein CTD PMID:12883741 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Terazosin results in increased expression of CDKN1B protein CTD PMID:12883741 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Il24 interleukin 24 increases expression ISO Terazosin results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases activity EXP Terazosin increases activity of Mmp2 protein in the prostate RGD PMID:16899336 RGD:1601417 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      application 19745
        pharmaceutical 19618
          drug 19618
            antineoplastic agent 17639
              terazosin 8
                terazosin hydrochloride dihydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    main group molecular entity 19956
                      s-block molecular entity 19752
                        hydrogen molecular entity 19745
                          hydrides 19114
                            inorganic hydride 17882
                              pnictogen hydride 17865
                                nitrogen hydride 17754
                                  azane 17503
                                    ammonia 17502
                                      organic amino compound 17502
                                        primary amino compound 8282
                                          terazosin 8
                                            terazosin hydrochloride dihydrate 0
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