The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A member of the class of rotenones that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted with geminal methyl groups at position 3, hydroxy group at position 7a and methoxy groups at positions 9 and 10 (the 7aR,13aR stereoisomer). It is isolated from the leaves and twigs of Antheroporum pierrei and exhibits antineoplastic and pesticidal activities.
tephrosin inhibits the reaction [EGF protein affects the phosphorylation of AKT1 protein]; tephrosin inhibits the reaction [NRG1 protein affects the phosphorylation of AKT1 protein] tephrosin results in decreased phosphorylation of AKT1 protein
tephrosin inhibits the reaction [EGF protein affects the phosphorylation of AKT1 protein]; tephrosin inhibits the reaction [EGF protein affects the phosphorylation of EGFR protein]; tephrosin inhibits the reaction [EGF protein affects the phosphorylation of ERBB2 protein]; tephrosin inhibits the reaction [EGF protein affects the phosphorylation of MAPK1 protein]; tephrosin inhibits the reaction [EGF protein affects the phosphorylation of MAPK3 protein]
tephrosin affects the localization of EGFR protein Chloroquine inhibits the reaction [tephrosin results in increased degradation of EGFR protein]; tephrosin inhibits the reaction [EGF protein affects the phosphorylation of EGFR protein]; tephrosin results in increased degradation of and results in decreased phosphorylation of EGFR protein
Chloroquine inhibits the reaction [tephrosin results in increased degradation of ERBB2 protein]; tephrosin inhibits the reaction [EGF protein affects the phosphorylation of ERBB2 protein]; tephrosin inhibits the reaction [NRG1 protein affects the phosphorylation of ERBB2 protein]; tephrosin results in increased degradation of and results in decreased phosphorylation of ERBB2 protein tephrosin affects the localization of ERBB2 protein
tephrosin inhibits the reaction [NRG1 protein affects the phosphorylation of ERBB3 protein]; tephrosin results in increased degradation of and results in decreased phosphorylation of ERBB3 protein
tephrosin results in decreased phosphorylation of MAPK1 protein tephrosin inhibits the reaction [EGF protein affects the phosphorylation of MAPK1 protein]; tephrosin inhibits the reaction [NRG1 protein affects the phosphorylation of MAPK1 protein]
tephrosin results in decreased phosphorylation of MAPK3 protein tephrosin inhibits the reaction [EGF protein affects the phosphorylation of MAPK3 protein]; tephrosin inhibits the reaction [NRG1 protein affects the phosphorylation of MAPK3 protein]
tephrosin inhibits the reaction [NRG1 protein affects the phosphorylation of AKT1 protein]; tephrosin inhibits the reaction [NRG1 protein affects the phosphorylation of ERBB2 protein]; tephrosin inhibits the reaction [NRG1 protein affects the phosphorylation of ERBB3 protein]; tephrosin inhibits the reaction [NRG1 protein affects the phosphorylation of MAPK1 protein]; tephrosin inhibits the reaction [NRG1 protein affects the phosphorylation of MAPK3 protein]
tephrosin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; tephrosin inhibits the reaction [TNF protein results in increased expression of BIRC3 protein]; tephrosin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; tephrosin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; tephrosin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
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