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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:parbendazole
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Accession:CHEBI:94267 term browser browse the term
Definition:A member of the class of benzimidazoles that is 1H-benzimidazole substituted by (methoxycarbonyl)amino and butyl groups at positions 2 and 5, respectively. It is a potent inhibitor of microtubule assembly and also exhibits anthelminthic activity.
Synonyms:exact_synonym: methyl (5-butyl-1H-benzimidazol-2-yl)carbamate
 related_synonym: 5-butyl-2-(carbomethoxyamino)benzimidazole;   Formula=C13H17N3O2;   Helatac;   Helmatac;   InChI=1S/C13H17N3O2/c1-3-4-5-9-6-7-10-11(8-9)15-12(14-10)16-13(17)18-2/h6-8H,3-5H2,1-2H3,(H2,14,15,16,17);   InChIKey=YRWLZFXJFBZBEY-UHFFFAOYSA-N;   N-(5-butyl-1H-benzimidazol-2-yl)carbamic acid methyl ester;   PBZ;   SK&F 29044;   SKF-29044;   SKF29044;   SMILES=CCCCC1=CC2=C(NC(NC(=O)OC)=N2)C=C1;   methyl 5-butylbenzimidazole-2-carbamate;   parbendazol;   parbendazolum
 xref: CAS:14255-87-9;   HMDB:HMDB0256126;   KEGG:D05365;   LINCS:LSM-4893
 xref_mesh: MESH:C100292
 xref: PDBeChem:H1C;   PMID:1036798;   PMID:1242825;   PMID:1573698;   PMID:22469223;   PMID:26420877;   PMID:31861153;   PMID:3445963;   PMID:3477162;   PMID:35478655;   PMID:35576703;   PMID:35646536;   PMID:3593136;   PMID:3617427;   PMID:37210557;   PMID:37446147;   PMID:38131223;   PMID:38267545;   PMID:3840535;   PMID:4430805;   PMID:4666441;   PMID:4845733;   PMID:5184664;   PMID:5404541;   PMID:5680252;   PMID:5812439;   PMID:6892671;   PMID:6894647;   PMID:6895936;   PMID:817814


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parbendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO parbendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      application 20621
        pesticide 18478
          nematicide 6506
            antinematodal drug 4718
              parbendazole 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                organic heterocyclic compound 19388
                                  organic heteropolycyclic compound 18651
                                    organic heterobicyclic compound 17545
                                      benzimidazoles 1225
                                        parbendazole 1
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