Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tephrosin
go back to main search page
Accession:CHEBI:9442 term browser browse the term
Definition:A member of the class of rotenones that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted with geminal methyl groups at position 3, hydroxy group at position 7a and methoxy groups at positions 9 and 10 (the 7aR,13aR stereoisomer). It is isolated from the leaves and twigs of Antheroporum pierrei and exhibits antineoplastic and pesticidal activities.
Synonyms:exact_synonym: (7aR,13aR)-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one
 related_synonym: (7aR,13aR)-13,13a-dihydro-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-3H-bis(1)benzopyrano(3,4-b:6',5'-e)pyran-7(7aH)-one;   Formula=C23H22O7;   InChI=1S/C23H22O7/c1-22(2)8-7-12-15(30-22)6-5-13-20(12)29-19-11-28-16-10-18(27-4)17(26-3)9-14(16)23(19,25)21(13)24/h5-10,19,25H,11H2,1-4H3/t19-,23-/m1/s1;   InChIKey=AQBZCCQCDWNNJQ-AUSIDOKSSA-N;   SMILES=[H][C@@]12COc3cc(OC)c(OC)cc3[C@]1(O)C(=O)c1ccc3OC(C)(C)C=Cc3c1O2;   deguelinol I;   hydroxydeguelin
 alt_id: CHEBI:68052
 xref: CAS:76-80-2;   KEGG:C10535;   KNApSAcK:C00002578;   LIPID_MAPS_instance:LMPK12060047
 xref_mesh: MESH:C480848
 xref: MetaCyc:CPD-12165;   PMID:17830264;   PMID:20572190;   PMID:21452840;   PMID:21966156;   PMID:22123175;   PMID:22237680;   PMID:22970736;   Patent:DE19707178;   Patent:GB350897;   Patent:GB437171;   Reaxys:5661956;   Wikipedia:Tephrosin


show annotations for term's descendants           Sort by:
 
tephrosin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization ISO tephrosin affects the localization of AIFM1 protein CTD PMID:20056314 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO tephrosin inhibits the reaction [EGF protein affects the phosphorylation of AKT1 protein]; tephrosin inhibits the reaction [NRG1 protein affects the phosphorylation of AKT1 protein]
tephrosin results in decreased phosphorylation of AKT1 protein
CTD PMID:20056314 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO tephrosin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein] CTD PMID:18841906 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO tephrosin inhibits the reaction [TNF protein results in increased expression of BIRC3 protein] CTD PMID:18841906 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Egf epidermal growth factor multiple interactions ISO tephrosin inhibits the reaction [EGF protein affects the phosphorylation of AKT1 protein]; tephrosin inhibits the reaction [EGF protein affects the phosphorylation of EGFR protein]; tephrosin inhibits the reaction [EGF protein affects the phosphorylation of ERBB2 protein]; tephrosin inhibits the reaction [EGF protein affects the phosphorylation of MAPK1 protein]; tephrosin inhibits the reaction [EGF protein affects the phosphorylation of MAPK3 protein] CTD PMID:20056314 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor affects localization
multiple interactions
ISO tephrosin affects the localization of EGFR protein
Chloroquine inhibits the reaction [tephrosin results in increased degradation of EGFR protein]; tephrosin inhibits the reaction [EGF protein affects the phosphorylation of EGFR protein]; tephrosin results in increased degradation of and results in decreased phosphorylation of EGFR protein
CTD PMID:20056314 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions
affects localization
ISO Chloroquine inhibits the reaction [tephrosin results in increased degradation of ERBB2 protein]; tephrosin inhibits the reaction [EGF protein affects the phosphorylation of ERBB2 protein]; tephrosin inhibits the reaction [NRG1 protein affects the phosphorylation of ERBB2 protein]; tephrosin results in increased degradation of and results in decreased phosphorylation of ERBB2 protein
tephrosin affects the localization of ERBB2 protein
CTD PMID:20056314 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 multiple interactions ISO tephrosin inhibits the reaction [NRG1 protein affects the phosphorylation of ERBB3 protein]; tephrosin results in increased degradation of and results in decreased phosphorylation of ERBB3 protein CTD PMID:20056314 NCBI chr 7:2,989,202...3,010,610
Ensembl chr 7:2,989,340...3,010,350
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions
ISO tephrosin results in decreased phosphorylation of MAPK1 protein
tephrosin inhibits the reaction [EGF protein affects the phosphorylation of MAPK1 protein]; tephrosin inhibits the reaction [NRG1 protein affects the phosphorylation of MAPK1 protein]
CTD PMID:20056314 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO tephrosin results in decreased phosphorylation of MAPK3 protein
tephrosin inhibits the reaction [EGF protein affects the phosphorylation of MAPK3 protein]; tephrosin inhibits the reaction [NRG1 protein affects the phosphorylation of MAPK3 protein]
CTD PMID:20056314 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO tephrosin inhibits the reaction [TNF protein results in increased expression of MMP9 protein] CTD PMID:18841906 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO tephrosin inhibits the reaction [TNF protein results in increased expression of NOS2 protein] CTD PMID:18841906 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nrg1 neuregulin 1 multiple interactions ISO tephrosin inhibits the reaction [NRG1 protein affects the phosphorylation of AKT1 protein]; tephrosin inhibits the reaction [NRG1 protein affects the phosphorylation of ERBB2 protein]; tephrosin inhibits the reaction [NRG1 protein affects the phosphorylation of ERBB3 protein]; tephrosin inhibits the reaction [NRG1 protein affects the phosphorylation of MAPK1 protein]; tephrosin inhibits the reaction [NRG1 protein affects the phosphorylation of MAPK3 protein] CTD PMID:20056314 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO tephrosin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] CTD PMID:18841906 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO tephrosin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; tephrosin inhibits the reaction [TNF protein results in increased expression of BIRC3 protein]; tephrosin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; tephrosin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; tephrosin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] CTD PMID:18841906 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pesticide 16263
          tephrosin 15
            4',5'-dihydro-11,5'-dihydroxy-4'-methoxytephrosin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      ketone 16140
                                        cyclic ketone 13810
                                          rotenones 3250
                                            tephrosin 15
                                              4',5'-dihydro-11,5'-dihydroxy-4'-methoxytephrosin 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.