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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:terazosin
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Accession:CHEBI:9445 term browser browse the term
Definition:A primary amino compound that has formula C19H25N5O4.
Synonyms:exact_synonym: 6,7-dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine
 related_synonym: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine;   Formula=C19H25N5O4;   InChI=1S/C19H25N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);   InChIKey=VCKUSRYTPJJLNI-UHFFFAOYSA-N;   SMILES=COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1;   Terazosine;   terazosina;   terazosinum
 xref: Beilstein:719452;   CAS:63590-64-7;   DrugBank:DB01162;   Drug_Central:3584;   KEGG:C07127;   KEGG:D08569;   LINCS:LSM-4997
 xref_mesh: MESH:C041226
 xref: Patent:DE2646186;   Patent:DE2831112;   Patent:US4026894;   Patent:US4251532;   Wikipedia:Terazosin


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terazosin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A affects binding EXP
ISO
Terazosin binds to ADRA1A protein CTD PMID:7536677, PMID:8183249, PMID:21544540 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Adra1b adrenoceptor alpha 1B affects binding ISO Terazosin binds to ADRA1B protein CTD PMID:8183249 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
JBrowse link
G Adra1d adrenoceptor alpha 1D affects binding ISO
EXP
Terazosin binds to ADRA1D protein CTD PMID:8183249, PMID:9294627 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Terazosin results in increased expression of BAX protein CTD PMID:12883741 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Terazosin results in decreased expression of BCL2 protein CTD PMID:12883741 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Terazosin results in increased expression of CDKN1B protein CTD PMID:12883741 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pharmaceutical 19272
          drug 19272
            antineoplastic agent 16982
              terazosin 6
                terazosin hydrochloride dihydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            inorganic hydride 17409
                              pnictogen hydride 17381
                                nitrogen hydride 17223
                                  azane 16940
                                    ammonia 16939
                                      organic amino compound 16938
                                        primary amino compound 7858
                                          terazosin 6
                                            terazosin hydrochloride dihydrate 0
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