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Accession:CHEBI:9442 term browser browse the term
Definition:A member of the class of rotenones that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted with geminal methyl groups at position 3, hydroxy group at position 7a and methoxy groups at positions 9 and 10 (the 7aR,13aR stereoisomer). It is isolated from the leaves and twigs of Antheroporum pierrei and exhibits antineoplastic and pesticidal activities.
Synonyms:exact_synonym: (7aR,13aR)-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one
 related_synonym: (7aR,13aR)-13,13a-dihydro-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-3H-bis(1)benzopyrano(3,4-b:6',5'-e)pyran-7(7aH)-one;   Formula=C23H22O7;   InChI=1S/C23H22O7/c1-22(2)8-7-12-15(30-22)6-5-13-20(12)29-19-11-28-16-10-18(27-4)17(26-3)9-14(16)23(19,25)21(13)24/h5-10,19,25H,11H2,1-4H3/t19-,23-/m1/s1;   InChIKey=AQBZCCQCDWNNJQ-AUSIDOKSSA-N;   SMILES=[H][C@@]12COc3cc(OC)c(OC)cc3[C@]1(O)C(=O)c1ccc3OC(C)(C)C=Cc3c1O2;   deguelinol I;   hydroxydeguelin
 alt_id: CHEBI:68052
 xref: CAS:76-80-2 "ChemIDplus";   CAS:76-80-2 "KEGG COMPOUND";   KEGG:C10535;   KNApSAcK:C00002578;   LIPID_MAPS_instance:LMPK12060047 "LIPID MAPS"
 xref_mesh: MESH:C480848
 xref: MetaCyc:CPD-12165;   PMID:17830264 "Europe PMC";   PMID:20572190 "Europe PMC";   PMID:21452840 "Europe PMC";   PMID:21966156 "Europe PMC";   PMID:22123175 "Europe PMC";   PMID:22237680 "Europe PMC";   PMID:22970736 "Europe PMC";   Patent:DE19707178;   Patent:GB350897;   Patent:GB437171;   Reaxys:5661956 "Reaxys";   Wikipedia:Tephrosin

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tephrosin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Birc2 baculoviral IAP repeat-containing 2 JBrowse link 8 6,014,014 6,036,668 RGD:6480464
G Birc3 baculoviral IAP repeat-containing 3 JBrowse link 8 6,048,590 6,076,828 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        pesticide 15800
          tephrosin 6
            4',5'-dihydro-11,5'-dihydroxy-4'-methoxytephrosin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      ketone 15789
                                        cyclic ketone 13094
                                          rotenones 1811
                                            tephrosin 6
                                              4',5'-dihydro-11,5'-dihydroxy-4'-methoxytephrosin 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.