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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile
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Accession:CHEBI:94355 term browser browse the term
Definition:An imidazopyridine that has formula C14H13N3.
Synonyms:related_synonym: CGS 16949A;   Formula=C14H13N3;   InChI=1S/C14H13N3/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14/h4-7,9-10,14H,1-3H2;   InChIKey=CLPFFLWZZBQMAO-UHFFFAOYSA-N;   SMILES=C1CC(N2C=NC=C2C1)C3=CC=C(C=C3)C#N;   fadrozole HCl;   fadrozole hydrochloride;   fadrozole monohydrochloride
 xref: CAS:102676-47-1;   Drug_Central:1126;   LINCS:LSM-5015
 xref_mesh: MESH:D017316


show annotations for term's descendants           Sort by:
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases expression EXP Fadrozole results in decreased expression of ACE protein CTD PMID:18586661 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin converting enzyme 2 increases expression EXP Fadrozole results in increased expression of ACE2 protein CTD PMID:18586661 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression EXP Fadrozole results in decreased expression of AGTR1 protein CTD PMID:18586661 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 increases expression EXP Fadrozole results in increased expression of AGTR2 protein CTD PMID:18586661 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 decreases activity ISO Fadrozole results in decreased activity of CYP11B1 protein CTD PMID:15743198 PMID:15771425 PMID:15985365 PMID:21341743 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 decreases activity ISO Fadrozole results in decreased activity of CYP11B2 protein CTD PMID:15743198 PMID:15771425 PMID:15985365 PMID:21341743 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity ISO Fadrozole results in decreased activity of CYP17A1 protein CTD PMID:15743198 PMID:15771425 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity
increases activity
multiple interactions		 ISO Fadrozole results in decreased activity of CYP19A1 protein
Fadrozole results in increased activity of CYP19A1 protein
Genistein inhibits the reaction [Fadrozole results in increased activity of CYP19A1 protein]		 CTD PMID:15743198 PMID:15771425 PMID:21341743 PMID:21854827 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp51 cytochrome P450, family 51 decreases activity ISO Fadrozole results in decreased activity of CYP51A1 protein CTD PMID:16989930 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Fadrozole binds to and results in decreased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Fadrozole binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO [Dexamethasone co-treated with Fadrozole] inhibits the reaction [Testosterone results in increased expression of TFF1 mRNA]; Fadrozole inhibits the reaction [bisphenol A results in increased expression of TFF1 mRNA]; Fadrozole inhibits the reaction [Testosterone results in increased expression of TFF1 mRNA] CTD PMID:15525692 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    chemical entity 19829
      atom 19829
        nonmetal atom 19767
          nitrogen atom 18955
            nitrogen molecular entity 18955
              organonitrogen compound 18804
                organonitrogen heterocyclic compound 18148
                  imidazopyridine 712
                    4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      p-block molecular entity 19779
                        carbon group molecular entity 19728
                          organic molecular entity 19724
                            organic molecule 19677
                              organic cyclic compound 19490
                                organic heterocyclic compound 18852
                                  organic heteropolycyclic compound 18295
                                    organic heterobicyclic compound 17240
                                      imidazopyridine 712
                                        4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile 12
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