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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:parbendazole
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Accession:CHEBI:94267 term browser browse the term
Definition:A member of the class of benzimidazoles that is 1H-benzimidazole substituted by (methoxycarbonyl)amino and butyl groups at positions 2 and 5, respectively. It is a potent inhibitor of microtubule assembly and also exhibits anthelminthic activity.
Synonyms:exact_synonym: methyl (5-butyl-1H-benzimidazol-2-yl)carbamate
 related_synonym: 5-butyl-2-(carbomethoxyamino)benzimidazole;   Formula=C13H17N3O2;   Helatac;   Helmatac;   InChI=1S/C13H17N3O2/c1-3-4-5-9-6-7-10-11(8-9)15-12(14-10)16-13(17)18-2/h6-8H,3-5H2,1-2H3,(H2,14,15,16,17);   InChIKey=YRWLZFXJFBZBEY-UHFFFAOYSA-N;   N-(5-butyl-1H-benzimidazol-2-yl)carbamic acid methyl ester;   PBZ;   SK&F 29044;   SKF-29044;   SKF29044;   SMILES=CCCCC1=CC2=C(NC(NC(=O)OC)=N2)C=C1;   methyl 5-butylbenzimidazole-2-carbamate;   parbendazol;   parbendazolum
 xref: CAS:14255-87-9;   HMDB:HMDB0256126;   KEGG:D05365;   LINCS:LSM-4893
 xref_mesh: MESH:C100292
 xref: PDBeChem:H1C;   PMID:1036798;   PMID:1242825;   PMID:1573698;   PMID:22469223;   PMID:26420877;   PMID:31861153;   PMID:3445963;   PMID:3477162;   PMID:35478655;   PMID:35576703;   PMID:35646536;   PMID:3593136;   PMID:3617427;   PMID:37210557;   PMID:37446147;   PMID:38131223;   PMID:38267545;   PMID:3840535;   PMID:4430805;   PMID:4666441;   PMID:4845733;   PMID:5184664;   PMID:5404541;   PMID:5680252;   PMID:5812439;   PMID:6892671;   PMID:6894647;   PMID:6895936;   PMID:817814


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parbendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO parbendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      application 19722
        pesticide 18092
          nematicide 6494
            antinematodal drug 4706
              parbendazole 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            organic molecule 19737
                              organic cyclic compound 19526
                                organic heterocyclic compound 18870
                                  organic heteropolycyclic compound 18315
                                    organic heterobicyclic compound 17265
                                      benzimidazoles 1178
                                        parbendazole 1
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